JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2020
·
IF 2.69
Mengjie Xu,Miao Qin,Xiumei Zhang,Xiaoyu Zhang,Jingxuan Li,Yinchun Hu,Weiyi Chen,Di Huang
In the present work, a new kind of porous polyvinyl alcohol/sodium alginate/hydroxyapatite (PVA/SA/HA) composite hydrogels with tunable structure and mechanical properties have been fabricated by dual-crosslinking method. The morphologies, moisture content, porosity and mechanical properties of the composite hydrogels have been investigated in detail. The PVA/SA/HA hydrogels present uniform, interpenetrating porous structure. The FTIR and XRD results indicate that PVA, SA and HA could be uniformly compounded. The mechanical properties, moisture content and porosity of the samples could be controlled by changing the mass ratio of PVA/SA/HA. The optimized compression modulus (41.74 ± 7.86 kPa), moisture content (86.99 ± 0.72%) and porosity (79.98 ± 1.61%) of the composite hydrogels could be achieved via fixing the weight ratio of PVA/SA/HA at 42:18:40. In vitro biodegradation and mineralization of the composite hydrogels show that the hydrogels could gradually be degraded in PBS solution and sheet-like HA nanocrystals are easily formed on the surface. Moreover, cell culture results indicate that the PVA/SA/HA hydrogels have no negative effects on MC3T3-E1 cell growth and proliferation. Alkaline phosphatase (ALP) activity expressions demonstrate that the nano-HA crystals incorporated composite hydrogels obviously improve the ALP activity of the cells. It confirms that the prepared PVA/SA/HA hydrogels could be a promising candidate for bone repair and bone tissue engineering.
研究领域:
生物材料学
·
组织工程学
✓ 已验证
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 72
·68371-68378
·
IF 3.289
Zhen Liu,Shaojie Han,Chong Xu,Yuwen Luo,Na Peng,Chenyang Qin,Mingjiong Zhou,Wenqin Wang,Liwei Chen,Shigeto Okada
A novel polymer binder, synthesized via in situ thermal cross-linking of water-soluble polyvinyl alcohol (PVA) and poly(ethylene imine) (PEI) precursor, is applied as a functional network binder to enhance the electrochemical performance of a silicon anode. The Si anode with PVA–PEI binder exhibits high specific capacity (3072.9 mA h g−1) in the initial cycle, high initial coulombic efficiency of 83.8% and excellent long-term cycling stability (1063.1 mA h g−1 after 300 cycles). Furthermore, the Si anode containing PVA–PEI binder also exhibits excellent rate performance, reaching a high specific capacity of 1590 mA h g−1 even at high current density of 10 A g−1. These outstanding electrochemical properties are ascribed to the reversibly-deformable polymer network and the binder's strong adhesion to the silicon particles. This low-cost and eco-friendly polymer binder has great potential to be used for silicon anodes in next generation Li-ion batteries.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
DOI
高影响因子
MATERIALS & DESIGN
·
2021
·
IF 7.991
Long Yang,Yan Zhao,Dongbing Cui,Yufei Liu,Qiang Zou,Shunen Xu,Siwei Luo,Chuan Ye
Poorly functioning scaffold materials and limitations in material-cell construction technology remain problems in bone tissue engineering. Electrospinning has been proven to be a suitable and available technique for production of 3D biomimetic scaffolds. To overcome these problems and retain the advantages of electrospinning, bioelectrospinning has been proposed to provide guidance by micropattern, homogeneous cell distribution, and effective nutrient utilization. Herein, we fabricated poly (3-hydroxybutyrate-co-4-hydroxybutyrate)/poly (vinyl alcohol) (P34HB/PVA) with human bone mesenchymal stem cells (hBMSCs) to biomimetic core-shell microfiber/cells complex by coaxial bioelectrospinning. Characterization of the fiber materials revealed that coaxial electrospinning combined the advantages of the two materials. In vitro cellular assays showed that after bioelectrospinning, the cells and material could be simultaneously spun while maintaining cell activity. The material provided a good 3D microenvironment allowing cell adhesion, proliferation, and differentiation. Both the in vitro and in vivo tests indicated the formation of mineralized nodules in both the co-spun and co-axial groups, while the implants formed bone-like tissue after 16 weeks of implantation. This study shows that coaxial bioelectrospinning technology can be used to construct tissue-engineered bone. Our technique might be applied in the future to fabricate more complex tissue and organs.
