CHEMICAL ENGINEERING JOURNAL
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2023
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IF 15.1
Kaiyuan Shen,Yu Tang,Qihang Zhou,Ying Zhang,Wen Ge,Xuxia Shai,Shuping Deng,Peizhi Yang,Shukang Deng,Jinsong Wang
Development of economical and high-efficient catalytic electrodes is a top priority for oxygen evolution reactions (OER). Non-precious metal based metal–organic frameworks (MOFs) in powder form remain a series of problems including the assistance of adhesive, poor conductivity and stability. Herein, a well-designed S-NiFe PBA@NiFe/NF composite with a unique Mott-Schottky heterojunction architecture was purposefully constructed by self-sacrificing template approach and electrodeposition. The growth of S-NiFe PBA@NiFe on NF through in situ synthesis promotes efficient electron conduction between the NF substrate and S-NiFe PBA@NiFe catalyst, leading to a stable and highly effective working state. The Mott-Schottky heterojunctions between S-NiFe PBA and NiFe-layered double hydroxides (LDH) effectively expedite electronic transmission. Consequently, S-NiFe PBA@NiFe/NF exhibits outstanding OER behavior at 1.0 M KOH, exhibiting a low Tafel slope of 39 mV dec −1 and at 10 mA cm −2 , reaching an unexpectedly low overpotential of 196.7 mV. Furthermore, the S-NiFe PBA@NiFe/NF maintains long-term durability without evident performance degradation for 100 h.
研究领域:
材料科学
·
电化学
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DOI
高影响因子
MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 11
·1-10
·
IF 5.705
Yang Haimei,Jie Xu,Wang Lu,Zhang Yue,Wang Min,Wei Weili
A fluorescent array based on the use of saccharide-functionalized multicolored quantum dots (s-QDs) and of 4-mercaptophenylboronic acid-functionalized MoS 2 nanosheets (PBA-MoS 2 ) was constructed for multiple identification and quantitation of lectins and bacteria. In this array, the fluorescence of the s-QDs is quenched by the PBA-MoS 2 nanosheets. In the presence of multiple lectins, s-QDs differentially detach from the surface of PBA-MoS 2 nanosheets, producing distinct fluorescence response patterns due to both quenching and enhancement of fluorescence. By analyzing the fluorescence responses with linear discriminant analysis, multiple lectins and bacteria were accurately identified with 100% accuracy. The limits of detection of Concanavalin A , Pisum sativum agglutinin, Peanut agglutinin, and Ricius communis I agglutinin are as low as 3.7, 8.3, 4.2 and 3.9 nM, respectively. The array has further been evidenced to be potent for distinguishing and quantifying different bacterial species by recognizing their surface lectins. The detection limits of Escherichia coli and Enterococcus faecium are 87 and 66 cfu mL −1 , respectively.
Schematic of a fluorometric array based on the use of saccharides-functionalized quantum dots (s-QDs) and 4-mercaptophenylboronic acid-functionalized MoS 2 (PBA- MoS 2 ) nanosheets. This array was successfully applied to simultaneously analysis of lectins, bacteria in real samples with high sensitivity and accuracy.
研究领域:
纳米技术
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分析化学
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生物传感器
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微生物学
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产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2023
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IF 6.6
Richeng Lian,Yihao Jiang,Yaqin Zhang,Qingyao Gao,Haocun Guan,Lei Liu,Xilei Chen,Chuanmei Jiao
In recent years, developing bio-based intumescent flame-retardant (IFR) epoxy coatings for fire protection of steel has become a research hotspot. However, how to endow bio-based IFR epoxy coatings with excellent fire protection, toxic gas suppression, and mechanical properties simultaneously remains a formidable challenge. Here, a bio-based IFR hybrid with the maize structure (PAbz@PBA) was easily constructed by an organic-inorganic hybrid strategy and employed to prepare high-performance IFR epoxy coatings. It has been shown that PAbz@PBA hybrids enhance the curing activity of epoxy coatings in addition to their good dispersion and interfacial compatibility. Notably, the epoxy coating containing 5.0 wt% PAbz@PBA (EP-5%PAbz@PBA) exhibits more efficient fire protection (peak heat release rate and total heat release are reduced by 48.3 % and 34.0 %, respectively), smoke suppression (total smoke production is decreased by 35.9 %), and toxic gas suppression (peak CO production rate is reduced by 39.6 %) compared to the virgin epoxy coating. Meanwhile, the heat insulation performance of EP-5%PAbz@PBA shows superiority compared to that of the virgin epoxy coating, as reflected by its lowest backside temperature (66.3 °C). Furthermore, compared with the virgin epoxy coating, EP-5%PAbz@PBA exhibits improved flexural and impact strengths. This work offers a viable idea for designing bio-based PAbz@PBA hybrids and preparing IFR epoxy coatings with various excellent properties.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
