JOURNAL OF MATERIALS SCIENCE
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2021
·Vol. 56
·期 20
·11736-11748
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IF 4.22
Gao Yuan,Zhou Xinghai,Zhang Maliang,Li Zhenhuan
In view of the disadvantages of concentration polarization and trade-off effects in the application of membrane in desalination field, oxide-nano graphene oxide/polyamide (O-NGO/PA) loose intermediate layer and PA ultra-thin dense layer were introduced to fabricate PA/O-NGO/polyphenylene sulfide composite membrane with sandwich structure via multi-step interfacial polymerization (MS-IP) method. The selective permeation mechanism of ultrathin layer produced by different aqueous monomers (PIP and MPD) was studied, the effect of its physicochemical structure on the relief of concentration polarization phenomenon and the breakthrough of trade-off effect was analyzed. The ultra-thin and dense PA layer mainly played the role of interception and shortened the water molecular penetration path. In the retention test of metal salt solution, compared with the rough surface, it was found that the smooth surface was more conducive to the diffusion of intercepted metal ions into the feed solution, thus alleviating the concentration polarization phenomenon. Graphical abstract
研究领域:
材料科学
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环境工程
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高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2022
·Vol. 223
·期 16
·2200088
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IF 2.996
Siqi Ma,Nian Liu,Pan Cheng,Wei Hu,Xiaodan Jia,Qihao Guo,Ming Xia,Qin Cheng,Ke Liu,Dong Wang
The pursuit of highly permeable thin-film nanocomposite (TFNC) nanofiltration (NF) membranes with desirable selectivity is an eternal topic for desalination and wastewater treatment. Herein, a facile route to engineer polyamide (PA) NF membranes is reported with a coral-reef-like thin PA active layer atop a polydopamine pre-decorated ethylene vinyl alcohol copolymer (EVOH) nanofiber scaffold (EVOH-PDA) via interfacial polymerization (IP). EVOH-PDA possesses a submicron pore size and super-hydrophilic surface, which provides abundant thin water layers covering nanofibers in the IP process resulting in the PA layer with a morphology of coral-reef-like highland surrounded by flat low-lying regions. The resultant NF membrane presents high permeance of 32.19 L m −2 h −1 bar −1 and high rejection of 96.52% to 1000 ppm Na 2 SO 4 feed solution with a stable performance against operation time and high salt concentration. This work provides a new approach to fabricating PA TFNC membranes with outstanding NF performance in liquid separation applications.
研究领域:
材料科学
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环境工程
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Nano Research
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2021
·Vol. 15
·期 3
·2288-2299
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IF 8.897
Du Yan,Liu Di,Sun Mingchen,Shu Gaofeng,Qi Jing,You Yuchan,Xu Yiting,Fan Kai,Xu Xiaoling,Jin Feiyang,Wang Jun,Shen Qiying,Zhu Luwen,Ying Xiaoying,Ji Jiansong,Wu Liming,Liu Daren,Du Yongzhong
Hepatocellular carcinoma (HCC) is a life-threatening disease for which there is no effective treatment currently. Novel theranostics simultaneously having excellent imaging and therapeutic functions are highly desired in cancer therapy. Herein, we develop the sialic acid (SA) modified polymeric micelles at an upper critical solution temperature (UCST) of 43 °C (sialic acid-polyethylene glycol)-poly(acrylamide- co -acrylonitrile), SA-PEG-p(AAm- co -AN)), which further encapsulated with doxorubicin (DOX) and Gd-CuS nanoparticles (Gd-CuS NPs) for chemo-photothermal treatment of HCC guided by magnetic resonance (MR)/photoacoustic (PA) dual-mode imaging. The resultant SA-PEG-p(AAm- co -AN)/DOX/Gd-CuS (SPDG) had an excellent photothermal conversion efficiency, enabling SPDG with an instantaneous release behavior of DOX under near-infrared (NIR) irradiation. This study also revealed that SPDG could actively target to HCC, which was due to that SA had a high affinity with E-selectin overexpressed at the tumor site. Moreover, benefiting from the HCC-targeted ability and NIR light-controlled on-demand delivery of DOX, SPDG showed a superior potential in MR/PA dual-mode imaging-guided chemo-photothermal treatment. Overall, our study reveals that the designed SPDG may be used as an ideal multifunctional nanoplatform for cancer theranostics.
