NANOTECHNOLOGY
·
2014
·Vol. 25
·期 29
·295103
·
IF 3.672
Jun Chen,Xiao-Quan Yang,Yuan-Zheng Meng,Huan-Huan Huang,Meng-Yao Qin,Dong-Mei Yan,Yuan-Di Zhao,Zhi-Ya Ma
Probe bismuth sulfide modified with Pluronic F127 (Bi2S3-PF127), which has high biocompatibility and dispersibility, is synthesized using triblock copolymer Pluronic F127 to modify hydrophobic Bi2S3 nanoparticles that are prepared by a hot injection method. TEM results show that most of the probe has a length of about 14.85 ± 1.70 nm and a breadth of about 4.79 ± 0.63 nm. After injected into the tail vein of a mouse, the probe has obvious CT contrast enhancement capability from x-ray CT imaging results. Meanwhile, the probe's in vivo toxicity is also studied. It is found that hematoxylin and eosin stains of major organs have no change. A biochemical analysis (alanine aminotransferase and aspartate aminotransferase) prove the probe has no adverse effects. The results of a blood analysis (white blood cell count, red blood cell count, hemoglobin, and platelet count) are also normal. The biological distribution of Bi by ICP-AES shows that most of nanoparticles are cleaned out after injection 48 h, and the circulation half-life of the probe is 5.0 h, suggesting that Bi2S3-PF127 has a long circulation and indicating that the Bi2S3-PF127 probe has good biocompatibility and safety.
研究领域:
医学影像学
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纳米医学
·
毒理学
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2026
·
IF 9
Ying Wang,Linlin Geng,Xiaoya Wang,Jianwen Wei,Xuecong Ma,Lei Liao
Amine-modified adsorbents exhibit remarkable potential for efficient CO 2 capture. In this study, a series of amine-based bifunctional solid adsorbents for CO 2 capture was synthesized via an impregnation method. Fe Zr cyanide frameworks were first functionalized with Pluronic F127, followed by the immobilization of diethanolamine (DEA) and tetraethylenepentamine (TEPA) at different loadings (20–40 wt%). Among the resulting materials, FZ(F)-D35% (DEA) and FZ(F)-T35% (TEPA), exhibited the maximum CO 2 adsorption capacity at 45 °C, reaching 1.846 and 2.377 mmol·g −1 . Compared with the unmodified material (FZ), which exhibits an adsorption capacity of 0.989 mmol/g, they increased by 47% and 59%, respectively. After 6 adsorption-desorption cycles, FZ(F)-D35% and FZ(F)-T35% still retained 93.4% and 95.2% of their original capacities, respectively, exhibiting excellent cycling stability. Kinetic analysis indicated that the adsorption process followed the Avrami model (R 2 = 0.999), suggesting a dual mechanism involving both physisorption and chemisorption. Infrared spectroscopy further confirmed the formation of carbamate and hydrogen bonding during the CO 2 adsorption, highlighting the critical synergistic role played by amine groups and hydroxyl groups in the CO 2 adsorption mechanism. It can therefore be inferred that the CO 2 adsorption mechanism is consistent with the zwitterion mechanism. These findings highlight the potential of amine-functionalized Fe Zr cyanide frameworks as robust, regenerable adsorbents for moderate-temperature CO 2 capture.
