ACS Applied Nano Materials
·
2025
·
IF 5.5
Jinyao Zheng,Juan Qin,Yuanhao Zhang,Zongjia Li,Miaomiao Zhang,Qianyu Guo,Ying Chen,Yu Chen,Wei Wei,Xiue Jiang,Jilin Tang
Infected wound healing is a multifaceted biological process, particularly in the context of the emergence of antibiotic-resistant bacteria that compromise the efficacy of conventional treatments, thereby rendering the management of infected wounds exceedingly challenging. Developing highly effective antibacterial materials to fight resistant bacteria and promote wound healing remains a major challenge. In this study, a graphene oxide (GO)-based synergistic multifunctional nanomaterial, GO-Ag-l-Arg, is developed to promote wound healing by effectively combating antibiotic-resistant bacterial infections and promoting angiogenesis. The excellent antibacterial activity of GO-Ag-l-Arg is attributed to the synergistic effect of highly dispersed silver nanoparticles (Ag NPs) and l-Arginine (l-Arg). GO-Ag-l-Arg can effectively avoid the aggregation of Ag NPs and fully exert the antibacterial ability of Ag NPs in GO-Ag-l-Arg. By precisely regulating the pH, l-Arg is further loaded onto the GO-Ag nanosheets through an esterification reaction between the hydroxyl on the surface of GO and l-Arg. The highly positively charged guanidyl in l-Arg can interact with negatively charged bacteria, improving the targeting ability between the nanocomposite and bacteria and further enhancing the antibacterial effect of GO-Ag-l-Arg. At the same time, GO-Ag-l-Arg can produce nitric oxide (NO) under the action of cells, thus effectively promoting angiogenesis. The in vivo experiments show GO-Ag-l-Arg exhibits an outstanding ability to accelerate the healing of bacterial-infected wounds by inhibiting bacterial growth and stimulating angiogenesis at the wound site, offering a promising strategy for the treatment of wounds infected by drug-resistant bacteria.
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Materials Today Communications
·
2025
·
IF 4.5
Xiaodong Wang,Qinghui Luo,Chunyu Zhang,Shuanglin Gong,Zihao Qin,Zhibo Yu,Yujie Liu,Shilong He,Tingting Cao
To address escalating waterborne heavy metal contamination and low utilization of agricultural waste, this study developed L-arginine-functionalized corn straw biochar (Arg-CSB) via hydrothermal treatment, leveraging the amino and carboxyl groups of arginine for surface modification. Multi-technique characterization revealed that Arg- CSB retained the native fibrous carbon skeleton of corn straw while enriching surface functional groups—notably carboxyl groups and guanidinium moieties. Adsorption experiments demonstrate selective Pb(II) binding by Arg-CSB, achieving 83.4 % removal efficiency at pH 6 and 20°C, which is double that of unmodified biochar (CSB). Kinetic analysis followed the pseudo-first-order model, indicating predominant chemical adsorption, while the Langmuir isotherm confirmed monolayer adsorption behavior with a theoretical maximum capacity of 33.29 mg/g. Furthermore, Arg-CSB demonstrated excellent stability, maintaining a 69.9 % Pb(II) removal rate after the fifth cycle experiment. This work presents a green, efficient strategy for upgrading agricultural waste into functional adsorbents, offering high-value resource recycling and targeted heavy metal remediation.
研究领域:
环境科学
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材料工程
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化学工程
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水处理技术
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农业废弃物管理
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Advanced Science
·
2025
·
IF 14.1
Yifei Wang,Yaojia Yang,Aoxue Wang,Chen Shen,Shenliang Tan,Changsheng Liu,Yuzheng Zhao,Xue Qu
Reactive oxygen species (ROS)-triggered oxidative eustress can stimulate regenerative signaling, yet its therapeutic window remains narrow. Mitochondrial respiratory complexes and superoxide dismutase (SOD) are canonical enzymatic sources of intracellular H 2 O 2 . Here we report a biomimetic polyphenol–amino acid nanozyme (PEAs) that couples the semiquinone radical of coenzyme Q (ubiquinone) with the Arg143 residue of Zn/Cu-SOD1. Through self-assembling epigallocatechin gallate (EGCG) and L-arginine (L-Arg), PEAs enable O 2 adsorption and activation with controlled H 2 O 2 generation. The H 2 O 2 output is finely tuned by modulating the nitrogen (N) content from L-Arg. Integrated experimental and computational analyses reveal that the N-sites introduced by L-Arg promote semiquinone electron delocalization, increase semiquinone abundance, thereby strengthening O 2 adsorption, facilitating electron/proton transfer, and lowering the reaction barrier for H 2 O 2 synthesis. Using the genetically encoded H 2 O 2 sensor HyPerion, this work validates the sustained intracellular modulation of H 2 O 2 by PEAs. In a mouse model of telogen effluvium, controlled H 2 O 2 delivery activates the follicular niche via Wnt/β-catenin upregulation and Ca 2+ /calcineurin/NFAT downregulation, resulting in robust follicle activation and a non-pharmacological approach to alopecia therapy. This polyphenol–amino acid nanozyme therefore provides a safe and effective strategy for in vivo pro-oxidative modulation, offering a tunable H 2 O 2 -based platform to harness beneficial oxidative stress for tissue renewal.