研究领域:
生物医学工程
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纳米技术
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癌症治疗
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分子成像
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Journal of Materials Chemistry B
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2023
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IF 7
Mengmeng Zhang,Tianze Wu,Hui Zhang,Zhenxia Chen,Yannan Yang,Yun Ling,Yaming Zhou
Asymmetric carbon has emerged as an important material to enrich morphologies as well as enhance functions for bioapplications. Here, asymmetric mesoporous carbon hemispheres (CHS) integrated with γ-Fe2O3 and GdPO4 (Fe–Gd) nanoparticles are proposed and prepared for potential imaging-guided photothermal therapy (PTT). Interestingly, Fe–Gd/CHS contributes to an almost 1.5 times enhancement in light harvesting and photothermal conversion efficiency as compared with its corresponding spherical analogue. The possible underlying mechanism is discussed in view of the unique asymmetric structure-featured carbon. Further identification of the inherited photoacoustic (PA) and magnetic resonance (MR) imaging properties leads to the consequent in vivo evaluation of its imaging and PTT performances, which demonstrates its capability as a function-integrated system for potential theranostics.
研究领域:
材料科学
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生物医学工程
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影像医学
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DOI
PubMed
高影响因子
Advanced Healthcare Materials
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2019
·Vol. 9
·期 1
·1901229
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IF 6.27
Shi-Zhao Lu,Xiao-Yan Guo,Mei-Shuai Zou,Zi-Qin Zheng,Yu-Chuan Li,Xiao-Dong Li,Li-Li Li,Hao Wang
The emergence of drug-resistant bacteria is becoming the focus of global public health. Early-stage pathogen bioimaging will offer a unique perspective to obtain infection information in patients. A photoacoustic (PA) contrast agent based on functional peptide modified gold nanoparticles (AuNPs@P1) is developed. These nanoparticles can be specifically tailored surface peptides by bacterial overexpressed enzyme inducing in situ aggregation of the gold nanoparticles. In the meantime, the close aggregation based on the hydrogen bonding, π–π stacking, and hydrophobic interaction of the peptide residues on the surface of gold nanoparticles exhibits a typical redshifted and broadened plasmon band. In addition, this active targeting and following in situ stimuli-induced aggregation contribute to increased nanoparticle accumulation in the infected site. Finally, the dynamic aggregation of AuNPs@P1 results in dramatically enhanced photoacoustic signals for bioimaging bacterial infection in vivo with high sensitivity and specificity. It is envisioned that this PA contrast agent may provide a new approach for early detection of bacterial infection in vivo.
研究领域:
生物医学工程
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纳米技术
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医学成像
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微生物学
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PubMed
高影响因子
ACS Applied Nano Materials
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2022
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IF 6.14
Jiqiao Liu,Quan Li,Yanhong Ji,Zhenyu Cui,Younas Mohammad,Jianxin Li,Benqiao He
Nanofiltration (NF) membranes commonly with a single polyamide (PA) barrier layer play a significant role in the fields of separation and purification. Herein, an NF membrane with double PA layers was successfully fabricated through interfacial polymerization (IP) of a diamine with trimesoyl chloride, and CaCO3 nanoparticles were used as scaffolds. The upper PA layer grounded on the nano-CaCO3 aggregates was incomplete with multidefects. Trimesoyl chloride solution could permeate through the multidefect PA layer to continue IP reaction with diamine underneath the multidefect PA layer to form a bottom defect-free PA layer. The double PA layers almost fitted together, and additional nanovoids were left after removing nano-CaCO3 particles by HCl. The NF membranes with double PA layers exhibited a high water permeance of 34.1 L·m–2·h–1·bar–1, 3.4-fold that of the control sample without sacrificing selectivity. This was attributed to the enhancement of the hydrophilicity and effective filtration area and decrease in PA layer thickness, as well as additional nanovoids to reduce transport resistance. The antifouling performance of the NF membrane was found to be superior to that of the control sample possibly because the upper thin PA layer as a protective layer reduced the contamination to the separation layer.
