Journal of Materials Chemistry B
·
2016
·Vol. 4
·期 23
·4110-4118
·
IF 4.872
Jing Zhang,Guangyu Hao,Chenfei Yao,Su Hu,Chunhong Hu,Bingbo Zhang
Glioma stem cells (GSCs) are considered the key to the occurrence, development, invasion, recurrence and sensitivity to treatment of brain tumors. Precise molecular imaging of GSCs by means of probes in vivo has therefore become a premise of solving the above problems. Herein, a sensitive, specific, accurate and biocompatible molecular nanoprobe is reported with MR/fluorescence imaging modalities for CD133+ glioma tumor bimodal targeted imaging. Cd-free high quality CuInS2/ZnS core/shell quantum dots (QDs) were synthesized for fluorescence imaging; DTPA-coupled BSA with Gd3+ chelation (BSA-DTPAGd) were prepared and used both for phase transfer of hydrophobic CuInS2/ZnS QDs and MR imaging modality. The resulting hydrophilic paramagnetic QDs (pQDs) were then linked with anti-CD133 monoclonal antibody, pQDs-CD133mAb denoting the framework of the entire molecular probe, for tumor targeting. The obtained pQDs-CD133mAb has a proper size (ca. 45 nm) and good colloidal stability. It exhibits a high quality fluorescent emission (ca. 630 nm) together with high longitudinal relaxivity (r1 = 15.2 mM−1 s−1) compared with that of commercial Magnevist (r1 = 3.12 mM−1 s−1). Dual modal imaging in vitro and in vivo shows potent tumor enhancement with administration of pQDs-CD133mAb. A biodistribution study indicates hepatobiliary and renal processing of pQDs-CD133mAb with no obvious toxicity. It could be therefore concluded, with a dual-modal imaging and targeting strategy, pQDs-CD133mAb presents a great potential as an alternative for accurate diagnosis of glioma.
研究领域:
医学影像学
·
肿瘤学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2014
·
IF 2.129
Xiangying Sun,Bin Liu,Chuanxiao Yang,Congcong Li
In this work we designed a fluorescent self-assemblied multilayers, with thrombin aptamers and ssDNA as aptamer fixed onto the outermost layer, respectively. This multilayers can effectively sense biomolecules by interfacial florescence resonance energy transfer from multilayers to graphene oxide. High fluorescence quenching efficiency of graphene oxide and self-assemblied membrane’ concentration results in good sensitivity for biosensing. A new interfacial sensing method with extremely high sensitivity for thrombin and DNA sequence was established, and the detection limit for thrombin and DNA was 16.2 pM and 72.6 fM, respectively.
研究领域:
生物传感器
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2014
·
IF 4.287
Yanjun Chen,Rongyi Yao,Yifeng Wang,Ming Chen,Tong Qiu,Chaocan Zhang
This article describes a straightforward gas–liquid microfluidic approach to generate uniform-sized chitosan microcapsules containing CdS quantum dots (QDs). CdS QDs are encapsulated into the liquid–core of the microcapsules. The sizes of the microcapsules can be conveniently controlled by gas flow rate. QDs-chitosan microcapsules show good fluorescent stability in water, and exhibit fluorescent responses to chemical environmental stimuli. α-Cyclodextrin (α-CD) causes the microcapsules to deform and even collapse. More interestingly, α-CD induces obvious changes on the fluorescent color of the microcapsules. However, β-cyclodextrin (β-CD) has little influence on the shape and fluorescent color of the microcapsules. Based on the results of scanning electron microscopy, the possible mechanism about the effects of α-CD on the chitosan microcapsules is analyzed. These stimuli-responsive microcapsules are low-cost and easy to be prepared by gas–liquid microfluidic technique, and can be applied as a potential micro-detector to chemicals, such as CDs.
