Current Pharmaceutical Analysis
·
2023
·Vol. 19
·期 3
·216-221
·
IF 0.6
Zhang Liang,Yang Dehui,Liu Ye
Background: A reversed-phase high-performance liquid chromatographic method for determining thrombin activity is described. The improved method can provide a high resolution between substrate Nα-P-toluenesulfonyl-L-arginine methyl ester (TAME) and the product of enzyme reaction,
Nα-P-toluenesulfonyl-L-Arginine (TA). Methods: When the substrate concentration was 5 mg/mL, the Michaelis equation approached the zero-order reaction, and the thrombin enzyme activity must have a good linear relationship with the consumption of TAME or the yield of TA. Results:
The method is suitable for quantitatively analyzing thrombin activity in formulation or serum. Conclusion: Three batches of thrombin lyophilized preparations were determined for activity.
研究领域:
生物化学
·
医学检测
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Chen Wang,Guo Lin,Jiling Zhao,Shixing Wang,Libo Zhang,Yunhao Xi,Xiteng Li,Ying Ying
A novel adsorbent (UiO-66-TA) was presented by modifying metal-organic framework composites with thioctic acid. UiO-66-TA were characterized by fourier transform infrared (FT-IR), field emission scanning electron microscopy (FESEM), thermogravimetric (TG), Brunner-Emment-Teller (BET) measurement and X-ray photoelectron spectroscopy (XPS), which indicating that it had excellent morphology and specific surface area. The adsorption performances of UiO-66-TA for Au(III) were studied. The results showed that UiO-66-TA had a strong adsorption capacity under acidic conditions and the optimal pH was 2.0. Isotherm and kinetic adsorption were also conducted and found that the experimental values correspond to Langmuir model and pseudo-second-order isotherm model, indicating that the mechanism is mainly chemical adsorption on a uniform surface. Wastewater experiment showed that UiO-66-TA can be used for highly selective recovery Au(III) in actual life. The regeneration and thermodynamic experiments indicated that UiO-66-TA can be reused and were a spontaneous endothermic process. XPS analysis and the zeta potential proved that the main adsorption mechanisms were ion exchange and chelation. DFT calculation found that there are two ways to combine Au with S on UiO-66-TA and their distances are 2.38 Å and 2.39 Å, indicating that the gold and sulfur play a major role in chelation. In summary, UiO-66-TA was a hopeful adsorbent and could be used to collect gold ions from wastewater in a sustainability perspective.
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xiaolong Hu,Hongyan Zhang,Zuan-Tao Li,Yu Chen,Hao Cheng,Bi-Huan Zhong,Yong-li Li,Xiao-Ping Liao,Jian Sun,Mei X. Wu,Gang-Biao Jiang
Regarding the several antibacterial hydrogels that have been created thus far, their fixed forms and limited mobility hinder their ability to fully eradicate the germs that are still present deep within the wound and to satisfy the requirements of wound healing. Hence, a remotely triggered phase change hydrogel (CMCS/Gel/OGG/TA/Fe 3+ , CGO-TF) was created for controlled release and promoting healing of infected wounds. The CGO-TF has excellent mechanical, tissue adhesion, injectability, and reactive oxygen species scavenging capabilities (76.08 % ± 3.46 %). Importantly, the hydrogel can remotely trigger morphological phase transition and TA ’on–off’ release when driven by NIR. To be specific, after exposure to NIR for 10 min, the hydrogel can undergo a “solid-liquid” phase transition to fill deep wound tissue gaps or irregular wounds; the controlled release of TA can be remotely triggered to work in tandem with the hydrogel’s photothermal response to create an efficient bacteriostatic effect that can stop the growth of MDRB. For the treatment of infected skin injury in mice, the hydrogel can promote wound healing by removing wound bacteria (99.88 % ± 0.08 %), activating M2-type macrophage polarization, stimulating vascular neogenesis, and accelerating granulation tissue proliferation (928.2 μm ± 74.71 μm). In conclusion, CGO-TF is a promising medical biomaterial.
