Polymer Chemistry
·
2025
·
IF 3.9
Yanlin Wang,Fan Rong,Xiaoyi Sun,Duohang Bi,Yin Wang,Yijing Liu,Jintao Zhu
Psoriasis is a common chronic skin disease. Current psoriasis treatments face challenges such as low drug bioavailability and side effects. Hydrogen sulfide (H2S) can be a potential therapeutic for psoriasis, while developing an effective delivery system and a controlled release strategy is essential to guarantee its efficacy and safety. We report a responsive microneedle (MN)-mediated transdermal H2S gas therapy for treating psoriasis. The phenylboronic acid-modified hyaluronic acid (HP) and a peptide H2S donor (AlaCOS) are synthesized, which assemble into H2S donating nanoparticles (HP-AC NPs). The HP-AC NPs efficiently release AlaCOS in aqueous solution or acidic conditions, which can further release H2S triggered by aminopeptidase N (APN) and carbonic anhydrase (CA). Moreover, the HP-AC NPs can effectively downregulate the pro-inflammatory cytokines in macrophages. Furthermore, the HP-AC NP-loaded MNs (HP-AC MN) are prepared with sufficient mechanical strength to penetrate the stratum corneum barrier. In the psoriatic mouse model, the mice receiving the HP-AC MN treatment exhibit decreased epidermal thickness, reduced levels of pro-inflammatory cytokines, and induced M2 polarization of macrophages. This MN-mediated H2S gas therapy represents a promising alternative for treating psoriasis.
研究领域:
皮肤病学
·
纳米医学
·
药物递送系统
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2018
·
IF 3.716
Xue Xiong,Meiling Qi
This work describes the separation performance of utilizing hexagonal boron nitride (h-BN) as the stationary phase for capillary gas chromatography (GC). The statically coated h-BN column showed moderate polarity and achieved column efficiencies of 3455 plates/m and 3800 plates/m for naphthalene and n -dodecane, respectively. With temperature-dependent structure properties, the h-BN stationary phase exhibited stronger retention for polycyclic aromatic hydrocarbons (PAHs) over phthalic acid esters (PAEs) and showed advantageous separation performance over the g-C 3 N 4 and commercial polysiloxane stationary phases. Moreover, it displayed preferential retention for halogenated analytes and high resolution performance for structural and positional isomers. In addition, the h-BN column showed good column repeatability with relative standard deviation (RSD) values of 0.03%–0.07% for run-to-run, 0.31%–0.71% for day-to-day and 2.6%–5.3% for column-to-column, respectively, and thermal stability up to 260 °C.
研究领域:
分析化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2024
·Vol. 36
·期 36
·2309572
·
IF 27.4
Bo Wang,Wen-tai Zhao,Xiao Xu,Chen Zhang,Shuai-ying Ding,Yue Zhang,Tie Wang
The construction of ultrathin porous membranes with stable structures is critical for achieving efficient gas separation. Inspired by the binary-cooperative structural features of bones and teeth—composed of rigid hydroxyapatite and flexible collagen, which confer excellent mechanical strength—a binary-cooperative porous membrane constructed with gel-state zeolitic imidazolate frameworks (g-ZIFs), synthesized using a metal-gel-induced strategy, is proposed. The enlarged cavity size and flexible frameworks of the g-ZIF nanoparticles significantly improve gas adsorption and diffusion, respectively. After thermal treatment, the coordination structures forming rigid segments in the g-ZIF membranes appear at the stacked g-ZIF boundaries, exhibiting a higher Young's modulus than the g-ZIF nanoparticles, denoted as the flexible segments. The g-ZIF membranes demonstrate excellent tensile and compression resistances, attributed to the effective translation of binary-cooperative effects of rigidity and flexibility into the membranes. The resulting dual-aperture structure, composed of g-ZIF nanoparticles surrounded by nanoscale apertures at the boundaries, yields a membrane with a stable CO 2 permeance of 4834 GPU and CO 2 /CH 4 selectivity of 90 within 3.0 MPa.
