APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Xinxin Ren,Qingbo Yu,Jia Pan,Qingping Wang,Yuqi Li,Naishen Shi,Shuli Deng
It is well known that the design of precursor structure is an effective method to optimize the photocatalytic activity of g-C 3 N 4 , and it will be interesting to investigate the relationship between the precursor structure and the structure of the target catalyst. In this paper, by adjusting the addition amount of glutaraldehyde (GA), three kinds of glutaraldehyde/dicyandiamide (GA/DCDA) precursors with equilibrium/imbalance hydrogen bond interaction can be obtained, and the carbonized glutaraldehyde (C-GA)/g-C 3 N 4 composite catalysts with different carbon content can be obtained after calcination. The obtained C-GA/g-C 3 N 4 composite catalysts have different photocatalytic activity for methylene blue degradation. Compared with the original g-C 3 N 4 , the photocatalytic activity of C-GA/g-C 3 N 4 -2 composite is increased by 2.69 times. Through the analysis of thermal decomposition kinetics and structural characterization, we can see that the equilibrium interaction in the structure of GA/DCDA-2 precursor can promote the conversion of dicyandiamide to melamine, and glutaraldehyde carbonization will form more C-GA, and form a composite catalyst with closer interaction with g-C 3 N 4 . C-GA with close interaction and higher content can effectively promote the separation of photogenerated carriers and visible light absorption, thus improving its photocatalytic activity.
研究领域:
材料科学
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Miao Zhang,Yin Chen,Shi Gang Liu,Xingbo Shi
L. monocytogenes (L. m) is one of the most common causes of foodborne diseases. To enable timely monitoring of L. m contamination, a highly efficient and sensitive electrochemical biosensor was developed for the precise determination of L.m . The biosensor was prepared by sequentially modifying glassy carbon electrode (GCE) with silicon methylene blue (Si@MB), gold nanoparticles (AuNPs) and aptamer (Apt). Differential pulse voltammetry (DPV) was used to quantify L.m . This biosensor could be finished in 1.5 h, which significantly reduced the detection time. The resulting electrochemical biosensor achieved good linear (10 2 -10 7 CFU/mL) and excellent detection limit of 2.6 CFU/mL. Moreover, the novel strategy has been successfully applied to actual samples, with the recoveries ranging from 84.7% to116.0% in lettuce and from 80.0% to 110% in fresh-cut fruit. This biosensor shows great potential application in monitoring bacterial food contamination and infectious diseases.
研究领域:
食品科学
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生物技术
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分析化学
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
BIOLOGICAL & PHARMACEUTICAL BULLETIN
·
2020
·Vol. 43
·期 1
·102-109
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IF 1.863
Qing-Xuan Zheng,Rui Wang,Yan Xu,Chang-Xin He,Cai-Yun Zhao,Zhi-Fang Wang,Rui Zhang,Wim Dehaen,Hui-Jing Li,Qi-Yong Huai
Glycyrrhetinic acid (GA) is a natural product with certain antitumor activity. In order to enhance the cytotoxicity, a total of eighteen derivatives of GA were designed and synthesized. Their cytotoxicity against MDA-MB-231cells (human breast cancer cells) and HeLa cells (human cervical cancer cells), were evaluated by the MTT method (3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide). The results indicated that these target compounds have a wide molar activity range and some of them show better activity than the commercial drugs gefitinib and doxorubicin. Compound 6g induces apoptosis of 7, 10 and 44% of MDA-MB-231 cells at 5, 10, and 20 µM, respectively.
