CERAMICS INTERNATIONAL
·
2021
·
IF 4.527
Lili Yang,Yongyong Li,Zhaoyu Hou,Caixia Shi,Guangjun Zhang,Fanrong Zeng,Juan Zhou,Shaorong Wang
As a new type of energy conversion device, solid oxide electrolysis cell (SOEC) has attracted much attention in recent years because of its advantages such as high efficiency and unlimited capacity. At present, SOEC mainly has such issues as the element diffusion or delamination at oxygen electrode/electrolyte interface under high oxygen partial pressure, which limits its operation lifetime. In this paper, La 1-x Ca x FeO 3-δ materials without Sr and Co were prepared by glycine-nitrate combustion method as SOEC oxygen electrodes. It is found that La 0.6 Ca 0.4 FeO 3-δ (LCF64) has excellent electrical conductivity and has a coefficient of thermal expansion matching with SSZ electrolyte. The hydrogen electrode supported single cells with structure of LCF64-GDC (6:4) | GDC | SSZ | NiO-SSZ active layer | NiO-YSZ transition layer | NiO-YSZ supported layer were prepared by tape casting and co-firing method showed good electrochemical performance in SOEC mode. The electrolysis current density is 457.46 mA cm -2 with 60% H 2 O-H 2 atmosphere and 1.3 V applied voltage at 800 °C. During the constant voltage (1.3V) electrolysis process, the SOEC showed an acceptable stable current density of approximate 280 mA cm -2 for more than 60 h.
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Catalysts
·
2020
·Vol. 10
·期 1
·119
·
IF 3.52
Yuyang Wei,Wenbin Zhang
Nickel electrodes under continuous potential cycling were applied for the electrooxidation of benzyl alcohol and glycine in KOH solutions, and their activities were measured and compared by cyclic voltammetry. It is shown that intrinsic activities of both reactions decrease with the increasing catalyst loadings, and a more significant decreasing trend was observed in glycine electrooxidation when compared to benzyl alcohol electrooxidation. These phenomena may be explained by an increasing of mass loading induced a decrease of the catalyst surface conductivity, structure changes of Ni(OH)2from α-phase to β-phase, and the intercalation of glycine molecules into nickel hydroxide interlayers.
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Innovative Food Science & Emerging Technologies
·
2026
·
IF 6.9
Min Zhang,Meng Yang,Yuqi Liu,Yiya Li,Yuanhong Zhuang,Jingna Liu,Peng Fei
To improve the quality stability of freeze-thaw noodles, glycine-amidated pectin was applied and its anti-freeze-thaw mechanism was systematically investigated through structural, microscopic, rheological, and textural characterization. Results showed that modified pectin induced high-crystallinity starch structure and α -helix-rich protein conformation (50% initial content), establishing dense and uniform matrix structure. After 5 freeze-thaw cycles, treated noodles exhibited highest α -helix content (40%), minimal β -sheet increase, and presented sparse rounded micropores rather than dense honeycomb-like tearing defects. Modified pectin-treated noodles exhibited springiness and chewiness retention rates exceeding 85%, significantly higher than those of the control, with shortest optimal cooking time (1.0 min). Water absorption and cooking loss followed the order of modified pectin < control < natural pectin, with modified pectin maintaining the lowest levels. This study revealed a two-stage stabilization mechanism of initial ordered network construction and controlled adjustment under freeze-thaw stress, providing theoretical foundations for high-quality freeze-thaw noodle development.
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Chinese Medicine
·
2020
·Vol. 15
·期 1
·1-17
·
IF 2.96
Tan Lihua,Tu Yanbei,Wang Kai,Han Bing,Peng Hongquan,He Chengwei
Background Glycine tabacina (Labill.) Benth, one of the traditional Chinese herbal medicines, has been used for treatment of nephritis, osteoporosis, rheumatism, and menopausal syndrome. The aim of this study was to illuminate the therapeutic effect and mechanism of Glycine tabacina aqueous extract (GATE) in the treatment of nephrotic syndrome (NS).Methods UHPLC-DAD-MS/MS was used to analyze the chemical profile of GATE. Adriamycin (ADR)-induced NS mouse model and network pharmacology methods were conducted to explore the protective effect and mechanism of GATE on NS treatment.Results GATE administration significantly ameliorated symptoms of proteinuria and hyperlipidemia in NS mice, as evidenced by reduced excretion of urine protein and albumin, and decreased plasma levels of total cholesterol and triglyceride. Decreased blood urea nitrogen (BUN) and creatinine levels in NS mice suggested that GATE could prevent renal function decline caused by ADR. GATE treatment also inhibited ADR-induced pathological lesions of renal tissues as indicated by periodic acid Schiff staining. Six flavonoids of GATE were identified by using UHPLC-DAD-MS/MS. Network pharmacology analysis indicated that the protection of GATE in treating NS might be associated with the regulation of oxidative stress and inflammation. In addition, the in vivo experiment validated that treatment with GATE markedly decreased reactive oxygen species production, malonaldehyde level, and increased superoxide dismutase activity both in plasma and renal tissues. TNF-α level in plasma and protein expression in kidney were significantly decreased in GATE treatment groups.Conclusion sCombination of network pharmacology analysis and experimental verification revealed that GATE exerts anti-NS effect possibly through modulating oxidative stress and inflammation, suggesting the potential application of GATE or its derivatives in the prevention and treatment of NS and other related kidney diseases.