研究领域:
材料科学
·
化学工程
·
膜技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Fangrong Qin,Muhammad Amin Padhiar,Shusheng Pan,Noor Zamin Khan,Yongqiang Ji,Sayed Ali Khan,Jahangeer Ahmed,Shaolin Zhang
All inorganic perovskite nanocrystals (NCs) have emerged as versatile materials for gas sensing due to their tunable optical properties and high surface-to-volume ratios. However, CsPbCl3 has limitations when it comes to gas sensing. In this study, we explore the potential of Mn2+-doped CsPbCl3 NCs as a room-temperature sensing platform for ammonia (NH3) gas detection. By incorporating Mn2+ dopants into the CsPbCl3 lattice, we enhance the sensitivity of the NCs to NH3 gas. Additionally, NH3 molecules interact with the NCs, leading to the dynamic passivation of Cl– vacancies. We systematically investigate the sensing performance of Mn:CsPbCl3 NCs by using varying NH3 concentrations, different exposure conditions, and exposure cycles, revealing a reversible and concentration-dependent response. The sensor based on Mn2+-doped CsPbCl3 NCs has good selectivity for NH3 at room temperature, showing a higher sensitivity (2.12 at 100 ppm) than the pure CsPbCl3 NC sensor (1.10 at 100 ppm), and good repeatability. The unique optical properties of Mn:CsPbCl3 NCs, coupled with their responsiveness to NH3, make them promising candidates for developing efficient and cost-effective room-temperature NH3 gas sensors. This work contributes to the advancement of NC-based gas sensing technologies and highlights the potential of Mn-doped CsPbCl3 NCs in environmental monitoring, industrial safety, and other gas sensing applications.
研究领域:
材料科学
·
传感器技术
·
环境监测
✓ 已验证
产品关联
DOI
高影响因子
LAB ON A CHIP
·
2024
·Vol. 24
·期 14
·3556-3567
·
IF 6.1
Shi-Hao Yang,Wan-Lu Song,Lin-Ling Fan,Chuan-Fu Deng,Rui Xie,Wei Wang,Zhuang Liu,Da-Wei Pan,Xiao-Jie Ju,Liang-Yin Chu
A facile strategy for efficient and continuous fabrication of monodisperse gas-core microcapsules with controllable sizes and excellent ultrasound-induced burst performances is developed based on droplet microfluidics and interfacial polymerization. Monodisperse gas-in-oil-in-water (G/O/W) double emulsion droplets with a gas core and monomer-contained oil layer are fabricated in the upstream of a microfluidic device as templates, and then water-soluble monomers are added into the aqueous continuous phase in the downstream to initiate rapid interfacial polymerization at the O/W interfaces to prepare monodisperse gas-in-oil-in-solid (G/O/S) microcapsules with gas cores. The sizes of both microbubbles and G/O/W droplet templates can be precisely controlled by adjusting the gas supply pressure and the fluid flow rates. Due to the very thin shells of G/O/S microcapsules fabricated via interfacial polymerization, the sizes of the resultant G/O/S microcapsules are almost the same as those of the G/O/W droplet templates, and the microcapsules exhibit excellent deformable properties and ultrasound-induced burst performances. The proposed strategy provides a facile and efficient route for controllably and continuously fabricating monodisperse microcapsules with gas cores, which are highly desired for biomedical applications.