研究领域:
生物材料
·
医学工程
·
药剂学
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DOI
高影响因子
CERAMICS INTERNATIONAL
·
2026
·
IF 6
Yuhui Wan,Jiachen Song,Fuxue Yan,Xu Lu,Shu Yang,Yonggui Shi,Pengrong Ren
Zn and Ta co-doped TiO 2 ceramics with the nominal composition (Zn 1/3 Ta 2/3 ) x Ti 1-x O 2 ) were prepared using a conventional solid-state reaction method. Phase analysis revealed that all samples consisted of a single rutile-type TiO 2 phase, exhibiting a dense microstructure and uniform grain size. At a doping level of x = 0.005, the material exhibited excellent dielectric properties. Specifically, at room temperature and 1 kHz, its dielectric permittivity reached 3.93 × 10 4 , with a dielectric loss of 0.031. Over the temperature range from −60 °C to 200 °C, the variation in the dielectric permittivity was less than 15%, while the dielectric loss remained below 0.02 between −60 °C and 112 °C. X-ray photoelectron spectroscopy (XPS) was employed to analyze the valence states of the constituent elements. Impedance spectroscopy and bias-voltage measurement, together with the XPS analysis, revealed the coexistence of multiple mechanisms in Zn and Ta co-doped TiO 2 ceramics Electron-pinned defect-dipole (EPDD) polarization was identified as the primary origin of the colossal dielectric behavior, while Maxwell-Wagner polarization also contributed to the dielectric response.
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DOI
高影响因子
Crystals
·
2018
·Vol. 8
·期 3
·113
·
IF 2.144
Hui Wang,Qin Li,Chaoyue Wang,Huan He,Jianding Yu,Jiayue Xu
High-quality Ta-doped La2Ti2O7(Ta-LTO) single crystal of about 40 mm in length and 5 mm in diameter was successfully prepared by the optical floating zone method. An X-ray rocking curve reveals that the crystal of LTO has excellent crystalline quality. As-grown crystals were transparent after annealing in air and the transmittance is up to 76% in the visible and near-infrared region. X-ray diffraction showed that this compound possessed a monoclinic structure with P21space group. The dielectric properties were investigated as functions of temperature (0~300 °C) and frequency (102Hz~105Hz). Dielectric spectra indicated an increase in the room-temperature dielectric constant accompanied by a drop in the loss tangent as a result of the Ta doping. One relaxation was observed in the spectra of electric modulus, which was ascribed to be related to the oxygen vacancy. The dielectric relaxation with activation energy of 1.16 eV is found to be the polaron hopping caused by the oxygen vacancies.Keywords:Ta-LTO single crystal;floating zone method;dielectric properties;oxygen vacancy
研究领域:
材料科学
·
物理学
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DOI
高影响因子
Journal of Materiomics
·
2023
·
IF 9.4
Chongsheng Wu,Kui Liu,Honglan Lai,Fang Xu
Herein, the sintering behavior and dielectric properties of Ta 5+ -doped Li 3 Mg 4 NbO 8 ceramics were investigated by solid-phase reactions in combination with first-principles calculations. In particular, Li 3 Mg 4 Nb 0.96 Ta 0.04 O 8 illustrates the best dielectric properties after sintering at 1,175 °C with ε r = 13.71 ± 0.20, Q × f = (132,112 ± 2,391) GHz (increased by 25%) and τ f = (25.07 ± 1.36) × 10 −6 °C −1 . The non-intrinsic factors reflect that a small amount of Ta 5+ doping produces a secondary phase, increased densification, and grain size, all of which optimize the dielectric properties. The dominant intrinsic factors indicate that the increase in bond ionicity, the greater polarization of Ta 5+ , and the blueshift of the Raman characteristic peak all lead to an increase in ε r . The increase in lattice energy and the decrease in the damping behavior of the Nb/Ta-O bond vibrations lead to an increase in Q × f . The weakening of the Nb/TaO 6 octahedral distortion leads to an optimization of τ f . The modified Li 3 Mg 4 Nb 0.96 Ta 0.04 O 8 ceramics have promising applications in microwave communications.