研究领域:
生物材料学
·
组织工程学
✓ 已验证
产品关联
DOI
高影响因子
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
·
2020
·
IF 6.444
Lu Wu,Longwei Li,Mingshuai Fan,Ping Tang,Shuaitao Yang,Lujun Pan,Hai Wang,Yuezhen Bin
A super strong poly (vinyl alcohol)/poly (acrylic acid) (PVA/PAA) anti-freezing hydrogel fiber has been successfully constructed and studied. The introduction of PVA chains significantly improves tensile strength and toughness to 3.8 MPa and 13.7 MJ/m 3 , respectively. In addition, glycerol in the hydrogel fiber ensures its good flexibility even in −15 °C. We coat hydrogel fiber with multi-walled carbon nanotubes (MWCNTs) and study their strain sensing properties. The composite hydrogel fiber has a high gauge factor of 25 at the strain of 40%, which is superior to those common hydrogel-based strain sensors. Notably, the composite hydrogel fiber shows a high stability and repeatability of 5000 cycles, and a fast response time of 225 ms. Besides, the composite hydrogel fiber can detect the large and subtle body movements accurately and timely. Therefore, this composite hydrogel fiber may be a very hopeful candidate for wearable sensing devices.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2023
·
IF 13.6
Bin Xiang,Jingling Gong,Yuqing Sun,Jian Li
The poor mechanical durability and weak fouling resistance of oil/water separation membranes severely restrict their applications in industry. Herein, a robust PVA/GO@MOF membrane with fast photothermal self-cleaning capability was developed through facile chemical crosslinking and suction-filtration strategies. Attributed to the powerful underwater superoleophobicity, the PVA/GO@MOF membrane exhibited extraordinary anti-oil adhesion even for high-viscosity crude oil and continuous crude oil emulsion purification capability with stable flux (1020 L m −2 h −1 bar −1 ) and exceptional efficiency (> 99.3%) even after 60 min. Most importantly, in comparison to reported photocatalytic self-cleaning oil/water separation membranes, the PVA/GO@MOF membrane can degrade organic contaminants more rapidly with a higher degradation rate (99.9%) in 50 min due to the superior photothermal conversion capacity. The synergistic photothermal and photocatalytic effects significantly enhanced photodegradation efficiency, which created opportunities for in-depth treatment of complex oily wastewater. Besides, the obtained membrane displayed excellent chemical and mechanical durability with underwater oil contact angle (UWOCA) above 150° even in harsh environments, such as corrosive solutions, UV irradiation, ultrasound treatment, abrasion experiment and bending test. Therefore, the developed PVA/GO@MOF membrane with robust durability and fast photocatalytic self-cleaning property is highly expected to purify oily wastewater and degrade organic pollutants .
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NON-CRYSTALLINE SOLIDS
·
2019
·
IF 2.6
Bocai Lin,Hongxing Hu,Zhengwei Deng,Libin Pang,Haizhen Jiang,Deping Wang,Jiusheng Li,Zhongtang Liu,Hui Wang,Xiangqiong Zeng
The synthetic hydrogel owns huge potential and broad prospects in cartilage tissue engineering due to a series of unique properties, such as bioactivity, the nutrition ions release ability, high mechanical properties and chondrogenesis capacity. Bioactive glass (BG) and PVA have been widely investigated and reported with safety and excellent biocompatibility as tissue engineering materials. In this study, we have synthesized a novel composite hydrogel formed by crosslinking between bioactive glass and PVA for cartilage repair, furthermore, we have explored the reaction mechanism of this hydrogel. It was found that hydrogen bonding was formed by the hydroxyl groups in PVA combining with the oxygen atoms from the non-bridge Si-O bond in bioactive glass, which can explain better mechanical properties for PM group than that of PVA. The tensile and compressive stress of PM5 hydrogel group has reached 4.8 MPa and 1.8 MPa equaling mechanical properties of natural articular cartilage. Moreover, the hydrogel can significantly support the proliferation of mice chondrocytes in vitro. Meanwhile, it can also effectively upregulate the expression of chondrogenesis related genes (AGGRECAN, SOX9, COL2). Therefore, the novel hydrogel possesses excellent properties in cartilage repair, and exhibits potential medical applications in the future.
