SEPARATION AND PURIFICATION TECHNOLOGY
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2025
·
IF 9
Huapu Zhao,Yaru Kong,Man Xu,Cunwen Wang,Yuan Liu,Yanbo Li
Pervaporation (PV) membranes for desalination show significant potential, attracting increasing attention. Herein, polyphenol (tannic acid) was used to crosslink chitosan to prepare composite membranes for pervaporation desalination. The effects of the coating method, the concentrations of chitosan (CS) and tannic acid (TA), the deposition time of CS and TA, and the thermal annealing time on the desalination performance of the pervaporation membranes were investigated to explore the relationship between membrane structure and pervaporation desalination performance. After optimizing the synthesis conditions, a high flux pervaporation desalination membrane (44 kg·m −2 ·h −1 at 50°C and 92 kg·m −2 ·h -1 at 70°C) with a NaCl rejection higher than 99.9 % was prepared by co-depositing chitosan and TA on a polysulfone support. This work demonstrates TA crosslinked CS composite membranes have promising research prospects and potential applications in pervaporation desalination.
研究领域:
材料科学
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环境工程
·
化学工程
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Tao Meng,Zhengyu Zhao,Mengqiang Song,Rui Wang,Xu Xu,Min Yang,Weihua Li,Shiyong Song
Viscosupplementation treatment of osteoarthritis with sodium hyaluronate (HA) is prevalent in clinical practice but always associated with rapid degradation. Another natural polysaccharide chitosan (CS) has the potential to be used in viscosupplementation but is limited by the poor aqueous solubility. Herein, we formulated a viscosupplementation agent with a zwitterionic polymer modified chitosan (CS-CBAA), which featured with bottle-brush structure and poly(carboxybetaine acrylate) side chains. It was found that the incorporation of zwitterionic sidechains greatly enhanced chitosan's solubility up to approximately 130 mg/ml in solutions of pH 7.4. A gel-like behavior was also found in CS-CBAA solution due to intermolecular interactions between zwitterionic sidechains. Compared to HA, the viscosity of CS-CBAA solutions was obviously retained when subjected to hyaluronidase degradation tests. CS-CBAA was also approved comparable protection effect to cartilage and prior effect to ceramic materials. In a papain induced osteoarthritis mice model, CS-CBAA solutions of 120 mg/ml offered comparable cartilage protection to HA. This work presented a systematic study on a new viscosity supplement CS-CBAA, which exhibits exceptional lubricating properties and holds promise as a potential replacement for the current HA-based viscosity supplement in the treatment of early-stage OA.
研究领域:
生物医学工程
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药学
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骨科
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高分子化学
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产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Junjie Deng,Rufang Wei,Haofeng Qiu,Xiang Wu,Yanyu Yang,Zhimao Huang,Jiru Miao,Ashuang Liu,Haiyang Chai,Xiao Cen,Rong Wang
Restoration of the lubrication functions of articular cartilage is an effective treatment to alleviate the progression of osteoarthritis (OA). Herein, we fabricated chitosan- block -poly(sulfobetaine methacrylate) (CS-b-pSBMA) copolymer via a free radical polymerization of sulfobetaine methacrylate onto activated chitosan segment, structurally mimicking the lubricating biomolecules on cartilage. The successful copolymerization of CS-b-pSBMA was verified by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and 1 H nuclear magnetic resonance. Friction test confirmed that the CS-b-pSBMA copolymer could achieve an excellent lubrication effect on artificial joint materials such as Ti6Al4V alloy with a coefficient of friction as low as 0.008, and on OA-simulated cartilage, better than the conventional lubricant hyaluronic acid, and the adsorption effect of lubricant on cartilage surface was proved by a fluorescence labeling experiment. In addition, CS-b-pSBMA lubricant possessed an outstanding stability, which can withstand enzymatic degradation and even a long-term storage up to 4 weeks. In vitro studies showed that CS-b-pSBMA lubricant had a favorable antibacterial activity and good biocompatibility. In vivo studies confirmed that the CS-b-pSBMA lubricant was stable and could alleviate the degradation process of cartilage in OA mice. This biomimetic lubricant is a promising articular joint lubricant for the treatment of OA and cartilage restoration.