研究领域:
材料科学
·
陶瓷
·
介电材料
·
微波工程
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DOI
高影响因子
ChemCatChem
·
2020
·Vol. 13
·期 1
·180-184
·
IF 4.853
Lang Pei,Hong Cai,Hao Jin,Taozhu Li,Heng Zhu,Yongjun Yuan,Jiasong Zhong,Shicheng Yan,Zhigang Zou
Graphical Photocatalysis : A nitrogen-doped tunable tunneled oxide ScTaO 4−x N x with an absorption edge of ca. 540 nm is identified as a narrow bandgap bifunctional photocatalyst for photocatalytic OER and HER. Screening of visible-light-responsive semiconductor photocatalysts is a significant target for solar water splitting systems. Herein, a newly designed Ta-based oxynitride, namely ScTaO 4−x N x , was successfully synthesized via nitrogen doping of ScTaO 4 oxide precursors at 1273 K under NH 3 flow. The ScTaO 4−x N x photocatalyst, with a strong band-to-band visible light absorption as far as 540 nm, can be employed for both water oxidation and reduction half-reactions under visible light illumination, demonstrating great potential for photocatalytic water splitting.
研究领域:
材料科学
·
能源化学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2021
·
IF 5.816
Na Ye,Zhao Jiang,Tao Fang
The low-palladium Pd/TaN–C catalyst is synthesized by a surfactant-free solvothermal approach and exhibits high activity (2613.18 mA mg Pd −1 ), durability and CO tolerance for MOR (methanol oxidation reaction) in alkaline media , 12.4 folds that of the commercial Pd/C. XPS and electrochemical results indicate that the interfacial Pd–TaNO bond is generated. This also brings the enhancement of OH ad adsorption responsible for anti-CO poisoning ability. Density Functional Theory (DFT) calculations indicate that the reaction pathway and the rate-determining step are changed for methanol decomposition to CO on the Pd 4 /TaN(001) surface compared with Pd (111). The preferred pathway can be described as: CH 3 OH→CH 3 O→CH 2 O→CHO→CO. Furthermore, the results indicate that the adsorption of OH is enhanced and the energy barrier of COOH formation from CO + OH is reduced with the high concentration of hydroxyl on the Pd 4 /TaN(001) surface, further confirming the bi-functional effect of hydroxyl on the CO tolerance.
研究领域:
电化学
·
催化材料
·
理论计算
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Yongcong Liu,Qingquan Lin,Guangyong Zeng,Liyi Zhang,Yinjie Zhou,Arijit Sengupta
Nature inspired ‘green’ method has been reported for the fabrication of nanoparticles from the plant derived polyphenol tannic acid (TA) and 3-aminopropyltriethoxysilane (APTES). In present investigation, TA-APTES nanoparticles decorated MXene nanosheets were acted as active layers and TA-APTES@MXene composite membrane were constructed by vacuum self-assembly on cellulose acetate support in order to improve membrane performance. The modified membrane showed an excellent hydrophilicity with a water flux of 5990.11 L·m −2 ·h −1 at 0.1 MPa, which is 15 times higher than pure MXene membrane. Moreover, the removal ratios of three different types of oil/water emulsions (petroleum ether, lubricating oil and vegetable oil) were found to be more than 98%. More importantly, the highly oleophobic membrane surface maintained a relatively high separation performances after four consecutive cycles of performances. This investigation achieves a leap of MXene-based membrane materials from nano- to micro-scale, which provides valuable insights in the field of oil/water separation.
