POLYMER TESTING
·
2022
·
IF 4.931
Yuezhou Liu,Yanjing Liu,Xiyue Li,Yongfang Qian,Lihua Lv,Ying Wang
In order to fabricate antibacterial nanofiber membranes for tissue engineering field, the oxidative damage of magnesium hydroxide nanoparticles (Mg(OH) 2 NPs) against the model system of Escherichia coli ( E. coli ) was researched by measuring the oxidative stress response, oxidative stress products and glucose metabolism. The toxicity of Mg(OH) 2 NPs to a normal biological system was evaluated in vivo through the acute oral toxicity, blood physiological and serum biochemical markers and acute skin irritation, indicating that the Mg(OH) 2 NPs exhibited great biosafety. The Mg(OH) 2 NPs with antibacterial property and biosafety were loaded on PCL/PVP nanofiber substrates through electrospinning technology to fabricate the Mg(OH) 2 /PCL/PVP nanofiber membranes. The results of characterization and antibacterial test showed that the Mg(OH) 2 /PCL/PVP nanofiber membranes with 8.0 wt% Mg(OH) 2 NPs present excellent antibacterial rate of 100% against E. coli that the Mg(OH) 2 NPs can be physically and evenly loaded on nanofiber substrates.
研究领域:
材料科学
·
纳米技术
·
组织工程
·
生物医学工程
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产品关联
DOI
高影响因子
NANOTECHNOLOGY
·
2020
·Vol. 32
·期 1
·015101
·
IF 3.551
Baoe Li,Xiaomei Xia,Jiatian Chen,Dan Xia,Ruodan Xu,Xianrui Zou,Hongshui Wang,Chunyong Liang
Electrospun composite nanofibrous scaffolds have been regarded as a potential carrier for local drug delivery to prevent tumor recurrence. Herein, a model drug (paclitaxel) was creatively loaded into lignin nanoparticles (PLNPs) and then encapsulated into the polymer of poly (vinyl alcohol)/polyvinyl pyrrolidone which has been fabricated into a composite nanofibrous membrane (PVA/PVP-PLNPs) for use as a drug carrier using the electrospinning technique. The fabricated PVA/PVP-PLNPs membranes exhibited good particle distribution, mechanical properties, thermal stability and biocompatibility. In vitro experiments showed that combining lignin nanoparticles by electrospinning not only improved the drug release profile, but also enhanced the hydrophilicity of nanofibrous membranes which was beneficial to cell adhesion and proliferation. Cellular experiments demonstrated that PVA/PVP-2%PLNPs membrane showed good cell inhibition ability, and the cell survival rate was only 21% at day 7. It indicates that the as-prepared PVA/PVP-PLNPs composite nanofibers are promising candidates for local anticancer therapy.
研究领域:
药学
·
生物医学工程
·
癌症研究
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材料科学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Chao Liu,Yawei Liu,Yongqiang Guo,Chao Wang,Zhen Hu,Chunhua Zhang
In this study, a novel PA-g/co-PVP reverse osmosis (RO) composite membrane with high-hydrophilic, antifouling, high salt rejection properties, was prepared according to the principle of sand-fixing grass effect for pharmaceutical wastewater treatment. N-vinyl-2-pyrrolidone (NVP) was used as a “seed agent” that was seeped into a low cross-linked polyamide (PA) film. A hydrophilic molecular brush of polyvinylpyrrolidone (PVP) grafted on the PA surface (PA-g-PVP) similar to grass growing on sand and a cross-linked copolymer layer of PA and NVP (PA-co-NVP) similar to grass roots distributed in sand, as well as an interlayer cross-linking between PA separation layer and PES ultrafiltration membrane with a highly stable interfacial structure, synchronously occurred through γ-ray radiation. Upon incorporation of 1.0% of NVP, the resultant PA-g/co-PVP membrane achieved 18.8° water contact angle and high flux recovery ratio (FRR) values of 91.23%, 96.28%, and 93.67% for the foulants of bovine serum albumin (BSA), sodium alginate (SA), and sodium dodecyl sulfate (SDS), respectively. The FRR value of pharmaceutical wastewater-polluted membrane after cleaning was 94.30%. The PA-g/co-PVP RO membrane showed outstanding separation stability due to the radiation cross-linking reactions, which limit matrix swelling and interface delamination similar to the action principle of sand-fixing grass. These merits prove that the RO membrane developed in this study can be used in many applications, including small organic molecular wastewater separation.
