Journal of Materials Chemistry B
·
2023
·Vol. 11
·期 22
·5010-5020
·
IF 7
Wen Li,Xiaole Hu,Hongsheng Liu,Jinhuan Tian,Lihua Li,Binghong Luo,Changren Zhou,Lu Lu
Reliable, fast and switchable gluing modes are critically important in medical adhesives and intelligent climbing robot applications. The octopus-bionic patch has attracted the attention of many scholars. The suction cup structure of the octopus achieves adhesion through differential pressure, showing strong adhesion in both dry and wet environments. However, the construction of the octopus-bionic patch remains limited in terms of adaptability, personalization and mass production. Herein, a composite hydrogel consisting of gelatin methacryloyl (GelMA), polyethylene glycol diacrylate (PEGDA) and acrylamide (AAM) was developed, and a structure mimicking the octopus sucker was constructed by digital light processing (DLP). The obtained octopus-bionic patch has strong adhesion, good biocompatibility and multi-functionality. Compared with the template method in most studies, the octopus-bionic patch constructed by the DLP printing method has the advantages of customizability and low cost. In addition, the DLP printing method endows the patch surface with an octopus-like groove structure for a better bionic effect.
研究领域:
生物医学工程
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材料科学
·
机器人学
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产品关联
DOI
PubMed
高影响因子
Applied Materials Today
·
2024
·
IF 7.2
Tianyu Yuan,Dongdong Liu,Qian Li,Meng Wei,Yingbao Sun,Hua Xie,Lina Du,Bochuan Yuan,Pei Deng,Yanli Guo,Yiguang Jin
Corrosive esophagitis (CE) is a severe disease caused by accidental or suicidal ingestion of corrosive chemical agents, leading to serious esophageal stenosis or fibrosis. However, the effective and safe treatment of CE is lacking. Here, a melatonin esophagus stent (MES) was prepared using the stereolithography three-dimensional (3D) printing technology with melatonin, polyethylene glycol diacrylate (PEGDA), polyethylene glycol (PEG) 400, and other additives. The MESs with the Roman columns, caduceus, Pagoda, and mace morphologies were designed and printed, respectively. Pagoda MESs exhibited good mechanical properties, retained in the esophagus for more than 24 h, and showed rapid melatonin release. MESs had high in vitro and in vivo safety. More importantly, the implanted MES was broken down into fragments in the gastrointestinal tract and then completely evacuated from the rat body. The CE rat model was established by injecting a strong alkaline solution into the esophagus. The Pagoda MES was conveniently implanted at the injury position, which remarkably alleviated the CE symptoms, reduced inflammation, and prevented esophagus stenosis and fibrosis. 3D-printed Pagoda MESs hold promise for the treatment of CE.
研究领域:
生物医学工程
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药学
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材料科学
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组织工程
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2024
·
IF 5.4
Xingguo Zhou,Bin Zou,Qinghua Chen,Gongxian Yang,Qingguo Lai,Xinfeng Wang
An ideal biomimetic periosteum should have excellent biocompatibility to promote osteoclast adhesion and improve osseointegration, which is significant in promoting bone regeneration. In this work, a bionic artificial periosteum printed by the SLA-3D printing was prepared, consisting of a poly (ethylene glycol) diacrylate (PEGDA)/chitosan/tricalcium phosphate (TCP) fibrous layer and a gelatin methacryloyl (GelMA)/ammonium molybdate (Mo) cambium layer. Distinct surface characteristics were achieved on both sides of the biomimetic periosteum. Among them, the fibrous layer has high mechanical properties and low porosity, which is conducive to preventing the pulling of muscle tissues and the invasion of soft tissues. The cambium layer has a porous structure and bioactive factors that can effectively promote osteogenic differentiation of preosteoblasts. Combined with mild photothermal therapy triggered by NIR light, the biomimetic periosteum could promote bone regeneration at both the chemical and physical levels. This 3D-printed bilayer hydrogel can provide a promising strategy for preparing advanced tissue-engineered periosteum with excellent physical and bone regeneration properties.
