LANGMUIR
·
2017
·
IF 3.833
Hui Xie,Hao Zhang,Danish Hussain,Xianghe Meng,Jianmin Song,Lining Sun
We report high-resolution multiparametric kelvin probe force microscopy (MP-KPFM) measurements for the simultaneous quantitative mapping of the contact potential difference (CPD) and nanomechanical properties of the sample in single-pass mode. This method combines functionalities of the force–distance-based atomic force microscopy and amplitude-modulation (AM) KPFM to perform measurements in single-pass mode. During the tip–sample approach-and-retract cycle, nanomechanical measurements are performed for the retract part of nanoindentation, and the CPD is measured by the lifted probe with a constant tip–sample distance. We compare the performance of the proposed method with the conventional KPFMs by mapping the CPD of multilayer graphene deposited on n-doped silicon, and the results demonstrate that MP-KPFM has comparable performance to AM-KPFM. In addition, the experimental results of a custom-fabricated polymer grating with heterogeneous surfaces validate the multiparametric imaging capability of the MP-KPFM. This method can have potential applications in finding the inherent link between nanomechanical properties and the surface potential of the materials, such as the quantification of the electromechanical response of the deformed piezoelectric materials.
研究领域:
纳米技术
·
材料科学
·
扫描探针显微学
·
表面科学
·
纳米力学
·
静电学
✓ 已验证
DOI
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2019
·Vol. 102
·期 10
·5899-5909
·
IF 3.094
Puxian Xiong,Mingying Peng,Jiangkun Cao,Xueliang Li
Mechanoluminescence (ML) is a phenomenon upon external mechanical stimuli and it has found diverse applications such as stress sensing, structure health diagnosis, 3-D signature, energy harvesting etc because of its unique properties of in situ and real-time response to the stimuli. However, ML of most of the state-of-art phosphors primarily appears within the spectral range from ultraviolet to visible, which does not lie in the biological transparent windows, and, therefore, limits its applications in biological field. Here, we report a strong near infrared (NIR) ML from orthorhombic Cmcm perovskite Sr 3 Sn 2 O 7 : Nd 3+ , which is peaked at ~ 900 nm and located exactly within the first optical transparent window of tissues. The ML apparates after gradual discharge of the traps deeper than 0.73 eV triggered by the external mechanical stimuli and subsequently excitation of Nd 3+ to the state of 4 F 3/2 . The rechargable ML presents well repeatable linearity to loaded force at least up to 5000 N, and it can penetrate tissues easily that are thick up to 30 mm such as pigskin and the ceramic disk of hydroxy apatite which is the main constituent of bone. These results demonstrate the potential application for in situ biomechanical sensor. Meanwhile, by recording and processing these ML signals during signing on a pellet sample, for the first time, we provide a novel signature system based on NIR ML. This could raise the security level of existed signature anti-countering to a higher level.
研究领域:
材料科学
·
生物医学工程
·
光学
·
安全系统
✓ 已验证
DOI
高影响因子
Science Advances
·
2026
·Vol. 12
·期 22
·
IF 13.9
Jinbin Pan,Li Ma,Hua Ma,Yuanlin Zhang,Iris. Y. Zhou,Nicholas J. Rotile,Dong Li,Onofrio A. Catalano,Shao-Kai Sun,Peter Caravan
Early, noninvasive, and spatially resolved assessment of renal dysfunction is essential for theranostics of kidney diseases, yet clinical biomarkers are criticized for averaging whole-kidney function and missing focal or unilateral injury. Here, we present a contrast-sparing computed tomography (CT) approach that maps renal dysfunction at the compartment level using renal-clearable glutathione-gold nanoclusters (GSH-Au NCs). The merits of ultrasmall hydrodynamic size (2.8 nanometers) and high x-ray attenuation ability enable GSH-Au NCs with fast renal clearance and robust intrarenal CT contrast. In three mechanistically distinct mouse models of acute kidney injury, low-dose GSH-Au NCs produced mechanism-specific imaging signatures and distinct time-attenuation behaviors, even before biomarkers changed. Notably, at an ultralow dose (32.5 milligrams of Au per kilogram), early bilateral cisplatin injury can be easily detected with an obvious bright band at the outer medulla area on CT, consistent with tubular injury and a cast/debris-mediated mechanism. This work establishes a dose-efficient CT workflow for early, noninvasive, spatial mapping of renal dysfunction, supporting diagnosis, classification, and monitoring of kidney disease.
