IEEE SENSORS JOURNAL
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2026
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IF 4.5
Mingxuan Zheng,Pengxiang Chang,Ailing Zhang,Fei Liu,Honggang Pan,Junfeng Wang,Jingcheng Wang,Tengfei Yang,Yongning Zhang
At present, optical fiber surface plasmon resonance (SPR) biosensing technology faces two significant challenges, enhancing the detection performance and expanding the detected target types. To address this, this paper proposes a novel optical fiber SPR biosensor, modified with programmable polypeptide nanofibers (PNs) and polydopamine nanospheres covered gold nanoparticles (Au@PDA NPs). Peptide sequences have been applied in optical fiber SPR sensing due to their editable, self-assembling, and low-toxicity properties. In reported sensors, peptide sequences are engineered to self-assemble into peptide nanofibers, increasing the sensor’s specific surface area and providing customizable active sites. Au@PDA NPs further enhance the refractive index sensitivity and surface activity of the sensor. In this study, an SPR biosensor was employed to detect rabbit IgG. The results demonstrate a biological sensitivity of 0.0262 nm/(ng/mL) and a detection limit of 3.85 ng/mL. Compared to SPR sensors modified with single nanoparticles, the proposed sensor exhibits significant improvements in both sensitivity and detection limit. In addition to performance enhancement, this work also offers a systematic approach to improving the performance of sensors for different targets. By programming peptide sequences, various detectable substances can be detected. The method is cost-effective and highly efficient, which holds great significance for improving the commercial value of optical fiber SPR sensors.
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高影响因子
IEEE SENSORS JOURNAL
·
2026
·
IF 4.5
Xin Yan,Lulu Wang,Rao Fu,Xiaobing Chen,Huina Tang,Shirong Zhang,Xue Zhou
The development of reliable diabetes management and precision medicine has driven the need for real-time glucose monitoring technologies that offer long-term stability. However, conventional enzymatic sensors are constrained by the inherent instability of enzymes. To address this limitation, we engineered a non-enzymatic optical fiber sensor by integrating molecularly imprinted polymer (MIP) technology with surface plasmon resonance (SPR). A key innovation lies in the successful construction of an MIP-based sensing interface featuring specific recognition cavities on a U-shaped optical fiber probe. Characterization confirmed its effective "imprinting-elution-rebinding" capability, while performance tests demonstrated a sensitivity of 9.875 nm/log(mM) within the 0.5-10 mM concentration range, coupled with a rapid response (time≤14 s) and outstanding specificity. The sensing strategy introduced here sets a new benchmark, delivering a powerful blend of specificity, speed, and stability that is essential for practical real-time glucose monitoring in complex biological media.
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OPTICS AND LASER TECHNOLOGY
·
2026
·
IF 5.2
Zhenye Guo,Peng Yang,Riqing Lv,Yu Wang,Ruijie Liu,Yong Zhao
Novel integration of PSBP with fiber SPR sensor for label-free, selective PSNPs detection. • Excellent selectivity against various interferents (heavy metal ions, antibiotics, microalgae, bacteria, etc.) in complex water environments. • Record-high spectral response of 72 nm within 8 minutes, surpassing existing nanoplastics sensors (<10 nm). This study proposes a fiber optic surface plasmon resonance (SPR) sensor integrated with polystyrene-binding peptide (PSBP) to enable the rapid and selective detection of polystyrene nanoplastics (PSNPs) in aqueous environments. PSBP immobilizes PSNPs onto the fiber surface via strong hydrophobic interactions, π-π stacking, and electrostatic forces, leading to SPR spectral modulation and specific detection. A strong linear correlation between the SPR wavelength shift and the concentration of PSNPs is observed over the range of 5-25 mg/mL, yielding a sensitivity of 3.458 nm/(mg/mL) and a correlation coefficient (R 2 ) of 0.987. For 300 nm PSNPs, the sensor achieves a stable spectral response within 8 min. Notably, the maximum spectral response of the sensor reaches 72 nm, significantly surpassing the limitation of less than 10 nm saturation shift reported in most existing PSNPs sensors. Furthermore, tests involving various typical interfering substances and temperature variations in water demonstrate that the sensor possesses excellent anti-interference capability. The sensor developed in this study exhibits rapid response, pronounced spectral variation, high specificity, and good environmental stability.