研究领域:
组织工程
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生物医用材料
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再生医学
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3D打印
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生物材料
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Mingxin Qiao,Zhengyi Xu,Xibo Pei,Yanhua Liu,Jian Wang,Junyu Chen,Zhou Zhu,Qianbing Wan
Hyperlipidemia negatively affects osteogenesis, thereby impairing bone healing. However, few biomaterials have been developed for bone tissue engineering to solve this problem. Herein, the preparation of specific biomaterials that can promote osteogenesis and suppress adipogenesis holds great promise for reconstructive bone defect treatment. In this study, we propose the construction of a nano simvastatin-laden zeolitic imidazolate framework-8 (nano [email protected] ) modified injectable high-intensity biohydrogel, composed of poly (ethylene glycol) diacrylate (PEGDA) and sodium alginate (SA) to form nano [email protected] /PEGDA/SA (defined as nSZPS), which can stimulate osteogenic differentiation and inhibit adipogenic differentiation. The characterization and drug loading efficiency of the nanoparticles were examined to confirm the successful synthesis of nano [email protected] Within the PEGDA/SA delivery platform, nSZPS showed excellent injectability and mechanical strength through rheological and mechanical tests. Moreover, owing to the sustained release of SIM and bioactive Zn ions, nSZPS not only possessed excellent biocompatibility but also significantly enhanced the osteogenic differentiation ability and inhibited the adipogenic efficacy of BMSCs in vitro. Furthermore, nSZPS showed excellent osseointegration and lipid-lowering abilities in healing bone defects of hyperlipidemic rats by decreasing PPARγ expression and increasing RUNX2 expression in vivo. In addition, the bidirectional regulatory mechanisms of nSZPS in bone defects may be closely related to the mutual regulation of the PPARγ and Wnt/β-CATENIN pathways. In summary, this nano [email protected] modified injectable high-intensity biohydrogel might be a promising strategy for complex bone regeneration, especially in hyperlipidemic microenvironments.
研究领域:
生物材料
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组织工程
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骨再生
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药物递送系统
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生物医学工程
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产品关联
DOI
高影响因子
MACROMOLECULAR RAPID COMMUNICATIONS
·
2022
·Vol. 44
·期 7
·2200814
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IF 5.006
Wu-yi Xiao,Xi Liu,Wenbo Wang,Xiaobin Zhang,Yuzhe Wang,Jinze Lan,Baoshi Fan,Lianxin Shi,Xizi Wan,Shutao Wang
Excessive exudate secreted from diabetic wounds often results in skin overhydration, severe infections, and secondary damage upon dressing changes. However, conventional wound dressings are difficult to synchronously realize the non-maceration of wound sites and rapid exudate transport due to their random porous structure. Herein, a self-pumping Janus hydrogel with aligned channels (JHA) composed of hydrophilic poly (ethylene glycol) diacrylate (PEGDA) hydrogel layer and hydrophobic polyurethane (PU)/graphene oxide (GO)/polytetrafluoroethylene (PTFE) layer is designed to rapidly export exudate and accelerate diabetic wound healing. In the design, the ice-templating process endows the hydrophilic hydrogel layer with superior liquid transport ability and mechanical strength due to the formation of aligned channel structure. The hydrophobic layer with controlled thickness functions as an effective barrier to prevent exudate from wetting the skin surface. Experiments in diabetic rat model show that JHA can significantly promote re-epithelialization and collagen deposition, shorten the inflammation phase, and accelerate wound healing. This unique JHA dressing may have great potential for real-life usage in clinical patients.