研究领域:
生物材料学
·
组织工程学
·
再生医学
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Jiang-Ping Chen,Qi-Jun Zhang,Chen-Xi Li,Chao-Yang Guo,Lu-Bin Zhong,Zhi-Hong Zheng,Jing-Yun Zhang,Zai-Dong Shao,Yu-Ming Zheng
The filtration of oil aerosols is crucial for safeguarding human health and protecting industrial machinery. While most research focuses on achieving high efficiency and low air resistance, limited studies have investigated filters that effectively combine these attributes with easy cleaning, primarily due to challenges associated with oil adhesion and the low mechanical strength of filter media. This study introduces a novel nanofibrous membrane (NFM) composed of fluorinated PVA/SiO 2 fibers, which exhibits cleanability alongside with high filtration efficiency. The F-PVA/SiO 2 NFM features a fibrous structure with periodic SiO 2 nano-protrusions on the PVA nanofibers, resembling the Chinese sweet Tanghulu . This design significantly enhances the surface roughness of the fibers. Moreover, the hydroxyl-rich PVA/SiO 2 matrix, in conjunction with the rough fiber surface, forms a durable amphiphobic coating after fluorination treatment. This coating retains its amphiphobic properties for over a year under ambient conditions while resisting swelling caused by organic solvents. Consequently, this design achieves an impressive filtration quality factor of 0.0190 Pa −1 , surpasses 95.58 % removal efficiency, and possessed an oil load capacity of 12.8 g m −2 . Furthermore, the filter can be easily regenerated through simple spray cleaning procedures without compromising its original filtration efficiency or experiencing significant pressure drop changes. Throughout ten consecutive filtration and cleaning cycles, the NFM consistently maintained its original filtration efficiency, with a 99 % restoration of pressure drop after each cycle. This F-PVA/SiO 2 NFM presents a practical solution for efficient oil aerosol filtration while offering excellent reusability and durability.
研究领域:
材料科学
·
环境工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Tissue Engineering and Regenerative Medicine
·
2015
·Vol. 11
·期 5
·1562-1573
·
IF 5.199
Quan Liu,Yuchen Huang,Yong Lan,Qinhua Zuo,Chenghua Li,Yi Zhang,Rui Guo,Wei Xue
Two important issues in skin tissue engineering are the vascularization and regeneration of the dermis. Basic fibroblast growth factor (bFGF) is known to promote angiogenesis and accelerate wound healing. Direct delivery of bFGF to the wound area, however, would lead to a loss of bioactivity. To this end, bFGF-loaded alginate microspheres (Ms) were fabricated and incorporated into carboxymethyl chitosan (CMCS)–poly(vinyl alcohol) (PVA) to form a composite hydrogel. Scanning electron microscopy (SEM) results indicated that the incorporation of Ms does not significantly affect the inner structure of CMCS–PVA. In an in vitro study, the release of bFGF from Ms–CMCS–PVA in a sustained manner retained higher bioactivity over a 2-week period. Full-thickness burn wounds were created in the dorsal area of rats for in vivo evaluation of skin regeneration treated with CMCS–PVA hydrogel, with and without bFGF. Compared with the control, CMCS–PVA and bFGF–CMCS–PVA groups, the bFGF/Ms–CMCS–PVA group revealed significantly faster wound recovery rates, with re-epithelialization and regeneration of the dermis. Moreover, the bFGF/Ms–CMCS–PVA group had the highest density of newly formed and mature blood vessels during the 2 mweek treatment period. The ability of the bFGF/Ms–CMCS–PVA hydrogel to accelerate wound healing in a full-thickness burn model suggests its potential for use in dermal tissue regeneration. Copyright © 2015 John Wiley & Sons, Ltd.
