INORGANICA CHIMICA ACTA
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2020
·
IF 2.304
Chanchan Xu,Yuzhe Li,Le Lv,Fang Lin,Feng Lin,Zhijuan Zhang,Chaoyun Luo,Dawei Luo,Wei Liu
Two new copper bromide based coordination compounds 0D-Cu 2 Br 2 (3,5-dimethyl-pyridine) 4 ( 1 ) and 1D-Cu 2 Br 2 (5-bromo-pyrimidine) 2 ( 2 ) have been synthesized and structurally characterized. X-ray diffraction analyses reveal that the inorganic module of both compounds is Cu 2 Br 2 rhomboid dimer coordinated by the organic ligands. Compound 1 is a zero-dimensional (0D) molecular complex while compound 2 is one-dimensional (1D) extended structure. Photoluminescence measurement results show that 1 emits green photoluminescence peaked at 520 nm, with an IQY of 82.4%. Compound 2 emits red photoluminescence peaked at 630 nm, with an IQY of 2.1%. Both compounds exhibit potential as rare-earth metal free lighting phosphor alternatives.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
·
IF 8.2
Cuicui Ding,Mengdie Tian,Yue Wang,Kuan Cheng,Yifan Yi,Min Zhang
The effect of carbohydrates on collagen self-assembly behavior has been widely investigated because of their regulation on collagen fibrogenesis in vivo. In this paper, β-cyclodextrin (β-CD) was selected as an external disturbance to explore its intrinsic regulating mechanism on collagen self-assembly. The results of fibrogenesis kinetics indicated that β-CD had a bilateral regulation on collagen self-aggregation process, which was closely related to the content of β-CD: collagen protofibrils with low β-CD content were less aggregated compared to collagen protofibrils with high β-CD content. However, typical periodic stripes of ~67 nm on collagen fibrils were observed from transmission electron microscope (TEM), indicating that β-CD did not disturb the lateral arrangement of collagen molecules to form a 1/4 staggered structure. Correspondingly, the degree of aggregation of collagen self-assembled fibrils was closely correlated with the addition of β-CD content, as confirmed by field emission scanning electron microscopy (FESEM) and atomic force microscope (AFM). In addition, collagen/β-CD fibrillar hydrogel had good thermal stability and cytocompatibility. These results provide a better understanding of how to construct a structurally reliable collagen/β-CD fibrillar hydrogel as a biomedical material in a β-CD-regulated environment.
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MICROPOROUS AND MESOPOROUS MATERIALS
·
2022
·
IF 5.876
Erjian Huang,Yueyang Xu,Yachun Ren,Peng Zhang,Yongping Zeng
Faujasite (FAU)-type zeolites are promising adsorbents for the removal of sulfides from fuels, but their micropores are not capable to accommodate the large-sized thiophenic compounds. FAU zeolites (NaX and NaY with the low and high Si:Al ratios, respectively) with hierarchical micro/mesoporous structures were synthesized by sequential acid-base treatment to enhance the adsorption capacity and reduce the limitations of diffusion for the sulfides. To further to improve the desulfurization performance, the hierarchical structure of FAU zeolites containing Cu + were prepared by ion-exchange and methanol vapor-induced reduction methods at a relatively low temperature (473 K). For the large-sized benzothiophene , both the HP-Cu(I)Y and HP-Cu(I)X zeolites with mesopores have a very high adsorption capacity, reaching 51.8 mg S/g and 56.1 mg S/g, respectively. In addition, the results show that HP-Cu(I)X has a higher adsorption capacity than that of some other FAU-type adsorbents reported.
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MATERIALS CHEMISTRY AND PHYSICS
·
2023
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IF 4.6
Wenjuan Zhang,Yuheng Li,Yaxian Wang,Youliang Wang,Miao Kou,Xiangyue Yang,Qianqian Chu,Kun Zhao
An efficient route is proposed to synthesize a novel three-dimensional (3D) magnetic MXene aerogel (3D MXene/Fe 3 O 4 ). 3D MXene were synthesized by self-assembly of 2D MXene Ti 3 C 2 T x using ethylenediamine (EDA) as crosslinking inducer, then Fe 3 O 4 was in situ coprecipitation onto 3D MXene. 3D MXene/Fe 3 O 4 was applied as an adsorbent for Ag(I) removal from aqueous solutions. 3D MXene/Fe 3 O 4 exhibits a cross-linked 3D porous network with magnetic Fe 3 O 4 nanoparticles uniformly dispersed on its surface and edges. The maximum adsorption capacity of 3D MXene/Fe 3 O 4 for Ag(I) was 2385 mg g −1 . The kinetics and isothermal process during adsorption were described accurately by the pseudo-second-order model and the Freundlich isotherm model, and the adsorption process was driven by chemisorption and multilayer adsorption, where the diffusion mechanism involved surface diffusion and intraparticle diffusion. Furthermore, the 3D MXene/Fe 3 O 4 are recyclable, retaining 71% of the initial removal rate after 5 adsorption/desorption cycles.