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PubMed
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
·
2019
·
IF 3.414
Yanbei Tu,Kai Wang,Yeer Liang,Xuejing Jia,Lili Wang,Jian-Bo Wan,Jianping Han,Chengwei He
Ethnopharmacological relevance The whole plant of Glycine tabacina (Labill.) Benth has been used as a traditional herbal medicine to treat rheumatism , ostealgia and nephritis in China. It is also one of the sources of the renowned native herbal medicine ‘I-Tiao-Gung’ in Taiwan. Aim of the study This study aimed to investigate the anti-arthritic effect of ethanol extract of G. tabacina (GTE) in a collagen-induced arthritis (CIA) rat model. Materials and methods The chemical profile of GTE was analyzed by HPLC-UV. The CIA was induced in male Wistar rats by intradermal injection of bovine type II collagen at tail root, back and ankle joints. The rats were orally administrated daily with GTE (1.11, 2.22 and 4.44 g dry weight of herb powder per kg body weight) from day 0 and continued for 30 days. Swelling volume and thickness of paw, arthritis index, X-radiographs and histopathological changes were examined to assess the severity of arthritis. Furthermore, the levels of pro-inflammatory cytokines, such as interleukin1β (IL-1β), IL-6 and tumor necrosis factor α (TNF-α), total superoxide dismutase (T-SOD) activity and malonaldehyde (MDA) level were measured to preliminarily explore the possible mechanisms. Results Oral administration of GTE significantly ameliorated the arthritic symptoms in CIA rat model, as indicated by the effects on paws swelling and arthritis index. X-radiographic analysis and histopathological examinations demonstrated that GTE effectively protected the bone and cartilage of joints from erosion, lesion and deformation. The efficacy of GTE treatment on CIA was comparable to that of indomethacin (positive drug). Besides, the overproduction of IL-1β, IL-6 and TNF-α was remarkably inhibited in the serum of all GTE treatment groups. The restoration of serum T-SOD activity and MDA level proved that GTE administration alleviated the oxidative stress in CIA rats. Conclusions GTE exhibited strong anti-CIA activity through inhibiting pro-inflammatory cytokines and oxidation in rats, suggesting its potential preventive and therapeutic effects on rheumatoid arthritis (RA).
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AAPS PHARMSCITECH
·
2016
·Vol. 18
·期 3
·729-737
·
IF 1.954
Li Yongquan,Xiao Yu,Yin Zongning
As an effective COX-2 inhibitor, celecoxib is widely used in anti-inflammation therapy. However, it may cause cardiovascular risks and renal adverse effects. In the present study, we aimed to construct a celecoxib prodrug with enhanced anti-inflammatory efficacy and reduced adverse effects using folate in order to target activated macrophages. Folate-glycine-celecoxib was synthesized and identified by 1 H-NMR, MS, and FTIR analyses. The cytotoxicity of folate-glycine-celecoxib was tested on murine macrophage cells (RAW264.7) using thiazolyl blue tetrazolium bromide. Cellular uptake studies were employed to determine targeting ability toward folate receptors via flow cytometry and confocal microscopy. Anti-inflammatory efficacy of folate-glycine-celecoxib was investigated by measuring the concentration of LPS-induced nitric oxide (NO). Folate-glycine-celecoxib exhibited lower cytotoxicity than conventional celecoxib, and this conjugate could be targetedly transported into RAW264.7 cells through binding with folate receptors on cell surface. Through targeting to RAW264.7 cells, folate-glycine-celecoxib exhibited better effects than equimolar celecoxib in NO inhibition, suggesting greater anti-inflammatory activity. These findings demonstrated that the prodrug folate-glycine-celecoxib had potential to treat inflammatory disease with low cytotoxicity and high targeting ability.