研究领域:
环境科学
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材料科学
·
药学
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产品关联
DOI
高影响因子
STARCH-STARKE
·
2017
·
IF 1.837
Quan Huo,Dong Liu,Jingjing Zhao,Jianshu Li,Rongna Chen,Suyan Liu
A new semi-interpenetrating network superabsorbent resin (semi-IPN SAR), starch-g-poly (sodium acrylate)/PVP, with a three-dimensional (3D) network structure constructed from a starch-g-poly(sodium acrylate) (starch-g-PNaA) network and linear poly(vinylpyrrololidone) (PVP) was synthesized by a free-radical solution polymerization method in the presence of initiator ammonium persulfate (APS) and crosslinker N,N′-methylene-bis-acrylamide (MBA). The synthesis conditions were systematically investigated. The optimum synthesis mass ratio of PVP, starch, APS, and MBA to AA was 20, 30, 1.25, and 0.15%, respectively, the neutralization degree of acrylic acid was 80%, and the reaction temperature was 60°C. Furthermore, the semi-IPN SAR was characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and three-dimensional X-ray diffraction microscopy (3D-XRDM). FTIR and TGA results agreed that PNaA had been grafted onto the starch macromolecular chains and the starch-g-PNaA network was penetrated by linear PVP polymers by a hydrogen binding action. Moreover, the surface morphology of the resin exhibited apparent wrinkling due to the introduction of PVP. The 3D-XRDM result further proved that the resin was provided with a three-dimensional network structure. The introduction of PVP and the formation of the semi-IPN structure greatly enhanced the water absorbency of the resin. The water and saline absorbency of the optimized material was improved to 2017.8 g/g distilled water and 89.7 g/g NaCl aqueous solution (0.9 wt%), respectively. Furthermore, kinetic analysis agreed that the pseudo-second-order kinetic model was fitted to describe a whole adsorption process, which indicated the adsorption process was not controlled by diffusion steps.
研究领域:
材料科学
·
高分子化学
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产品关联
DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2017
·Vol. 29
·期 2
·835-842
·
IF 1.907
Shengqiang Nie,Hui Qin,Lulu Li,Chunmei Zhang,Wei Yan,Yuan Liu,Jun Luo,Ping Chen
In this study, the influence of variations in chain length of polyvinylpyrrolidone (PVP) brushes on the blood compatibility of silicon wafer surfaces to which they were chemically attached was studied. Si surfaces were functionalized with various lengths of PVP brush using atom transfer radical polymerization technology and confirmed by elliptical polarized light, atom force microscopy, and X-ray photoelectron spectroscopy. The blood compatibility of these biointerfaces were systematically investigated by measuring protein adsorption, clotting time, platelet adhesion, contact activation, and complement activation. The results indicate that the hemocompatibility of the surfaces was highly related to PVP brush chain length and hydrophilicity of the surfaces. Our results contribute to rational biointerface design for specific biomedical applications. The results reveal that the PVP brushes with a long chain length have great potential for blood contacting applications due to their reduced protein absorption and cell activation following its contact with blood.
研究领域:
生物医学工程
·
材料科学
·
表面化学
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Siyu Wu,Jiayi Ma,Jun Liu,Chun Liu,Su Ni,Ting Dai,Yan Wang,Yiping Weng,Hongbin Zhao,Dong Zhou,Xiubo Zhao
Biomaterial–immune system interactions play an important role in postimplantation osseointegration to retain the functionality of healthy and intact bones. Therefore, appropriate osteoimmunomodulation of implants has been considered and validated as an efficient strategy to alleviate inflammation and enhance new bone formation. Here, we fabricated a nanostructured PCL/PVP (polycaprolactone/polyvinylpyrrolidone) electrospinning scaffold for cell adhesion, tissue ingrowth, and bone defect padding. In addition, telmisartan, an angiotensin 2 receptor blocker with distinct immune bioactivity, was doped into PCL-/PVP-electrospun scaffolds at different proportions [1% (TPP-1), 5% (TPP-5), and 10% (TPP-10)] to investigate its immunomodulatory effects and osteoinductivity/conductivity. Telmisartan-loaded scaffolds displayed in vitro anti-inflammatory bioactivity on lipopolysaccharide-induced M1 macrophages by polarizing them to an M2-like phenotype and exhibited pro-osteogenic properties on bone marrow-derived mesenchymal stem cells (BMSCs). Histological analysis and micro-CT results of a rat skull defect model also showed that the telmisartan-loaded scaffolds induced a higher M2/M1 ratio, less inflammatory infiltration, and better bone regenerative patterns. Furthermore, activation of the BMP2 (bone morphogenetic protein-2)-Smad signaling pathway was found to be dominant in telmisartan-loaded scaffold-mediated macrophage–BMSC interactions. These findings indicate that telmisartan incorporation with PCL/PVP nanofibrous scaffolds is a potential therapeutic strategy for promoting bone healing by modulating M1 macrophages to a more M2 phenotype at early stages of postimplantation.