研究领域:
纳米医学
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皮肤科学
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氧化还原生物学
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生物材料
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再生医学
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酶模拟物（纳米酶）
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毛囊生物学
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高影响因子
JOURNAL OF FLUORESCENCE
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2023
·Vol. 33
·期 5
·2075-2084
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IF 2.7
Chen Ting,Ge Zicheng,Fang Min,Zhu Weiju,Li Cun
In this paper, a novel amino acid surface-functionalized semiconductor CdTe quantum dot fluorescent probe amidated by carboxyl and amide groups was synthesized to detect pyrophosphate ions (P 2 O 7 4− , PPi). L-Arginine (L-Arg) was grafted onto cysteine modified CdTe quantum dots (Mea-CdTe QDs) to form a new L-Arginine-functionalized quantum dot fluorescent probe (L-Arg@Mea-CdTe). The prepared probe has good optical properties with multiple grafted functional groups on the surface. The guanidine group of the L-Arg@Mea-CdTe fluorescent probe is strongly basic and will be fully protonated under physiological conditions. The resulting hydrogen bonds bound to pyrophosphate lead to significant changes in the fluorescence of CdTe quantum dots. IR and XPS characterization were performed to confirm it. The addition of PPi induces a significant fluorescence quenching of L-Arg@Mea-CdTe in aqueous solution. The fluorescent QDs probe can also detect pyrophosphate with good sensitivity and anti-interference performance. The detection limit of the L-Arg@Mea-CdTe fluorescence probe for PPi is as low as 0.30 μM. In addition, the novel nano-fluorescent probe was successfully applied to detect PPi in water and in cell imaging.
研究领域:
分析化学
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纳米技术
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生物成像
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材料科学
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MICROCHIMICA ACTA
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2018
·Vol. 185
·期 2
·1-8
·
IF 5.705
Liu Mingwang,Li Na,He Yu,Ge Yili,Song Gongwu
Glutathione coated gold and silver nanoclusters (GSH-Au/AgNCs) were synthesized by one-pot reduction methods and are found to be viable fluorescent nanoprobes for cysteine (Cys) and arginine (Arg), with good selectivity over other amino acids. The GSH-Au/AgNCs have two emissions at 616 nm and 412 nm when excited at 360 nm. With the increased concentration of Cys, the ratio of the emission intensities (I 616 /I 412 ) linearly decreases with Cys in concentration ranging from 0.05 to 10 μM and from 10 to 50 μM, respectively. With increased concentrations of Arg, the ratio of I 616 /I 412 linearly decreases with Arg concentration ranging from 0 to 50 μM and from 50 to 100 μM, respectively. The probe was applied to the determination of Cys and Arg in spiked samples of serum and urine where it gave good recoveries.
Glutathione-coated gold and silver nanoclusters (GSH-Au/AgNCs) were synthesized by one-pot reduction and are found to be viable fluorescent nanoprobes for cysteine (Cys) and arginine (Arg).
研究领域:
生物化学
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分析化学
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纳米医学
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Zhihui Chai,Chenglin Li,Yuan Zhu,Xiaorong Song,Manyi Chen,YuLing Yang,Dong Chen,Xinquan Liang,Junhua Wu
The presence of phenolic substances in sugarcane juice seriously affects the color value of sugar products. Magnetic chitosan (MCS) was prepared using an ionic cross-linking technique, and then was modified with arginine to prepare arginine-modified magnetic chitosan (AMCS) for use as a new sucrose clarifying adsorbent. Gallic acid (GA) is a representative phenolic substance and was used to test the adsorption properties of the prepared AMCS. The adsorption kinetics indicated that the adsorption of GA on AMCS conformed to the pseudo-second-order model, the main adsorption mechanism was chemisorption. The Langmuir equation fit well and with good linearity, and indicated a maximum adsorption capacity of 48.38 mg g −1 . The adsorption process was consistent with monolayer adsorption and spontaneous endothermic process. The prepared AMCS exhibited excellent regenerability, and can effectively remove GA in sugarcane juice to improve product safety.