研究领域:
材料科学
·
环境科学
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DOI
高影响因子
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
·
2025
·
IF 3.8
Kaiqiang Wang,Xiaoyan Duan,Ye Tian,Hong Lin,Limin Cao,Jianxin Sui
In this work, a novel method for sensitive detecting heavy metal Pb (II) in aquatic products was developed using UiO-66-NH 2 @tannic acid (UiO-66-NH 2 @TA) solid-phase extraction combined with laser-induced breakdown spectroscopy (LIBS). UiO-66-NH 2 @TA adsorbent could effectively extract Pb (II) from the digestive solution of aquatic products. Characterization of the morphology of the adsorbent was performed using transmission electron microscopy and scanning electron microscopy. The optimal experimental conditions for LIBS detection, including sample preparation, substrate type, laser energy, and delay time, were investigated. The results showed that the strongest Pb I 405.7 nm spectral signal can be obtained by dripping UiO-66-NH 2 @TA adsorbent onto a silicon wafer for LIBS testing. The limit of detection and limit of quantification for Pb (II) in aqueous solution were 0.18 μg/mL and 0.61 μg/mL, respectively. The calibration curve demonstrated good sensitivity and accuracy for Pb (II) detection with a correlation coefficient of 0.9905. Spiked recovery experiments on large yellow croakers and scallops yielded recovery rates of 75.25 % - 99.08 %, which was consistent with the results from atomic absorption spectrometry. This study underscores the potential of the solid-phase extraction combined with laser-induced breakdown spectroscopy for practical application in food safety monitoring, demonstrating its effectiveness and reliability in detecting Pb (II) in aquatic products.
研究领域:
分析化学
·
食品安全
·
环境科学
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产品关联
DOI
高影响因子
ACS Omega
·
2019
·
IF 2.584
Xueting Zhao,Ning Jia,Lijuan Cheng,Ruoxi Wang,Congjie Gao
The development of antifouling membranes plays a vital role in the widespread application of membrane technology, and the hybridization strategy has attracted a significant amount of attention for antifouling applications. In this work, TA/PEI@TiO2 hierarchical hybrid nanoparticles (TPTi HHNs) are first synthesized through a simple strategy combining the multiple catechol chemistries of phenolic tannic acid (TA) with the biomimetic mineralization chemistry of titania. The TPTi HHNs are used as nanofillers to prepare PVDF/TPTi hybrid membranes. The TPTi HHNs endow the membrane with higher porosity, hierarchical roughness, greater hydrophilicity, and underwater superoleophobicity. Upon TPTi HHN loading, the PVDF/TPTi hybrid membranes exhibit enhanced antifouling performance. The flux recovery ratio can reach 92% when utilized to separate oil-in-water emulsion. Even being applied to the three-cycle filtration of oil-in-water emulsion with much higher concentration, the PVDF/TPTi membrane can still maintain a high flux recovery ratio about 85%. This study will provide a facial polyphenol-based platform to fabricate antifouling hybrid nanofillers and antifouling hybrid membranes with promising applications in oil/water separation.
研究领域:
材料科学
·
环境工程
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DOI
高影响因子
DRUG DELIVERY
·
2021
·
IF 6.419
Wei Xin,Yumei Wang,Yan Bian,Jiahui Lin,Wenhao Weng,Xinyi Zhao,Kaijun Gou,Xianmou Guo,Heran Li
The aim of this study was to build up a novel chiral mesoporous silica called PEIs@TA-CMS through a facile biomimetic strategy and to explore its potential to serve as a drug carrier for improving the delivery efficiency of poorly water-soluble drug. PEIs@TA-CMS was synthesized by using a chiral crystalline complex associated of tartaric acid and polyethyleneimine (PEIs) as templates, scaffolds and catalysts. The structural features including morphology, size, pore structure and texture properties were systematacially studied. The results showed that PEIs@TA-CMS was monodispersed spherical nanoparticles in a uniformed diameter of 120–130 nm with well-developed pore structure (SBET: 1009.94 m2/g, pore size <2.21 nm). Then PEIs@TA-CMS was employed as nimodipine (NMP) carrier and compared with the drug carry ability of MCM41. After drug loading, NMP was effectively transformed from the crystalline state to an amorphous state due to the space confinement in mesopores. As expected, PEIs@TA-CMS had superiority in both drug loading and drug release compared to MCM41. It could incorporate NMP with high efficiency, and the dissolution-promoting effect of PEIs@TA-CMS was more obvious because of the unique interconnected curved pore channels. Meanwhile, PEIs@TA-CMS could significantly improve the oral adsorption of NMP to a satisfactory level, which showed approximately 3.26-fold higher in bioavailability, and could effectively prolong the survival time of mice on cerebral anoxia from 10.98 to 17.33 min.
研究领域:
材料科学
·
药学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
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