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高影响因子
Journal of Macromolecular Science Part A-Pure and Applied Chemistry
·
2019
·
IF 1.163
Huayao Chen,Junlong Hu,Hongjun Zhou,Xinhua Zhou,Hua Xu
The triblock copolymer F127 (molecular formula (EO)106(PO)70(EO)106) was adopted as template with TMOS as the silica source. They were hydrolyzed by acidic aqueous solution in which chlorpyrifos (CH) and metal ions (Mn+) were introduced to the products to construct "F127-Mn+-CH" coordination structure in one step. Different sustained release systems were prepared through changing the composition of acidic aqueous solution added during the preparation. The characterization results confirmed the coordination interaction existing among metal ions, mesoporous silica and chlorpyrifos. It was also proved that the chlorpyrifos loaded in the sustained release system existed as amorphous state. According to SEM and TEM observation, the pore of the material presented as face-centered cage-type cubic structure with IM-3M symmetry similar to SBA-16 which is in accordance with N2 adsorption isotherms. The as-synthesized system showed significant pH sensitivity in the sustained release process indicating that the sustained release system can be well stored in neutral environment and activated while sprayed into earth in acid or basic environment. Their sustained release curves can be described by Korsmeyer-Peppas equation in neutral while accords with Higuchi under acid or basic environment.
研究领域:
材料科学
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纳米技术
·
药物递送系统
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环境化学
·
农药制剂
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DOI
高影响因子
POLYMER
·
2021
·
IF 4.43
Jun Yin,Hui-fang Zhang
The block copolymer , Pluronic F127- block -poly(acrylic acid) (PAA-b-F127-b-PAA) was firstly synthesized via RAFT polymerization . Then, the copolymer was utilized as the blending modifier for fabricate polyethersulfone (PES)/PAA-b-F127-b-PAA composite membrane by nonsolvent induced phase separation technique. The hydrophilic PAA segments were concentrated onto the membrane surface due to the surface segregation phenomenon in the membrane formation process, which improved the hydrophilicity of the membrane surface and provided active sites for further surface grafting modification. Subsequently, the amine-terminated poly(sulfobetaine methacrylate) (NH 2 -PSBMA) was prepared through ARGET ATRP and used as surface modifier to fabricate PES/PAA-b-F127-b-PAA/PSBMA composite membrane by amination reaction. The composite membrane exhibited the highest pure water flux and oil flux around 358.25 and 217.53 L m −2 h −1 , which equal to 5.6 times and 19.6 times of unmodified PES membrane respectively. The flux recovery rate increased from 45.74% to 94.64%, suggesting the fouling-resistance of the composite membranes was greatly improved. The hydrophobic PPO segments of PAA-b-F127-b-PAA used as anchor segments and amalgamated with PES molecular by hydrophobic interaction and physical intertwisting, resulting in the PAA-b-F127-b-PAA was firmly embedded in the membrane. Moreover, the PSBMA segments were grafted onto the membrane surface by forming strong chemical bonds, exhibiting excellent stability. It shows that this membrane material prepared by physical blending and surface grafting has a good application prospect in oil/water separation.
研究领域:
材料科学
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环境工程
·
化学工程
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产品关联
DOI
高影响因子
MODERN PHYSICS LETTERS B
·
2023
·
IF 1.9
Bin Wang,Miao Tang,Wanting Li,Wenjing Dong,Xiaowen Ge,Naibao Huang
In order to increase the activity and decrease the cost of oxygen reduction reaction (ORR) catalyst, S self-doped porous carbon nanospheres ORR catalyst was prepared by pyrolyzing the block copolymer F127 grafted with 3-mercapto-propanoicaci. The composition and microstructure were characterized and its electrochemical performance was also investigated in O 2 -saturated 0.1 M KOH solutions. The results showed that, among all the obtained samples, C-S-750 had a porous carbon nanosphere structure with the doped sulfur of 7.08 at % and a maximum specific surface area of 776.3 m 2 /g. The onset potential, half-wave potential and limiting current density of C-S-750 were 0.92 V (versus RHE) and 0.80 V (versus RHE) and 5.77 mA/cm 2 @0.45 V in O 2 -saturated 0.1 M KOH solution, respectively, which were close to that of commercial 20% Pt/C catalysts. This provides a new way to introduce and increase the doped heteroatom in metal-free ORR catalysts.