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CHEMICAL ENGINEERING JOURNAL
·
2016
·
IF 5.31
Changjun Li,Naiyun Gao,Wenhai Chu,Tom Bond,Xingya Wei
Trihalomethane (THMs) and haloacetonitriles (HANs) are typical and frequently detected carbonaceous (C–) and nitrogenous (N–) disinfection by-products (DBPs) in water treatment , and amine acids (AAs) are important precursors of DBPs. However, previous researches mainly focused on free AAs and few investigations evaluated the DBPs formation potential of combined AAs, especially combined histidine . The formation of THMs and HANs from free and combined histidine and glycine during chlorination was firstly examined and compared in this study with an emphasis on their differences. The impacts of chlorine dose, pH, ammonia nitrogen and bromide were evaluated and mechanistic formation pathways were proposed. In comparison with free AAs, combined AAs generated more chloroform (CF, 125%–671%) but less dichloroacetonitrile (DCAN, 4.66%–87.5%) at all chlorine doses. The effect of solution pH on combined AAs was slighter than that on free AAs. During chloramination, both free AAs and combined AAs generated much smaller amounts of DBPs, especially DCAN (<9.01%), compared with chlorination. At any bromide dose, there was more bromine merging into THMs than DHANs, especially for combined AAs. At the beginning of chlorination, the combined AAs decomposed in three different ways: hydrolysis, decarboxylation and scission , leading to differing amounts of CF and DCAN compared with the free AAs.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Tingting Liu,Chunli Xu,Dicheng Ma,Lidong Cao,Shenguang Ge,Yuanbo Li
The development of multifunctional pesticide-delivery system is of practical significance for realizing efficient utilization of pesticides and minimizing environmental risks. In this work, methoxyfenozide (Met)-loaded glycine-doped zeolitic imidazolate framework-8 composites (Met@Gly@ZIF-8) for intelligent-release of Met and effective pest management were facilely constructed. The physical properties of Met@Gly@ZIF-8, including ultraviolet (UV) resistance, deposition and release profiles were evaluated. Compared with Met, the residual content after UV irradiation and retention content on cabbage leaves of Met@Gly@ZIF-8 increased by 121.2% and 98.2%, respectively, and the contact angle on foliar decreased by 26.5% compared with Met suspension concentrate (SC), demonstrating better photolysis resistance, deposition and wetting ability. Release experiments indicated that Met@Gly@ZIF-8 possessed significant stimuli-responsive release characteristics which were negatively correlated with pH, due to the acidic degradation of ZIF-8. The biological activity experiments showed that Met@Gly@ZIF-8 possessed elevated control efficacy on Plutella xylostella compared with Met and reduced the LC 50 value by 53.2%. The application performance experiments indicated that the penetration amount of Met@Gly@ZIF-8 in cabbage leaves increased by 194.7% and the translocation factor (TF leaf ) increased by 63.3%, respectively, as compared with those of Met. Compared with the blank control, Gly@ZIF-8 and Met@Gly@ZIF-8 increased the total biomass of cabbage by 37.8% and 25.7%, respectively, exhibiting nutritional functions for plants. Toxicity test showed that Met@Gly@ZIF-8 was relatively safe for zebrafish compared with Met. The present approach could be strategically promising for constructing functional and environmentally friendly smart-nanopesticide.
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2025
·
IF 8.4
Yaxin Guo,Zongcheng Yao,Xiating Zhao,Yuting Wang,Qiming Xian
The structural specificity of organic nitrogen sources in modulating cyanobacterial physiology and toxin production remains poorly understood. This study systematically evaluated the bioavailability of exogenous glycine peptides in Microcystis aeruginosa ( M. aeruginosa ) and their regulatory roles in algal growth and microcystins (MCs) synthesis through an integrated physiological and transcriptomic approach. Glycine peptides demonstrated hierarchical bioavailability: glycine (Gly) > Glycylglycine (Gly2) > Tetraglycylglycine (Gly4) > Hexaglycylglycine (Gly6) > Cycloglycylglycine (CGly2). Gly and Gly2 were rapidly assimilated by M. aeruginosa , supporting robust algal growth comparable to the control group with nitrate as nitrogen source, while CGly2 and Gly6 induced nitrogen stress, damaging biomass and photosynthetic pigments. Notably, M. aeruginosa cultured with Gly4 as sole nitrogen source uniquely enhanced intracellular MCs production, and shifted MCs variants toward the highly toxic MC-LR. The shift in MCs variants ratios (MC-RR/MC-LR) reflected nitrogen availability, demonstrating a trade-off between nitrogen storage and toxin potency. Transcriptomic profiling unveiled nitrogen-centric metabolic rewiring, resulting in enhanced nitrogen assimilation, mcy genes for MCs biosynthesis, photosynthetic efficiency, and resource reallocation. While exogenous glycine peptides represent only a minor component of organic nitrogen in natural systems, these findings provide mechanistic insights into how peptide structure can influence cyanobacterial physiology and toxin profiles, contributing to a more nuanced understanding of organic nitrogen utilization by harmful cyanobacteria.