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Jiming Wei,Yaqi Wang,Boyuan Wang,Rongmei Ma,Qian Qiao,Jiagen Lv,Tuanrui Dong,Jitong Lyu
Herein, a novel Sierpiński fractal material-based chemiluminescent (CL) nanosensor (CL-ST) capable of real-time mapping of singlet oxygen ( 1 O 2 ) dynamics and quantitative monitoring of inflammatory progression in murine models is presented. The CL-ST nanosensor is engineered through supramolecular self-assembly of Zn 2+ -coordinated terpyridine ligands (L1 and L2), followed by encapsulation within polyethylene glycol (PEG)-functionalized liposome to enhance biocompatibility. The formation of the supramolecular structure restricts the rotation of the terpyridine moieties in L1 and L2, resulting in the restriction of nonradiative exciton relaxation, which in turn enhances the fluorescence efficiency. As a result, the CL intensity of the supramolecular structure is 8–70 times higher than that of L1 and L2 nanoparticles, respectively. In vitro characterization reveals the lysosome-targeting capability and negligible cytotoxicity of CL-ST. Systemic toxicity assessments further confirm the nanosensor's biosafety profile, enabling efficient systemic delivery via peripheral circulation without eliciting significant biological perturbations. Capitalizing on the CL-ST nanosensor's exceptional selectivity and sensitivity towards 1 O 2 , this study pioneers the application of fractal materials in developing optical biosensors for in vivo biomarker monitoring. Through successful visualization of 1 O 2 generation in acute peritonitis and auricular edema models, the CL-ST platform achieves precise inflammatory site localization and quantitative inflammation status assessment through target/non-target (T/NT) photon ratio analysis. This research establishes a non-invasive methodology for dynamic inflammation tracking. The potential of fractal nanomaterials to construct innovative chemical and biochemical sensors for multidimensional disease diagnostics is anticipated.
✓ 已验证
DOI
高影响因子
The Innovation
·
2025
·
IF 25.7
Xiangling Li,Shantao Zheng,Mengyi He,Xinshuo Huang,Cheng Yang,Jingshan Mo,Jingbo Yang,Chengduan Yang,Huijiuan Chen,Xi Xie
Monitoring multiplexed biochemical markers is beneficial for the comprehensive evaluation of diabetes-associated complications. Techniques for multiplexed analyses in interstitial fluids have often been restricted by the difficulties of electrode materials in accurately detecting chemicals in complex subcutaneous spaces. In particular, the signal stability of enzyme-based sensing electrodes often inevitably decreases due to enzyme degradation or interference in vivo . In this study, we developed a self-calibrating multiplexed microneedle (MN) electrode array (SC-MMNEA) capable of continuous, real-time monitoring of multiple types of bioanalytes (glucose, cholesterol, uric acid, lactate, reactive oxygen species [ROSs], Na + , K + , Ca 2+ , and pH) in the subcutaneous space. Each type of analyte was detected by a discrete MN electrode assembled in an integrated array with single-MN resolution. Moreover, this device utilized an MN-delivery-mediated self-calibration technique to address the inherent problem of decreased accuracy of implantable electrodes caused by long-term tissue variation and enzyme degradation, and this technique might increase the reliability of the MN sensors. Our results indicated that SC-MMNEA could provide real-time monitoring of multiplexed analyte concentrations in a rat model with good accuracy, especially after self-calibration. SC-MMNEA has the advantages of in situ and minimally invasive monitoring of physiological states and the potential to promote wearable devices for long-term monitoring of chemical species in vivo .