研究领域:
材料科学
·
电化学
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产品关联
DOI
高影响因子
Advanced Therapeutics
·
2023
·Vol. 7
·期 2
·2300229
·
IF 4.6
Jinyong Wu,Wenjuan Xiao,Shiyu Xu,Lihua Zhao,Zhongzhen Ren,Dechao Niu
Recently, nanomaterials with natural enzymatic activity and photothermal effect offer an alternative pathway to combat bacterial infections and the abuse of antibiotics. Unfortunately, the development of these reported antibacterial nanoagents is always hampered by insufficient enzymatic activity and low photothermal conversion efficiency. To address these issues, herein, novel ultra-small osmium clusters-loaded F127-organosilica micelles (Os@FOMs) are developed as antibacterial nanoagents for efficient infected-wound healing. The preparation of nanoagents mainly involves the confined sol-gel transition of thiol-containing silane coupling agent in the hydrophobic region of F127 micelles and subsequent self-reduction process of osmium salt in the thiols/disulfides-doped organosilica framework. As a promising candidate for bacterial-infected wound healing, Os@FOMs exhibit not only high photothermal conversion efficiency of 70% under 808 nm near infrared (NIR) irradiation, but also display peroxidase (POD)-like activity in acidic conditions, which together contribute excellent antibacterial ability in acidic bacterial infectious microenvironment. On the other hand, Os@FOMs possess good catalase-like effect in neutral or weak alkaline conditions, thus protecting normal tissues from the POD-like protocol with exogenous H 2 O 2 damage for efficient wound healing. It is highly expected that the new noble metal@organosilica-based nanoagents present a promising paradigm to fight antibiotic-resistant pathogens.
研究领域:
生物医学工程
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纳米医学
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材料科学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2015
·
IF 4.321
Nannan Gao,Shaoyu Lü,Chunmei Gao,Xinggang Wang,Xiubin Xu,Xiao Bai,Chen Feng,Mingzhu Liu
Combination chemotherapy as a preferred strategy for cancer treatment has been widely developed recently. However, single drug carriers of the combination chemotherapy systems are difficult to address the performance requirement that delivers hydrophilic and hydrophobic drugs simultaneously. In this work, a smart dual drug delivery system of injectable micelle/hydrogel composite was developed. This smart drug delivery system consists of curcumin (Cur) loaded shell-crosslinked F127 micelle and 5-fluorouracil (Fu) dispersed chitosan/oxidized dextran (CS/ODex) hydrogel. Both of the shell-crosslinked F127 micelle and CS/ODex hydrogel were prepared based on Schiff base bonds, which provides pH-sensitivity and biodegradability for the system. In addition, disulfide bonds were introduced in the shell of F127 micelle, allowing for redox-sensitivity of the system. The system was detailed characterized by 1 H NMR, FTIR, TEM, SEM, DLS and fluorescence spectroscopy. Independent release behaviors of the two drugs are observed under conditions of different precursor concentration, different CS/ODex proportion, different pH and different concentration of DTT. The results show that the drug carrier has pH and redox sensitivity and the release rate can be adjusted by the concentration of the precursor solution. In vitro degradation experiment and cytotoxicity assay determine that the system has good biodegradability and biocompatibility. These results indicated that the injectable shell-crosslinked F127 micelle/hydrogel composite may load and deliver hydrophobic and hydrophilic drugs simultaneously and find application in combination chemotherapy for cancer treatment.
