ANALYTICAL LETTERS
·
2015
·
IF 1.03
Xiaojun Wang,Jingjing Chen,Ying Zhou,Xiaoyi Liu,Hongzhou Yao,Farooq Ahmad
A rapid and novel two-step dispersive liquid–liquid microextraction and dispersive micro-solid phase extraction method was established for the separation and enrichment of trace cadmium, nickel, and copper in food and environmental water prior to determination by inductively coupled plasma-mass spectrometry (ICP-MS). In the first microextraction step, carbon tetrachloride was employed to extract metal-diethyldithiocarbamate chelates from aqueous solution with ultrasound. In the following step, Fe3O4 magnetic nanoparticles were added and used to collect the analytes in the organic solvent. The sample pH, type and volume of extraction solvent, mass of magnetic nanoparticles, concentration of the chelating agent, concentration of sodium chloride, and sonication time were optimized. The linear dynamic range was from 0.01 to 20 micrograms per liter with correlation coefficients between 0.9990 and 0.9992. Enrichment factors were 78, 79, and 81 for cadmium, nickel, and copper, respectively. The limits of detection for cadmium, nickel, and copper were 0.007, 0.009, and 0.017 micrograms per liter, with relative standard deviations from 1.1 to 2.6 percent. The developed method was validated by the determination of cadmium, nickel, and copper in rice and mussel certified reference materials, food, and environmental water with satisfactory results.
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Yafei Zhen,Tao Lin,Hanjiao Chen,Jing Hu,Xiandeng Hou
This technical note reports for the first time the simultaneous vapor generation of 16 rare-earth elements (REEs) via reaction with sodium tetrahydroborate (THB). Significant improvement in REE vapor generation efficiency was discovered in the presence of arsenazo III (ARS). Subsequent to a critical evaluation on the impacts of various experimental variables, including the concentrations of acids, THB, and ARS, blank-limited (reagent contamination and impurity from ARS) detection limits (LODs) in the range of 0.004–0.15 μg L–1 were achieved based on three times the standard deviation of the method blank by the proposed vapor generation inductively coupled plasma mass spectrometry (ICP-MS). The nature of released REE species was studied by various approaches and identified to be REE nanoparticles and REE-ARS chelates; a dual-route mechanism for the vapor generation of REEs was thereby proposed.
研究领域:
分析化学
·
无机化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2025
·
IF 6.1
Haowen Hu,Zhengxian Lv,Yixin Guo,Li Yi,Limin Yang,Xiaowen Yan,Qiuquan Wang
Inductively coupled plasma mass spectrometry (ICP-MS) has demonstrated high sensitivity, accuracy, and multi-element detection capacity for biomolecule analysis. However, traditional ICP-MS-used antibody-elemental tags (AETs) are typically constructed through random antibody modification, resulting in structural heterogeneity that compromises binding affinity, specificity, and analytical performance. To overcome this limitation, we developed a traceless, site-specific conjugation strategy that enables precise attachment of a single-stranded DNA (ssDNA) to the K248 residue of IgG antibodies. The “traceless” feature ensures that no residual peptide remains on the antibody after labeling, thereby preserving its native structure and binding activity. The ssDNA serves as a bridge for hybridization with europium (Eu)-loaded MS2 capsid nanoparticles, which act as signal amplifiers by delivering a large payload of metal atoms. Through the integration of precise antibody modification and high-capacity MS2 elemental carriers, the resulting site-specific AETs (ssAETs) exhibit exceptional structural uniformity, stability, and sensitivity. Using human epidermal growth factor receptor 2 (HER2) as a model, the AETs synthesized through our strategy demonstrated exceptional specificity and quantitative performance, achieving 1.8-fold stronger single-cell signals and labeling 1.5 times more HER2-positive cells compared with randomly conjugated antibodies. This traceless, site-specific ssAET platform offers a versatile and precise approach for highly sensitive and quantitative single-cell bioanalysis using ICP-MS.