研究领域:
材料科学
·
生物化学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2018
·Vol. 411
·期 2
·537-544
·
IF 3.307
Ran Hui,Lin Zheng-Zhong,Yao Qiu-Hong,Hong Cheng-Yi,Huang Zhi-Yong
A facile and practical ratiometric fluorescence probe based on two CdTe quantum dots (QDs) coated with molecularly imprinted polymers (MIPs) was prepared for the detection of trace malachite green (MG) in fish. Two CdTe QDs coated with MIPs were fabricated by a one-pot method using MG, (3-aminopropyl) triethoxysilane (APTES) and tetraethyl orthosilicate (TEOS) as template, functional monomer, and cross-linker, respectively. CdTe QDs with λ em 530 nm (gQDs) and 630 nm (rQDs) were used as the referential fluorophore and target sensitive fluorophore, respectively. The fluorescence intensity of gQDs remained unchanged in the presence of MG, while the fluorescence of rQDs could be quantitatively quenched by MG based on the strategy of fluorescence resonance energy transfer. The ratiometric fluorescence probe (MIPs@gQDs&rQDs) was characterized by transmission electron microscopy and Fourier transform infrared spectroscopy. The linear range of MG detection was 0.1–32 μmol L −1 with a detection limit of 8.8 μg kg −1 . The constructed probe has been successfully applied to the detection of MG in fish with the recoveries of 92.3–109.1%, which were validated by the method of HPLC. The result indicated that the probe possessed rapid response, wide linear range, high sensitivity, and relatively high selectivity, and was low-cost and easy in operation in the detection of MG in fish samples.
研究领域:
分析化学
·
环境科学
·
食品安全
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano Energy
·
2022
·
IF 19.069
Junyao Zhang,Tianli Sun,Sheng Zeng,Dandan Hao,Ben Yang,Shilei Dai,Dapeng Liu,Lize Xiong,Cairong Zhao,Jia Huang
For the achievement of robust neuromorphic computing with simple device integration and low energy consumption, the development of artificial synaptic devices incorporating multiple excitation modes has attracted wide interests. In this regard, a multi-functional and energy-efficient CsPbBr 3 quantum dots-based optoelectronic synaptic transistor is designed capable of realizing required synaptic plasticity with both photonic and electric modulation modes in one device. Important synaptic behaviors, including excitatory post-synaptic current and paired-pulse facilitation, are simulated utilizing both photonic and electric stimulations. Furthermore, the transition of short-term plasticity (STP) to long-term plasticity (LTP) can also be implemented through either the adjustment of input photonic pulses or the co-modulation of photonic and electric operations. The excellent tunability between STP and LTP of the synaptic device further leads to the STP-based “Morse-code” optical decoding scheme and LTP-based simulation of visual object recognition. More significantly, the synergistic modulation of photonic and electric operations enables the implementation of logic functions. The multi-functional optoelectronic synaptic transistors are also mechanically flexible, and no distinct synaptic performance variation is observed even when the bending radius of the devices is down to 1 mm. This work suggests a new path for developing flexible and multifunctional neuromorphic electronics.
研究领域:
神经形态计算
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Bing Yang,Yue Song,Yang Song,Ziyu Ma,Jianbo Sun
2D transition metal selenides are facing challenges in the field of gas sensing due to their short carrier lifetime and low utilization rate. Along these lines, in this work, MoSe 2 nanosheets were successfully synthesized by solvothermal method , and modified with TiO 2 QDs. P-N heterostructures with the advantage of quantum dot constraint effect are constructed. The developed heterojunction can effectively promote the separation and transfer of the generated charges, under the excitation of ultraviolet light , while the room temperature sensitivity of the material for the detection of NO 2 is enhanced.
研究领域:
材料科学
·
传感器技术
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Imtiaz Ahmad,Mohammed Abohashrh,Abdur Rahim,Sadia Ahmad,Tahir Muhmood,Hongli Wen
The substantial optical features of perovskite quantum dots (PQD) lead to rapid growth in the investigation of their surface and lattice doping for optoelectronic and biochemical sensor advancements. Herein, we have used the surface ligand crafting model of PQD by ammonia and its optimum response to recognise ammonia in the sensing cellulose paper. The PQD with acetyl amine and octanoic acid capped were synthesized and entrapped in zeolites imidazole framework to delay the instant quenching and envisaged response to ammonia with high sensitivity. The hybrid perovskite quantum dots and Zeolite imidazolate framework-8 (PQD@ZIF-8) materials were further immersed in cellulose paper for solid-state sensor fabrication for the detection of ammonia by naked-eye and a Xiaomi Note-5 mobile camera. The ammonia was measured with high sensitivity at ambient conditions, with a detection limit of 16 ppm and a linear detection range of 1 to 500 ppm. This research provides a new platform for designing sensor selectivity and sensitivity, which could be used to further develop fluorescent nanomaterials-based sensors for small molecule detection.