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OPTICS AND LASER TECHNOLOGY
·
2025
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IF 5
Fengtong Zhu,Kun Liu,Jianying Jing,Lu Xiao,Xiaohan Zhan,Jinchang Liu,Yiyang Xiong,Junfeng Jiang,Tianhua Xu,Shuang Wang,Tiegen Liu
A SnS 2 -polydopamine (PDA) enhanced nearly guided-wave surface plasmon resonance (NGW-SPR) refractive index (RI) probe with high sensitivity and high-resolution has been proposed. For the first time, we systematically analyze the high-resolution demodulation methods for the optical fiber SPR sensor in terms of the wavelength resolution of the sensing system, rather than the spectrometer parameter. The sensor resolution is improved by increasing the sensor sensitivity and reducing the standard deviation of the resonance wavelength monitoring values. Taking advantage of the popular thermoelectric material SnS 2 with high carrier mobility and PDA with mussel adhesion properties, the composite material SnS 2 -PDA can effectively improve the sensitivity of the RI probe. To ensure accurate and high-resolution extraction of the SPR resonance wavelength, a wavelet packet denoising demodulation algorithm based on the self-calibrating polynomial fitting is developed. Experimental results demonstrate that the average sensitivity of the proposed RI probe achieves up to 3191.61 nm/RIU within the range of 1.3330 ∼ 1.3560 RIU. The probe offers a resolution of 3.47 × 10 −5 RIU, which is 1 ∼ 2 orders of magnitude higher than previously reported RI sensors. The proposed high-resolution NGW-SPR RI probe provides a new idea for the detection of small molecules interaction analysis with low limit of detection (LOD) in biochemistry.
研究领域:
光学传感器
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材料科学
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生物化学
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高影响因子
BIOSENSORS & BIOELECTRONICS
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2024
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IF 10.7
Lu-feng Wang,Ya-nan Zhang,Mao-qing Chen,Yu Wang,Pengqi Gong,Yong Zhao
Due to the serious biological toxicity and environmental refractory of heavy metal ions, the detection of heavy metal ions in liquids has attracted great attention. A novel fiber optic surface plasmon resonance (SPR) sensor is presented for detecting lead ions (Pb 2 + ) with temperature compensation. The sensitivity of SPR channel to Pb 2+ is up to -41.55 nm/μM and the detection limit is 7.05 nM after three parallel experiments by synthesizing Schiff base and fixing it on the sensor surface. Using femtosecond laser-induced two-photon polymerization (TPP) technology, a compact fiber-tip miniature Fabry-Perot interferometer (FPI) was printed at the end of the fiber-optic SPR sensor, thus realizing the temperature measurement in the process of detecting Pb 2 + . The FPI channel exhibits a linear response to temperature and remains unaffected by Pb 2+ concentration, thus facilitating temperature correction. The experimental results also show that the proposed sensor has the advantages of compact structure, easy to prepare, good stability, specificity and repeatability. Therefore, this kind of sensor has great potential in various biochemical test applications, and opens up a new way to prepare compact and flexible optical sensors.
研究领域:
生物医学工程
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光学工程
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环境科学
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PubMed
高影响因子
Plasmonics
·
2026
·
IF 4.3
Zheng Mingxuan,Chang Pengxiang,Zhang Ailing,Liu Fei,Pan Honggang,Wang Junfeng,Yang Tengfei,Wang Jingcheng,Zhang Yongning
Two important issues in the surface plasmon resonance (SPR) biosensing field are improving sensor performance and expanding detectable target species. To address these challenges, this paper proposes an SPR biosensor modified with self-assembling polypeptides and gold nanoparticles (AuNPs). Peptide sequences are widely used in optical fiber SPR sensing due to their editable properties, self-assembly capability, and low toxicity. Here, engineered peptides self-assemble into nanofibers, increasing the sensor’s specific surface area and providing customizable active sites. AuNPs further enhance refractive index sensitivity. The biosensor allows programmable peptide sequences and hybridization schemes to adapt to various sensitivity-enhancing strategies and detection requirements. We tested the sensor for rabbit IgG detection, achieving a biosensitivity of 0.0365 \(\:nm/(ng/mL)\) and a detection limit (LOD) of 2.74 \(\:ng/mL\) . Compared to SPR sensors modified with single nanoparticles, our design demonstrates superior sensitivity and lower LOD. Beyond enhancing detection capabilities, this methodology establishes a universal framework for target-specific sensor customization. The economically optimized design protocol demonstrates strong translational potential to facilitate market adoption of optical fiber SPR biosensing platforms.