研究领域:
生物材料学
·
组织工程学
·
医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Applied Materials Today
·
2025
·
IF 6.9
Zerong Wang,Ge Yan,Yi Ning,Xiaoli Zhou,Xin Lu,Qianqian Zhou,Qiwei Tian
Transarterial embolization (TAE) is a primary clinical treatment for hepatocellular carcinoma (HCC); however, its therapeutic efficacy is limited by its functional constraints. To enhance treatment outcomes, this study aims to develop a multifunctional embolic microsphere, LUT-Fe@PVA, for the combined treatment of HCC. This approach leverages a synergistic strategy that integrates TAE, sonodynamic therapy (SDT), and chemodynamic therapy (CDT) to improve the therapeutic efficacy. The LUT-Fe@PVA microspheres were synthesized via a microemulsion crosslinking method and loaded with luteolin-iron complexes to enable ultrasound-triggered reactive oxygen species (ROS) generation and Fenton reaction for enhanced tumor destruction. In vitro results demonstrated that the combination therapy significantly kills the tumor cells. In vivo, 18 F-FDG microPET/CT imaging revealed significantly reduced uptake values, while histological analysis confirmed extensive tumor cell necrosis and apoptosis in the combined therapy group. This study presents a promising multifunctional approach for HCC treatment by integrating embolization, SDT, and CDT, offering a novel strategy for effective and selective tumor treatment with minimal side effects.
研究领域:
肿瘤学
·
生物医学工程
·
药剂学
·
影像医学
·
介入治疗学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL PHYSICS LETTERS
·
2021
·
IF 2.328
Dongxin He,Wei Cao,Deshun Huang,Haimin Li,Jing Zhu,Pengxiang Zhao
Safety use of hydrogen leads to the development of highly sensitive materials for hydrogen sensing. Herein, Pd(II)@alkyne-PVA/ d -Ti 3 C 2 T x composite was prepared by spin-coating Pd(II)@alkyne-PVA solution onto the filter membrane supported with delaminated Ti 3 C 2 T x ( d -Ti 3 C 2 T x ). The properties of the composite were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy, and X-ray photoelectron spectroscopy (XPS). The results demonstrate that the composite shows high sensitivity and stability for hydrogen sensing.
研究领域:
材料科学
·
化学工程
·
纳米技术
✓ 已验证
DOI
高影响因子
POLYMER
·
2022
·
IF 4.432
Jinming Li,Heng Li,Chengwei Wu,Wei Zhang
The self-healing ability of articular cartilage is poor, and hydrogel materials are expected to be used for cartilage replacement due to their high-water content and good biocompatibility. Here, the polyvinyl alcohol-acrylamide-agarose multi-network hydrogel was proposed. The hydrogel has a compressive modulus of 1.19 MPa and a compressive strength limit of 8.87 MPa, as well as a tensile modulus of 0.63 MPa and a tensile strength limit of 1.08 MPa. The mechanical properties of hydrogel meet the requirement for cartilage replacement materials. The in vitro cell experiments indicate that the introduction of agarose improves the cell adhesion of the hydrogel, which is expected to be beneficial in the field of biomedicine.
研究领域:
生物医学工程
·
材料科学
·
组织工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2024
·
IF 3.6
Min Xiao,Zifeng Wang,Yanru An,Yingqi Dai,Xinghao Wang,Zhigang Zhu
Microneedles offer minimally invasive, user-friendly, and subcutaneously accessible transdermal drug delivery and have been widely investigated as an effective transdermal delivery system. Ibuprofen is a common anti-inflammatory drug to treat chronic inflammation. It is crucial to develop microneedle patches capable of efficiently delivering ibuprofen through the skin for the effective treatment of arthritis patients requiring repeated medication. In this study, the mechanical properties of a new type of polymer microneedle were studied by finite element analysis, and the experimental results showed that the microneedle could effectively deliver drugs through the skin. In addition, a high ibuprofen-loaded microneedle patch was successfully prepared by micromolding and subjected to evaluation of its infrared spectrum morphology and dissolve degree. The morphology of microneedles was characterized by scanning electron microscopy, and the mechanical properties were assessed using a built linear stretching system. In the in-vitro diffusion cell drug release test, the microneedle released 85.2 ± 1.52% (210 ± 3.7 μg) ibuprofen in the modified Franz diffusion within 4 h, exhibiting a higher drug release compared to other drug delivery methods. This study provides a portable, safe and efficient treatment approach for arthritis patients requiring daily repeated medication.
研究领域:
药剂学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）