研究领域:
材料科学
·
化学传感器
·
光学检测
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ULTRASONICS SONOCHEMISTRY
·
2023
·
IF 8.4
Zongbo Zhang,Changbin Xu,Shiliang Song,Yan Ding,Nan Meng,Xuesheng Liu,Yuan Zhang,Liang Gong,Wenting Wu
Ag 2 S quantum dots (QDs) have aroused extensive concerns in intravital imaging field due to their merits of narrow bandgap, low biological toxicity and decent fluorescence emission properties in the second near-infrared (NIR-II) window. However, low quantum yield (QY) and poor uniformity of Ag 2 S QDs are still main obstacles for its application. In this work, a novel strategy of utilizing ultrasonic field is presented, which can enhance the microdroplet-based interfacial synthesis of Ag 2 S QDs. The ultrasound increases the presence of ions at the reaction sites by enhancing the ion mobility in the microchennels. Therefore, the QY is enhanced from 2.33 % (optimal QY without ultrasound) to 8.46 %, which is the highest value of Ag 2 S ever reported without ion-doping. Also, the decrease of the corresponding full width at half maximum (FWHM) from 312 nm to 144 nm indicates the obvious uniformity improvement of the obtained QDs. Further mechanism exploration illustrates that ultrasonic cavitation significantly increases the interfacial reaction sites by splitting the droplets. Meanwhile, the acoustic flow field strengthens the ion renewal at the droplet interface. Consequently, the mass transfer coefficient increases by more than 500 %, which is favorable to improve both the QY and quality of Ag 2 S QDs. This work serves both fundamental research and practical production for the synthesis of Ag 2 S QDs.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Xiaoke Luo,Di Wang,Shiyi Liu,Hailong Yan,Jinbing Cheng,Yang Lu,Deyang Zhang,Huan Pang
The redox reactions occurring at positive electrode of the lithium-sulfur (Li-S) batteries involve several key electrocatalytic processes that significantly impact the overall performance of the electrochemical energy storage system. This study presents a heterogeneous catalytic composite material composed of CoSe quantum dots (QDs) integrated with Sn 3 O 4 nanosheets, which enhances the overall ionic conductivity and accessibility of active sites within the cathode. This controlled migration effectively traps polysulfides within the cathode, reducing their dissolution into the electrolyte and mitigating the shuttle effect. Li-S batteries incorporating CoSe QDs/Sn 3 O 4 porous carbon nanofibers (PCNFs) demonstrate a high discharge capacity of 1596.9 mAh g −1 at 0.1 C, along with remarkable cycling stability, achieving 1500 cycles at 2 C with a minimal capacity decay of 0.024 % per cycle. Even under a high sulfur loading conditions of 8.61 mg cm −2 and a low electrolyte to sulfur ratio of approximately 4.6 μL mg −1 , the CoSe QDs/Sn 3 O 4 PCNFs cathode delivers an initial discharge-specific capacity of 732.0 mAh g −1 at 0.2 C. Through this method, we accomplished the size control and uniform distribution of CoSe QDs, and this method can be extended to the synthesis of other metal oxide and metal sulfide QDs, offering a novel idea for the application of QDs in polysulfide catalysis.