研究领域:
分析化学
·
免疫学
·
分子生物学
·
肿瘤学
·
转化医学
·
生物标记物检测
·
单细胞分析
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2016
·
IF 4.052
Li Ma,Zhaoguang Yang,Qian Kong,Lin Wang
Extraction of arsenic (As) species in leafy vegetables was investigated by different combinations of methods and extractants. The extracted As species were separated and determined by HPLC-ICP-MS method. The microwave assisted method using 1% HNO 3 as the extractant exhibited satisfactory efficiency (>90%) at 90 °C for 1.5 h. The proposed method was applied for extracting As species from real leafy vegetables. Thirteen cultivars of leafy vegetables were collected and analyzed. The predominant species in all the investigated vegetable samples were As(III) and As(V). Moreover, both As(III) and As(V) concentrations were positive significant ( p < 0.01) correlated with total As (tAs) concentration. However, the percentage of As(V) reduced with tAs concentration increasing probably due to the conversion and transformation of As(V) to As(III) after uptake. The hazard quotient results indicated no particular risk to 94.6% of local consumers. Considerably carcinogenic risk by consumption of the leafy vegetables was observed.
研究领域:
环境科学
·
食品安全
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2019
·
IF 5.256
Zhongtang Wang,Zhaoya Huang,Yun Xie,Zhaoyi Tan
Plutonium has been extensively studied in the environment, for the purpose of radiological assessment, environmental behavior study and nuclear emergency response. To determine Pu isotopes in environmental soil and sediment, a novel analytical method was established in this study using a new type of extraction resin, TK200 resin. Firstly an investigation was performed to study the extraction behaviors of Pu, U, Th, Hg, Tl, Pb, Bi and Hf on TK200 resin. On the basis of the results, a new chromatographic procedure was then proposed to separate Pu from the elements that interfere the accurate determination of Pu isotopes by mass spectrometry. Owing to the excellent separation efficiency between Pu and interfering elements (IEs) of the developed procedure, high decontamination factors (DFs) were obtained for IEs, e.g. the DF(U) (>7.5 × 10 7 ) was the highest reported value. The separation procedure was finally combined with HNO 3 leaching, CaF 2 /LaF 3 coprecipitation and sector field-inductively coupled plasma mass spectrometry (SF-ICPMS) measurement to establish a complete method. The established method was evaluated by analyzing four standard reference materials (soil, sediment), and the results showed that both 239+240 Pu activity and 240 Pu/ 239 Pu isotopic ratio were accurately determined, with stable and high Pu chemical recoveries (81–91%). The whole analytical method only took about 15 h, and the limits of detection were calculated to be 0.13–0.24 fg g −1 for Pu isotopes (for 2 g soil or sediment), guaranteeing the rapid determination of ultra-trace level Pu in soil and sediment samples.
研究领域:
环境科学
·
核化学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2018
·
IF 4.61
Dandan Wang,Bowen Yang,Yuxuan Ye,Weiming Zhang,Zhongbo Wei
The electroless nickel (EN) industry has suffered from the reduction in Ni concentration to lower than 0.1 mg/L. Hence, Ni speciation along a typical sequential treatment scheme has important implications to optimize the design of advanced treatment. For the first time, we revealed the Ni speciation in segmented EN outfall effluents by virtue of multiple analytical methods. After ensuring all the Ni-bearing complexes were completely dissolved by size-fractioned ultrafiltration trials, customized mass spectra analysis was conducted. In a series of ICP-MS assays, the potential polyatomic interfering species was primarily excluded. The chromatography hyphenated IC-ICP-MS and SEC-ICP-MS results demonstrated that the dominant Ni species in the EN effluents was similar to EDTA-Ni but with a smaller size. The LC-MS experiment further distinguished several typical Ni-bearing complexes. Although Ni concentration declined continuously along the treatment scheme, the number of detected Ni-bearing complexes gradually increased but with lower molecular weights . Most of the detected mononuclear complexes had higher indexes of hydrogen deficiency (IHD) than EDTA-Ni, whereas it was believed that the similar stereo ring shape was widespread in the EN effluent. Considering the efficient Ni decrease after the Fenton unit, further post-treatment approaches featuring higher active radical yields were suggested.
