Materials Chemistry Frontiers
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2026
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IF 8.1
Yandai Lin,Wei Wang,Fengqi Xuan,Zhe Liu
The blood brain barrier (BBB) is pivotal to protect brain from external interferences and to maintain homeostasis for normal physiological processes. However, it also becomes a vital obstacle for drug delivery across BBB and undermines efficiency of brain tumor therapies. In this study, an amphiphilic peptide with cell-penetrating sequence and hydrophilic targeting terminal (RGD) was self-assembled with encapsulation of Rose Bengal (RB) to generate the functionalized nanomicelles (PRN). With active target capacity, the integration of PRN and medical ultrasound was applied to enhance BBB penetration and achieve consecutive glioblastoma-targeted sonodynamic therapy. The temporary BBB opening and penetration enhancement have been validated in vitro and in vivo under US irradiation, and the efficacious tumor growth inhibition and lesion elimination were evidenced by a mechanism of in situ ROS-induced tumor cell apoptosis. Meanwhile, therapeutic efficacies by both intravenous injection and intranasal dripping of PRN were investigated, and a rationale of immune-actuation and multilateral cell death were proposed for this therapeutic modality of drug-device-field integration (DDFI). This research has provided an advanced glioblastoma treatment by different administrations and delivery pathways across BBB, and outlook an inspiring vision with a cutting-edge DDFI modality for broader applications of disease-oriented treatments.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.6
HaoTian Wu,WenYu Luo,EnZhou Liu,Bing Wang,LinYu Jiao,Zhuo Li,XiaoXun Ma
The performance of photocatalysts is often limited by charge recombination and sluggish kinetics at heterojunction interfaces. This study develops a multi-strategy interfacial modulation approach by constructing Bi S covalent bonds at the BiVO 4 /Mn 0.5 Cd 0.5 S(MCS) interface to serve as electron transport “bridges”, while simultaneously filling sulfur vacancies (V S ) in MCS with Ti atoms to eliminate recombination centers. This dual optimization of interfacial charge dynamics is realized in a BiVO 4 /MCS/TiO 2 (BMT) ternary system. The design facilitates an efficient dual S-scheme heterojunction that, driven by an interfacial built-in electric field, enables highly efficient separation of photogenerated carriers while maximizing redox capability. Under visible-light irradiation, the composite achieves a degradation rate of 89.51% for norfloxacin within 30 min, along with excellent cycling stability. Combined spectroscopic analysis and theoretical calculations confirm that the Bi S bonds significantly reduce the interfacial charge-transfer barrier, while the Ti-V S structure effectively suppresses carrier recombination. The synergy between these two mechanisms is key to constructing an efficient S-scheme charge-transfer pathway. This work provides a clear strategy for designing high-performance photocatalytic systems through the cooperative integration of interfacial bonding and defect engineering. We developed a TiO 2 /Mn 0.5 Cd 0.5 S/BiVO 4 ternary system with dual interfacial modulation using Bi S covalent bonds as electron bridges and Ti filling of sulfur vacancies to construct a dual S-scheme heterojunction that suppresses charge recombination and enhances redox capacity. This synergy enables efficient norfloxacin degradation and stability under visible light. Download: Download high-res image (139KB) Download: Download full-size image
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RARE METALS
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2025
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IF 11
Ren Xiao-Qian,Chen Meng-Xin,Cao Xun,Dai Yu-Long,Yu Wen-Xiao,Liu Zhe,Wen Xin-Xin,Ma Guo-Xin,Guo Bing-Rong,Tan Sze-Xing,Liu Jia,Xu Ping,Gao Jia-Jian,Li Si-Wei
Metal oxohydroxides (MOOH) are widely accepted as the true active species for oxygen evolution reaction (OER). However, the MOOH converted from pre-catalysts usually exhibits better catalytic performance than those directly synthesized. The underlying structural reason for this phenomenon remains controversial. In this work, CoOOH and Co(OH) 2 with similar morphology are employed as model catalysts to investigate the origin of in-situ converted catalyst’s high activity, as Co(OH) 2 can be fully converted to CoOOH during OER. In-situ Raman, electron paramagnetic resonance, HR-TEM, and X-ray spectroscopic studies reveal that O vacancies in the CoOOH converted from Co(OH) 2 play a key role in its higher intrinsic activity towards OER than directly synthesized CoOOH. Furthermore, theoretical calculations and electrochemical methods indicate that O vacancies in CoOOH affect the interaction between Co–O bond, downshift the d-band center of Co, further weaken the adsorption of OH*, and finally facilitate the OER process over CoOOH. This work not only provides a deep understanding of pre-catalyst’s high OER activity by taking Co(OH) 2 as an example but also deliver insights into the activation process of other electrochemical oxidation reactions. Graphical