研究领域:
药理学
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肿瘤学
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药物化学
✓ 已验证
DOI
PubMed
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 4
·872
·
IF 4.2
Ying Zhao,Zhang-Gui Ding,Yu-Jie Yan,Rui Yang,Miao-Miao Qi,Shu-Kang Pan,Ji-Ling Xie,Yu-Hui Sun,Jin Xiang
Breast cancer is a significant threat to life and health, which needs more safe and effective drugs to be explored. Teadenol B is a characteristic chemical component of microbial fermented tea. This study discovered that teadenol B could exhibit obvious inhibitory effects on all four different clinical subtype characteristics of breast cancer cells. Proteomic studies show that deoxycytidine triphosphate deaminase (DCTD), which could block DNA synthesis and repair DNA damage, had the most significant and consistent reduction in all four types of breast cancer cells with the treatment of teadenol B. Considering MDA-MB-231 cells exhibit poor clinical prognosis and displayed substantial statistical differences in KEGG pathway enrichment analysis results, we investigated its impact on the size and growth of MDA-MB-231 triple-negative breast tumors transplanted into nude mice and demonstrated that teadenol B significantly suppressed tumor growth without affecting body weight significantly. Finally, we found that the conversion of LC3-I to LC3-II in MDA-MB-231 increased significantly with teadenol B treatment. This proved that teadenol B could be a strong autophagy promotor, which explained the down-regulation of DCTD to some extent and may be the potential mechanism underlying teadenol B’s anti-breast cancer effects. This finding provides new evidence for drinking fermented tea to prevent breast cancer and highlights the potential of teadenol B as a novel therapeutic option for breast cancer prevention and treatment, necessitating further investigations to clarify its exact target and the details involved.Keywords:teadenol B;breast cancer;autophagy
研究领域:
肿瘤学
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药理学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
OPTICAL MATERIALS
·
2021
·
IF 3.08
Xuyang Li,Zongxue Yu,Liangyan Shao,Xiaofang Feng,Haojie Zeng,Yuchuan Liu,Runxuan Long,Ximei Zhu
In order to effectively solve the two major problems of photocatalyst recovery and membrane fouling , this research combines photocatalyst and membrane separation technology . In this study, the NH 2 -MIL-88B(Fe)/CDs@GO material with good photocatalytic properties was synthesized by hydrothermal method and mechanical stirring, and the photocatalytic membrane was obtained by vacuum filtration. The results show that the NH 2 -MIL-88B(Fe)/CDs@GO membrane can effectively intercept and degrade methylene blue (MB). After 10 cycles, the rejection rate of MB can still reach 99.5%, which is about 2.5 times of pure GO membrane (40%). After 15 min of visible light irradiation, the Flux recovery rate (FRR) of NH 2 -MIL-88B(Fe)/CDs@GO membrane can reach 95%, and the antifouling performance is excellent. In this study, the composite photocatalytic membrane shows excellent stability, photocatalytic performance and self-cleaning property, which is conducive to widening the application prospect of wastewater treatment .
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
BIOELECTROCHEMISTRY
·
2021
·
IF 5.373
Shengzhong Rong,Lina Zou,Yang Li,Yue Guan,Huilin guan,Ze Zhang,Yingcong Zhang,Hongmin Gao,Hongwei Yu,Fuyang Zhao,Hongzhi Pan,Dong Chang
Early finding and diagnosis are critical for prevention and treatment of hepatocellular carcinoma (HCC). Alpha-fetoprotein (AFP) is a typical biomarker of HCC. Since AFP level can reflect the severity of HCC, it is essential to ensure the accurate detection of AFP. In this study, through a combination of the advantages exhibited by ordered mesoporous carbon (OMC)@gold nanoparticles (AuNPs) composites and AuPt-methylene blue (AuPt-MB), a disposable ultrasensitive sandwich-configuration electrochemical immunosensor for determination of AFP was designed. Characterized by excellent conductivity, highly ordered pore distribution and great surface area, OMC can be effective in promoting electron transfer and loading a large number of AuNPs. In the meantime, AuNPs can also immobilize AFP-Ab 1 through Au-N bonds. As a new redox-active species, rod-like AuPt-MB demonstrates high conductivity, uniform morphology and excellent biocompatibility, which makes it capable not only to fix AFP-Ab 2 , but also to release electrochemical signals. A wide linearity of 10 fg mL −1 -100 ng mL −1 and a low detection limit of 3.33 fg mL −1 (S/N = 3) were obtained. Moreover, the proposed immunosensor exhibited acceptable selectivity, high stability and reproducibility. The excellent performance in detecting serum samples endows the proposed immunosensor with broad prospects of extensive application in the detection of disease biomarkers.
