SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Seokjoon Kim,Seungjin Lee,Seokhwan Kim,Jiye Shin,Byung Seok Cha,Eun Sung Lee,Ki Soo Park
Globally, over 200 million people are at risk of exposure to high levels of arsenic due to increasing environmental pollution; thus, there is high demand for detection methods to monitor arsenic contamination in the natural environment. In this study, we developed a cost-effective method for detecting arsenite [As(III)] ions using sodium dodecyl sulfate (SDS)-coated gold nanoparticles (AuNPs) and Tris. Positively charged Tris molecules induce aggregation of AuNPs by neutralizing the negative charge of SDS; however, this is prevented by the presence of As(III), which has a high affinity for AuNPs. This proposed method is able to detect 5 parts per billion (ppb) and 1.85 ppb of As(III) through naked eye and spectrophotometric measurements, respectively. Furthermore, a chitosan-based lateral flow (LF) strip was devised to enhance the visual signal intensity by concentrating AuNPs on its test zone, since AuNPs of lower concentration were more effective for detecting low As(III) concentrations. As a result, As(III) was detected at 500 parts per trillion (ppt) without any interference from other metal ions, which is a 10-fold improvement from solution-based assays. Importantly, the colorimetric signal amplification strategy (using the chitosan-based LF strip) is versatile and can be applied to many other AuNP- or nanomaterial-based technologies. The proposed system enables the detection of As(III) in facility-limited or point-of-care settings, making it ideal for use in underdeveloped countries because it requires a small sample volume (approximately 20–30 µL) with a small amount of AuNPs, and takes only 10 min to generate colorimetric results.
研究领域:
环境科学
·
纳米技术
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2024
·
IF 6.2
Yujie Sha,Duo Zhang,Jiazichao Tu,Ruyue Zhang,Yijia Shao,Jimei Chen,Shaoyou Lu,Xiang Liu
Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is a widely used organophosphate ester that can adversely affect animal or human health. The intestinal microbiota is critical to human health. High-dose exposure to TDCIPP can markedly affect the intestinal ecosystem of mice, but the effects of long-term exposure to lower concentrations of TDCIPP on the intestinal flora and body metabolism remain unclear. In this study, TDCIPP was administered to Sprague–Dawley rats by gavage at a dose of 13.3 mg/kg bw/day for 90 days. TDCIPP increased the relative weight of the kidneys ( P = 0.017), but had no effect on the relative weight of the heart, liver, spleen, lungs, testes, and ovaries ( P > 0.05). 16 S rRNA gene sequencing revealed that long-term TDCIPP exposure affected the diversity, relative abundance, and functions of rat gut microbes. The serum metabolomics of the rats showed that TDCIPP can disrupt the serum metabolic profiles, result in the up-regulation of 26 metabolites and down-regulation of 3 metabolites, and affect multiple metabolic pathways in rat sera. In addition, the disturbed genera and metabolites were correlated. The functions of some disturbed gut microbes were consistent with the affected metabolic pathways in the sera, and these metabolic pathways were all associated with kidney disease, suggesting that TDCIPP may cause kidney injury in rats by affecting the intestinal flora and serum metabolism.
研究领域:
毒理学
·
微生物学
·
代谢组学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2024
·
IF 8.2
Sujing Wang,Na Zheng,Qirui An,Xiaoqian Li,Yining Ji,Yunyang Li,Changcheng Chen,Zhifei Xiu
The flame retardant tri (1, 3-dichloro-2-propyl) phosphate (TDCIPP) is widely present in environmental media and organisms. People have paid much attention to the growth and developmental toxicity of TDCIPP, but there is little information about its cardiotoxicity and potential mechanisms. In this study, marine medaka ( Oryzias melastigma ) embryos were exposed to TDCIPP solutions (0, 0.05, 0.5, 5, and 50 μg/L) for 21 days to investigate the adverse effects of TDCIPP on cardiac development. The results showed that TDCIPP exposure altered the heart rate at different stages of embryonic development. In addition, 50 μg/L TDCIPP resulted in increased sinus venosus (SV)–bulbus arteriosus (BA) distance, pericardial cysts, and cardiac linearization in newly hatched fish. During embryonic development, the expression level of key genes regulating cardiac development is disturbed. The early stage of cardiac development is the sensitive window period for the toxic effects of TDCIPP. Oxidative stress was observed in newly hatched juveniles, but no significant lipid peroxidation damage was observed. In addition, vitellogenin (VTG) levels in juvenile fish were significantly reduced. Our results show that TDCIPP exposure induces cardiotoxicity in marine medaka embryos, which is induced in the early stages and promotes heart defects by amplifying inflammatory responses at a later stage.