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IEEE SENSORS JOURNAL
·
2026
·
IF 4.5
Xin Yan,Huina Tang,Rao Fu,Xiaobing Chen,Lulu Wang,Shirong Zhang,Xue Zhou
We proposed a surface plasmon resonance (SPR) biosensor based on a multimode-multi-core-multimode fiber (MMF-MCF-MMF) structure, where the cladding of the MCF was etched using hydrofluoric acid (HF). The sensing region of the etched MCF was sequentially coated with Ag-GeSe-Au triple-layer films for detecting alpha-fetoprotein (AFP), a key biomarker of liver cancer cells. The structure and film thickness of the sensing region were optimized to enhance the sensitivity and detection accuracy of the fiber optic sensor. By specifically immobilizing AFP antibodies on the sensor surface, directional detection of AFP was achieved. The sensor demonstrated an AFP detection range of 0-2000 ng/mL with a sensitivity of 1.477 nm/log(ng/mL) and a low limit of detection (LoD) of 1.072 ng/mL. The proposed MCF sensor integrates optical fiber sensing with biological detection. To enhance the detection capability for low-concentration biomolecules, efforts have been focused on improving the sensor's detection accuracy and sensitivity. The biosensor enables highly specific and trace-level detection, holding significant potential for preventive screening and early diagnosis of liver cancer.
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OPTICS AND LASER TECHNOLOGY
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2024
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IF 4.6
Xue Zhou,Yaping Hui,Zhenxiang Chen,Ying Yang,Fang Wang,Yanan Zhang,Yong Zhao,Stephen C. Warren-Smith,Linh V. Nguyen,Xuegang Li
In this work, an integrated temperature compensated surface plasmon resonance (SPR) biosensor based on C-type special fiber is proposed and its application to DNA hybridization is demonstrated. Dual SPR effects were realized on the open microcavity by coating the C-type fiber with a gold film and filling the open microcavity with the temperature-sensitive material polydimethylsiloxane (PDMS). One effect occurs at the gold-analyte interface, where the presence of target DNA molecules interacting with the probe DNA immobilized on the fiber surface modulates the SPR response. The other effect occurs at the PDMS-gold interface, where temperature changes cause the change of PDMS refractive index (RI), altering the SPR response. The proposed sensor demonstrates exceptional capabilities. It can simultaneously detect DNA hybridization and temperature with high sensitivity. Specifically, the sensor exhibits a response of 0.11 nm/nM for DNA molecules and a significant response of −1.97 nm/°C for temperature. Additionally, it boasts a low limit of detection (LOD) of 7.9 nM, making it suitable for applications where early detection is crucial. Beyond its impressive performance, the sensor offers the advantages of compactness and ease of fabrication. This combination makes it a promising candidate for integration into portable devices, enabling on-site and real-time DNA detection with integrated temperature compensation.
研究领域:
生物传感器技术
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分子生物学
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光学传感
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IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
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2024
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IF 5.6
Hongxin Zhang,Xuegang Li,Xue Zhou,Fang Wang,Yanan Zhang,Yong Zhao
Tributyrin is widely used in medical treatment, drug development, and other fields. Lipase can decompose one tributyrin into one glycerol and three butyric acids, causing the effective refractive index (RI) and pH to change. Detecting the RI change or pH change during the experiment is usually used to determine the tributyrin in the sample. However, these methods encounter limitations at low or high concentrations. The RI difference detection method is difficult to implement in low-concentration detection, but the pH detection method is difficult to apply in high-concentration detection. In this article, we present an optical fiber sensor with dual channels based on surface plasmon resonance (SPR) to achieve the measurement of tributyrin. Polyacrylic acid (PAA)/chitosan (CS) pH-sensitive material is coated on half of the SPR sensor as channel 1 to monitor tributyrin-induced pH changes, and the lipase is bonded on the polydopamine (PDA)/maleic acid (MA) coated on the fiber as channel 2 to decompose tributyrin. Experimental results show that channel 1 realizes high pH sensitivity (34.52 nm/pH) and the tributyrin sensitivity reaches 12.8 nm/mM with a concentration between 0.1 and 1 mM. In the concentration range of 1–4 mM, channel 2 exhibits a tributyrin sensitivity of 4.85 nm/mM. In addition, the sensor proposed in this article has excellent stability and selectivity. Thus, the dual-channel optical fiber SPR sensor holds significant potential for drug development and biomedicine.