研究领域:
材料科学
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电化学
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高影响因子
International Journal of Surgery
·
2025
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IF 10.1
Wang Xuesheng,Zhang Fan,Zhou Zhonghan,Fu Qiang,Liao Limin
Background: Bladder augmentation with gastrointestinal segments is a widely used surgical procedure for neurogenic bladder, but it carries a risk of many side effects. However, there have been no systematic studies on which biomaterials are suitable for bladder augmentation and reconstruction. The aim of this study was to compare the safety and applicability of small intestinal submucosa (SIS), poly(l-lactic) acid (PLLA) nanofibrous scaffold, and PLLA/gelatin composite nanofibrous scaffold as a potential bladder wall substitute material in tissue-engineered bladder augmentation and reconstruction. The results provide a scientific basis for selecting appropriate materials in clinical applications. Materials and Methods: The microstructure, cytocompatibility, cell adhesion, and histocompatibility of scaffolds including SIS, PLLA nanofiber scaffold, and PLLA/Gelatin were observed. Furthermore, bladder augmentation rabbit models were constructed using scaffolds with and without adipose-derived stem cells (ASCs) implantation. Cystography and urodynamic examination were performed to evaluate the morphology and function of the reconstructed bladder. Histologic and immunofluorescence were used to assess the regeneration status of the reconstructed bladder. Results: Compared to SIS and PLLA/Gelatin scaffolds, the PLLA scaffold possessed appropriate mechanical properties, pore size and porosity, which could facilitate suturing, maintain bladder form, and promote the adhesion and proliferation of seeded ASCs. All animals survived in the experiment with no complications, and the structural integrity of the implantation site was demonstrated using cystography and urodynamics. Histological and immunohistochemical analyses indicated that the three kinds of scaffold could regenerate the bladder wall structure at 6 and 12 weeks. Bladder reconstructed with the ASCs-PLLA scaffold showed superior structural and functional properties, with no significant differences in the regenerated urothelium, smooth muscle, or vessels of the ASCs-PLLA and control groups. Conclusion: The ASCs-PLLA scaffold—composed of PLLA with favorable biological properties and ASCs with facilitating regeneration—presents a promising candidate as an ideal scaffold for bladder augmentation and reconstruction.
研究领域:
生物医学工程
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组织工程
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泌尿外科学
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材料科学
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干细胞研究
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PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2023
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IF 22.1
Qingjie Luan,Xiangdong Xue,Hongtai Feng,Lu Tao,Dongxue Zhou,Tengfei Chen,Mengxi Tan,Wenjun Dong
Molecular-type cocatalysts can achieve the maximum electron transfer and minimum light absorption loss by virtue of their size advantage. Herein, a novel hydrophilic molecule-semiconductor hybrid P 4 @Vs-ZnIn 2 S 4−x photocatalyst was successfully developed by in-situ P 4 molecular anchoring on S defect ZnIn 2 S 4−x (V S -ZnIn 2 S 4−x ). The electron-rich P 4 molecules are anchored on the Zn-S 4 surface through S vacancies, forming Zn-P and S-P bonds that can promote electron injection from the electron-rich P 4 molecular to Vs-ZnIn 2 S 4−x substrate and reduce the adsorption/desorption barrier of H intermediate on S atom of Zn-S 4 plane. Meanwhile, the electrostatic potential depression around P 4 promoted the directional migration of in-plane photogenerated electrons, and pooled electrons to the highly active P sites and S sites, thereby accelerating the kinetics of hydrogen evolution. As a result, P 4 @Vs-ZnIn 2 S 4−x achieves an optimal photocatalytic hydrogen evolution activity of 26.1 mmol g −1 h −1 under visible light, which is 6.2 times higher than 4.2 mmol g −1 h −1 for Vs-ZnIn 2 S 4−x .