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CATALYSIS TODAY
·
2025
·
IF 5.3
Jianxin Shi,Tengfei Jiang,Wu Yanjuan,Yanxin Mao,Yin Zhibao,Xuan Wen,Liang Wang,Hao Zhang,Hongman Sun,Song Linhua,Zhuang Zhuang
Although 13X zeolite is commonly used to remove oxygenates from Fischer-Tropsch oil, it still suffers from limited adsorption selectivity. In this study, glycine was used as a modifier to functionalize 13X zeolite by grafting polar groups, and applied for the removal of oxygenates from Fischer-Tropsch oil. The results indicate that the modified zeolite exhibits a high adsorption capacity for oxygenates. Specifically, the adsorption capacity for butanol, hexanal, and 2-hexanone increased by approximately 90%, reaching 0.60 g·g -1 , 0.36 g·g -1 , and 0.35 g·g -1 . The adsorption capacity for hexanol and octanol increased by approximately 50%. The enhancement in adsorption capacity for carbonyl compounds and long-chain alcohols (such as hexanol, heptanol, and octanol) was particularly notable, with an average increase of about 80%. Mechanistic studies revealed that the adsorption of oxygenates on the modified zeolite is primarily physical adsorption, involving hydrogen bonding interactions and van der Waals forces. The adsorption process can be divided into two stages: surface adsorption and pore diffusion, and is jointly influenced by factors such as zeolite pore size, adsorbate molecular size, and their interactions with the pore channels. This study provides a novel strategy for the removal of oxygenated compounds from Fischer-Tropsch oil.
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POLYMER ENGINEERING AND SCIENCE
·
2021
·Vol. 61
·期 5
·1405-1414
·
IF 2.428
Fuqiang Liu,Nan Ma,Jun Liu,Qiongqiong Zhu,Ting Yue,Junhui Ma,Yuan Wang,Wei Qu,Paul K. Chu,Yan Tang,Wei Zhang
The chains and segments of unordered cationic polypeptides are complex and may produce unexpected biological activities. Herein, the Ugi's 4CC reaction is adopted to synthesize a cationic alternating copolymer comprising ornithine and glycine (poly(Orn-alter-Gly)) with an ordered sequence for enhanced bacterial resistance. In this technique, potassium isocyanate, 4-(N-carbobenzyloxyamino)-1-butyraldehyde and 1-(4-Methoxyphenyl)ethylamine react to produce MPE-substituted poly(Orn-alter-Gly) in one step without using a catalyst and then poly(Orn-alter-Gly) is obtained by removing the N-(1-p-methoxyphenethyl) (MPE) group. 1 H NMR, Fourier transform infrared spectroscopy, and automatic amino acid analysis confirm that ornithine and glycine are linked alternately in the poly(Orn-alter-Gly) chains. Both MPE-substituted poly(Orn-alter-Gly) and poly(Orn-alter-Gly) have excellent antibacterial activity against Staphylococcus aureus , Escherichia coli , Klebsiella pneumoniae , and Pseudomonas aeruginosa as well as excellent biocompatibility. The synthesis strategy and materials provide new information on how to obtain ordered sequence cationic polypeptides.
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MICROSCOPY RESEARCH AND TECHNIQUE
·
2021
·Vol. 85
·期 4
·1518-1526
·
IF 2.769
Leilei Hong,Lichan Yuan,Xiaoxu Xu,Yuhuan Ma,Li Meng,Junyi Wang,Na Zhao,Xiaoliang Wang,Junqing Ma
Titanium (Ti) alloys, particularly Ti 6 Al 4 V, are the most commonly used biomedical implant material. Ti alloys are biologically inert, so there have been continuous efforts to improve their osteogenic properties and clinical performance. Since TiO 2 nanotubes (NT) appear to be excellent drug platforms, and strontium reportedly enhances osteogenesis, we constructed a TiO 2 nanotube coating on the surface of Ti 6 Al 4 V and immersed it in Sr (OH) 2 solution in order to incorporate Sr into TiO 2 nanotubes (NT-Sr). The results of field emission scanning electron microscope and X-ray diffraction analysis verified the fabrication of NT-Sr. We next added polydopamine (PDA) and cyclo- (arginine–glycine–aspartic acid–phenylalanine–cysteine) [c(RGDfC)] peptides to further promote biocompatibility of the implant. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy confirmed the existence of PDA and c(RGDfC). Mesenchymal stem cells (MSCs) were planted on Ti, NT, NT-Sr, NT-Sr/PDA, and NT-Sr/PDA-RGD surfaces. The adhesion and differentiation of MSCs on different surfaces were evaluated. The mRNA expression of alkaline phosphatase, runt-related transcription factor 2 (Runx2) and type I collagen (Col I) of different groups were also tested. Finally, we observed that the NT-Sr/PDA-RGD group showed significantly better performance than other groups in terms of the differentiation and osteogenesis-related gene expression of MSCs. Thus, the NT-Sr/PDA-RGD complex may be an important modification strategy for Ti, as it shows excellent osteogenic potential.
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