研究领域:
医学工程
·
生物传感器
·
糖尿病研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2024
·
IF 10.7
Haotian Zhao,Jiaqi Cheng,Jianji Wang,Shu Xiao,Nour F. Attia,Mingzhu Liu,Saihua Jiang
Cholesteric liquid crystal elastomers (CLCEs) possess tunable optical properties and excellent thermal responsiveness, making them ideal for temperature monitoring applications. However, their broad applications are hindered due to the lack of an efficient method to correlate sample color with temperature. In this study, we developed two machine learning models: a Color-based Temperature Value Prediction Model (CTVPM) and a Color Array-based Temperature Mapping Model (CATMM), to predict temperature values and temperature maps, respectively, from images of colored CLCE samples. CLCE samples with thermal-responsive color are synthesized taking advantage of solvent evaporation-induced molecular alignment and dynamic bond-enabled crosslinking. Experimental results demonstrated that temperature values can be accurately predicted based on RGB images using CTVPM, particularly in the temperature range of 50–70 °C, corresponding to the phase transition temperature range of the CLCE samples. Furthermore, temperature distributions can be effectively mapped using CATMM. Applying machine vision to CLCE samples offers an intuitive and cost-effective method for temperature monitoring and mapping. These findings pave the way for combining CLCEs with deep learning algorithms for sensing and safety-related applications.
研究领域:
材料科学
·
人工智能
·
光学
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-11
·
IF 16.6
Xu Zijie,Cao Leo N. Y.,Li Chengyu,Luo Yingjin,Su Erming,Wang Weizhe,Tang Wei,Yao Zhaohui,Wang Zhong Lin
Real-time monitoring of flow turbulence is very difficult but extremely important in fluid dynamics, which plays an important role in flight safety and control. Turbulence can cause airflow to detach at the end of the wings, potentially resulting in the aerodynamic stall of aircraft and causing flight accidents. Here, we developed a lightweight and conformable system on the wing surface of aircraft for stall sensing. Quantitative data about airflow turbulence and the degree of boundary layer separation are provided in situ using conjunct signals provided by both triboelectric and piezoelectric effects. Thus, the system can visualize and directly measure the airflow detaching process on the airfoil, and senses the degree of airflow separation during and after a stall for large aircraft and unmanned aerial vehicles.
研究领域:
航空工程
·
流体力学
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry B
·
2019
·Vol. 7
·期 12
·2074-2080
·
IF 5.047
Yong Jian Jiang,Min Lin,Tong Yang,Rong Sheng Li,Cheng Zhi Huang,Jian Wang,Yuan Fang Li
Nitrite (NO2−) is one of the important pollutants in food and the environment, which can seriously endanger the health of human beings. Therefore, detecting nitrite in food, environmental and biological samples is very significant for health monitoring. Herein, polymer carbon dots (PCDs) doped with nitrogen and phosphorus were prepared by polymerization of ascorbic acid (AA) and polyethylenimine (PEI) with phosphoric acid, and exhibited excellent stability, adjustable fluorescence emissions and good biocompatibility. It was found that the PCDs presented a sensitive response to nitrite (NO2−), and they were successfully applied for NO2− analysis in water and milk samples, and the dynamic monitoring of nitrite entry into Hep-2 cells.
研究领域:
分析化学
·
环境科学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Jie Tang,Qiong Zhang,Jie Zhou,Huichao Fang,Haifeng Yang,Feng Wang
This study investigated the effectiveness of gelatinized starch (GS) in the removal of surface and internalized pesticide residues from basil leaves. Surface activity of GS was confirmed by surface tension and fluorescence study. Surface-enhanced Raman scattering (SERS) mapping was applied for in situ and real-time tracking of pesticides over time. Results showed that gelatinized starch has better and safer pesticide removing effect compared to commercial surfactants. Simulation study showed that starch fragment can adjust its three-dimensional conformation according to the size of the guest with ~ four repeating α-1,4- d -glucopyranose residues interacting efficiently with pesticides. However, washing by small molecular weight surfactants will lead to a “secondary contamination” due to its amphilphilic nature and small molecular size, which can escort pesticide deeper into the leaf. Due to the wide availability, easy fabrication, efficient rinsing effect and bio-safety nature, GS should be highly recommended in family practice.
