Science of Advanced Materials
·
2018
·Vol. 10
·期 6
·808-817
·
IF 1.318
Han Boning,Yu Zengchao,Yang Yanmin,Yang Lin,Hu Fan,Li Zhiqiang,Chen Wei
CuGaS2 quantum dots (CGS QDs) with a chalcopyrite crystal structure were synthesized by a hot-injection method. The structural and optical characteristics of the obtained nanocrystals were investigated in the reaction temperature range of 210 °C to 260 °C, it was
found that the CuGaS2 QDs were governed by the surface groups functionalized with 1-dodecanethiol capping ligands in the reaction system. The appropriate reaction temperature favored the decomposition of the surface ligand. CGS QDs synthesized at 230 °C exhibited a narrow particle
size distribution and good crystallinity. In terms of the optical spectra, with an increase in the reaction temperature, the excitonic absorption peaks and band gap emission peaks were systematically red-shifted, thus exhibiting a quantum confinement effect. A mechanism for the growth and
formation of nanoparticles on the basis of the reaction temperature is proposed. Furthermore, the obtained CGS QDs showed promising visible-light-driven photocatalytic activity during degradation of rhodamine 6G.
研究领域:
材料科学
·
纳米技术
·
光催化
·
化学
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2022
·Vol. 14
·期 10
·1589-1598
·
IF 1.067
Jin Hong,Wu Yali,Li Yanzhong
Adsorption method has attracted extensive attention in heavy metal wastewater treatment due to its low cost, abundant sources, and simple operation. Kaolin is utilized as raw material, waterborne polyurethane is utilized as dispersion medium, and dimethyl sulfoxide (DMSO) is utilized
as intercalation agent, to prepare intercalation polymerization modified kaolin material (KBEP). It is then characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), thermogravimetry (TG), and other methods. The polymer is utilized
for static adsorption of Cu2+ and Pb2+, and the kinetic analysis of the adsorption process is carried out. The results show that the layer spacing of kaolin increases substantially (from 0.69 nm to 0.81 nm) after modification. When the content of kaolin is less than 1.7%,
kaolin exists in intercalation or stripping state in waterborne polyurethane matrix. When the content of kaolin is higher than 1.7%, kaolin can exist in the form of agglomeration with waterborne polyurethane matrix. Compared with pure polyurethane, the composite’s thermal stability is
improved, and the maximum thermal weight loss of the hard section is increased by 50 °C. When kaolin content is 2.5%, the temperature of the hardness and the fastest thermal decomposition rate of the soft section increases by 30 °C and 26 °C, respectively. The adsorption test reveals
that the Cu2+ elimination rate reaches 93.7% when the addition amount of the prepared material reaches 1.5 g/L. When the addition amount of the prepared material reaches 0.6 g/L, the Pb2+ elimination rate reaches 95.8%. With the increase of the dosage of kaolin composite,
the adsorbability of the polymer to the two metal ions decreases gradually. Kinetic experiments show that the adsorption of Cu2+ and Pb2+ is in line with the pseudo-second-order kinetic (PSOK) equation. The adsorbability of Cu2+ and Pb2+ is 75.3
mg/g and 268.6 mg/g, respectively. The adsorption way is mainly chemical adsorption.
研究领域:
环境科学
·
材料科学
·
化学工程
·
废水处理
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2015
·Vol. 7
·期 6
·1213-1220
·
IF 2.598
Yu Chenggong,Zhu Ting,Zhang Xingxiang,Liu Haihui
Graphene films with different lateral sizes and poly(vinylbutyral) (PVB)/graphene composites were fabricated. The morphological structural and mechanical properties were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform
infrared spectroscopy (FT-IR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), four-probe conductivity measurements and tensile strength testing (TST). The results show that, graphene oxide (GO) and reduced graphene oxide (RGO) with different lateral sizes were fabricated
successfully. As the lateral size of the GO decreased, the tensile strength and modulus of GO films was improved; however, the tensile modulus of the film fabricated with nanoscale GO film decreased. RGO samples with a large area and those that are nanosized exhibited high electrical conductivities
of 867 S/m and 927 S/m, respectively. The tensile strength and modulus of the PVB/GO and PVB/RGO composites increased at low filler contents, exhibiting a maximum at 0.1 wt%. The tensile strength increased by 31% and 29%, and the tensile modulus increased by 20% and 24%, respectively, for
the composites fabricated with the smallest GO and RGO. In contrast, the elongation at break of the PVB/graphene composite materials decreased.