研究领域:
药剂学
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化疗
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药物递送系统
·
生物材料
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Hailong Yang,Hantian Lu,Yueyue Miao,Yang Cong,Yubin Ke,Jun Wang,Hua Yang,Jun Fu
Non-swelling super-tough polymer hydrogels have great potentials for stable applications in wet conditions. It has been challenging since most polymer hydrogels uptake water from the environment and swell, which deteriorates the mechanical strength and toughness. Here, we present multi-responsive non-swelling polymer hydrogels ( PHFGs ) by using amphiphilic triblock copolymer micelles as non-covalent crosslinkers. Pluronic F127 (or polyethylene oxide- block -polypropylene oxide- block -polyethylene oxide, PEO-PPO-PEO) (F-127) micelles are used as a prototype for the synthesis of micelle-crosslinked poly-(2-hydroxyethylene methacrylate) (PHEMA) hydrogels, without using any modification of F-127 or other crosslinkers. FT-IR and 1 H NMR studies provide first evidence that F-127 micelles form extensive hydrogen bonding and hydrophobic association with PHEMA chains. The non-covalent crosslinked hydrogels show a high fracture elongation about 460 %, a fracture strength about 240 kPa, and a fracture toughness about 660 kJ/m 3 . Negligible swelling is observed for the polymer hydrogels in aqueous solutions. The hydrogels are self-healable, and responsive to variations in pH or water content to change volume, shape, and transparency. Such multiple-responsive polymer hydrogels are utilized as smart switches and shape memory materials that are actuated by environmental stimuli in a controllable manner.
研究领域:
材料科学
·
高分子化学
·
智能材料
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DOI
高影响因子
DYES AND PIGMENTS
·
2016
·
IF 4.055
Yue Li,Fengli Zhang,Xiao-Feng Wang,Gang Chen,Xueqi Fu,Wenjing Tian,Osamu Kitao,Hitoshi Tamiaki,Shin-ichi Sasaki
Herein three synthesized chlorophyll derivatives (ZnChl-1, H 2 Chl-2, ZnChl-2) featuring hydrophilic hydroxy/carboxy groups were employed as precursors for fluorescent organic nanoparticles (NPs) with biocompatible Pluronic F127 as the encapsulation matrix for the first time. Such red NPs exhibited broad absorption bands and high hydrophilicity . Three chlorophyll derivatives with different substituent groups show varying degrees of changes after loaded with F127. As a result, ZnChl-2 exhibited the best retainable photoluminescence yield after encapsulation among these chlorophyll derivatives. It reveals that ZnChl-2@F127 is the most suitable NPs for cell imaging by comparing not only different three chlorophyll derivatives, but also free ZnChl-2 and ZnChl-2@F127. Application of ZnChl-2@F127 NPs for cancer cell imaging was successfully demonstrated and such chlorophyll-based NPs showed bright fluorescence signals and low toxicity. These studies indicate that the F127 encapsulated low-costed chlorophyll derivatives NPs are efficient fluorescent dyes for biological imaging. It is further directed towards photodynamic therapy based on chlorophyll derivatives.
研究领域:
生物医学工程
·
材料科学
·
光学成像
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DOI
高影响因子
Tissue Engineering Part A
·
2021
·
IF 3.845
Hang Zhang,Zijie Pei,Changbao Wang,Mingshan Li,Hongtao Zhang,Jing Qu
Tissue engineering (TE) studies for Achilles tendon (AT) defects are a difficult and popular field in orthopedic medical practice. In this study, we applied electrohydrodynamic three-dimensional (3D) printing technology to construct scaffolds made of poly-(ɛ-ɛ-caprolactone) (PCL) and Pluronic F127 (F127) with different mass-volume ratios. The fibers and porous capabilities of the scaffolds were controlled using this technology. We found that F127 improved the hydrophilicity and degradation of PCL in vitro. The PCL scaffolds with 5% F127 were mostly favorable for cell adhesion and growth, suggesting that the scaffolds had good biocompatibility in vitro. Scaffolds with 5% F127 seeded with C3H10T1/2 cells were transplanted into AT defects in rats. A histological analysis indicated that the TE scaffolds were beneficial for the accumulation and arrangement of collagen fibers. Thus, this study provides fundamental experimental data for future clinical applications regarding TE for ATs.Impact statementElectrohydrodynamic three-dimensional (3D) printing can be used to construct tissue-engineered scaffolds with controllable fibers and good porosity. Pluronic-F127 (F127) improved the hydrophilicity and degradation of the poly-(ɛ-ɛ-caprolactone) (PCL), and a better microscale structure was obtained. The scaffolds with 5% F127, with good pore structures, were favorable for C3H10T1/2 cell growth and cellular morphology, indicating that they had good biocompatibility. In vivo transplantation experiments showed that scaffolds with 5% F127 improved the arrangement of collagen fibers, encouraging their potential application in the construction of future tissue-engineered tendons.