研究领域:
材料科学
·
电化学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanomaterials
·
2022
·Vol. 12
·期 3
·542
·
IF 5.719
Liqin Yang,Zhihong Chen,Xin Wang,Mingliang Jin
The practical application of photocatalytic H2-evolution is greatly limited by its sluggish charge separation, insufficient active sites, and stability of photocatalysts. Zero-dimensional (0D) Ti3C2MXene quantum dots (MQDs) and amorphous Ti(IV) have been proven to be potential substitutes for noble co-catalyst to accelerate the separation of photogenerated electron-hole pairs and prevent the self-oxidation of photocatalysts, leading to better photocatalytic H2-evolution performance with long-term stability. In this study, amorphous Ti(IV) and MQDs co-catalysts were successfully deposited on ZnIn2S4(ZIS) microspheres composed of ultra-thin nanosheets via a simple impregnation and self-assembly method (denoted as MQDs/ZIS/Ti(IV)). As expected, the optimal MQDs/ZIS/Ti(IV) sample exhibited a photocatalytic H2-evolution rate of 7.52 mmol·g−1·h−1and excellent photostability without metallic Pt as the co-catalyst in the presence of Na2S/Na2SO3as hole scavenger, about 16, 4.02 and 4.25 times higher than those of ZIS, ZIS/Ti(IV), and MQDs/ZIS, respectively. The significantly enhanced photocatalytic H2-evolution activity is attributed to the synergistic effect of the three-dimensional (3D) flower-like microsphere structure, the amorphous Ti(IV) hole co-catalyst, and a Schottky junction formed at the ZIS–MQDs interface, which offers more active sites, suppresses self-photocorrosion, and photo-generates the charge recombination of ZIS.
研究领域:
材料科学
·
能源化学
✓ 已验证
DOI
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2022
·Vol. 28
·期 66
·e202202256
·
IF 5.02
Niuniu Zhang,Xia Wu,Kangjia Lv,Yujie Chu,Haimei Qin,Dongdi Zhang,Guan Wang,Jingyang Niu
Graphical An excellent 2D photocatalyst was synthesized by loading Au nanoparticles and CdS quantum dots on niobate nanosheets. This CdS/Au/HNb 3 O 8 photocatalyst not only increased the photocatalytic hydrogen evolution rate by 254 times compared with the pure niobate nanosheet, but also showed outstanding photocatalytic performance for oxidative self-coupling of benzylamine and degradation of organic dyes. Niobate nanosheets have aroused widespread interest in recent years for their prospects in catalysis. The exploration of 2D niobate catalysis with stable and efficient properties is still the focus in chemistry and materials science. Herein, the successful fabrication of 2D CdS/Au/HNb 3 O 8 catalyst is demonstrated which revealed efficient photocatalytic properties in H 2 evolution, oxidative self-coupling of amines to imines, and degradation of dyes. Especially the assembled architecture can give a rate of 5.85 mmol ⋅ g −1 ⋅ h −1 of photocatalytic H 2 evolution, an ∼254-fold enhancement, compared with bare HNb 3 O 8 nanosheets under identical conditions. In accordance with density functional theory (DFT) and X-ray adsorption fine structure (XAFS) analyses, the vast improvements are benefited from efficient migration and separation of charge carriers. Besides, the surface plasma resonance (SPR) effect of Au NPs enhances the light harvesting capacity and boosts the generation of hot electrons, efficiently improving the visible-light absorption.
✓ 已验证
DOI
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2019
·
IF 3.218
Xiangfei Zheng,Guichun Mo,Yongyu He,Dongmiao Qin,Xiaohua Jiang,Weiming Mo,Biyang Deng
[email protected] QDs were synthesized by a simple one-step method. The prepared [email protected] quantum dots ( [email protected] QDs) composite showed a strong cathode ECL emission using potassium persulfate (K 2 S 2 O 8 ) as a co-reactant. The poly-(diallyldimethylammonium chloride) (PDDA) reduced graphene oxide (PDDA-rGO) composite provided a larger activity site could conjugate more [email protected] QDs and second antibody (Ab 2 ) to improve the sensitivity of the ECL immunosensor. The electrode modified with Au NPs was employed for immobilization of primary antibodies (Ab 1 ) and enhancing the electronic transmission rate of the immunosensor. A novel ECL immunosensor was constructed using Au NPs as a sensing platform and PDDA-rGO/ [email protected] QDs composite as signal probe for highly-sensitive carcinoembryonic antigen (CEA) detection in human serum. Under optimal conditions, a range of 0.0001–100 ng/mL and the detection limit of 0.029 pg/mL for CEA were obtained. This ECL immunosensor possesses long-term stability, good reproducibility and high sensitivity. These are promising qualities for detecting biomarkers, drugs, and environmental pollutants .
研究领域:
分析化学
·
生物传感器
·
纳米技术
·
医学诊断
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）