研究领域:
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
·
2022
·
IF 2.731
Quan Zeng,Ting Xu,Qinshu Kang,Shengqing Li
The existence of inorganic elements in natural water is heterogeneous due to the suspended micro colloidal and nanoparticles. In this work, the signals of Fe, Cu, Cd, Pb content in natural water samples collected from a city lake were examined using the single-particle inductively coupled plasma mass spectrometry (ICP-MS) under the time resolved detection mode. Total numbers, data distributions and central values of the detected signals were obtained based on statistical analysis using the Excel and the Origin software. Both fractionation filtration (0.22, 0.45 and 3.0 µm membranes) and centrifugation (2000, 4000, 6000 and 8000 rpm rotating speed) have a significant effect on the detection of metals coexisted in the natural colloidal particles (NCPs) in water. Notable number of single-particle signals still presents in the lake water samples even after the pretreatment of 0.22 µm filtration or 8000 rpm centrifugation, which reveals the ubiquitous existence of micro aggregates or colloids in natural water. Sampling with online dilution is proved to be a direct, simple and effective method for the implementation of time resolved analysis of metallic micro NCPs in lake water by ICP-MS, especially for elements with high dissolved concentration. The results enhance the knowledge of how-to evaluation of the quantity and chemical stability of metal-containing aggregates, colloids and nanoparticles that may exist in natural water.
研究领域:
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2018
·Vol. 316
·期 1
·411-417
·
IF 1.181
Wang Zhongtang,Wen Wei,Quan Wei,Du Liang,Wang Ping,Lin Jinxian,Xie Yun,Tan Zhaoyi
Plutonium is one of the key radionuclides in nuclear decommission. In this study, a rapid method was developed to analyze Pu for concrete samples using total digestion, CaF 2 /LaF 3 coprecipitation, extraction chromatography using TEVA and DGA resins, and ICP-MS measurement. The whole analytical process can be achieved within 2 days, with sufficiently high decontamination factors of interfering elements and high Pu chemical recovery (57–93%). The high throughput (22 samples/2 days) and low LODs (0.008 mBq g −1 for 239 Pu and 0.02 mBq g −1 for 240 Pu) allow this method to effectively detect low level Pu contamination in concrete samples.
研究领域:
分析化学
·
核科学与技术
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2017
·
IF 4.529
Yuyu Jia,Lin Wang,Li Ma,Zhaoguang Yang
A comparative study between microwave assisted and sonication methods was carried out to extract arsenic (As) species in shellfish samples using different extractants. Six As species including arsenite [As(III)], arsenate [As(V)], monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), arsenobetaine (AsB) and arsenocholine (AsC) were simultaneously separated and determined by the HPLC–ICP-MS method. The microwave assisted method exhibited higher efficiency than sonication, especially using diluted HNO 3 as extractant. By compromising extraction efficiency, pretreatment time and stability of As species, the microwave assisted method using 1% HNO 3 at 100 °C for 1.5 h was selected to extract As from real samples. The proposed method has been applied to extract and determine As species in shellfish samples. The result of correlation analysis indicated that the proportion of AsB in the shellfish samples was decreased with total As concentration increasing due to the biotransformation threshold from inorganic As to AsB.