研究领域:
环境毒理学
·
发育生物学
·
心血管毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanomaterials
·
2021
·Vol. 11
·期 7
·1757
·
IF 5.076
Xiaohua Ma,Dehua Deng,Ning Xia,Yuanqiang Hao,Lin Liu
Nanocatalysts are a promising alternative to natural enzymes as the signal labels of electrochemical biosensors. However, the surface modification of nanocatalysts and sensor electrodes with recognition elements and blockers may form a barrier to direct electron transfer, thus limiting the application of nanocatalysts in electrochemical immunoassays. Electron mediators can accelerate the electron transfer between nanocatalysts and electrodes. Nevertheless, it is hard to simultaneously achieve fast electron exchange between nanocatalysts and redox mediators as well as substrates. This work presents a scheme for the design of electrochemical immunosensors with nanocatalysts as signal labels, in which pyrroloquinoline quinone (PQQ) is the redox-active center of the nanocatalyst. PQQ was decorated on the surface of carbon nanotubes to catalyze the electrochemical oxidation of tris(2-carboxyethyl)phosphine (TCEP) with ferrocenylmethanol (FcM) as the electron mediator. With prostate-specific antigen (PSA) as the model analyte, the detection limit of the sandwich-type immunosensor was found to be 5 pg/mL. The keys to success for this scheme are the slow chemical reaction between TCEP and ferricinum ions, and the high turnover frequency between ferricinum ions, PQQ. and TCEP. This work should be valuable for designing of novel nanolabels and nanocatalytic schemes for electrochemical biosensors.Keywords:electrochemical immunosensor;nanocatalyst;redox cycling;quinone
研究领域:
生物传感
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Ying Peng,Zhi-Gang Wang,Bao-Ping Qi,Cui Liu,Bo Tang,Zhi-Ling Zhang,Shu-Lin Liu,Dai-Wen Pang
Carbon nanodots (C-dots) with good biocompatibility have been extensively utilized as co-reactants for electrochemiluminescence (ECL) of the tris(2,2′-bipyridine)ruthenium(II) (Ru(bpy) 3 2+ ) system. However, the ECL intensity of this system is still relatively low and the mechanism of C-dots as co-reactants remains unclear, which greatly limits its further application in bio-analysis. In this work, we revealed that the carboxyl groups on C-dots are co-reactant sites for Ru(bpy) 3 2+ ECL by systematically investigating the contribution of carboxyl, hydroxyl and carbonyl groups on the surface of C-dots to the ECL intensity. Further treatment with hydrogen peroxide to increase the carboxyl-group content on C-dots resulted in a 10-fold increase in ECL intensity over the original Ru(bpy) 3 2+ /C-dots system. This work provides new insights for the rational design of ECL systems with C-dots as co-reactants and offers new chances for further applications of C-dots in the field of ECL.
研究领域:
分析化学
·
生物医学工程
✓ 已验证
DOI
高影响因子
ACS Applied Polymer Materials
·
2026
·
IF 5.2
Rui Zhang,Zhengfeng Xie,Yujie Hu,Jie Li,Hong Liao,Junjie Gao,Wei Shi,Chuxiang Zhou
The complexity of pollutants in water, including endocrine-disrupting chemicals, dyes, and antibiotics, poses a challenge to existing water treatment agents. Therefore, we successfully cross-linked tris(4-formylphenyl)amine (TFPA) onto β-cyclodextrin (β-CD) to synthesize a β-cyclodextrin polymer (TFPA-N-β-CD). This unique adsorbent provides essential adsorption properties from each of its components: β-CD offers a cavity structure and hydrophilic groups capable of removing organic micropollutants through host–guest interactions, while TFPA not only constructs a three-dimensional network structure to enhance the specific surface area (63.68 m2/g) but also provides adsorption sites. In single-component systems, the adsorption of bisphenol A (BPA), methylene blue (MB), and tetracycline (TC) follows the pseudo-second-order kinetic model and the Sips adsorption isotherm model. The maximum adsorption capacities are 164.73 (BPA), 272.03 (MB), and 33.89 mg/g (TC). In binary system mixed adsorption, each pollutant still maintains significant adsorption capacity, with adsorption capacity ratios (Rq) greater than 0.80. This reveals the different mechanisms behind the adsorption of TFPA-N-β-CD. During the adsorption of BPA, host–guest interactions dominate, while electrostatic forces are stronger than hydrophilic and inclusion interactions in MB adsorption, and hydrophilic interactions play a dominant role in TC adsorption. Additionally, after 10 consecutive adsorption–desorption cycles, the adsorption capacity of TFPA-N-β-CD for the target pollutants was maintained at over 55% of its initial value, demonstrating its excellent cycling stability and potential for reuse. These characteristics make it highly promising for the treatment of complex real wastewater.