研究领域:
生物医学工程
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分析化学
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药物开发
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高影响因子
INSTRUMENTATION SCIENCE & TECHNOLOGY
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2022
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IF 1.509
Ze-Ying Hao,Yao Liu,Zhou-Hao Zhao,Qi Wang
Although surface plasmon resonance (SPR) methods are frequently employed due to their remarkable advantages such as reduced sample requirements, they confront a significant challenge in terms of sensitivity improvement. GeSe is an appropriate material for resolving this issue. According to the theoretical basis of the research, GeSe is a two-dimensional material which is a direct band gap semiconductor that may be utilized to promote electron transport and stimulate greater SPR phenomena. The first use of GeSe in an optical fiber sensor is reported in this study. A U-shaped optical fiber-GeSe-Au sensor is proposed. As a two-dimensional material with comparable physical characteristics to GeSe, MoS2 is compared to GeSe to characterize its influence upon the sensitivity. The sensitivity of fiber-GeSe-Au sensor is 7398.1 nm/refractive index unit (RIU), which is nearly twice as sensitive as a gold film SPR sensor and 1.5 times as sensitive as a sensor utilizing MoS2 nanosheets with the same structure. This study introduces a novel approach for enhancing the sensitivity, which gives a new option for monitoring biological substances at low concentrations with high sensitivity and stability and demonstrates that GeSe nanosheets have significant promise for future applications.
研究领域:
材料科学
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光学工程
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生物传感
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高影响因子
Nanophotonics
·
2019
·Vol. 9
·期 2
·327-336
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IF 6.908
Yuting Zhao,Shuaiwen Gan,Leiming Wu,Jiaqi Zhu,Yuanjiang Xiang,Xiaoyu Dai
Germanium selenide (GeSe) nanosheets are stable and inexpensive and considered to have a great potential for photovoltaic applications, however we have demonstrated that GeSe nanosheets are also promising for sensing technology, in this paper. By spin-coating the GeSe nanosheets on the surface of noble metal (Au), we have obtained a surface plasmon resonance (SPR) sensor with significantly enhanced sensitivity, and the performance of the sensor is closely related to the thickness of the GeSe film. By detecting different refractive index solutions, we have obtained the optimized sensitivity with 3581.2 nm/RIU (which is nearly 80% improvement compared to traditional SPR sensors) and figure of merit with 14.37 RIU −1 . Moreover, the proposed SPR sensor was vastly superior in sensing Pb 2+ heavy metal ions after coating it with chitosan and GeSe composite. A maximum sensitivity of 30.38 nm/μg/l has been verified, which is nearly six times better than that of conventional SPR sensor. Our results demonstrated that GeSe nanosheets overlayer with modified SPR sensor has its great potential in heavy metal detection and chemical-specific molecular identification.
研究领域:
纳米技术
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光学
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传感器
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环境科学
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2025
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IF 7.7
Wenwei Wu,Lixia Qian,Jie Shen,Hongmei Li,Liang-cheng Li
Cancer remains a leading cause of mortality worldwide, with China bearing a particularly high burden. Early detection through reliable biomarkers is essential for improving patient outcomes. This study reports the development and validation of a highly specific aptamer-based biosensor for detecting the complement protein C1QC, a promising cancer biomarker. Using a multi-step selection process involving Magnetic beads-SELEX, qPCR, flow cytometry, high-throughput sequencing, surface plasmon resonance (SPR), pull-down, and western blotting, we identified Apt 13, a slow-dissociation aptamer with high specificity and affinity for C1QC (K D = 48.7 nM). SPR confirmed the formation of a sandwich complex between Apt 13, C1QC, and Anti_C1QC, confirming their distinct binding sites. We developed two biosensor platforms based on this aptamer: the enzyme-linked antibody-aptamer sandwich (ELAAS) and chemiluminescent antibody-aptamer sandwich (CLAAS) biosensors. The ELAAS biosensor, designed for visual colorimetric detection, demonstrated a limit of detection (LOD) of 98 ng/mL. In contrast, the CLAAS system, utilizing acridinium ester-modified antibodies, achieved an enhanced LOD of 0.375 ng/mL. Receiver Operating Characteristic (ROC) analysis on serum samples from 75 hepatocellular carcinoma (HCC) patients and 20 healthy controls yielded an AUC of 0.942, with 86.67 % sensitivity and 95.00 % specificity, demonstrating CLAAS’s high diagnostic accuracy in differentiating HCC from controls. Further testing in HCC patient serum samples revealed significantly elevated C1QC levels compared to healthy controls, underscoring C1QC’s potential as a HCC cancer biomarker. Apt 13 presents a promising tool for the development of innovative, sensitive, and cost-effective diagnostic technologies for C1QC detection and may offer future potential for targeted therapies.
研究领域:
癌症研究
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分子诊断
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生物传感器
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适配体技术
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蛋白质组学
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临床诊断
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高影响因子
危险品化学品经营许可证（带存储）