研究领域:
材料科学
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化学
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高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
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2025
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IF 11.3
Teng Zhang,Peizeng Yang,Yuefei Ji,Junhe Lu
Dissolved natural organic matter (NOM) significantly influences the performance of water treatment processes. It is generally recognized that NOM acts as a radical scavenger, thus inhibiting the degradation of organic pollutants in advanced oxidation processes (AOPs). This study examined the impacts of 8 different NOM isolates on the degradation of 4-chlorophenol (CP), a representative phenolic pollutant, in sulfate radical (SO4•–)-based AOPs. We developed an improved probe method to measure the steady-state concentration of SO4•– ([SO4•–]ss) in both the absence and presence of NOM. Results show that adding 1.00 mgC L–1 NOM resulted in only a 1.3–3.4% decrease in [SO4•–]ss. However, the apparent rate constants of CP degradation decreased by 76–88%. This discrepancy indicates that radical scavenging cannot be the primary mechanism for observed inhibition. We proposed NOM primarily acts as a reducing agent, reacting with the phenoxy radical intermediates generated from the single-electron oxidation of CP by SO4•–. Based on this hypothesis, we developed and validated a kinetic model using experimental data. The reductive capacity of NOM, as determined by the kinetic model, correlates positively with its electron-donating capacity. These findings enhance the understanding of NOM’s role in SO4•–-based AOPs and provide a foundation for developing strategies to mitigate its adverse effects.
研究领域:
环境科学
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水处理工程
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PubMed
高影响因子
CHEMOSPHERE
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2021
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IF 7.086
Jialin Liang,Xiaojian Liao,Maoyou Ye,Zhijie Guan,Zhihua Mo,Xian Yang,Shaosong Huang,Shuiyu Sun
The stabilization and dewaterability of waste activated sludge (WAS) are essential factors for downstream disposal or reuse. Herein, two types of zero-valent metals, zero-valent iron (Fe 0 ) and zero-valent aluminum (Al 0 ), were compared for their ability to activate peroxymonosulfate (PMS) during the WAS conditioning process, with the effects of PMS activation by these two metals on WAS dewaterability and the potential environmental risks evaluated. Results showed that compared to Al 0 /PMS treatment, Fe 0 /PMS treatment achieved superior WAS dewaterability and reduced operational costs. Using PMS combined with Fe 0 and Al 0 treatments under optimal conditions, the water content (Wc) of dewatered sludge decreased to 55.7 ± 2.7 wt% and 59.4 ± 1.3 wt%, respectively. Meanwhile, application of the Fe 0 /PMS treatment system reduced the total annual cost by approximately 33.1%, compared to the Al 0 /PMS treatment. Analysis of the dewatering mechanism demonstrated that in the Fe 0 /PMS treatment, Fe 3+ /Fe 2+ flocculation played an important role in the enhancement of WAS dewatering, while sulfate radical ( S O 4 • − ) oxidation was the dominant factor for WAS dewaterability improvement in Al 0 /PMS treatment. The greater enhancement of WAS dewaterability by Fe 0 /PMS treatment, was mainly attributed to more efficient reduction of hydrophilic extracellular polymeric substances (EPS) and an increase in surface charge neutralization. Environmental risk evaluation results indicated that Fe 0 /PMS and Al 0 /PMS treatments both effectively alleviated the environmental risks of heavy metals and faecal coliforms in dewatered sludge. Overall, this study proposes a novel perspective for the selection of an optimal PMS activator in sludge treatment .