研究领域:
医学诊断
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生物医学工程
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纳米技术
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分析化学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2024
·
IF 4.1
Qian Zhang,Yanlan Cen,Bo Chen,Jiajin Li,Xinqi Zheng,Xiaoping Wu,Songbai Qiu,Tiejun Wang
Direct synthesis of alternative higher alcohols from aqueous bio-ethanol has received increasing attention because of its promising application in value-add fine chemicals and bio-jet fuels, yet the efficient carbon chain growth towards C6 + higher alcohols still facing great challenges. Herein, the polypropylene-based melt-blown cloth (MB) was adopted as novel precursor to fabricate the high-active Ni@MB catalysts for the direct mild upgrading of aqueous ethanol (50 wt%). Superior higher alcohols yield of 46.9 % with 74.1 % ethanol conversion was achieved at 170 °C over Ni@MB-1/20–500. The nitrogenous MB facilitated the formation of N-doped graphene structure that promoting the aldol-coupling and dehydrogenation capability of Ni@MB. For further enhancing the efficient carbon chain growth towards C6 + higher alcohols, a novel staged-reaction-cooling (SRC) strategy was developed and optimal C6 + higher alcohols selectivity up to 72.1 % with 83.2 % ethanol conversion was achieved. This work gains new insight to mild synthesis of C6 + higher alcohols from readily-accessible bio-ethanol.
研究领域:
化学工程
·
催化材料科学
✓ 已验证
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Wei Du,Guancheng Wang,Haijiao Dong,Tianxia Zhao,Mingze Lu,Zhirui Guo,Ming Ma,Yu Zhang
Current assays for POD-like catalytic specific activity of nanozymes are often under homogeneous dispersion in solution, however, in practical applications, nanozymes are often immobilized in various media, such as gels, necessitating new methods to characterize the catalytic activity of immobilized nanozymes. This study introduces an electrochemical method to evaluate the catalytic activity of POD-like nanozymes immobilized in thin films, using iron oxide nanozymes synthesized via co-precipitation as a model. The approach normalizes the current intensity of the methylene blue (MB) reduction peak to the electrochemically active surface area, calculating the charge transfer per unit area per unit time ( μC s −1 cm −2 ) to determine specific catalytic activity. The catalytic activities for various nanozymes, including cc-Fe 3 O 4 NPs, γ-Fe 2 O 3 NPs, α-Fe 2 O 3 NPs, H-Fe 3 O 4 NPs, Fe 3 O 4 -TEG NPs, Co 3 O 4 NPs, and Prussian blue nanoparticles (PB NPs), are measured as 38.18, 7.78, 2.13, 56.94, 47.66, 43.42, and 339 μC s −1 cm −2 , respectively, consistent with colorimetric methods. This method also allows the evaluation of nanozyme dependence on H 2 O 2 concentration, offering new insights into nanozyme properties and their potential applications in biosensing.
研究领域:
生物化学
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纳米生物学
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分析化学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Xikun Zhang,Yang Su,He Zhang,Yukai Wang,Yu Chang,Shurui Yi,Junzheng Chen,Di Fang,Xue Lv,Lu Liu
A novel composite hydrogel prepared from polyacrylamide (PAM), polydopamine-modified montmorillonite (PDA@MMT), graphene and hydroxypropyl cellulose (HPC), loaded with Ag NPs, was prepared for the catalytic degradation of methylene blue (MB) and Congo red (CR) using in situ reduction. HPC significantly enhanced the dispersion of PDA@MMT within the hydrogel, endowing the hydrogel with excellent mechanical properties, with stress and strain of 1773 kPa and 4005 %, and elastic modulus and toughness of 43.4 kPa and 29.54 MJ/m 3 , respectively. The introduction of graphene (GN) increased the rate of electron transfer during the catalytic process and significantly improved the catalytic efficiency, with catalytic rate constants of 1.360 and 0.803 min −1 for MB and CR at 20 °C, respectively. The hydrogels were endowed with excellent antimicrobial properties due to the introduction of Ag NPs. In the future, this hydrogel is expected to play an important role in environmental pollution control.