研究领域:
材料科学
·
纳米技术
·
复合材料
·
机械工程
·
电气工程
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2015
·Vol. 7
·期 12
·2508-2514
·
IF 2.598
Zhong Suni,Chen Yanzhong,Song Fenyun,Tian Yong,Wang Xiufang
The synthesis of magnetic mesoporous carbon spheres (FeMCs) with sucrose, silica, and hydrated iron nitrite Fe(NO3)3 · 9H2O under neutral conditions was achieved by the ultrasonication method. Indomethacin (INC) was selected as the model drug.
FeMCs before and after INC-loading FeMCs were characterized by scanning electron microscopy (SEM), wide-angle X-ray diffraction (WXRD), nitrogen sorption isotherms, and differential scanning calorimetry (DSC). Release tests were conducted to confirm improvements in drug release kinetics. The
experimental results showed that the mesoporous carbon spheres exhibited BET surface areas of 615–876 m2/g and pore volumes of 1.36–2.25 cm3/g. INC showed an amorphous state after it was incorporated into the mesoporous channels of the FeMCs. Release kinetics
revealed that the release rate of INC from FeMCs was significantly higher than that of pure INC. This finding may be attributed to the reduced crystallinity of INC in the composites. FeMCs could be exploited as an alternative delivery system for poorly water-soluble indomethacin. The crystallinity
of the loaded drug and the drug release kinetics could be well controlled by FeMCs developed in this method.
研究领域:
材料科学
·
药学
·
纳米技术
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2016
·Vol. 8
·期 10
·1901-1907
·
IF 1.812
Yang Zhenglong,Liu Xinyan,Xu Xiaoli,Chen Sai,Li Feng,Zhu Xingyi,Du Yuchuan
The temperature and pH dual-responsive polyhedral oligomeric silsesquioxane/poly[2-(dimethylamino)-ethyl methacrylate]-b-poly(N-isopropylacrylamide) hybrid materials (POSS/PDMAEMA-b-PNIPAM) were synthesized via combination of reversible addition-fragmentation chain
transfer (RAFT) polymerization and thiol-ene "Click Chemistry." Their structures and self-assembly behaviors were characterized by 1HNMR, TEM, UV-vis absorbance and DLS measurements. POSS/PDMAEMA-b-PNIPAM could self-assemble into thermo- and pH-sensitive micelles with the
POSS heads forming as a core and the PDMAEMA-b-PNIPAM chains as a corona. Hydrophobic dyes could be encapsulated in the micelles, so it can be used to absorb dyes. It was found that POSS/PDMAEMA-b-PNIPAM aqueous solution (5 mg/mL, 2 mL) could rapidly remove 98% of methyl red
and 90% of diphenylthiocarbazone in petroleum ether with the initial concentrations of 50 mg/L (2 mL). In view of the good adsorption efficiency of POSS/PDMAEMA-b-PNIPAM hybrid materials, they will be a potential candidate for absorption of organic dyes.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2022
·Vol. 14
·期 7
·1175-1184
·
IF 1.067
Mei Qing,Shou Diwen,Quan Ying,Cheng Jiemin,Pan Pan,Chen Huiting,Huang Hongli,Li Yongqiang,Xia Yu,Zhou Yongjian
Lipid deposition is a key predisposing factor of nonalcoholic fatty liver disease (NAFLD). FOXO1 is obviously expressed in polarized M1 macrophages and may cause liver cell steatosis. Thus, silencing FOXO1 during M1 macrophage polarization using small interfering RNA (siRNA) technology
may alleviate lipid deposition in liver cells. However, a lack of effective and biocompatible carriers is challenging for such siRNA-delivery to macrophages. To improve this, RGDfC peptide-modified selenium nanoparticles (RGDfC-Se NPs) were fabricated as a siFOXO1 delivery carrier system.