研究领域:
生物医学工程
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材料科学
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伤口愈合
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组织工程
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产品关联
DOI
PubMed
高影响因子
Energy Storage Materials
·
2021
·
IF 17.789
Chengzhao Luo,Qinyi Li,Dongyang Shen,Ronghong Zheng,Dong Huang,Yu Chen
All-solid-state batteries suffer from drastic interfacial reactions between the solid electrolyte and electrode, which restricts the performance of the full cell. Herein, a hybrid solid polymer electrolyte with high ionic conductivity and stability has been fabricated by in-situ polymerization of poly(ethylene glycol) diacrylate (PEGDA) on glass fiber matrix, followed by polyethylene glycol (PEG) infiltration . Such hybrid electrolyte, namely GF@PEGDA@PEG (GFPP), is featured with an interconnecting ionic conducting network and demonstrates high ionic conductivities of 0.8 × 10 −4 S cm −1 at 20 °C and 4.5 × 10 −3 S cm −1 at 60 °C. The ex-situ Attenuated Total Reflectance-Fourier Transform Infrared spectroscopy (ATR-FTIR) of Na/GFPP/Na symmetrical battery proves the excellent stability of GFPP. Furthermore, in-situ Electrochemical Impedance Spectroscopy (EIS) analysis and in-situ Raman spectra confirm the enhanced interfacial dynamics achieved by GFPP, being conducive to the intercalation/deintercalation of Na + . Meanwhile, the optical microscope and X-ray photoelectron spectroscopy (XPS) demonstrate the formation of a stable SEI film and limited interfacial side reaction by the incorporation of GFPP. Full sodium metal batteries based on GFPP have been assembled and demonstrated satisfactory electrochemical performance. After being tested for 1100 cycles at a rate of 0.3 C, the Coulombic efficiency of Na 3 V 2 (PO 4 ) 3 (NVP) /GFPP/Na full cell remains at almost 99%, with a capacity retention of 91.4%.
研究领域:
材料科学
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电化学
·
能源存储
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Jingsheng Chen,Zelin Zhu,Jiaqing Chen,Yiting Luo,Lin Li,Kun Liu,Shan Ding,Hong Li,Mingxian Liu,Changren Zhou,Binghong Luo
We develop a kind of photocurable liquid crystal hydrogels with bone extracellular matrix (ECM)-like liquid crystal state and viscoelasticity , as well as different chargeability. First, positively charged chitin whiskers (CHWs) and negatively charged maleic anhydride chitin whiskers (mCHWs) were prepared, which further self-assemble to form chiral nematic liquid crystals under ultrasonic treatment, respectively. Subsequently, poly (ethylene glycol) diacrylate (PEGDA) and photo initiator were added, and then two kinds of liquid crystal hydrogels with bone ECM-like viscoelasticity and different chargeability were prepared under ultraviolet (UV) irradiation. Benefiting from the bone ECM-like liquid crystal state and viscoelasticity, the prepared liquid crystal hydrogels exhibit remarkable cell affinity and osteogenic ability. Moreover, the liquid crystal hydrogel with negatively charged mCHWs is more favorable for cell adhesion , spreading and osteogenic differentiation than that with positively charged CHWs. This work provides a promising strategy to prepare the hydrogels with bone ECM-like liquid crystal properties and viscoelasticity for bone repair .