研究领域:
环境科学
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污水处理
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PubMed
高影响因子
WATER AIR AND SOIL POLLUTION
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2026
·Vol. 237
·期 19
·1104
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IF 3.5
Wei Wei,Li Cheng-cheng,Hu Haodong,Yan Xinlong,Feng Yujie
The use of pH buffers, such as borate, is a common strategy to mitigate metal leaching in heterogeneous peroxymonosulfate (PMS) activation systems, but their potential interference with reactive oxygen species (ROS) and degradation mechanisms is often overlooked. This study systematically investigates the dual role of a borate buffer in a Ni‑Co layered double oxide (Ni/Co‑LDO)/PMS system using phenol and benzoic acid (BA) as model pollutants. The Ni/Co‑LDO catalyst alone achieved 100% phenol removal within 15 min and 59% BA removal within 40 min. Upon addition of the borate buffer, phenol removal remained high (94% at 40 min), whereas BA removal dropped dramatically to only 6.35%, indicating a selective suppression of radical pathways. The buffer reduced metal leaching by approximately 68% for Ni 2+ and 65% for Co 2+ , and improved catalyst reusability (86.4% phenol removal after three cycles vs. 52.1% without buffer). Mechanistic probes revealed that the borate buffer shifts the dominant pathway from radical‑mediated to non-radical‑dominated, as evidenced by quenching tests and PMSO assays. These findings quantitatively demonstrate that while borate buffer enhances catalyst stability, it severely distorts standard mechanistic diagnostics and limits degradation of electron‑deficient pollutants. This work provides a critical, evidence‑based caution for interpreting reaction mechanisms in buffered PMS systems.
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BIOMACROMOLECULES
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2026
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IF 5.9
Xin Pan,Qingpeng Ou,Zhaoyang Wei,Jie Liu,Chao Chen,Jun You,Zhao Wang,Dean Shi,Weiwei Lei,Liqun Zhang,Robert K. Y. Li
Abstract The bio-based monomer 2,5-furandicarboxylic acid (FDCA) endows thermoplastics such as poly(ethylene furanoate) with superior gas barrier properties. However, its application and mechanistic role in cross-linkable elastomers remain underexplored. To examine the possible contribution of the furan oxygen within this compositional framework, we synthesized partially bio-based, cross-linkable polyester elastomers with varied FDCA-to-isophthalic acid (IPA) ratios. IPA, sharing a similar nonlinear geometry but lacking the oxygen heteroatom, served as an internal reference. The synthesized elastomers exhibited high molecular weights (Mn ≥ 24,800 g/mol) and excellent thermal stability (Td,5% up to 359 °C). Dynamic mechanical analysis showed that increasing FDCA content was accompanied by suppressed β-relaxation; specifically, the IPA-based reference showed a β-relaxation peak area 1.8 times larger than that of the FDCA-rich elastomer. Correspondingly, the oxygen permeability coefficient decreased substantially from 1.99 to 0.81 Barrer as the FDCA content increased from 0 to 60 mol %. These results support an important contribution of the oxygen-containing furan unit to restricted local segmental dynamics and improved oxygen barrier performance in cross-linked copolyester elastomers. This work provides a composition-based design strategy for sustainable elastomers requiring both elasticity and gas barrier properties.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2025
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IF 6.6
Mingzheng Duan,Ting Jiang,Xi Wang,Kangjian Song,Xu Xiao,Xiaoting Fu,Sijiu He,Jieming Feng,Muhammad Junaid Rao,Hengcui Guo
Strawberries ( Fragaria × ananassa ) are prized for bioactive flavonoids and anthocyanins, contributing to antioxidant capacity and health benefits. However, decades of breeding for yield and shelf-life have eroded their phytochemical diversity. To explore this trade-off, we compared wild strawberries ( Fragaria nilgerrensis , HM) with three cultivated varieties (pink-FY, red-RF, white-DX) using integrated LC-MS/MS metabolomics and transcriptomics. Wild HM strawberries contained twice the vitamin C (134.2 mg/100g), 2.5× more total flavonoids (138.7 mg/100g), and higher antioxidant activity (367 μg Trolox/g) than commercial varieties. In contrast, red-fruited RF showed abundant anthocyanins (pelargonidin-3-glucoside 6.6% abundance), while the wild HM genotype accumulated higher levels of flavonoids, with neohesperidin, lonicerin, hyperin and ternatumoside II collectively representing 20.9% of total flavonoids - concentrations 3-169 times greater than those observed in the three commercial varieties (FY, RF, DX). Transcriptomic analysis (RNA-seq, Illumina HiSeq 2500) revealed distinct MYB transcription factor associations: FxaYL_611g0111200 (MYB66) showed strong positive correlation with anthocyanin biosynthesis in RF (r=0.92, **p<0.005 ), while FxaYL_242g0472670 (MYB44-like) was significantly associated with HM's unique antioxidant flavonoid profile (r=0.96, ***p<0.0001 ). These regulatory relationships were corroborated by hierarchical clustering demonstrating varietal-specific expression patterns and principal component analysis (82.6% variance explained), collectively providing molecular targets for enhancing nutritional quality in strawberry breeding programs.