We showed that RGDfC-Se NPs effectively increased siFOXO1 cellular uptake and silenced FOXO1 expression in human peripheral blood monocyte-like macrophages (THP-1 cells). Additionally, RGDfC-Se@siFOXO1 blocked M1 polarization in these cells. Also, FOXO-1-suppressed cell supernatants extenuated
lipid deposition in LO2 liver cells probably by down-regulating the expression of lipid deposition-related fat metabolic enzymes acetyl-CoA carboxylase 1 and fatty acid synthase. Furthermore, our in vivo analyses showed that RGDfC-Se@siFOXO1 attenuated hepatic steatosis by inhibiting
M1 macrophage polarization in mouse liver tissue. Our studies represent a new strategy and clinic treatment target for NAFLD.
研究领域:
药理学
·
分子生物学
·
纳米技术
·
肝病学
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2024
·Vol. 16
·期 3
·415-425
·
IF 0.9
Zhao Xue,Xu Yuanshen,Fang Jinyan
This research aimed to better exert the efficacy of dexamethasone (DEX) and fabricate an intercellular adhesion molecule A (ILDMA) monoclonal antibody (mAb)-modified nanostructured lipid carrier (NSLC). The anionic DEX NSLC was fabricated by the aqueous solvent diffusion methodology
using DEX as the model drug and in combination with various types of lipids. Using N,N’-succinimidyl carbonate as the link, anti-ILDMA mAb-modified anion DEX NSLC (ILDM/DEX/NSLC) and anti-IgG mAb-modified cation DEX NSLC (IgG/DEX/NSLC) were prepared. The total lipid content was controlled
unchanged, 3% mass ratio of glyceryl monostearate (MS) in the original prescription was replaced with 3% mass ratio of octadecylamine (ODA), and ILDM/DEX/ODA-NSLC and IgG/DEX/ODA-NSLC were fabricated in the same way. The four NSLCs prepared in the experiment were round in shape and uniform
in size. The nanoparticles with a size of approximately 230 nm were similar, and the zeta potentials were (−29.8±21.5) mV, (−27.9±1.6) mV, (36.8±0.8) mV, and (33.7±2.9) mV, respectively. In vitro drug release demonstrated a cumulative release
rate of more than 55% of DEX NSLC. The inhibitory rate of DEX NSLC on the activated human vascular endothelial cell line (EAhy926 cell) was dose dependent, and ILDM/DEX/NSLC could transport DEX to activated endothelial cells more efficiently, thus enhancing the intervention ability on diseased
endothelium. For the establishment of a sepsis-induced acute lung injury (ALI) mouse model, ILDM/DEX/NSLC was highly distributed in the lung of the model, and its infiltration effect on inflammatory cells was superior to that of other drugs (P < 0.05). Meanwhile, ILDM/DEX/NSLC could
more markedly repair the pathological features in the mouse model than other drugs did (P < 0.05). The nanodrug inhibited the protein level of TLR9 in mouse lung tissue to the maximum extent (P < 0.05), thereby enhancing the survival rate of the mice.