Journal of Energy Storage
·
2023
·
IF 9.4
Xin Xu,Shang Wu,Xin Sun,Shuo Tian,Chaoyang Liu,Penghui Zhang,Shuaishuai Fu,Yanbin Wang,Qiong Su,Xia Wang,Quanlu Yang
The rectangular nanorods microstructure with abundant pores can reduce structural damage caused by the volume contraction during charging-discharging processes and enhance the specific capacitance. In this work, to enhance the energy density and accelerate the marketable applications of supercapacitors , Bi 2 O 3 /BiFeO 3 rectangular nanorods with rich mesoporous structure derived from the iron‑bismuth based Prussian blue analogue are rationally designed to achieve a large specific capacitance through precipitation and annealing measures. There are a huge specific capacity of 741 F g −1 and long cycle life. The NiCo-LDH/rGO (954 F g −1 ) demonstrated an impressive stability of 86 % after 10,000 cycles and is utilized to establish asymmetric supercapacitor device. Amazingly, the NiCo-LDH/rGO//Bi 2 O 3 /BiFeO 3 device achieves an enormous energy density of 59.7 Wh kg −1 at 800 W kg −1 . In addition, the capacity retention ratio is 79.3 % after 7000 cycles. The work has suggested that Bi 2 O 3 /BiFeO 3 has great potential as a negative electrode of supercapacitors.
研究领域:
材料科学
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能源存储技术
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产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2024
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IF 6.1
Qingchen Feng,Mei Zhang,Guanning Zhang,Hongxiang Mei,Chongying Su,Lisa Liu,Xiaoxia Wang,Ziqianhong Wan,Zhengyi Xu,Liangkui Hu,Yu Nie,Juan Li
Elevated glucose levels, multiple pro-inflammatory cytokines and the generation of excessive reactive oxygen species (ROS) are pivotal characteristics within the microenvironments of chronic periodontitis with diabetes mellitus (CPDM). Control of inflammation and modulation of immune system are required in the initial phase of CPDM treatment, while late severe periodontitis requires a suitable scaffold to promote osteogenesis, rebuild periodontal tissue and reduce alveolar bone resorption. Herein, a whole-course-repair system is introduced by an injectable hydrogel using phenylboronic acid functionalized oxidized sodium alginate (OSA–PBA) and carboxymethyl chitosan (CMC). Epigallocatechin-3-gallate (EGCG) was loaded to simultaneously adjust the mechanical property of the OSA–PBA/CMC + EGCG hydrogel (OPCE). This hydrogel has distinctive adaptability, injectability, and ROS/glucose-triggered release of EGCG, making it an ideal drug delivery carrier. As expected, OPCE hydrogel shows favourable antioxidant and anti-inflammatory properties, along with a regulatory influence on the phenotypic transition of macrophages, providing a favourable immune microenvironment. Apart from that, it provides a favourable mechanical support for osteoblast/osteoclast differentiation regulation at the late proliferation stage of periodontal regeneration. The practical therapeutic effects of OPCE hydrogels were also confirmed when applied for treating periodontitis in diabetic rats. In summary, OPCE hydrogel may be a promising whole-course-repair system for the treatment of CPDM.
研究领域:
口腔科学
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生物材料
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药学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2017
·Vol. 5
·期 15
·2823-2831
·
IF 4.543
Dan Zhao,Xiaoqing Yi,Jiaqi Xu,Gongdao Yuan,Renxi Zhuo,Feng Li
Using the host–guest interaction between β-cyclodextrin (β-CD) and adamantane (Ad), and borate formation between phenylboronic acid (PBA) and cis-diols, a smart pH-responsible targeting drug delivery nanovehicle, PBA–PEG–CD/Ad-lys(Diol)–PCL, was prepared via one-step self-assembly. Under physiological conditions, the targeted PBA function could be restrained by binding PBA with diol components located at the interface of self-assemblies, and hydrophilic PEG segments could be shielded simultaneously. When the environmental pH decreased, the PBA groups could be unbound and exposed on the surface of self-assemblies, leading to recovery of its targeted function, as shown using fluorescence spectroscopy, in vitro cell toxicity, and uptake. Under acidic conditions, PBA–PEG–CD/Ad-lys(Diol)–PCL/Dox showed significantly increased uptake and toxicity toward HepG2 cells in comparison with the control group. The smart vehicles were further utilized to test their efficiency in overcoming drug resistance in chemotherapy. Compared with free Dox, PBA–PEG–CD/Ad-lys(Diol)–PCL delivered six times more Dox into MCF-7/ADR cells and showed greater toxicity toward the ADR cells. As a result, this may be a facile strategy toward constructing efficient targeting vehicles through the rational utilization of noncovalent interactions.