研究领域:
材料科学
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生物医学工程
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骨科
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组织工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
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2020
·Vol. 109
·期 6
·911-920
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IF 2.831
Xin Yi,Chengyong Wang,Xiao Yu,Weiwei Su,Zhishan Yuan
Chronic wounds are greatly health threatening owing to the increasing morbidity, and bacterial biofilm is a major cause of chronic wounds. The critical for bacterial biofilm eradication is overcome the barrier of extracellular polymeric substances (EPS) produced by the bacteria, and promote the diffusion of drugs within the biofilm. In this article, composite microneedles (MNs) of chitosan and zinc nitrate (CS-Zn[II] MNs) were investigated to eradicate bacterial biofilm. The CS-Zn(II) MNs combined the structure characteristic of MNs with the antibacterial properties of CS and Zn 2+ . The MNs can pierce the EPS due to the needle-like structure, and can transport directly the CS and Zn 2+ into the bacterial biofilm. The needle-like structure of MNs also increased the contact area between drug carrier and bacterial biofilm nearly 14–23% comparing with membrane without needle-like structure, and facilitated the diffusion of drugs. What is more, the synergistic effect of CS and Zn 2+ make the CS-Zn(II) MNs obtain excellent antibiofilm properties. Counting the colony forming units and bacterial live/dead staining tests confirmed the fascinating antibacterial abilities (up to 100% inhibition) and biofilm eradication properties, respectively, of the CS-Zn(II) MNs. The inhibition zone test shown that the antibiofilm effect of MNs was superior to membrane and the antibiofilm effect of MNs was become increasingly obvious along with the increase of the treatment time. Besides, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays proved that the CS-Zn(II) MNs possess brilliant cytocompatibility. These results indicate that the CS-Zn(II) MNs are promising method for bacterial biofilm eradication.
研究领域:
医学
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材料科学
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微生物学
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DOI
高影响因子
POLYMER SCIENCE SERIES A
·
2020
·Vol. 62
·期 5
·494-501
·
IF 0.968
Fei Liang,Zhao Jing,Deng Chunyu
Abstract— Hydrogel is a kind of new functional polymer material with application value and economic benefit. It has wide application in biomedical field because of its good biocompatibility and hydrophilicity.In this work, chitosan hydrogel was prepared by free radical graft copolymerization using natural biodegradable polymer chitosan as the carrier, temperature sensitive N -isopropylacrylamide (NIPAm) and pH sensitive 2‑acrylamido-2-methylpropane (AMPS) as monomers. The adsorption and drug release properties of chitosan hydrogel are discussed emphatically.The adsorption performance of chitosan hydrogel on copper ions showed that the temperature and the concentration of copper ions had influence on the adsorption. When the concentration of copper ions was 800 mg/L at 25°C, the equilibrium adsorption capacity was 225.8 mg/g, quasi-second order kinetic equation was suitable for describing the adsorption process. With the methylene blue as the drug model, the controlled release results showed that the temperature and the initial drug dosage had great effect on controlled release performance, and the cumulative release rate of 48 h was about 70%, which could achieve sustained release and controlled release to a certain extent.The experimental results also showed that the chitosan hydrogel can be completely degraded for about 20 days with excellent degradation performance. In conclusion, chitosan hydrogel has broad application prospects in drug controlled release, tissue engineering, environmental engineering and so on.
研究领域:
生物医学工程
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材料科学
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环境工程
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DOI
高影响因子
Journal of Biobased Materials and Bioenergy
·
2017
·Vol. 11
·期 6
·533-542
·
IF 0.975
Kong Song,Bai Yunxia,Wang Lijun,Liu Xinliang,Wang Shuangfei
In this study, a multilayered natural polysaccharide coating consisting of aldehyde-nanocellulose and chitosan was established on the base paper using the layer-by-layer assembly technique. The physical and barrier properties of the base and assembled paper were investigated. The results
shown that the smoothness of base paper assembled with 20 bilayers was significantly increased to 941.7 s/s and the moisture permeability was also improved. The assembled paper was characterized by FT-IR spectrometer and scanning electron microscope (SEM). In order to further understand the
capacity of chitosan and nanocrystalline cellulose blended with each other, molecular dynamics (MD) simulations of CS and DANC were conducted based on Force field, which implied the hydrogen bonding enhanced binding between CS and DANC, with the binding energy increased slightly from 1.42
to 1.56 kcal/(mol Å2) at 298 and 398 K. All results indicate that nanocellulose and chitosan have a positive effect on paper which can be used to prepare barrier and other functional papers.