研究领域:
骨科
·
组织工程
·
生物医学工程
·
再生医学
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2015
·
IF 4.152
Wei Xu,Xiaohui Fan,Yanli Zhao,Lingbing Li
The aim of the present study is to construct a cysteine modified polyion complex micelles made of Pluronic F127-chitosan (PF127-CS), Pluronic F127-cysteine (PF127-cysteine) and sodium cholate (NaC) and to evaluate the potential of the micelles as an oral drug delivery system for paclitaxel. Systematic studies on physicochemical properties including size distribution, zeta-potential and morphology were conducted to validate the formation of micelle structure. Compared with Pluronic micelles, drug-loading capacity of PF127-CS/PF127-cysteine/NaC micelles was increased from 3.35% to 12.77%. Both the critical micelle concentration and the stability test confirmed that the PF127-CS/PF127-cysteine/NaC micelles were more stable in aqueous solution than sodium cholate micelles. Pharmacokinetic study demonstrated that when oral administration the area under the plasma concentration–time curve (AUC 0–∞ ) and the absolute bioavailability of paclitaxel-loaded micelles were five times greater than that of the paclitaxel solution. In general, PF127-CS/PF127-cysteine/NaC micelles were proven to be a potential oral drug delivery system for paclitaxel.
研究领域:
药剂学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Chengdong Li,Lingfeng Li
PA/F127 co-assembly forms robust Si–O–P bonds and uniform microstructure in silica xerogels. • Xerogels integrate high strength, monolithicity, self-extinguishing ability, and thermal insulation. • PA's dual role enables rapid gelation, bypassing conventional slow acid-catalyzed growth. • Excellent fire resistance with minimal flame damage outperforms commercial silica aerogel sheets. • A green, additive-free strategy overcomes the flame-retardancy vs. mechanical-integrity trade-off. Conventional flame-retardant additives often raise environmental and health concerns due to their toxicity and persistence. Developing high-performance, inherently fire-resistant silica xerogel monoliths via scalable ambient pressure drying remains a significant challenge, as mechanical robustness, monolithic integrity, and flame retardancy are typically mutually exclusive. This study addresses this issue by introducing a green and synergistic strategy using bio-derived phytic acid (PA) and the amphiphilic block copolymer Pluronic F127 to direct the sol-gel co-assembly of a methyltrimethoxysilane/tetraethoxysilane (MTMS/TEOS) system. PA serves dual roles: as a potent biobased acid catalyst, it accelerates precursor hydrolysis, and as a non-toxic, multidentate cross-linker, it forms persistent Si–O–P bonds that chemically reinforce the silica network. F127 acts as a microstructure director, templating a homogeneous gel network with robust inter-particle connectivity. This cooperative action enables rapid gelation (within 1–20 min) and yields monolithic phosphorus-incorporated silica (P-silica) xerogels. The optimized material exhibits excellent mechanical performance (compression strength = 0.140 MPa, strain = 60.3%), outstanding thermal stability (90.3 wt% residual mass at 1000 °C), and superior fire resistance, showing immediate self-extinguishment and minimal damage upon direct flame impingement. It also provides effective thermal insulation, surpassing commercial silica aerogel sheets at a thickness of 3 mm. By replacing conventional hazardous flame retardants with benign, biobased PA and achieving a unique property synergy, this work presents a viable and environmentally sound design principle for advanced thermal insulation materials in fire-risk environments, contributing to safer and more sustainable material solutions. Download: Download high-res image (123KB) Download: Download full-size image
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高影响因子
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