研究领域:
材料科学
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化学工程
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食品科学
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PubMed
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 35
·20149-20160
·
IF 3.049
Dandan Chen,Qiang Chen,Tianyu Liu,Jian Kang,Ruizhang Xu,Ya Cao,Ming Xiang
To prepare polyamide thin-film composite reverse osmosis (PA-TFC-RO) membranes with high performance, L-arginine (Arg) was used as an additive in m-phenylenediamine (MPD) aqueous solution. Arg with active amine groups can react with 1,3,5-benzenetricarboxylic chloride (TMC) to be incorporated into the polyamide selective layer during interfacial polymerization. X-ray photoelectron spectroscopy verified the successful introduction of Arg into the polyamide selective layer. Scanning electron microscopy, atomic force microscopy, contact angle and zeta potential measurements manifested that the polyamide selective layer was thinner, smoother, more hydrophilic and less negatively charged after the incorporation of Arg. The thinner and more hydrophilic polyamide selective layers favor the boosting of the permeability of the RO membrane by decreasing the hydraulic resistance to water permeation. Consequently, when the content of Arg was 0.5 wt%, the water flux and salt rejection of the resulting membranes increased from the original 46.46 L m−2 h−1 and 96.34% to 54.13 L m−2 h−1 and 98.36%. Besides, the modified membranes showed excellent fouling-resistance and easy-cleaning properties when tested by using bovine serum albumin (BSA) and dodecyltrimethyl ammonium bromide (DTAB) as model foulants.
研究领域:
材料科学
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环境工程
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Materials Science & Engineering C-Materials for Biological Applications
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2015
·
IF 3.088
Xuefang Shang,Leiming Luo,Kui Ren,Xiaofang Wei,Yaqian Feng,Xin Li,Xiufang Xu
Inspired from biological counterparts, chemical modification of azo derivatives with function groups may provide a highly efficient method to detect amino acid. Herein, we have designed and prepared a series of azo nano-materials involving –NO 2 , –COOH, –SO 3 H and naphthyl group, which showed high response for Arginine (Arg) among normal twenty kinds of (Alanine, Valine, Leucine, Isoleucine, Methionine, Aspartic acid, Glutamic acid, Arginine, Glycine, Serine, Threonine, Asparagine, Phenylalanine, Histidine, Tryptophan, Proline, Lysine, Glutamine, Tyrosine and Cysteine). Furthermore, theoretical investigation further illustrated the possible binding mode in the host-guest interaction and the roles of molecular frontier orbitals in molecular interplay. In addition, nano-material 3 exhibited high binding ability for Arg and low cytotoxicity to KYSE450 cells over a concentration range of 5–50 μmol · L − 1 which may be used a biosensor for the Arg detection in vivo.
研究领域:
生物化学
·
纳米医学
·
药物化学
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高影响因子
ENERGY & FUELS
·
2016
·
IF 2.835
Shufeng Shen,Ya-nan Yang
The mass transfer and kinetics of CO2 absorption into aqueous potassium argininate (ArgK) solutions were investigated using a wetted-wall column at concentrations ranging from 0.26 to 1.23 M and temperatures from 298 to 333 K. Absorption rates of CO2 were compared by the absorption flux and a fall-in-pressure method among basic amino acid salts (AAS) and two amine standards for capture technology. Results showed that ArgK has comparable kinetics toward CO2 with the standard monoethanolamine (MEA) but lower kinetics than piperazine (PZ). The kinetic results were interpreted using two models based on zwitterion mechanism and termolecular mechanism for the reactive absorption of CO2. It was found that the partial reaction orders vary from 1.25 to 1.60 with respect to ArgK. Under the pseudo-first-order regime, the overall reaction rate constants were obtained and the individual reaction rate constants in these models were derived. The calculated values from two models agree well with the experimental data within 7.5% AAD.