研究领域:
农业化学
·
食品科学
·
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2018
·
IF 6.042
Sarju Adhikari,Xiaoyue Yang,Yu Xia
Herein, we report the development of a new photochemical system which enables rapid and tunable disulfide bond reduction and its application in disulfide mapping via online coupling with mass spectrometry (MS). Acetone, a clean and electrospray ionization (ESI) compatible solvent, is used as the photoinitiator (1% volume) in the solvent system consisting of 1:1 alkyl alcohol and water. Under ultraviolet (UV) irradiation (∼254 nm), the acetone/alcohol system produces hydroxyalkyl radicals, which are responsible for disulfide bond cleavage in peptides. Acetone/isopropanol is most suitable for optimizing the disulfide reduction products, leading to almost complete conversion in less than 5 s when the reaction is conducted in a flow microreactor. The flow microreactor device not only facilitates direct coupling with ESI-MS but also allows fine-tuning of the extent of disulfide reduction by varying the UV exposure time. Near full sequence coverage for peptides consisting of intra- or interchain disulfide bonds has been achieved from complete disulfide reduction and online tandem mass spectrometry (MS/MS) via low energy collision-induced dissociation. Coupling different degrees of partial disulfide reduction with ESI-MS/MS allows disulfide mapping as demonstrated for characterizing the three disulfide bonds in insulin.
研究领域:
生物化学
·
分析化学
·
蛋白质组学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Soft Science
·
2025
·Vol. 5
·期 4
·N
·
IF 9
Yuyang Sun,Dongsheng Li,Ruxiao Yang,Zhicun Zhou,Tianci Ji,Bo Lu,Lining Sun,Huicong Liu
Current human-robot interaction (HRI) systems for training embodied intelligent robots often suffer from limited motion dimensionality and unintuitive control. This work presents the Touch-Code Glove, a multimodal HRI interface integrating functional materials, structural intelligence, and deep-learning decoding. A triboelectric digital interface is embedded into the Wrist-pad via a mosaic-patterned array of polyamide/polytetrafluoroethylene-doped silicone rubber films, generating polarity-dependent digital signal pairs upon contact. A co-electrode layout enables 16 touch points with minimal wiring, allowing multiplexed, programmable tactile input via sliding or multi-point gestures. Coupled triboelectric signals are accurately decoded using a convolutional neural network and long short-term memory model, achieving over 98% recognition accuracy. Complementarily, a double-network conductive hydrogel composed of sodium alginate, polyacrylamide, and sodium chloride is integrated into the Finger-fibers and the Wrist-pad to provide strain-sensing capabilities with excellent stretchability, high linearity, low hysteresis, and long-term stability. The system incorporates three concurrent sub-mapping strategies: gesture-driven control, wrist posture-based movement, and touch path-guided input, which together enable real-time control of robotic hands and arms without requiring professional training. This triboelectric-hydrogel hybrid interface offers a materials-centric solution for intelligent, wearable, and accessible HRI, paving the way for next-generation multimodal robotic control systems in assistive and industrial applications.
研究领域:
人机交互
·
可穿戴电子
·
软体机器人
·
智能传感器
·
机器人中的机器学习
·
功能材料
·
摩擦电传感
·
水凝胶传感器
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Jianjun Liao,Feng Chang,Xiaohu Han,Chengjun Ge,Shiwei Lin
Portable, rapid, and cost-effective detection of environmental contamination remains an important challenge in the field of water quality analysis. Herein, we described a smartphone-based water quality monitoring system that allowed for the quantification of Pb 2+ ions and chemical oxygen demand (COD) at an exact location. The system was composed of four main parts: (i) a whole-copper electrochemical sensor, (ii) a hand-held detector, (iii) a smartphone installed with a custom application program, and (iv) a Cloud map website. The sensor chips were made of low-cost copper, including microfabricated Cu working electrodes, Cu counter electrodes, and Cu/CuCl 2 reference electrodes. The hand-held detector (∼50 g) can perform several types of electroanalytical techniques, including chronoamperometry, cyclic voltammetry, linear sweep voltammetry, and square wave voltammetry. With an Application (App), the smartphone was used to control the detector and visualize the testing results in real time. A Cloud map website was used to receive and display the contamination concentrations and geographic locations for public sharing and viewing. Since the smartphone-based system is cost-effective, small in size, field-portable, and fully wireless, it shows great potential for applications in resource-limited settings.
研究领域:
环境科学
·
分析化学
✓ 已验证
DOI
高影响因子
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