研究领域:
材料科学
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生物材料
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组织工程
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Yubin Yuan,Qianyi Yang,Qiang Wu,Xiangrui Bu,Xuming Wang,Weihua Liu,Chuanyu Han,Long Hu,Xin Li,Xiaoli Wang
Flexible electronics have been extensively investigated in recent years due to their convenient and wearable properties. Considering the practical applications in the external environment, the demand for portable and miniaturized sensing systems is prominent, for example, detecting harmful and toxic gases. Flexible sensors provide a potential novel solution for achieving the above goals, which is wearable sensing. In this paper, we develop a flexible sensor based on the ionic gel (Ion-Gel) for the detection of dimethyl methylphosphonate (DMMP). DMMP is a kind of organophosphorus gas, which may cause pollution to the environment and harm to biology. The Ion-Gel sensitive film is prepared through in-situ copolymerization of the polymer monomer poly(ethylene glycol) diacrylate (PEGDA), ionic liquid 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (EMIM-TFSI) and gas-sensing group hexafluoroisopropyl alcohol (HFIPA) under 365 nm ultraviolet light . The sensitive film can be patterned through a shadow mask on the interdigital electrodes ultimately. The sensor exhibits good sensitivity to the DMMP, with a lower limit of detection reaching 100 ppb under room temperature . Noteworthily, the sensor’s detecting upper limit is successfully extended to high gas concentrations at 800 ppm and maintains good linearity. A flexible print board circuit (FPCB) front-end is developed for the flexible DMMP sensor to construct a wearable platform that can be attached to the hand to achieve real-time detection. When the alarm threshold is set to 2 ppm DMMP, the proposed wearable detection platform can successfully give an alarm signal within 15 s
研究领域:
柔性电子
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传感器
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可穿戴技术
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环境监测
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有毒气体检测
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产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Ming Yang,Lang Chu,Yanfeng Zhuang,Cheng Qi,Si Meng,Zhou Liu,Tiantian Kong
The challenges of replicating the complex mechanical and structural diversity of natural tissues in vitro by leveraging multi-material digital light processing (DLP) bioprinting are addressed. This technique utilizes PEGDA-AAm bio-ink to develop multi-component, cell-laden hydrogel constructs with varying moduli. These constructs not only possess heterogeneous mechanical properties but also feature complex architectures and precisely engineered surface microstructures. The hydrogel microfluidic chips are successfully fabricated with perfusable microchannels, embedding various cell types within the matrix. This approach enables the bioprinting of intricate cell-laden structures with unique surface topologies, such as spiral grooves and triply periodic minimal surfaces (TPMS), which effectively influence cell alignment, spreading, and migration. By integrating various cell-laden PA hydrogels, the diverse mechanical moduli of biological tissues, including bone, liver lobules, and vascular networks are replicated. This technique ensures high-fidelity differentiation between cell types and regions. These findings provide valuable insights into the impact of substrate modulus and structure on cell behavior, underscoring the potential of multi-component, multi-modulus hydrogel constructs in creating sophisticated structures with custom-tailored mechanical properties. This study significantly advances the field by demonstrating the feasibility and effectiveness of multi-material DLP bioprinting in developing complex, functionally relevant tissue models for tissue engineering and regenerative medicine.
研究领域:
生物打印
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组织工程
·
再生医学
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材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Nano
·
2024
·
IF 15.8
Xiaobin Hui,Zhen Zhan,Zeyu Zhang,Jingya Yu,Pengyan Jiang,Zhengzheng Dang,Jian Wang,Songhua Cai,Yanming Wang,Zheng-Long Xu
Solid-state polymer electrolytes (SPEs) are promising for high-performance zinc metal batteries (ZMBs), but they encounter critical challenges of low ionic conductivity, limited Zn2+ transference number (tZn2+), and an unstable electrolyte-electrode interface. Here, we present an effective approach involving a missing-linker metallic organic framework (MOF)-catalyzed poly(ethylene glycol) diacrylate (PEGDA)/polyacrylamide (PAM) copolymer SPE for single Zn2+ conduction and seamless electrolyte-electrode contact. The single-Zn2+ conduction is facilitated by the anchoring of the OTF– anions onto the unsaturated metal sites of missing-linker MOF, while the PEGDA and PAM chains in competitive coordination with Zn2+ ions promote rapid Zn ion transport. Our all-solid-state electrolyte simultaneously achieves a superior ionic conductivity of 1.52 mS cm–1 and a high tZn2+ of 0.83 at room temperature, alongside uniform Zn metal deposition (1000 cycles in symmetric cells) and high Zn plating/striping efficiencies (>99% after 600 cycles in asymmetric cells). Applications of our SPE in Zn//VO2 full cells are further demonstrated with a long lifespan of 2000 cycles and an extremely low-capacity degradation rate of 0.012% per cycle. This work provides an effective strategy for using a missing-linker MOF to catalyze competitively coordinating copolymers for accelerating Zn2+ ion conduction, assisting the future design of all-solid-state ZMBs.