研究领域:
材料科学
·
环境科学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Catalysts
·
2024
·Vol. 14
·期 5
·324
·
IF 3.8
Jing Wang,Lingling Feng,Zikang Zhao,Yan Wang,Ying Zhang,Shan Song,Shengwei Sun,Junshuang Zhou,Faming Gao
Given the energy crisis and escalating environmental pollution, the imperative for developing clean new energy is evident. Hydrogen has garnered significant attention owing to its clean properties, high energy density, and ease of storage and transportation. This study synthesized four types of catalysts—FeS(DI/MB), FeS(ET/MB), Fe(DI/MB), and Fe(ET/MB)—using two distinct solution systems: DI/MB and ET/MB. The FeS(DI/MB) catalyst, synthesized using the layered solution system (DI/MB), demonstrates a uniformly distributed and dense nanosheet structure, exhibiting excellent resistance to strong bases and superior catalytic properties. The FeS(DI/MB) electrode showed OER overpotentials of 460 mV and 318 mV in 1 M and 6 M, respectively, at current densities of up to 500 mA cm−2. Under industrial electrolysis test conditions, the FeS(DI/MB) electrode required only 262 mV to achieve a current density of 500 mA cm−2, operating in a high-temperature, strong alkaline environment of 6 M at 60 °C. Furthermore, the FeS(DI/MB) electrode exhibited excellent OER catalytic activity and stability, as evidenced by a 60 h stability test These findings provide valuable insights into the preparation of iron nickel sulfide-based catalysts, and further in-depth and comprehensive exploration is anticipated to yield the excellent catalytic performance of these catalysts in the realm of electrolytic water hydrogen production.
研究领域:
化学
·
能源科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 192
·期 1
·1-13
·
IF 5.3
Liu Junjie,Wu Shengxi,Zhang Lu,Zhang Mingjun,Wu Haotian,Shi Miwan,Weng Yuan,Ye Wenqiao,Gu Kui
A novel proposal is introduced with an unlabeled electrochemical immunosensor for the detection of tumor broad-spectrum biomarker vascular endothelial growth factor (VEGF165) Copper-based metal organic frameworks (Cu MOFs)-carbon nanotubes (MWCNTs) were employed as its substrates, functionalized with methylene blue (MB) for signal enhancement. Cu-MOFs-MWCNTs nanocomposites were synthesized successfully via a solvothermal method and were then deposited on the surface of a glassy carbon electrode (GCE), with the addition of methylene blue to amplify the signal. Due to the expansive specific surface area provided by the carbon nanotubes and the amino groups facilitated by the metal–organic framework nanomaterials, the anti-VEGF165 monoclonal antibody was immobilized on the electrochemical immunosensor through covalent bonding, which could bind specifically to VEGF165, thereby causing a detectable change in the current. The developed immunosensor exhibited a linear detection range for VEGF165 spanning from 1 to 100,000 pg/ml, with the R 2 value of 0.997 by differential pulse voltammetry (DPV) method, and the limit of detection was as low as 0.9686. Additionally, the electrochemical immunosensor presented commendable selectivity, availability, and reproducibility, along with an effective capacity for detecting VEGF165 in clinical samples. Consequently, the immunosensor is expected to revolutionize early screening for VEGF165-related diseases, which offer a promising, cost-effective, and precise diagnostic tool for clinical utility. Graphical
研究领域:
生物医学工程
·
肿瘤学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2023
·
IF 6.7
Xinxin Li,Cheng Wang,Shang Li,Fucheng Yin,Heng Luo,Yonglei Zhang,Zhongwen Luo,Yifan Chen,Siyuan Wan,Lingyi Kong,Xiaobing Wang
Currently available PARP inhibitors are mainly used for the treatment of BRCA-mutated triple-negative breast cancer (TNBC), with a narrow application range of approximately 15% of patients. Recent studies have shown that EZH2 inhibitors have an obvious effect on breast cancer xenograft models and can promote the sensitivity of ovarian cancer cells to PARP inhibitors. Here, a series of new dual-target PARP1/EZH2 inhibitors for wild-BRCA type TNBC were designed and synthesized. SAR studies helped us identify compound 12e , encoded KWLX-12e , with good inhibitory activity against PARP1 (IC 50 = 6.89 nM) and EZH2 (IC 50 = 27.34 nM). Meanwhile, KWLX-12e showed an optimal cytotoxicity against MDA-MB-231 cells (IC 50 = 2.84 μM) and BT-549 cells (IC 50 = 0.91 μM), with no toxicity on normal breast cell lines. KWLX-12e also exhibited good antitumor activity with the TGI value of 75.94%, more effective than Niraparib plus GSK126 (TGI = 57.24%). Mechanistic studies showed that KWLX-12e achieved synthetic lethality indirectly by inhibiting EZH2 to increase the sensitivity to PARP1, and induced cell death by regulating excessive autophagy. KWLX-12e is expected to be a potential candidate for the treatment of TNBC.
研究领域:
肿瘤学
·
药理学
·
癌症生物学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
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