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PHYTOMEDICINE
·
2022
·
IF 6.656
Qianqian Jiang,Xu Chen,Xue Tian,Jingmei Zhang,Siming Xue,Yanyan Jiang,Tiantian Liu,Xiaoping Wang,Qianbin Sun,Yiqin Hong,Chun Li,Dongqing Guo,Yong Wang,Qiyan Wang
Background Doxorubicin (DOX) is a powerful anti-tumor anthracycline drug . However, its clinical use is limited due to the side effect of cardiotoxicity . Tanshinone I (Tan I) is one of the major tanshinones isolated from Salvia miltiorrhiza . Studies have shown that Tan I is effective in the treatment of cardiovascular diseases. However, the potential effects of Tan I against DOX-induced cardiotoxicity (DIC) have yet to be explored. Purpose This study aimed to explore whether Tan I can protect against DIC and to reveal whether Tan I can exert anti-oxidative effect by regulating nuclear erythroid factor 2-related factor 2 (Nrf2) pathway. Methods DIC models were established in vivo by intravenous injection of DOX. Echocardiography was used to monitor the cardiac function of mice. Transmission electron microscopy was used to assess mitochondrial damage. Oxidative stress was measured by dihydroethidium (DHE) staining and western blotting . The accumulation and nuclear translocation of Nrf2 was detected by immunofluorescence. H9C2 cellular DIC model was established in vitro to explore the pharmacological mechanism. Nrf2 small interfering (si)-RNA was applied to H9C2 cells to explore whether Tan I exerted protective effect against DIC through Nrf2 signaling pathway . The protective effects of Tan I on mitochondrial function and mitochondrial membrane permeability were measured by MitoSOX™ Red and JC-1 staining assays, respectively. Results In vivo experiments revealed that Tan I could improve cardiac function and protect against DOX-induced myocardial structural damages in mice models. The oxidative stress induced by DOX was suppressed and apoptosis was mitigated by Tan I treatment. Tan I protected against DOX-induced mitochondrial structural damage. Meanwhile, key proteins in Nrf2 pathways were upregulated by Tan I treatment. In vitro studies showed that Tan I attenuated DOX-induced generation of reactive oxygen species (ROS) in cultured H9C2 cells, reduced apoptotic rates , protected mitochondrial functions and up-regulated Nrf2 signaling pathway. Tan I promoted accumulation and nuclear translocation of Nrf2 protein. In addition, interference of Nrf2 abrogated the anti-oxidative effects of Tan I and reversed the expressions of key proteins in Nrf2 pathway. The protective effects of Tan I on mitochondrial integrity was also mitigated by Nrf2 interference. Conclusion Tan I could reduce oxidative stress and protect against DIC through regulating Nrf2 signaling pathway. Nrf2 is a potential target and Tan I is a novel candidate agent for the treatment of DIC.
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NUCLEIC ACIDS RESEARCH
·
2022
·Vol. 50
·期 10
·5850-5863
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IF 19.16
Lei Yixuan,Fei Panyu,Song Bin,Shi Wenjia,Luo Cheng,Luo Dahai,Li Dan,Chen Wei,Zheng Jie
DDX58 encodes RIG-I, a cytosolic RNA sensor that ensures immune surveillance of nonself RNAs. Individuals with RIG-IE510V and RIG-IQ517H mutations have increased susceptibility to Singleton-Merten syndrome (SMS) defects, resulting in tissue-specific (mild) and classic (severe) phenotypes. The coupling between RNA recognition and conformational changes is central to RIG-I RNA proofreading, but the molecular determinants leading to dissociated disease phenotypes remain unknown. Herein, we employed hydrogen/deuterium exchange mass spectrometry (HDX-MS) and single molecule magnetic tweezers (MT) to precisely examine how subtle conformational changes in the helicase insertion domain (HEL2i) promote impaired ATPase and erroneous RNA proofreading activities. We showed that the mutations cause a loosened latch-gate engagement in apo RIG-I, which in turn gradually dampens its self RNA (Cap2 moiety:m7G cap and N1-2-2′-O-methylation RNA) proofreading ability, leading to increased immunopathy. These results reveal HEL2i as a unique checkpoint directing two specialized functions, i.e. stabilizing the CARD2-HEL2i interface and gating the helicase from incoming self RNAs; thus, these findings add new insights into the role of HEL2i in the control of antiviral innate immunity and autoimmunity diseases.