研究领域:
膜科学
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材料科学
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纳米技术
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环境工程
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2026
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IF 3.9
Jizhe Liu,Yishen Lu,Yuhao Wu,Tingting Li,Xiaohui Wang,Feng Mei,Jinlong Xu,Ru Xiao,Peng Ji
This study aims to improve the melt-spinning processability of polyamide 66 (PA 66) by trace blending with a dendritic polyamide-amine (701A) flow promoter. The strategy addresses inherent limitations of PA 66, including its narrow processing window and poor melt stability during spinning, which result from high melt viscosity and susceptibility to thermal degradation. The strategy is also enhancing fiber mechanical properties. Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) analyses confirmed that incorporation of 701A did not alter the chemical structure of PA 66. Melt flow measurements showed that 701A increased the melt flow index by a factor of 2.3–2.5. Rheological studies revealed that 701A reduced the apparent viscosity, structural viscosity index, and viscous-flow activation energy under low shear rate, while increasing the non-Newtonian index and viscous-flow activation energy under high shear rate. These effects are attributed to the dendritic architecture and abundant terminal groups of 701A. Nonisothermal crystallization kinetics further indicated that 701A promoted heterogeneous nucleation, elevating both the crystallization temperature and rate of PA 66/701A blends. Notably, microblending with only 0.2 wt % 701A enabled the production of PA 66 monofilaments with superior mechanical performance at reduced processing temperatures.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Yan Zhang,Hai Yu,Jie Liu,Ying Pei,Xuejing Zheng,Keyong Tang
Antibacterial hydrogels have garnered significant attention in wound healing research, yet the development of multifunctional wound dressings remains a challenge. In this work, we designed a gelatin-based composite hydrogel with exceptional antibacterial efficacy, robust anti-oxidant capacity, and strong adhesive properties, tailored for advanced wound management. The hydrogel incorporates dialdehyde microfibrillated cellulose (DAMFC) to enhance its mechanical strength through fibril reinforcement and Schiff-base reactions between DAMFC's aldehyde groups and gelatin's amide chains. Additionally, proanthocyanidin (PA) was employed as both a reducing agent and a capping layer for the green synthesis of nanosilver particles (AgNPs@PA). The resulting AgNPs@PA/DAMFC/gelatin composite hydrogel exhibited outstanding mechanical properties, including a tensile strength of 300 kPa and an elongation at break of 250 %, alongside excellent adhesion (18 kPa) and self-healing capability (70 %), ensuring durable wound protection. Remarkably, AgNPs@PA possess excellent antioxidant capacity (effective DPPH and ABTS radical scavenging) and antibacterial properties (antibacterial rate > 99 %). This feature effectively mitigates wound inflammation and accelerates the healing process (by day 12, wound closure was 92 %). Collectively, the AgNPs@PA/DAMFC/gelatin hydrogel demonstrates immense potential as a multifunctional wound dressing, offering a promising solution for advanced wound care applications.
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PubMed
高影响因子
Frontiers in Immunology
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2025
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IF 5.9
Shuo Qi,Lei Zhou,Weinan Liu,Lian Shen,Yuping Yao,Bingzhang Tian,Changjun Liu,Wei Cheng,Kang Chen
Introduction: Early-stage hepatocellular carcinoma (HCC) poses a significant challenge due to its poor prognosis, necessitating advancements in diagnostic and therapeutic strategies. The integration of near-infrared photoacoustic (PA) imaging with magnetic resonance (MR) imaging offers enhanced temporal and spatial resolution, exceptional optical contrast, and profound tissue penetration, positioning this combination as a highly promising technique for accurate and sensitive HCC diagnosis.Methods: In this study, we developed a multifunctional and highly biocompatible nanoplatform, designated as ICG/Mn-PDA-PEG-CXCR4 (IMPP-c). This nanoplatform is designed to diagnose and treat early-stage HCC through PA/MR imaging-guided noninvasive photothermal therapy (PTT) and photodynamic therapy (PDT).Results: Both in vitro and in vivo experiments demonstrated enhanced accumulation of IMPP-c nanoparticles (NPs) within HCC. Notably, the dual-modal PA/MR imaging facilitated by IMPP-c achieved high resolution and substantial deep tissue penetration, enabling precise localization of early orthotopic small hepatocellular carcinoma (SHCC) lesions. In vivo tumor phototherapy experiments, guided by PA/MR imaging, revealed that SHCC was completely eradicated through noninvasive PTT/PDT without recurrence. Additionally, the metabolism of IMPP-c NPs was observed in major organs throughout the treatment process, confirming its reliable biocompatibility.Discussion: This study introduces a novel method for diagnosing and implementing non-invasive therapeutic interventions in early HCC using nanoparticle systems such as IMPP-c, paving the way for potential future clinical applications.