研究领域:
生物材料
·
免疫学
·
组织工程
·
再生医学
·
药理学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Meng Wang,Yanwen Zhou,Zhaohui Wang
The critical shortage of antifungal drugs and increasingly emerged resistant fungi urgently call for the development of novel fungicidal agents with translational potential. Although nanodrugs compose a new antifungal arsenal, the fungicidal efficacy barely exceeds clinical molecules. In this study, a CuFeSe 2 -PVP nano-blade, is unexpectedly discovered with ultrapotent intrinsic fungicidal efficacy. This nanostructure is facilely fabricated by a specific aqueous precipitation method with the nucleation of tetragonal eskebornite CuFeSe 2 at PVP chains. The unique semiconductor CuFeSe 2 -PVP demonstrates superior antifungal activity than the commonly used small-molecule drugs and metal nanoparticles in both planktonic fungi and biofilm. Intriguingly, electron microscopy visualizes that the nano-blades cut fungal membranes with fungi surfaces inserted by the blades. Such a membrane-piercing effect results in the loss of important intracellular components, including nucleic acids , proteins, and potassium ions. Increased intracellular reactive oxygen species (ROS) is also observed. Encouragingly, in mice with subcutaneous fungal infection, the nanodrug achieves absolute fungi clearance, effectively alleviating inflammation and promoting collagen fiber recovery. Moreover, the excellent biocompatibility of CuFeSe 2 -PVP promises great potential for further translation. This study not only provides a novel fungicidal drug candidate, but also inspires the future design of anti-fungal nanomedicine .
研究领域:
纳米技术
·
药学
·
微生物学
·
材料科学
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产品关联
DOI
高影响因子
COMPOSITES PART B-ENGINEERING
·
2024
·
IF 12.7
Yong-song Tan,Weiyi Han,You Wu,Dajiang Kuang,Liyang Song,Chaoxia Wang
The development of wearable gesture recognition systems, capable of converting intricate human gestures into electric signals and graphical representations , poses significant challenges for future advancements in health monitoring and human-machine interfaces. In response to this demand, we present an approach centered on a cell-inspired, multiscale hierarchical structural piezoresistive pressure sensor designed for gesture recognition applications. The breathable, hierarchically interlocked textile pressure sensor (PFPA), featuring a SWCNTs/polyvinylpyrrolidone (PVP)/reduced graphene oxide (rGO) dendritic structure combined with a PANI/PVA cylindrical array, exhibits remarkable properties. The dendritic electrodes, composed of SWCNTs and PVP in a 1:2 ratio, maintain optimal regularity. Meanwhile, the cylindrical PANI/PVA array is meticulously engineered with a radius of 200 μm, a height of 200 μm, and an inter-cylindrical spacing of 150 μm. The PFPA demonstrates an unprecedented ultrahigh sensitivity of 80.8 kPa −1 across a pressure range of 0–5 kPa, coupled with a rapid response time of 150 ms and minimal hysteresis of 16.1 %. The PFPA also demonstrates outstanding repeatability, with no significant performance degradation observed after 4000 cycles. By correlating the bending angles of finger joints with resistance changes, we successfully integrated these sensors into a glove, enabling precise gesture recognition. The multilayer SWCNTs/PVP/rGO dendritic and PANI/PVA cylindrical array pressure sensor exhibits superior sensing performance and accurate posture capture. This demonstrates its significant potential for applications in wearable electronics and intelligent devices, marking a substantial advancement in the field.
研究领域:
材料科学
·
生物医学工程
·
可穿戴设备
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产品关联
DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2024
·Vol. 171
·期 1
·010512
·
IF 3.1
Manyang Xu,Yanli Zhang,Weiwei Shao,Xiaoning Li,Jiakun Zhou,Wenzhang Zhou,Wenjuan Zhang,Yan Feng,Ding Zhang,Kehua Dai
The performance of sodium-ion batteries critically depends on the cathode materials used, making it essential to explore and optimize suitable candidates. Among them, O3-structured NaNi0.33Fe0.33Mn0.33O2 has emerged as one of the most promising cathode materials due to its outstanding electrochemical properties. However, there still exists a knowledge gap regarding the detailed synthesis conditions and the comprehensive performance of the full cell using this material. In this study, we investigated the influence of synthesis temperature, time, and sodium content on the electrochemical performance and charge-discharge kinetics of O3-structured NaNi0.33Fe0.33Mn0.33O2, prepared via the PVP-gel combustion method. Through systematic analysis, we elucidated the impact of these synthesis parameters on the material’s properties and battery performance. The results revealed that the optimized conditions led to a cathode material with superior electrochemical performance, exhibiting enhanced capacity with 139 mAh g−1 at 0.1 C and 96 mAh g−1 at 10 C. Additionally, a full cell using the optimized cathode material was studied, showing promising performance. This research sheds light on the significance of synthesis parameters in tailoring the electrochemical properties of O3-structured NaNi0.33Fe0.33Mn0.33O2 for sodium-ion batteries. The insights gained from this study hold valuable implications for the further development of practical sodium-ion battery cathode materials.