研究领域:
环境科学
·
分析化学
·
食品安全
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
·
2024
·
IF 7.6
Wei Li,Zixia Hu,Chenyang Jia,Wei Guo,Weiwei Li,Ying Peng,Jiang Zheng
Human exposure to furan-containing pollutants (FCPs) has raised concerns due to their high risk of toxicity. A substantial number of approximately 8500 recorded compounds containing a furan ring exist which have been analytically or in biologically studied. A significant portion of these compounds is found in the everyday environments of individuals, particularly when ingested through food. Consequently, there is a need for a universal approach to rapidly predict the potential toxicity trends of FCPs. In this study, we developed a bromine labeling-based platform that combines LC-ICP-MS and LC-ESI-MS techniques to absolutely quantify FCP-induced protein adduction. The LC-ESI-MS approach facilitated the identification of FCP-derived protein adducts and optimized liquid chromatographic conditions for analyte separation. By employing a well-designed bromine-containing compound as a general internal standard, LC-ICP-MS-based technique enabled to absolutely assess bromine-labeled protein adduction. The protein adduction efficiencies of furan, 2-methylfuran, and 2,5-dimethylfuran were found to be 2.68, 2.90, and 0.37 molecules per 10,000 FCP molecules that primary hepatocytes received, respectively. Furthermore, we observed that 2-methylfuran exhibited the highest cytotoxicity, followed by furan and 2,5-dimethylfuran, which aligned with the order of their protein adduction. Thus, the protein adduction efficiency of FCPs could serve as a potential index for predicting their toxicity trends.
研究领域:
环境生物学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Fang Hao,Zhu-Ying Yan,Zhenyu Wang,Xiu-Ping Yan
The uptake of plastic particles by plants and their transport through the food chain make great risks to biota and human health. Therefore, it is important to trace plastic particles in the plant. Traditional fluorescence imaging in plants usually suffers significant autofluorescence background. Here, we report a persistent luminescence nanoplatform for autofluorescence-free imaging and quantitation of submicrometer plastic particles in plant. The nanoplatform was fabricated by doping persistent luminescence nanoparticles (PLNPs) onto polystyrene (PS) nanoparticles. Cr3+-doped zinc gallate PLNP was employed as the dopant for autofluorescence-free imaging due to its persistent luminescence nature. In addition, the Ga element in PLNP was used as a proxy to quantify the PS in the plant by inductively coupled plasma mass spectrometry (ICP-MS). Thus, the developed nanoplatform allows not only dual-mode autofluorescence-free imaging (persistent luminescence and laser-ablation ICP-MS) but also ICP-MS quantitation for tracking PS in plant. Application of this nanoplatform in a typical plant model Arabidopsis thaliana revealed that PS mainly distributed in the root (>99.45%) and translocated very limited (<0.55%) to the shoot. The developed nanoplatform has great potential for quantitative tracing of submicrometer plastic particles to investigate the environmental process and impact of plastic particles.
研究领域:
环境科学
·
植物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2022
·
IF 11.357
Weiping Cai,Yujun Wang,Yu Feng,Peng Liu,Shuofei Dong,Bo Meng,Hua Gong,Fei Dang
Nanoparticulate mercury (Hg-NPs) are ubiquitous in nature. However, the lack of data on their concentration in soils impedes reliable risk assessments. This is due to the analytical difficulties resulting from low ambient Hg concentrations and background interferences of heterogeneous soil components. Here, coupled to single particle inductively coupled plasma-mass spectrometry (spICP-MS), a standardized protocol was developed for extraction and quantification of Hg-NPs in natural soils with a wide range of properties. High particle number-, particle mass-, and total mass-based recoveries were obtained for spiked HgS-NPs (74–120%). Indigenous Hg-NPs across soils were within 107–1011 NPs g–1, corresponding to 3–40% of total Hg on a mass basis. Metacinnabar was the primary Hg species in extracted samples from the Wanshan mercury mining site, as characterized by X-ray absorption spectroscopy and transmission electron microscopy. In agreement with the spICP-MS analysis, electron microscopy revealed comparable size distribution for nanoparticles larger than 27 nm. These indigenous Hg-NPs contributed to 5–65% of the measured methylmercury in soils. This work paves the way for experimental determinations of indigenous Hg-NPs in natural soils, which is critical to understand the biogeochemical cycling of mercury and thereby the methylation processes governing the public exposure to methylmercury.
研究领域:
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）