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PubMed
高影响因子
RESEARCH ON CHEMICAL INTERMEDIATES
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2025
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IF 3.5
Guo Fang,Liu Yijun,Zhong Yu,Feng Wanyun,Shang Xiaoqiang,Chen Yufeng
In order to improve the loading capacity of the drug delivery system based on magadiite for procainamide (PA), the cationic PA was inserted into the interlayer of magadiite by the intercalation of tetra-n-butylammonium ions and multi-step ultrasonic ion exchange. X-ray diffraction, compositional analyses, and IR results confirmed that the cationic PA was successfully loaded into the interlayer of magadiite, and the loading capacity of the drug delivery system based on magadiite for PA was about 25.0%. Thermogravimetric analysis indicated that the thermal stability of PA was obviously improved after it was loaded into the interlayer of magadiite. Drug release revealed the sustained and controlled release of PA from drug delivery system either in phosphate buffer solution (PBS, pH = 7.4, simulating intestinal fluid) or in HCl solution (pH = 1.35, simulating gastric fluid). This sustained release of drugs will be beneficial to improve the availability and efficacy of drugs. Moreover, the kinetic behavior of drug release either in PBS or in HCl can be fitted to ExpAssoc model. Nuclear magnetic resonance (NMR) results indicated that there is an interaction between the magadiite and PA in the drug delivery system, and this interaction may determine the kinetic behavior of drug release. The present work may provide a refer for improving the loading capacity of positively charged drugs in some layered silicates, which would be important in medical field.
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CELLULOSE
·
2024
·Vol. 31
·期 10
·6517-6533
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IF 4.9
Li Qingyi,Zong Yakun,Jiang Yuanzhang,Zhang Jun,Zhao Ruifang,Chen Jianming,Shi Yidong,Tan Lin
Cotton fabrics are widely used in clothing, packaging, and medical applications because of their excellent comfort, breathability, and low cost. However, it poses a threat to use them in specific scenarios, where flame retardance and antibacterial activity are highly desired. In this work, we propose the functionalization route by using layer-by-layer assembly of polyethyleneimine (PEI), phytic acid (PA), iron (Fe 3+ ), and aluminum (Al 3+ ) ions on cotton fabrics. Interestingly, the modified cotton fabric showed good biocompatibility in the cell viability (> 70%) and hemolysis (< 3%) test. In addition to biocompatibility, the antibacterial performance was largely improved for the modified cotton fabric with the antibacterial efficacy of > 99% due to the presence of Fe 3+ and Al 3+ that work in a synergistic manner. In term of flame retardance, the modified cotton fabric exhibited self-extinguishing characteristics in vertical burning experiments, with the Limiting Oxygen Index (LOI) of 35.0%. The excellent flame-retardant property was further supported by the results in cone calorimetry test, thermal gravimetric analysis, and TG-IR test, elucidating the underlying mechanism that rapid formation of dense char layer by the thermal decomposition of PEI/PA/FeAl system is effective to prevent the spreading of flame and thus protect the cotton from burning. This work provides a strategy to achieve multifunctionality on cotton fabrics, which may inspire the design on other types of fabrics or materials for extended applications.
研究领域:
材料科学
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纺织工程
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生物医学工程
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Qin Cheng,Jinping Gan,Kai Cai,Ming Xia,Yi Wu,Shanshan He,Pan Cheng,Qihao Guo,Ke Liu,Dong Wang
High-quality polyamide (PA) nanofiltration (NF) membrane with excellent selectivity and permeability is of great research significant because of their high practical application value, especially for the precise separation of divalent and monovalent ions, such as Mg 2+ and Li + . Herein, UiO-66-NH 2 nanoparticles (NPs) decorated ethylene vinyl alcohol copolymer (EVOH) nanofiber substrate (M-NFM) was utilized to construct high-quality Janus NF membrane through interfacial polymerization (IP) reaction using polyethyleneimine (PEI) and piperazine (PIP) as aqueous phase monomers and trimesoyl chloride (TMC) as organic phase monomers. The incorporation of UiO-66-NH 2 NPs significantly influenced the hydrophilicity, surface morphology, and pore structure of the substrate, thereby enhancing the properties of the resulting NF. Optimally prepared membranes demonstrated improved separation performance, permeability, stability, and antifouling characteristics compared to the unmodified substrate. Notably, at a Mg 2+ /Li + ratio of 30, the resultant NF membrane achieved a separation factor (S Mg 2+ /Li + ) of 28.4 and a salt permeation flux of 156.8 L·m -2 ·h -1 ·MPa -1 . Additionally, the membrane exhibited over 98% rejection rates for FeCl 3 , CuSO 4 , CaCl 2 , MgSO 4 , MgCl 2 and Na 2 SO 4 with fluxes exceeding 150 L·m -2 ·h -1 ·MPa -1 , highlighting its effectiveness in rejecting multivalent ions. This research presents a simpler and more reliable approach to the fabrication of high-quality Janus PA NF membrane, offering promising potential for industrial-scale applications.
研究领域:
材料科学
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环境工程
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化学工程
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高影响因子
危险品化学品经营许可证（带存储）