✓ 已验证
产品关联
DOI
高影响因子
AQUATIC TOXICOLOGY
·
2020
·
IF 4.346
Hui Hao,Siliang Yuan,Shiyang Cheng,Qian Sun,John P. Giesy,Chunsheng Liu
As a typical organophosphorus flame retardant, tris (2-chloroethyl) phosphate (TCEP) has been widely detected in various environmental media. Toxicity of TCEP to vertebrates have been investigated, but potential effects on lower trophic level species were unknown to date. In this study, toxic effects and molecular mechanisms of toxic actions of TCEP on the aquatic protozoan Tetrahymena thermophila were evaluated by use of phenotypic observations, transcriptome sequencing analysis and real-time quantitative PCR detection. Exposure to 0.044, 0.411 or 4.26 mg/L TCEP for 5 days decreased the theoretical population, cell viability, number of cilia and cell size of Tetrahymena thermophila in a time- and dose-dependent manner. Meanwhile, RNA-Seq analysis indicated that exposure to 4.26 mg/L TCEP significantly changed expression of 2932 genes (up-regulation: 1228; down-regulation: 1704). Of these, expressions of 9, 10 and 17 genes that were enriched in soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) interaction in vesicular transport, proteasome and endocytosis pathway respectively were down-regulated. Data collected during this study suggested that exposure to high concentrations of TCEP might affect growth and reproduction of Tetrahymena thermophila through down-regulating transcriptional levels of genes encoding proteins associated with vesicle trafficking, proteasome and endocytosis.
研究领域:
环境毒理学
·
分子生物学
·
原生动物学
✓ 已验证
DOI
PubMed
高影响因子
Processes
·
2025
·Vol. 13
·期 1
·232
·
IF 2.8
Jiulong Che,Jian Zhang,Qing Lang,Jiayuan Yu,Yixiao Yang,Longqi Luo,Zhiyi Liu,Jiahui Ye,Gang Wang
Dual-ion batteries (DIBs) were demonstrated as a promising technology for large-scale energy storage due to their low cost, recyclability, and impressively fast charge capability. Graphite as a commonly used cathode material in DIBs, however, suffers from poor compatibility with commercial Li-ion electrolytes and graphite anodes, making it difficult to directly utilize the well-established infrastructure for Li-ion batteries. Herein, we report a small aromatic amine molecule 4,4′,4″-tris(diphenylamino)triphenylamine (N4) functioning as a compatible anion host in the EC-containing Li-ion electrolyte. With an average discharge voltage of 3.6 V (vs. Li+/Li), the N4 electrode delivers a reversible specific capacity of 108 mAh/g, which is much higher than 29 mAh/g for the graphite cathode at the same condition. The high capacity retention of 91.3% was achieved after 500 cycles at 1 A/g. The N4 electrode also exhibited good rate performance. Via different characterization techniques like Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, the energy storage mechanism of N4 was revealed as a conversion between amine and quaternary amine cations, accompanied by PF6−(de-)insertion. As consequences, the assembled N4||graphite DIB w showed a high discharge capacity of 90 mAh/g within 1.5–4.1 V, and good cycling stability with a 98% capacity retention after 40 cycles. Decent rate performance was achieved in the N4||graphite DIB as well. This work provides new insights into designing a compatible anion host for affordable DIBs.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION SCIENCE AND TECHNOLOGY
·
2016
·
IF 1.083
Mei Zhang,Qingye Yan,Yunbin Zhao
In the present article, a new separation system was employed for the extraction of cadmium from nitric acid solutions for the first time. Phosphine oxide, tris[(dibutylamino)methyl]-(7CI,8CI),which contains nitrogen atoms and phosphorus atom in molecular, was used as extractant. The influence of the following parameters was investigated: the organic/aqueous phase ratio (O/A), pH, contact time, temperature, the concentration of extractant, cadmium (Ⅱ), sodium nitrate and sodium chloride. Results demonstrated that quantitative extraction of cadmium was feasible from 50 mg/L cadmium feed solution in a single stage at pH 3.0, 15 min and O/A phase ratio 1:5 with 20% extractant in cyclohexane diluent. The cadmium extraction isotherm under different cadmium ion concentrations was established. The loaded cadmium could be stripped by 4 mol/L ammonium chloride aqueous solutions. A contrast study was carried out, and the results indicated that phosphine oxide, tris[(dibutylamino)methyl] –(7CI,8CI), could take the place of commercial organo-phosphorous extractants in the process of cadmium(II) extractions for its effectivity, stability and low price.