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ACS Applied Electronic Materials
·
2022
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IF 4.494
Jiakun An,Gaoyu Chen,Xia Zhu,Xin Lv,Jianchun Bao,Xiangxing Xu
All-inorganic perovskite CsPbX3 (X = Cl, Br, and I) quantum dots (QDs) are emerging as attractive materials for photodetectors due to their prominent positive photoresponse. In this work, ambipolar photodetectors were constructed based on heterojunctions of CsPbX3 QDs and ZnO nanocrystals (NCs). The transition between the positive photoconductivity (PPC) and negative photoconductivity (NPC) was successfully controlled not only by the drain-source voltage (VDS) but also by the excitation wavelength and CsPbX3 crystal size. A high responsivity (R), on–off ratio (η), and detectivity (D*) were achieved for NPC (R = 1046 mA/W, η = 281, and D* = 1.65 × 1011 Jones), with PPC (R = 146 mA/W, η = 64, and D* = 1.54 × 1011 Jones) simultaneously revealed in the same device. A general mechanism combining the type-II heterojunction, the component and size-related band structure, and most critically the in-band trap states of the perovskites was established for understanding the unique ambipolar property. It exhibits application potential in developing functional photodetectors, memristors, and optical logic devices.
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Materials
·
2023
·Vol. 16
·期 21
·7007
·
IF 3.4
Yuzhe Wang,Yueqi Zhong,Jiangzhi Zi,Zichao Lian
Conventional single-component quantum dots (QDs) suffer from low recombination rates of photogenerated electrons and holes, which hinders their ability to meet the requirements for LED and laser applications. Therefore, it is urgent to design multicomponent heterojunction nanocrystals with these properties. Herein, we used CdSe quantum dot nanocrystals as a typical model, which were synthesized by means of a colloidal chemistry method at high temperatures. Then, CdS with a wide band gap was used to encapsulate the CdSe QDs, forming a CdSe@CdS core@shell heterojunction. Finally, the CdSe@CdS core@shell was modified through the growth of the ZnS shell to obtain CdSe@CdS@ZnS heterojunction nanocrystal hybrids. The morphologies, phases, structures and performance characteristics of CdSe@CdS@ZnS were evaluated using various analytical techniques, including transmission electron microscopy, X-ray diffraction, UV-vis absorption spectroscopy, fluorescence spectroscopy and time-resolved transient photoluminescence spectroscopy. The results show that the energy band structure is transformed from type II to type I after the ZnS growth. The photoluminescence lifetime increases from 41.4 ns to 88.8 ns and the photoluminescence quantum efficiency reaches 17.05% compared with that of pristine CdSe QDs. This paper provides a fundamental study and a new route for studying light-emitting devices and biological imaging based on multicomponent QDs.
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Journal of Materials Chemistry A
·
2020
·Vol. 8
·期 19
·9951-9962
·
IF 11.301
Yuemei Li,Jia Liu,Xiaodong Wan,Rongrong Pan,Bing Bai,Hongzhi Wang,Xingzhong Cao,Jiatao Zhang
Cation exchange has evolved into a powerful tactic for synthesis of semiconductor nanocrystals (NCs) that are not readily accessible otherwise. Here we have investigated the In3+-for-Cu+ cation exchange in the dodecahedral-shaped Cu7S4 NCs and found that surface passivation, either caused by excess guest cations or ligand molecules, can be exploited to engineer the structural properties of the NCs. By monitoring the parallel reactions carried out under systematically varied conditions, together with the positron annihilation spectroscopy investigation, we have demonstrated that the key element accounting for the observed surface passivation is associated with the copper vacant sites on the surface of Cu7S4 NCs. The reduction in In3+/Cu+ ratio and the presence of strong-binding ligands could enhance the density of surface copper vacancies and boost cation exchange reaction, which therefore alters the competition between the in-diffusion of In3+ and out-diffusion of Cu+ ions. Such capability to control the inter-diffusion balance in cation exchange (and the accompanying Kirkendall effect) enables the creation of a series of CuInS2 (and Cu7S4@CuInS2) NCs with various exotic structures, which show different photocatalytic abilities in singlet oxygen generation. This study can not only add more structural complexity and diversity to the semiconductor NCs achievable by cation exchange, but also presents an important guideline for establishing a unifying mechanistic understanding of the reaction kinetics in cation exchange process.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Yun Gao,Tong Xuan,Fu Chen,Yiping Wu,Xiaoyu Guo,Ying Wen,Haifeng Yang
As one of the most potent carcinogens, aristolochic acid I (AAI) can be founded in many plants, which are widely used as raw materials in traditional Chinese medicine. Surface enhanced Raman scattering (SERS) method would be developed to detect the AAI in rapid way. However, hydrophobic AAI molecule with small scattering section hardly approaches onto the surface of metal nanoparticles, resulting in poor Raman detection sensitivity. In this work, bovine serum albumin (BSA) decorated silver nanoparticles (Ag NPs) with core-shell structure (Ag@BSA NPs) are successfully synthesized. The molecular docking induced strong interaction between BSA and AAI is validated by molecular simulation and Ag@BSA NPs could actively capture AAI and anchor the target molecule into the hot spots of Ag NPs, which greatly improves SERS response of AAI. The dynamic linear range for SERS detection of AAI is from 0.5 to 50 μM (R 2 = 0.9910) and the lowest detectable concentration of 0.28 μM is reached, which meeting the strict limitation of national standard regulation for AAI in cosmetic products. In addition, the method is applied for AAI determination in skin care products and good results are achieved.