研究领域:
药剂学
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纳米技术
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药物递送系统
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癌症研究
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2021
·
IF 9.229
Liming He,Xianyan Qin,Donghao Fan,Chenglan Feng,Qin Wang,Jiyu Fang
The nontargeted distribution and uncontrolled in vivo release of drugs impede their efficacy in the treatment of rheumatoid arthritis (RA). Delivering drugs to arthritic joints and releasing drugs on demand are a feasible solution to achieve the effective treatment of RA. In this paper, we report a facile method to assemble dual-stimuli responsive polymeric micelles from polyethylene glycol–phenylboric acid–triglycerol monostearate (PEG–PBA–TGMS, PPT) conjugates with the aim of delivering dexamethasone (Dex) to arthritic joints and controlling the release of Dex by inflammatory stimuli. We show that the release of Dex from the PPT micelles is accelerated in response to acidic pH and overexpressed matrix metalloproteinases. In an adjuvant-induced arthritis model, the PPT micelles preferentially accumulate in arthritic joints and show an excellent therapeutic efficacy after being intravenously administrated. Our results highlight the potential of the dual stimuli-responsive micelles as a promising therapeutic option for the effective treatment of inflammatory diseases.
研究领域:
药学
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纳米技术
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生物医学工程
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炎症研究
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENT INTERNATIONAL
·
2024
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IF 10.3
Haining Du,Jiaxin Li,Xiangjuan Wei,Daqian Yang,Boya Zhang,Xingpei Fan,Meimei Zhao,Ruijiao Zhu,Ziyi Zhang,Yuxia Zhang,Xiaoyan Li,Ning Gu
Methylparaben (MP), a preservative widely used in daily supplies, exists in both the environment and the human body. However, the potential health risks posed by MP remain unclear. This study aimed to unravel the mechanisms by which MP disrupts glucose and lipid homeostasis. For this, we administered MP to mice and observed changes in glucose and lipid metabolism. MP exposure led to hyperglycemia, hyperlipidemia, visceral organ injury, and hepatic lipid accumulation. RNA sequencing results from mice livers indicated a close association between MP exposure and endoplasmic reticulum (ER) stress, inflammatory response, and glucose and lipid homeostasis. Western blotting and quantitative reverse transcription–polymerase chain reaction revealed that MP activated ER stress, particularly the inositol-requiring enzyme 1 (IRE1)/X-box binding protein 1 (XBP1) pathway, which further promoted the activation of the nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways. The activation of these pathways phosphorylated insulin receptor substrate-1 (IRS1) (ser 307), resulting in decreased phosphorylation of protein kinase B (Akt) (ser 473), leading to insulin resistance. Additionally, MP exposure promoted lipogenesis through ER stress. To explore potential remedies, we administered the ER stress inhibitor 4-phenylbutyric acid (4-PBA) and the IRE1α-XBP1 pathway inhibitor toyocamycin to mice, both of which protected against metabolic disorders and organ injury caused by MP. These findings suggest that MP induces disruptions in glucose and lipid metabolism through ER stress, primarily through the IRE1α-XBP1 pathway.
研究领域:
毒理学
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代谢
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内分泌学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2018
·
IF 2.829
Xueting Lu,Yangyang Li,Wei Feng,Shuang Guan,Peipei Guo
In this report, the self-healable hydrogels containing hydroxypropyl guar gum (HPG), acrylamide (AM) and 3-acrylamidophenylboronic acid (AAPBA) were prepared through a facile strategy. The double bond in AAPBA could polymerize with AM to form copolymers. Moreover, the boronic acid groups of AAPBA can interact with cis-diol of HPG which make AAPBA act not only polymer but cross-linkers simultaneously connecting PAM and HPG chains. The mechanical strength of the hydrogels was systematically investigated as a function of AAPBA content, HPG content, AM content and pH. It was found the hydrogels exhibited higher stress, elongations and self-healing properties due to the synergistic interaction of H-bond and dynamic covalent phenylboronic (PBA)-diol ester bonds. Furthermore, the hydrogels showed yielding phenomenon depending on the content of AM and pH, which could play a vital influence on the crosslinking manners and density. The detailed discussions of the relationship between crosslinking manners and yielding phenomenon provide a better understanding on the appearance of yielding phenomenon and their correlation with hydrogel structure.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Zhiyu Zheng,Ruxin Xiao,Xiaochen Ma,Ziqian Yu,Jiaxin Zeng,Liqiong Liao
Three-dimensional (3D) cell culture technology can mimic the physiological characteristics of tissues and organs, making it highly suitable for cell therapy, organ chips, and tissue engineering applications. However, achieving a uniform cell distribution within the 3D matrix while mitigating the effects of reactive oxygen species (ROS) accumulation generated during the 3D cell culture remains a critical challenge. Hydrogel actuators, with their excellent bioactivity and controllable self-rolling behavior, provide an optimal microenvironment for the 3D cell culture. To support normal cellular function, hydrogel actuators must be triggered by external stimuli that are biocompatible with the cell culture process. Glucose, a key intermediate in energy metabolism and biological processes, is ubiquitous in cell culture media and physiological systems. In this work, a glucose-responsive hydrogel actuator (AP@Que/gelatin) with controllable self-rolling behaviors and ROS scavenging capability was constructed for 3D cell culture, which consists of an active layer composed of phenylboronic acid (PBA)–quercetin (Que) complexes and a passive layer of a biocompatible gelatin hydrogel. The hydrogel actuator exhibited excellent glucose response performance, characterized by notable reswelling behavior, favorable ductility, and cytocompatibility. Its self-rolling behavior in high-glucose culture media was synchronized with cell adhesion timelines, enabling its application as a 2D-to-3D dynamic substrate for cell culture and expansion. Meanwhile, Que was released from the hydrogel actuator through the competitive reaction of PBA with glucose and Que. The formation of the 3D tubular architecture during cell culture facilitated cell growth, while the sustained release of Que effectively eliminated ROS generated during cell passaging. These findings highlight the potential of AP@Que/gelatin hydrogel actuators as an advanced platform for a 3D cell culture.