研究领域:
材料科学
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生物化学
·
计算模拟
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DOI
高影响因子
MOLECULES
·
2018
·Vol. 23
·期 8
·1921
·
IF 3.098
Huanlu Song,Hao Wu,ShuJing Li,Huafeng Tian,YanRu Li,JianGuo Wang
Using a solvent formed of alkali and urea, chitosan was successfully dissolved in a new solvent via the freezing–thawing process. Subsequently, quaternized chitosan (QC) was synthesized using 3-chloro-2-hydroxypropyl trimethyl ammonium chloride (CHPTAC) as the cationic reagent under different incubation times and temperatures in a homogeneous system. QCs cannot be synthesized at temperatures above 60 °C, as gel formation will occur. The structure and properties of the prepared QC were characterized and quaternary groups were comfirmed to be successfully incorporated onto chitosan backbones. The degree of substitution (DS) ranged from 16.5% to 46.8% and the yields ranged from 32.6% to 89.7%, which can be adjusted by changing the molar ratio of the chitosan unit to CHPTAC and the reaction time. QCs inhibits the growth ofAlicyclobacillus acidoterrestriseffectively. Thus, this work offers a simple and green method of functionalizing chitosan and producing quaternized chitosan with an antibacterial effect for potential applications in the food industry.Keywords:chitosan;homogeneous system;quaternization;characterization;Alicyclobacillus acidoterrestris
研究领域:
生物化学
·
食品科学
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DOI
PubMed
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2013
·Vol. 15
·期 12
·1-10
·
IF 2.175
You Jie,Li Wenfeng,Yu Chang,Zhao Chengguang,Jin Langping,Zhou Yili,Xu Xuzhong,Dong Siyang,Lu Xincheng,Wang Ouchen
A series of amphiphilic N -(2-hydroxy)propyl-3-trimethylammonium-chitosan-cholic acid (HPTA-CHI-CA) polymers were synthesized by grafting cholic acid (CA) and glycidyltrimethylammonium chloride onto chitosan. The self-assembly behavior of HPTA-CHI-CA was studied by fluorescence technique. The polymers were able to self-assemble into NPs in phosphate buffered saline with a critical aggregation concentration (CAC) in the range of 66–26 mg/L and the CAC decreased with the increasing of the degree of substitution (DS) of CA. The size of cationic HPTA-CHI-CA NPs ranges from 170 to 220 nm (PDI < 0.2). It was found that doxorubicin (DOX) could be encapsulated into HPTA-CHI-CA NPs based on self-assembly. The drug loading content and efficiency varies depending on the DS of CA and feeding ratio of DOX to polymer. In vitro release studies suggested that DOX released slowly from HPTA-CHI-CA NPs without any burst initial release. Besides, the confocal microscopic measurements indicated that DOX-HPTA-CHI-CA NPs could easily be uptaken by breast cancer (MCF-7) cells and release DOX in cytoplasm. Anti-tumor efficacy results showed that DOX-HPTA-CHI-CA NPs have a significant activity of inhibition MCF-7 cells growth. These results suggest cationic HPTA-CHI-CA may have great potential for anticancer drug delivery.