研究领域:
材料科学
·
生物医学工程
·
微流控技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Chemistry
·
2026
·
IF 20.2
Wang Wentao,Li Weihong,Yu Fengjiao,Pu Qihao,Miao Jinguo,Han Shaojie,Wu Yuping,Chen Liwei,Shen Yanbin,Chen Yuhui
LiFe x Mn 1 − x PO 4 positive electrode materials show significant potential for enhancing battery safety, power density and cost-effectiveness. However, gas evolution shortens the cyclability and raises additional safety concerns, presenting a major challenge. The gas evolution mechanisms in LiFe x Mn 1 − x PO 4 batteries are poorly understood, impeding the material improvement efforts. Here we examine a LiFe x Mn 1 − x PO 4 -graphite full cell, simultaneously quantifying and probing gas evolution from positive and negative electrodes. We found over 90% of the evolved gas was composed of CO 2 and H 2 . CO 2 originated from side reactions at LiFe x Mn 1 − x PO 4 , with almost equal contributions from electrochemical and chemical pathways. H 2 resulted from chemical side reactions at the graphite’s solid–electrolyte interface and was closely associated with the dissolution of Mn/Fe ions from the LiFe x Mn 1 − x PO 4 . We developed a LiFe x Mn 1 − x PO 4 with a dense carbon layer coating, which inhibited metal ion dissolution by an order of magnitude and minimized side reactions at both electrodes. A 4.1-Ah pouch cell exhibited stable performance over 540 cycles with over 90% capacity retention.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
·
2026
·
IF 9.4
Yonghua Wang,Xueyan Zhao,Qian Zhang,Jingze Xue,Jinkai Xu,Huadong Yu,Luquan Ren
Hydrodynamic drag in marine engineering leads to high fuel consumption, increased emissions, and diminished operational efficiency. Superhydrophobic surfaces (SHS) are widely used for drag reduction, yet maintaining stable air films remains challenging. To overcome this challenge, we fabricated a grooved-microporous superhydrophobic surface (GMSHS) via nanosecond laser processing. Compared to its non-grooved microporous counterpart (MSHS), the GMSHS demonstrated superior hydrophobic durability, enhanced pressure resistance, and a maximum water contact angle of 160.3° ± 1.6°. Our investigation further revealed a nonlinear relationship between the gas injection rate and the drag reduction rate. By optimizing the injection parameters to balance air film stability with turbulence suppression, a maximum drag reduction of 32% was achieved. Additionally, simulation results confirmed that the GMSHS is more effective in trapping and retaining gas. The optimal efficiency for unidirectional gas permeation occurred with a conical pore taper angle of 15°. This work offers a viable strategy for sustained drag reduction on high-speed marine vessels.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2020
·
IF 0
Qi Hu,Jiaqi He,Junyu Chang,Jianmei Gao,Jiahui Huang,Liang Feng
The accurate and rapid monitoring of triethylamine (TEA) is highly desired for human health, environmental protection, and food safety. Herein, we have fabricated a WO3 sample with a morphology of needle-shaped nanorods via a simple hydrothermal method and subsequent calcination. The WO3 needle-shaped nanorods with 5 μm length and 400 nm diameter possess a uniform and homogeneous morphology, which avails large-scale industrialization. The sensing based on needle-shaped WO3 nanorods exhibits an ultrasensitive response to TEA, with a response up to 6.7 toward 1 ppm TEA at 250 °C. The outstanding selectivity and repeatability are observed as well. The excellent sensing performance is tentatively attributed to the uniform and large-scale morphology, highly active C–N bonds in TEA, and the effective interaction between WO3 and TEA. Furthermore, the sensor is directly employed to monitor the TEA given off from a grass carp in 48 h, and a good linearity (R2 = 0.996) between the response and preserving time is obtained, proving its promising prospect in daily use. The architecture strategy opens an available route for large-scale practical fabrication of WO3 needle-shaped nanorods, and it is a pioneering attempt to apply the sensor for trace TEA detection in marine food safety testing.