研究领域:
化学工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Defen Feng,Yeyu Wu,Xuecai Tan,Quanyou Chen,Jun Yan,Min Liu,Chenhao Ai,Yanni Luo,Fangkai Du,Shaogang Liu,Heyou Han
Metal-organic frameworks (MOFs) are microporous materials that consist of metal ions or clusters and organic ligands. Their luminescence activities can be improved by functionalization, and the present work describes the synthesis of a luminescence-functionalized MOF in which tris(2,2′-bipyridyl) dichlororuthenium(II) hexahydrate (Ru(bpy) 3 2+ ) was introduced into the MOF. The synthesized RuMOF was then fabricated as an ECL sensor that can be used for the rapid and sensitive detection of melamine in dairy products. The optimum detection conditions were established by single-factor analysis and surface response multivariate optimization. Under optimum conditions, the ECL intensity was proportional to log(melamine) concentration in the range 10 −10 –10 −4 M with a detection limit of about 3.8 × 10 −11 M (signal/noise = 3). In an application to the detection of melamine in milk and infant formula powder, recoveries in the range 98–104% and 95–103%, respectively were obtained from spiked samples. Thus this novel ECL sensor represents a potentially valuable product for the analysis of melamine food samples.
研究领域:
分析化学
·
食品科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2022
·Vol. 38
·期 3
·816-822
·
IF 2.726
Hu Shifan,Wang Yafeng,Su Bin
Electrochemiluminescence(ECL) is a powerful transduction technique used in biosensing and in vitro diagnosis, while the mechanism of ECL generation is complicated and affected by various factors. Herein the effect of ionic strength on ECL generation by the classical tris(2,2′-bipyridyl)ruthenium(II)[Ru(bpy) 3 2+ ]/tri- n -propylamine(TPrA) system was investigated. It is clear that the ECL intensity decreases significantly with the increase of ionic strength, most likely arising from the reduced deprotonation rate of TPrA +· . We further combined microtube electrode(MTE) with ECL microscopy to unravel the evolution of ECL layer with the variation of ionic strength. At a low concentration of Ru(bpy) 3 2+ , the thickness of ECL layer(TEL) nearly kept unchanged with the ionic strength, indicating the surface-confined ECL generation is dominated by the oxidative-reduction route. While at a high concentration of Ru(bpy) 3 2+ , ECL generation is dominated by the catalytic route and TEL increases remarkably with the increase of ionic strength, because of the extended diffusion length of Ru(bpy) 3 3+ at a reduced concentration of TPrA · .
研究领域:
分析化学
·
生物传感
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2015
·
IF 5.056
Yan Chao Xu,Xi Quan Cheng,Jun Long,Lu Shao
The main drawback of polyimide (PI) based OSN membrane capable to separate molecules is the declined solvent permeance after crosslinking. In this study, the hydrophilic monoamine named as Tris(hydroxymethyl) aminomethane (Tris) was first utilized to modify polyimide OSN membranes by adding Tris into the dope solution before phase inversion and diamino crosslinking for improving membrane-solvent mutual affinity so as to obtain high-performance OSN membranes. Such Tris modified membranes were proved by chemical characterizations, and the further contact angles and surface energy measurements revealed that the hydrophilicity and surface energy of the novel membranes increased with the Tris loading. Interestingly, the morphological observation demonstrated that the macrovoids shown in the pristine membranes can be completely displaced by sponge-like pores in Tris modified membranes. Surprisingly, the isopropanol (IPA) permeance of 10% Tris modified crosslinked membranes increased to 270% of the original value with only slight decline in dyes rejections. Besides, the fundamental study on the relationship between IPA or N,N-dimethylformamide (DMF) permeance and the membrane-solvent solubility parameter distance were performed. Our novel monoamine modification strategy can provide a new incentive to develop advanced membranes applicable to aqueous solution separation, gas separation and pervaporation for future sustainable usages.
研究领域:
材料科学
·
化学工程
·
膜技术
·
可持续分离
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）