研究领域:
生物材料
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组织工程
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细胞培养技术
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药物递送系统
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生物执行器
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2022
·
IF 9.221
Peilin Wang,Zizhun Wang,Zhenrun Li,Yuan Wang,Qiang Ma
In this work, a novel electrochemiluminescence (ECL) biosensor was fabricated to detect the mutant KRAS gene in the tumor tissues. Firstly, a new kind of chitosan-based dots was prepared and regulated by phenylboronic acid (PBA) as ECL nanoprobe. Furthermore, the electrochemically deposited Ag structures with controllable morphology have been developed on the electrode. The detailed electrochemical deposition condition of Ag structure has been investigated deeply. Due to the synergistic effect of the large active surface area and the high conductivity , the layered Ag flower-like structure with branches can significantly enhance the ECL intensity of CS-PBA dots by 12.1 times. Finally, the toehold mediated strand displacement strategy was employed in the ECL biosensor to quantitatively detect mutant KRAS gene with the range of 0.01 pM to 10 nM. The limit of detection was 3.3 fM. This biosensor has been used successfully to analyze the target DNA in the tumor tissues of actual cancer patients . The results showed the novel sensing platform possessed great potential for clinical analysis.
研究领域:
生物医学工程
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分析化学
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分子生物学
·
癌症研究
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产品关联
DOI
高影响因子
BIOLOGICAL RESEARCH
·
2024
·Vol. 57
·期 1
·1-12
·
IF 4.3
Ma Lin-Wei,Liu Yu-Fan,Zhang Hui,Huang Chang-Jun,Li Ang,Qu Xin-Zhe,Lin Jia-Piao,Yang Yan,Yao Yong-Xing
Studies have suggested that endoplasmic reticulum stress (ERS) is involved in neurological dysfunction and that electroacupuncture (EA) attenuates neuropathic pain (NP) via undefined pathways. However, the role of ERS in the anterior cingulate cortex (ACC) in NP and the effect of EA on ERS in the ACC have not yet been investigated. In this study, an NP model was established by chronic constriction injury (CCI) of the left sciatic nerve in rats, and mechanical and cold tests were used to evaluate behavioral hyperalgesia. The protein expression and distribution were evaluated using western blotting and immunofluorescence. The results showed that glucose-regulated protein 78 (BIP) and inositol-requiring enzyme 1α (IRE-1α) were co-localized in neurons in the ACC. After CCI, BIP, IRE-1α, and phosphorylation of IRE-1α were upregulated in the ACC. Intra-ACC administration of 4-PBA and Kira-6 attenuated pain hypersensitivity and downregulated phosphorylation of IRE-1α, while intraperitoneal injection of 4-PBA attenuated hyperalgesia and inhibited the activation of P38 and JNK in ACC. In contrast, ERS activation by intraperitoneal injection of tunicamycin induced behavioral hyperalgesia in naive rats. Furthermore, EA attenuated pain hypersensitivity and inhibited the CCI-induced overexpression of BIP and pIRE-1α. Taken together, these results demonstrate that EA attenuates NP by suppressing BIP- and IRE-1α-mediated ERS in the ACC. Our study presents novel evidence that ERS in the ACC is implicated in the development of NP and provides insights into the molecular mechanisms involved in the analgesic effect of EA.
研究领域:
神经科学
·
疼痛管理
·
分子生物学
·
针灸
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）