研究领域:
材料科学
·
环境科学
·
传感器技术
✓ 已验证
产品关联
DOI
ACS Applied Nano Materials
·
2021
·
IF 5.097
Meng Wu,Yipeng An,Ru Yang,Zhenhua Tao,Qixun Xia,Qianku Hu,Mian Li,Ke Chen,Zhanying Zhang,Qing Huang,Shu-hong Ma,Aiguo Zhou
In this paper, the performance and fundamental mechanisms on gas sensing of V2CTx and Ti3C2Tx MXenes were investigated. The MXenes nanosheets with the same chemical composition can show positive or negative response to the same gas due to the change of surface chemistry, which, in turn, is affected by the etching solution to make the samples. The residual Li or Na atoms on the surface of MXenes have a weak impact on the gas sensing performance; however, the ratio of Cl/F has a strong impact. V2CTx made in HF showed positive/zero response to the eight gases tested in this paper and had excellent sensing performance to methane. However, V2CTx made in LiF+HCl showed negative/zero response, while that made in NaF+HCl displayed positive response only to formaldehyde. Ti3C2Tx made in NaF+HCl showed a positive response to all detected gases while that made in ZnCl2 had better gas detection ability but showed a negative response to ammonia, triethylamine, and toluene. On the basis of the theoretical simulations, the structure-sensitive sensing behavior of MXenes as gas sensors is mainly ascribed to the structure-dependent electron transmission mechanism upon adsorbed gas molecule. This study is significant to the application of MXene sensors for designing specific gases.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
CARBON
·
2021
·
IF 9.594
Jian Liu,Xin Li,Lingie Zhang,Xiangyang Liu,Xu Wang
The transformation of graphene into sp 3 -bonded carbon films through ultra-high pressure, hydrogenation or fluorination has been studied for years. It is considered that only few layers of graphenes on metal surfaces can realize this transformation and the electron orbitals hybridization between metal substrate and graphene layer is thought to be the drving force and stabilize the formed sp 3 carbon structure. Here, we use nanographene molecule, hexa-peri-hexabenzocoronene (HBC), as the model compound to exploit the fluorination reaction between graphene and fluorine gas. MALDI-TOF mass, XPS and XRD results show that the direct fluorination realized the intermolecular cross-linking of nanographene molecules without the assistence of mental substrate. Combining with theoretical calculation and EPR test results, we proved that the fluorination of nanographene molecules with F 2 follows a free-radical mechanism, and the carbon radicals formed during fluorination caused the covalent cross-linking between graphene molecules which have a tight π-π stacking. Meanwhile, the fluorination of other small nanographene molecules, pyrene and perylene, further confirmed the universality of this free-radical cross-linking mechanism. This would provide a further understanding for the chemical transformation from graphene layers to 2D diamond structure under chemical adsorption process.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Sensors
·
2020
·
IF 7.333
Hui Zhi,Jianmei Gao,Liang Feng
In this study, an innovative gas sensing mechanism, self-responsive sensing mechanism, has been detected in the supramolecular hydrogel-based sensors. The self-responsive ability of as-fabricated hydrogel-based sensors to the target gas (e.g., NO2, NH3, etc.) is determined by three synergetic supramolecular interactions, namely, hydrogen bonding, molecule crystallization, and electrostatic interactions existing in hydroxyls, poly(vinyl alcohol) (PVA) crystallization, and poly(ionic liquids) of the intrinsic hydrogel networks, respectively. On account of unique synergetic supramolecular interactions, the sensors not only exhibit a rapid, reversible, and reproducible response but also show good tensile and compressive properties and excellent recovery property. The results demonstrate the potential of the self-responsive sensing mechanism as a pathway to realize a new generation of highly responsive hydrogel-based gas sensors.
研究领域:
材料科学
·
化学传感器
·
超分子化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2020
·
IF 3.594
Ji Yang,Zuogang Zhu,Jinsheng Feng,Min Xue,Zihui Meng,Lili Qiu,Nyv Mondele Mbola
Colorimetric sensors were fabricated by embedding three dimensional (3D) inverse opal photonic crystal (IOPC) structure inside a dimethyl sulfoxide (DMSO) infiltrated carboxymethyl cellulose membrane for gas sensing. The DMSO infiltrated IOPC (DMSO-IOPC) carboxymethyl cellulose sensors can perform visual, on-site monitoring for analytes including alcohols, acetone and hydrogen peroxide (H 2 O 2 ). After exposed to alcohols and acetone, the mean effective refractive index (RI) and lattice constant of DMSO-IOPCs were changed, which led to a redshift of diffraction peak of the incident light. Sequentially their structural color changed remarkably. The limit of detection (LOD) for methanol and ethanol vapors are 110 ppm and 102 ppm, respectively. The H 2 O 2 sensor is also achieved by using DMSO-IOPCs, and the diffraction blue-shifted when they were exposed to H 2 O 2 vapor. In addition, this DMSO-IOPC sensor shows excellent selectivity and reversibility. The sensing mechanism of the DMSO-IOPC membranes was explained and simulated using finite-different time-domain (FDTD) method, and the experimental results were consistent with the simulated results. The DMSO-IOPCs demonstrate promising potential for in-situ monitoring of alcohol vapors, and could be used for peroxides detection and as a cheap and minimally invasive breathalyzer.
研究领域:
材料科学
·
化学传感
·
光学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）