研究领域:
植物科学
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食品化学
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分子生物学
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营养学
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代谢组学
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高影响因子
Journal of Materials Chemistry C
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2025
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IF 5.1
Ksenia A. Maleeva,Arina Pavlova,Georgii V. Zmaga,Alexander V. Baranov,Anton P. Tkach,Mikhail A. Baranov,Evgeny Smirnov,Kirill V. Bogdanov
Surface-enhanced Raman scattering (SERS) tags based on polymer microspheres (PMS) show significant promise for applications in liquid environments, particularly in the study of biological systems. The core principle of this fabrication method is to concentrate gold nanoparticles within a single point, with dimensions comparable to the diameter of the laser spot. These tags remain clearly visible in the solution and, owing to the formation of interparticle hot spots, yield enhanced SERS signals. In this work, we developed gold nanoparticle (AuNP) decorated polymer microspheres (PMS) for use as efficient SERS tags. A well-established layer-by-layer deposition technique was compared with nanoparticle aggregation from quasi-stable colloidal solution to fabricate SERS tags. The SERS performance of these AuNP-decorated PMS was evaluated using rhodamine 6G as a non-resonant model molecule. Structures fabricated by the aggregation method showed a higher surface filling factor (FF = 32%) and notably greater analytical enhancement (AEF of 1.4 × 104), significantly outperforming those from layer-by-layer deposition (14% FF, 7.5 × 103 AEF). Furthermore, the practical applicability of these SERS tags was validated through two applications: the quality assessment of motor oil in the non-aqueous environment and the quantitative analysis of 2,4-dinitrophenol in the aqueous solution. These results underscore the potential of the AuNP-decorated PMS SERS tags for diverse analytical and quality control applications.
研究领域:
生物医学工程
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分析化学
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纳米技术
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Xiaoyan Zhang,Wenkang Ni,Xuanyu Yue,Zhijie Wang,Zizhong Zhang,Ke Wang,Wenxin Dai,Xianzhi Fu
Converting CO 2 into CO, CH 4 , and other hydrocarbons using solar energy presents a viable approach for addressing energy shortages. In this study, photocatalysts with S-deficient WO 3 /Zn 3 In 2 S 6 (WO 3 /V S -ZIS) S-scheme heterojunctions have been successfully synthesized. Under UV–vis light irradiation, 20 %WO 3 /V S -ZIS demonstrated significantly improved CO 2 reduction activity and CH 4 selectivity. Detailed characterization and density functional theory (DFT) calculations reveal that the enhanced performance is due to the synergistic optimization of the S-scheme heterojunction and sulfur vacancies (V S ) for CO 2 reduction. The presence of V S aids in the adsorption and activation of CO 2 and enhances the separation of charge carriers. The 2D/2D S-scheme heterostructure assembled with WO 3 nanosheets not only accelerates the migration and separation of photoexcited charge carriers but also improves the adsorption of H 2 O and the formation of V S , thereby increasing the adsorption and activation of CO 2 and facilitating the protonation of CO* to produce CH 4 . This study clarifies the synergistic effect of V S and S-scheme heterostructures in improving photocatalytic performance, offering valuable insights into the photoactivation process of CO 2 at V S in S-scheme heterojunctions.
研究领域:
材料科学
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环境科学
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化学
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PubMed
高影响因子
危险品化学品经营许可证（带存储）