研究领域:
药剂学
·
免疫学
·
病理学
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2013
·Vol. 5
·期 11
·1649-1657
·
IF 2.509
Mi Qian,Hu Juncheng,Luo Man,Huang Zhengxi,Li Jinlin
CdS hollow spheres supported on graphene oxide sheets were successfully synthesized via a simple template-free, biomolecule-assisted method. The samples were characterized by X-ray diffraction (XRD), Transmision electron microscopy (TEM), Fourier transform infrared spectrum (FT-IR),
Ultraviolet–visible diffuse reflectance spectroscopy (DRS), Brunauer–Emmett–Teller (BET) and Photoluminescence spectra (PL). The photocatalytic activities of the GO/CdS hollow spheres nanocomposites were evaluated by photodegradation of methylene blue and salicylic acid under
visible light irradiation. Compared with pure CdS hollow spheres and degussa P25, the GO/CdS hollow spheres nanocomposites show enhanced photocatalytic activity, which is ascribed to graphene oxide as an excellent electron acceptor and transporter, thus reducing the recombination of charge
carriers.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2014
·Vol. 6
·期 11
·2395-2399
·
IF 2.908
Xie Beibei,Li Ya,Shang Juanjuan,Xin Jing,Yang Xiao,Zhang Renjie
Ultrafine GO nanosheets with the lateral dimension of 20–40 nm are prepared first by a modified Hummers' method to obtain GO microsheets, then by using periodic acid (HIO4) to oxidize the GO microsheets. The ultrafine GO nanosheets are so small that they cannot be separated
by centrifugation but by dialysis. However, the HIO4 with strong oxidization renders dialysis tubing easily broken, leading to the failure of purification. A solution is found by the employment of ethylene glycol (EG) to reduce the HIO4 before dialysis. The ultrafine
GO nanosheets have the O content of 73.5% with a large edge-to-area ratio, dispersing very well in water. These ultrafine GO with quinoid structure emit fluorescence under acidic condition and the fluorescence can be tuned by changing the pH of the dispersion solution. Green fluorescence with
an emission peak centred at 530 nm was given off at pH 1.0. The fluorescence color changes from green to yellow with the emission peak red-shifting to 590 nm when the pH is increased to 6.0. No fluorescence is observed at pH 12.0. A schematic fluorescence of the GO under acidic condition is
proposed. This work on one hand presents a method of regulating the fluorescence of GO, on the other hand might be promising for providing guidance to apply GO in the fields of fluorescence immunoassay, biosensors and drug delivery.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2020
·Vol. 12
·期 7
·1065-1077
·
IF 1.117
Xu Jingfeng,Zhao Yilei
From the perspective of targeting factors, iron acetylacetonate and nickel acetylacetonate were used as major materials, and oleylamine was used as a solvent. Through thermal decomposition, the uniformly distributed nanoparticle FeNi3 was obtained. Then, the α-methyltryptophan
(AMT) was used to modify FeNi3, thereby the material (FeNi3-AMT) would be biocompatible. The prepared material was used as a targeting factor to explore whether it could target the epileptogenic focus in temporal lobe epilepsy model rats. In the experiment, the animal
models of temporal lobe epilepsy were constructed by using the lithium chloride-pirocarpine method. According to the injection of the nuclear magnetic factor, the models were divided into the FeNi3 group, the FeNi3-AMT group, and the saline group. The model rats received
intravenous injections 48 hours after the onset of epilepsy. The activity of the epileptic seizure sites before and after injection, the penetration of nanoparticles, and the toxic and side effects of the material were compared. The results showed that the rat models of temporal lobe epilepsy
were successfully constructed (the success rate was more than 85%). Meanwhile, the epilepsy lesions of the rat models added with nanoparticles were darker (P < 0.05). The staining of rat brain sections confirmed the distribution of iron particles. In the FeNi3-AMT group,
there were more iron particles distributed (P < 0.05). In addition, various abnormal neurons appeared in the hippocampus of the three groups, and there was no significant difference between the different groups (P < 0.05). There was no significant difference in the number
of positive neurons in the CA3 region of the brain between different groups (P < 0.05). However, the imaging effect based on FeNi3-AMT was more prominent (P < 0.05), which confirmed that the FeNi3-AMT group had better targeting location effects. The
study confirmed that the iron nano alloy particle material had excellent application values in the localization of temporal lobe epilepsy.