研究领域:
化学工程
·
环境科学
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高影响因子
International Journal of Nanomedicine
·
2016
·
IF 4.32
Mazhar Ali Raja,Shah Zeenat,Muhammad Arif,Chenguang Liu
Curcumin (Cur) is a striking anticancer agent, but its low aqueous solubility, poor absorption, hasty metabolism, and elimination limit its oral bioavailability and consequently hinder its development as a drug. To redress these limitations, amphiphilic chitosan (CS) conjugate with improved mucoadhesion and solubility over a wider pH range was developed by modification with hydrophobic acrylonitrile (AN) and hydrophilic arginine (Arg); the synthesized conjugate (AN–CS–Arg), which was well characterized by Fourier transform infrared and 1H nuclear magnetic resonance spectroscopy. Results of critical aggregation concentration revealed that the AN–CS–Arg conjugate had low critical aggregation concentration and was prone to form self-assembled nanoparticles (NPs) in aqueous medium. Cur-encapsulated AN–CS–Arg NPs (AN–CS–Arg/Cur NPs) were developed by a simple sonication method and characterized for the physicochemical parameters such as zeta potential, particle size, and drug encapsulation. The results showed that zeta potential of the prepared NPs was 40.1±2.81 mV and the average size was ~218 nm. A considerable improvement in the aqueous solubility of Cur was observed after encapsulation into AN–CS–Arg/Cur NPs. With the increase in Cur concentration, loading efficiency increased but encapsulation efficiency decreased. The in vitro release profile exhibited sustained release pattern from the AN–CS–Arg/Cur NPs in typical biological buffers. The ex vivo mucoadhesion study revealed that AN–CS–Arg/Cur NPs had greater mucoadhesion than the control CS NPs. Compared with free Cur solution, AN–CS–Arg/Cur NPs showed stronger dose-dependent cytotoxicity against HT-29 cells. In addition, it was observed that cell uptake of AN–CS–Arg/Cur NPs was much higher compared with free Cur. Furthermore, the in vivo pharmacokinetic results in rats demonstrated that the AN–CS–Arg/Cur NPs could remarkably improve the oral bioavailability of Cur. Therefore, the developed AN–CS–Arg/Cur NPs might be a promising nano-candidate for oral delivery of Cur.
研究领域:
药剂学
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生物医学工程
·
肿瘤学
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2020
·
IF 7.183
Jingyuan Guan,Lin Fan,Ya-nan Liu,Benbing Shi,Jinqiu Yuan,Runnan Zhang,Xinda You,Mingrui He,Yanlei Su,Zhongyi Jiang
Nanofiltration membranes featuring excellent separation and antifouling performances are highly desired for applications such as water purification . In this study, inspired by the phenomenon of coordination-driven self-assembly and the structures of aquaporins in nature, an arginine (Arg)-Fe III complex was designed and incorporated into the polyamide layer during interfacial polymerization, endowing the resultant nanofiltration membranes with enhanced water permeance and prominent antifouling performance. Owing to the active amine groups, the Arg-Fe III complex could react with trimesoyl chloride (TMC) and thus act as the aqueous additive in company with piperazine (PIP), which improved the compatibility between the organic phase and aqueous phase. The interfacial channels between the Arg-Fe III complex and the polyamide matrix as well as the hydrogen bonds interaction between water and the Arg-Fe III complex facilitated the rapid water transfer. When the content of the Arg-Fe III complex reached 0.3 g/L, the water permeance was elevated significantly, twice than that of the pristine polyamide membrane. Meanwhile, the rejections for Na 2 SO 4 and dyes were close to those of the pristine polyamide membrane. Furthermore, the resultant membranes displayed exceptional antifouling performance. Introducing the metal-organic complex into the interfacial polymerization process proves an effective and promising attempt to fabricate membranes with high performance for water resource reclamation.
研究领域:
环境科学
·
材料科学
·
化学工程
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高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Yu-Tong Ye,Hai Zhang,Jun-Ling Deng,Mi-Zhuan Li,Zhong-Xiu Chen
In this work, the rapid unfolding kinetics of pancreas α-amylase (PPA) induced by l -arginine and the interaction mechanism were investigated. The unfolding followed a first-level reaction kinetics equation, without intermediates. l -arginine interacted with PPA though diffusion-controlled process rather than complexion. The interaction between l -arginine and PPA resulted in a pronounced decrease in β-sheet and a significant increase in random coil, and thereby the enzyme activity decreased. However, the unfolding of PPA could be compensated and the second structure change could be recovered to some extent by the macromolecular crowded medium of Pluronics. Further insight into the mechanism disclosed that the broken H-bond network of water may contribute to PPA unfolding. This work provides a new perspective on the interaction of l -arginine with digestive enzyme. The unfolding mechanism of enzymes by may help to understand the effects of other structurally similar drugs, which is of concern in food-drug interactions.
研究领域:
生物化学
·
酶学
·
药理学
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高影响因子
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