研究领域:
生物材料学
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药剂学
·
肿瘤学
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DOI
高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Hao Huang,Zexin Liu,Hanxin Jian,Yuan Yao,Bing Xue,Shuguang Yang
Humidity is a critical environmental parameter that greatly affects the performance of many materials. Alginate (ALG) and chitosan (CHI) are abundant naturally occurring polymers, and their complex based on electrostatic interaction is widely used in various fields, especially in the biomedical area. Due to the strong hygroscopicity of ALG and CHI, the mechanical properties of ALG/CHI complex are significantly influenced by humidity; however, there remains a lack of quantitative understanding regarding this phenomenon. Here, we prepared ALG/CHI complex fiber and systematically studied the humidity effect. The humidity-adaptive behaviors of ALG/CHI fiber were investigated by tensile test, stress relaxation, and creep. Time–water superposition (TWSP) and time–temperature superposition (TTSP) principles were applied to elucidate the mechanical behaviors in a long-time scale using the dynamic mechanical analysis (DMA) data of frequency sweep at different humidity and temperature. The cyclic humidification and dehumidification test demonstrated that ALG/CHI fiber quickly and reversibly responds to environmental humidity variation. The study provides fundamental understanding on humidity adaptability of ALG/CHI fiber, which can facilitate further development of ALG/CHI complex as an advanced responsive and adaptive material.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
Gels
·
2025
·Vol. 11
·期 4
·285
·
IF 5.3
Lin Zhang,Xiaoling Lu,Hao Li,Hongjie Chen,Qi Yin,Xuehan Hu,Kang Yang,Fang Yang,Liya Chen,Zeng Yang,You Long,Chao Shen,Bo Yao,Chenghong Huang
The medicinal value of vanillin and its isomers has not been well developed, so it is necessary to prepare crystals of vanillin and its isomers as well as to investigate their crystallization rules in detail using advanced crystallization techniques in polymer gel. Based on molecular simulation, the maximum number of hydrogen bonds between CMCS with Van, IsoVan and oVan were reached at molar ratios of 1:9 and 1:4 and 1:5, respectively. The gel hardness and apparent viscosity of CMCS/Van isomers were proportional to the mole ratio, while elongation at break and tensile strength decreased with an increase in molar concentration depending on the position of the side chain group of the Van isomer, exposure of the benzene ring, steric resistance and the number of hydrogen bonds formed. The crystallization of Van, IsoVan and oVan in CMCS gel unexceptionally follow classical supersaturation theory in the case that nVan mainly exhibits a unique growth pattern from needle to strip, IsoVan’s growth style changes from plate to bulk and oVan adapts growth pattern from needle to branch bifurcating. It was also found that the Van crystal changed from II-type to I-type under long-term heating. Studies have further confirmed that the discrepancy of physicochemical characteristics of CMCS/Van blend gel can be attributed to differences in the number of hydrogen bonds compared to CMCS with given group positions of Van isomers. This study provides powerful technical support for the gel crystallization of van isomers.
研究领域:
材料科学
·
药剂学
·
高分子化学
·
分子模拟
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yefeng He,Siqi He,Hongji Wang,Xiaoyu Li,Liying Cui,Zhongkai Liu,Shengkai Liu,Xiaoshuai Wang,Mengqi Liu,Yujie Fu,Zhiguo Liu
Cyclodextrin-based metal-organic frameworks (γ-CD-MOFs) are promising biocompatible nanocarrier. However, it faces the problem of poor stability in aqueous solution. This study explores camptothecin delivery using a natural polymer-based shell (chitosan/carboxylated cellulose nanofibers) modified γ-CD-MOF core, establishing a novel strategy for safe and efficient CPT delivery. The γ-CD hydrophobic cavities significantly enhance CPT solubility and loading. The fabricated nanocarrier achieve CPT loading and encapsulation efficiencies of 26.4 ± 2.52 % and 70.2 ± 2.88 % respectively. Furthermore, the CPT load nanocarrier demonstrate <5 % hemolysis at the concentration of 800 μg/mL, exhibit drug release behavior conforming to the Higuchi equation, and show significant antiproliferative effects against MDA-MB-231 cells.
研究领域:
药剂学
·
纳米技术
·
材料科学
·
生物医学工程
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Desalination and Water Treatment
·
2024
·
IF 1
Bangchang Wei,Zheng Ji,Ya Xu,Shengnan Kong,Yansong Zhang,Chuanrun Li,Huchuan Wang
In this paper, we successfully prepared magnetic modified chitosan composites by mixing hydroxyapatite with polypropylene glycol modified chitosan and wrapping magnetic nanoparticles. The adsorption study of Cr(VI) revealed that the adsorption process was more in accordance with the pseudo-second-order kinetic and followed the Langmuir isotherm adsorption process, which indicated that the adsorption process was monolayer adsorption, and the fitted calculations showed that the maximum adsorption capacity of Cr(VI) was 795.14 mg·g –1 . Thermodynamic model reflected that the adsorption process was spontaneous heat absorption.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）