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Drug Design Development and Therapy
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2018
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IF 2.935
Ankit Parikh,Krishna Kathawala,Chun Chuan Tan,Sanjay Garg,Xin-Fu Zhou
Background Edaravone (EDR) is known for its free radical scavenging, antiapoptotic, antinecrotic, and anticytokine effects in neurological and non-neurological diseases. It is currently available clinically as Radicava® and Radicut®, intravenous medications, recently approved for the treatment of amyotrophic lateral sclerosis and cerebral infarction. However, the oral use of EDR is still restricted by its poor oral bioavailability (BA) due to poor aqueous solubility, stability, rapid metabolism, and low permeability. The present study reports the development of novel EDR formulation (NEF) using self-nanomicellizing solid dispersion (SNMSD) strategy with the aim to enable its oral use.Materials and methods The selection of a suitable carrier for the development of NEF was performed based on the miscibility study. The optimization of EDR-to-carrier ratio was conducted via kinetic solubility study after preparing SNMSDs using solvent evaporation technique. The drug–polymer carrier interaction and self-nanomicellizing properties of NEF were investigated with advanced characterization studies. In vitro permeation, metabolism, and dissolution study was carried out to examine the effect of the presence of a carrier on physico-chemical properties of EDR. Additionally, the dose-dependent pharmacokinetic study of NEF was conducted and compared with the EDR suspension.Results Soluplus® (SOL) as a carrier was selected based on the potential for improving aqueous solubility. The NEF containing EDR and SOL (1:5) resulted in the highest enhancement in aqueous solubility (17.53-fold) due to amorphization, hydrogen bonding interaction, and micellization. Moreover, the NEF demonstrated significant improvement in metabolism, permeability, and dissolution profile of EDR. Furthermore, the oral BA of NEF showed 10.2-, 16.1-, and 14.8-fold enhancement compared to EDR suspension at 46, 138, and 414 µmol/kg doses.Conclusion The results demonstrated that SNMSD strategy could serve as a promising way to enhance EDR oral BA and NEF could be a potential candidate for the treatment of diseases in which oxidative stress plays a key role in their pathogenesis.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
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IF 2.7
Yujie Qi,Haoqi Zhai,Xing Huang,Mengquan Shi,Yuxi Zhang,Yuxia Zhao
As the largest renewable source of aromatic feedstock in nature, lignin has good thermal stability, strong ultraviolet (UV) absorption, and mechanical reinforcing property. In this study, a lignin-based Type I macromolecular photoinitiator (macro PI) named DAL-11ene-TPO is designed and synthesized through covalently grafting 10-undecenoyl chloride (11ene) and 2,4,6-trimethylbenzoyl-ethoxy-phenylphosphine oxide (TPO-L, a commercial small molecular PI) into dealkaline lignin (DAL) skeleton. A series of characterizations were performed to prove that DAL-11ene-TPO was synthesized successfully, including 1 H NMR, FTIR, UV–vis, 31 P NMR, GPC (gel permeation chromatography). The formed active free radicals were monitored by electron spin resonance (ESR). DAL-11ene-TPO can high-efficiently initiate the monomers polymerization upon the irradiation of 405 nm LED. The resulting polymer films showed strong UV-blocking performance and good visible light transmittance. Moreover, the elongation at break of the polymer film containing 0.5% DAL-11ene-TPO is improved by 50% compared with that of TPO-L control group. Furthermore, DAL-11ene-TPO has polymerizable groups, which can be bonded into the network of the polymers, resulting in a high biosafety of the end products. The results indicate that DAL-11ene-TPO can be used as a high-efficient bio-based macro PI for preparing high performance UV-blocking films.
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