研究领域:
材料科学
·
电化学
·
能源存储
·
无机功能材料
·
电池技术
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Xiangdong Zhang,Jian Zhang,Bowen Hou,Xueying Yang,Junlian Ren,Chen Shao
Selective removal of organic pollutants by PMS-activated heterogeneous catalytic system has become one of the commonly used methods, but the adsorption of the catalyst is often ignored in the degradation process. Metal-organic frameworks (MOFs) are often used in the field of environment because of their high porosity and structural diversity/adjustability. However, there are still difficulties in the aggregation and recycling of nanoparticles . This study effectively synthesized the material CuS-PVP@ZIF-67 by using hollow spherical CuS as the carrier of Co-MOF (ZIF-67) to solve these problems. A high concentration of oxytetracycline hydrochloride (OTC) can be successfully adsorbed by electrostatic attraction and π-π interaction, and small amount of PMS may be quickly activated, and the removal rate of OTC is 94.82 % in 20 min. The catalyst used can be easily recovered by suction filtration and has good reusability. In addition, a potential cooperating mechanism for adsorption-PMS activation has additionally been proposed. The degradation pathway of OTC is determined, and the potential harm of intermediate products is analyzed. This work aims to create a heterogeneous catalytic system with significant adsorption and catalytic ability to remove refractory organic contaminants in water.
研究领域:
环境科学
·
催化材料
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产品关联
DOI
高影响因子
IONICS
·
2021
·Vol. 27
·期 10
·4439-4448
·
IF 2.817
Huang Xiangjin,Li Jianwen,Xie Chunsheng,Zhang Huasheng,Wei Shoulian,Lai Wenfeng,Xian Shaoling,Huang Sicong
Herein, a nanocomposite comprising polyvinyl pyrrolidone (PVP) and cobalt(II) hydroxide (Co(OH) 2 ) nanoparticles (PVP–Co(OH) 2 ) was synthesized via a hydrothermal method and used for detection of Cu(II) ions. Using PVP grafted nanosized Co(OH) 2 as a surfactant could decrease the aggregation and reduce the particle size. The conducted morphology investigations showed that PVP–Co(OH) 2 nanocomposite was composed of small spherical particles with a diameter of 40–80 nm that could accelerate mass diffusion and favor the deposition-stripping process of Cu(II) ions. High catalytic activity of Co(OH) 2 and good affinity of PVP to Cu(II) ions synergistically enhances sensing performance of the PVP–Co(OH) 2 nanocomposite-modified electrode than Co(OH) 2 - and PVP-modified electrodes. A linear response was obtained for Cu(II) ion concentration over a range of 1.0–90.0 μg/L, with a detection limit of 0.26 μg/L (S/N = 3). The proposed electrode exhibited good performance in terms of selectivity, stability, and reproducibility. It was also employed to detect Cu(II) ions in water and food samples, and the results were in good agreement with those obtained by graphite furnace atomic absorption spectrometry.
研究领域:
分析化学
·
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2025
·
IF 7.3
Longxiang Qian,Hao Xu,Yiwei Lu,Zezhong Chen
In response to the adverse events caused by the detachment of coatings during coronary guidewire interventions, this research investigates and optimizes the preparation process of a polyvinyl alcohol (PVA)/polyvinylpyrrolidone (PVP) coating with high adhesion and hydrophilicity. Using thermoplastic polyurethane (TPU) as the substrate, the coating was prepared via polydopamine (PDA) deposition and UV curing technology. The amounts of PVA, PVP, and polyethylene glycol diacrylate (PEGDA), as well as the proportion of the photoinitiator, were optimized through orthogonal experiments, significantly enhancing the hydrophilicity and adhesion of the coating. The optimized hydrophilic coating achieves a minimum water contact angle of 7.4°. The coating with the optimized formulation has a water contact angle of 12.2°, reaches grade 0 adhesion in the cross-cut test, and maintains a stable friction coefficient of 0.16. After water exposure, the water contact angle was 22.6°, and the friction coefficient remained below 0.2. Cytotoxicity tests showed cell viability between 90 % and 110 %, and the hemolysis rate was less than 5 %. These results indicate that the coating exhibits excellent hydrophilicity, adhesion, water resistance, and stability, offering significant potential to improve the safety and operability of coronary interventional guidewires, reduce coating-related adverse events, and enhance surgical quality and safety.
研究领域:
生物医学工程
·
材料科学
·
表面工程
·
医疗设备
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）