研究领域:
材料科学
·
电化学
·
能源存储
·
电池技术
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry B
·
2024
·
IF 6.1
Wenhui Lyu,Yuyue Zhang,Shaopei Ding,Xiang Li,Tong Sun,Jun Luo,Jian Wang,Jianshu Li,Lei Li
In bone tissue, nerves are primarily located in the periosteum and play an indispensable role in bone defect repair. However, most bone tissue engineering approaches ignored the reconstruction of the nerve network. Herein, we aimed to develop a bilayer hydrogel simulating periosteum-bone structure to induce innervated bone regeneration. The bottom “bone” layer consisted of gelatin methacryloyl (GelMA), poly (ethylene glycol) diacrylate (PEGDA), and nano-hydroxyapatite (nHA), whereas the upper “periosteum” layer consisted of GelMA, sodium alginate (SA) and MgCl2. The mechanical properties of the upper and bottom hydrogels were designed to be suitable for neurogenesis and osteogenesis, respectively. Besides, Mg2+ from the “periosteum” layer released at the early stage (within 7 d), which aligned with the optimal time window for nerve regeneration and osteogenic related neuropeptide release. Simultaneously, the prevention of long-term Mg2+ release (after 7 d) could avoid osteogenic inhibition caused by prolonged Mg2+ exposure. Additionally, the incorporation of nHA in the bottom “bone” layer supported the long-term osteogenesis due to its osteoconductivity and slow degradation. In vitro biological experiments revealed that the bilayer hydrogel (GS@Mg/GP@nHA) promoted neurite growth and calcitonin gene-related peptide (CGRP) expression in rat dorsal root ganglion (DRG) neurons, as well as the osteogenesis of rat bone-derived mesenchymal stem cells (BMSCs). Moreover, the in vivo experiments demonstrated that GS@Mg/GP@nHA hydrogel efficiently promoted nerve network reconstruction and bone regeneration of rat calvarial bone defects. Altogether, the bilayer hydrogel GS@Mg/GP@nHA could promote innervated bone regeneration, providing new insights for biomaterial designing for bone tissue engineering.
研究领域:
组织工程
·
生物材料
·
再生医学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Bio Materials
·
2019
·
IF 0
Feng Guo,Yunen Liu,Kai Jiao,Rui Yang,Mingxiao Hou,Xing Zhang
Currently, the only treatment for moderate and severe aortic valve calcification disease is valve replacement. The clinical use of bioprosthetic heart valves (BHVs) is limited because of device failure caused by structural degeneration, such as the calcification of BHV leaflets. In the present study, poly(ethylene glycol) diacrylate (PEGDA) was incorporated with zwitterion (2-[methacryloyloxy]ethyl)dimethyl-(3-sulfopropyl) ammonium hydroxide (SBMA) forming a balanced charged network, which was further used to modify decellularized heart valves (DHV) and improve anticalcification properties. Valvular prostheses were designed and manufactured to comply with the requirements of ISO-5840 for valve fluid dynamics (i.e., effective orifice area = 1.9 cm2, regurgitant fraction = 1.5% for Φ25 mm surgical valve at heart stroke of 80 mL). Weight loss of artificial heart valves (PEGDA-SBMA-DHV) was less than 5.5% after enzymatic hydrolysis for 12 h. No obvious calcification was observed in artificial heart valves that were modified with PEGDA-SBMA, whereas calcification was found in decellularized heart valves and the PEGDA-modified group. Furthermore, histological staining results indicated that artificial heart valves (PEGDA-SBMA-DHV) with a balanced charged network elicited negligible inflammation. Thus, balanced charged networks of PEGDA-SBMA with cationic and anionic groups can prevent the transportation of Ca2+ ions and enzyme molecules, conferring efficient anticalcification properties to artificial heart valves.
研究领域:
生物医学工程
·
材料科学
·
心血管医学
✓ 已验证
产品关联
DOI
PubMed
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