研究领域:
神经科学
·
纳米技术
·
医学成像
·
药理学
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2021
·Vol. 13
·期 6
·1114-1124
·
IF 1.474
Jiang Ning,Cao Fang
Nanomedicine has developed rapidly for improving the solubility of anti-cancer drugs, prolonging the circulation time in the body, and enhancing the accumulation in the lesion through the enhanced permeability and retention (EPR) effect. First, a new type of dithiolane trimethylene
carbonate (MGN) was synthesized, and an amphiphilic polymer PEG-P (ERF-MGN) was synthesized based on MGN and trimethylene carbonate (ERF). Then, N-hydroxysuccinimide (NHS)-PEG-P (ERF-MGN) was prepared by further polymerizing NHS, which was amidated with polypeptide to obtain CC11-PEG-P (ERF-MGN).
Finally, it was reacted with PEG-P (ERF-MGN) (mass ratio was 1:4), and CC11-PS was made by solvent exchange method. Through pH gradient method, doxorubicin (Dox) was loaded to prepare Dox nanobubble (CC11-PS-Dox). The prepared nanobubble was compared with the commonly utilized polyethylene
glycol liposome Dox (Lipo-Dox) for tumor suppression, and CC11-PS-Dox had a relatively higher tolerated dose. After intravenous administration at a dose of 150 mg/kg, tumor growth in ovarian cancer mice bearing SKOV-3 was effectively inhibited, toxic and side effects were reduced, and the
survival time of mice was dramatically increased (P < 0.05). In addition, CC11-PS-Dox was configured as a solution injected into patients with ovarian cancer, phosphate buffer saline (PBS) was injected as a control, and the tumor was irradiated with near-infrared laser (NIR). The
tumor’s warming range was detected, and the tumor tissue was removed and stained with hematoxylin-eosin (HE) to observe the growth of the tumor. The results showed that CC11-PS-Dox + NIR can promote the tumor to heat up to 55 °C or more, while PBS + NIR can only promote the tumor
to heat up to 37 °C. HE staining results showed that CC11-PS-Dox + NIR can promote tumor loss and cause cell damage. Therefore, it was verified that CC11-PS-Dox can be adopted for photothermal treatment of ovarian cancer.
研究领域:
药学
·
纳米技术
·
肿瘤学
·
生物医学工程
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2021
·Vol. 13
·期 4
·683-693
·
IF 1.474
Zhou Yang,Lou Xupeng,Zhao Jialin,Chen Zhe,Le Fuhuan,Fang Yousheng
Conducting polymers (CPs) can regulate cell behavior and promote the regeneration of damaged tissues, which are widely applied in tissue engineering. In this study, poly(3-hexylthiophene) (PHTP) was first obtained by the catalyst + transfer poly-condensation method, and then, it was
mixed with poly(lactide-co-glycolide) (PLGA) to obtain a composite material with superconductivity (PHTP/PLGA). Besides, ferric chloride (FeCl3) was selected as the dopant, and the doping time was changed, so as to obtain 5 PHTP/PLGA materials with different conductivity (10-7
S/cm, 10-6 S/cm, 10-5 S/cm, 10-4 S/cm, and 10-3 S/cm). While PHTP/PLGA was physically characterized, the cell proliferation ability and blood compatibility of this series of materials were further analyzed, and the materials were made into medical
sutures for the treatment of congenital thumb deformities. In the experiment, the surface morphology, hydrophilicity, and hydrophobicity of materials with different conductivity would not affect the difference in cell behavior. Using mouse embryonic osteoblasts (MC3T3-E1) as the research objects,
increasing PHTP/PLGA conductivity could promote MC3T3-E1 alkaline phosphatase activity cell mineralization, and collagen type I expression. PHTP/PLGA series materials had a low hemolysis rate and were not easily affected by platelet adhesion and activation, meaning that they would not cause
coagulation. The material was applied in the direct suture method of hammer deformity, and the results showed that the patient’s deformed thumb had a knot reaction and local skin edge necrosis. After dressing change, it gradually improved. Moreover, the excellent and good rate of deformed
thumb based on this material was higher than that of wire extraction method and Kirschner wire fixation method (P < 0.05).
研究领域:
生物材料
·
组织工程
·
生物医学工程
·
骨科手术
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）