JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2022
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IF 5.062
Haozhan Feng,Minlan Li,Zifeng Xing,Xiao-kun Ouyang,Junhong Ling
Fucoxanthin (FX) is a natural carotenoid pigment that exhibits antitumor activity and is found primarily in brown seaweed. However, its effectiveness as a therapeutic agent varies owing to low bioavailability, poor water solubility, and poor physicochemical stability. The acidic nature of the tumor microenvironment may be utilized to design and construct a targeted magnetic, acid-labile nano-carrier (FX@Fe 3 O 4 -mSiO 2 -TA) with improved FX bioactivity. A nano-drug delivery system composed of magnetic mesoporous silica coated with a tannic acid–iron network (TA/Fe 3+ ) was designed and constructed to improve FX bioactivity based on pH and magnetic targeting in a tumor microenvironment. The external magnetic field guided the carrier to the tumor site. TA/Fe 3+ in the outer coating of the carrier was decomposed, resulting in FX release, which was attributed to the low pH of the tumor microenvironment. Drug release was sustained and pH-dependent in vitro , which significantly improved the stability and bioavailability of FX. The simplicity of its preparation and efficacy of the targeted therapeutic suggest the potential of this nano-carrier for application in tumor therapy.
研究领域:
药剂学
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肿瘤学
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材料科学
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DOI
高影响因子
ACS Applied Materials & Interfaces
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2022
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IF 10.383
Shuxian Tang,Xiang Ke,Hao Wang,Jing Xie,Jiaojiao Yang,Jun Luo,Jianshu Li
Hydrogels composed of polyphenols and various macromolecules have been widely reported to have the advantage of facile preparation, mainly through the formation of hydrogen bonds. However, the traditional preparation method involves the direct mixing of polyphenols and macromolecules, which generally occurs too quickly and uncontrollably, and results in poor homogeneity, injectability, and shape designability. Here, inspired by the intermediate precursor during biomineralization, to facilitate transformation in a controllable way, we propose a novel and universal internal gelation method that creates an intermediate precursor by controlling the pH value to manipulate the elimination and generation of hydrogen bonds between a polyphenol and macromolecules. The precursor strategy greatly improves the homogeneity, injectability, and shape designability of the hydrogel while also achieving a controllable gelation process, and the gelation time can be accurately adjusted. The hydrogels prepared with this method exhibited superior capability to seal leaks, provided complete wound coverage, and showed the potential to be a shape-designable wearable strain sensor. Our study opens up a new way to construct and apply polyphenol–macromolecule hydrogels in a more controllable manner.
研究领域:
材料科学
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生物材料
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组织工程
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生物医学工程
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纳米技术
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DOI
PubMed
高影响因子
Journal of Bioresources and Bioproducts
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2024
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IF 20.2
Yuanlong Guo,Pengcheng Liu,Lei Deng,Changwei Lui,Michael North,Gang Hu,Qitian Huang,Zongbao Kent Zhao,Haibo Xie
Phenolation is one of the effective strategies to synthesize lignin-based polyphenols, improve lignin's properties, and extend its value-added applications in biological, medicinal and cosmetic fields. Herein, by taking the structural feature advantage of lignin, an effective and green strategy was developed to molecularly engineer lignin into a robust lignin-3-(2-hydroxyphenyl)propionate ester (LPPE) derivative via a transesterification reaction between 3,4-dihydrocoumarin (DHC) and the aliphatic hydroxyls in lignin under organocatalysis. The strategy is optimized and the novel derivative was systematically characterized by 1 H, 13 C and 31 P nuclear magnetic resonance (NMR) and Fourier transform infrared (FT-IR) spectroscopy. The findings indicated that the successful introduction of 3-(2-hydroxyphenyl)propionate groups using a OH groups/DHC/organic base molar ratio of 1꞉1꞉0.3 at 120 °C for 6 h increased the content of phenolic hydroxyl groups from 1.793 1 to 3.017 9 mmol/g, and the LPPE exhibited excellent ultraviolet-absorbing and antioxidant performance with up to 90% free radical scavenging activity within 20 min using 5 mg/mL of LPPE. In addition, good biocompatibility and a high Sun protection factor (SPF) value of 40.9 were achieved at 5% ( w ) dosage of LPPE in the cream, indicating its significant application potential in sunscreen.
研究领域:
生物化学
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化妆品科学
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材料科学
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产品关联
DOI
高影响因子
MOLECULAR PHARMACEUTICS
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2025
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IF 4.5
Jun Zhou,Wensong Wang,Yong Li,Qianqian Liu,Fan Liu,Qiao Zhang,Yunfei Zhang,Can Jiang,Si Chen,Fei-Peng Du,Jinxuan Fan
Nanocarriers have been extensively utilized to improve the stability of photothermal agents in vivo, enhance delivery efficiency, and reduce drug side effects. However, challenges, such as the low safety of carrier materials, insufficient loading of therapeutic agents, and complex preparation procedures, still persist. In this study, the photothermal agent IR780 was encapsulated in network TA-Fe3+ (TF) which was self-assembled by tannic acid (TA) and Fe3+ to synthesize an acid-responsive multifunctional nanophotothermal agent TF@IR780 (TR). In the slightly acidic tumor microenvironment (TME), network shell TF is degraded, and the internal photothermal agent IR780 is exposed. On the one hand, the TF network can improve the solubility and stability of photothermal agent IR780 in vivo and significantly increase the uptake efficiency in tumor cells. On the other hand, Fe3+ exhibits magnetic resonance imaging (MRI) functionality, which combined with the fluorescence imaging of IR780 endows TR with multimodal imaging capabilities. In addition, TR is easy to release photosensitizers through acid response in the low pH environment of TME, and achieves precise damage to mitochondria through mitochondrial anchoring and light regulation. This overcomes the drawbacks of traditional tumor treatment methods, such as poor specificity, and demonstrates efficient and controllable antitumor activity.
研究领域:
纳米医学
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肿瘤学
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生物材料学
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Yue Gao,Furong Tang,Juan Zhang
A metal-polyphenol network functionalized on surface of zeolitic imidazolate framework-8 (MPN@ZIF-8) were fabricated for efficient removal of fluoroquinolones (FQs) antibiotics. Polyphenol as one kind versatile molecular glue was employed as organic ligand as well as linkage for growth and deposition of metal-polyphenol network (MPN) on ZIF-8 supporter. The prepared MPN@ZIF-8 composite was characterized by various methods. The parameters including the dosage of adsorbents, pH value, adsorption time and salt concentration affecting the adsorption process were systematically investigated. FQs adsorption isotherms and kinetics best fitted the Langmuir isotherm (R 2 > 0.980) and pseudo-second-order model (R 2 > 0.987), respectively. Thermodynamic studies showed that adsorption process of norfloxacin (NOR), ciprofloxacin (CIP) and enrofloxacin (ENR) were all spontaneous. The adsorption capacity of MPN@ZIF-8 were 104.60, 86.23 and 66.21 mg g −1 for NOR, CIP and ENR, respectively, which were significantly higher than those of precursor ZIF-8. The potential adsorption mechanism was stated, most likely involved in π-π interaction, hydrogen-bond and electrostatic interaction between the FQs and the MPN@ZIF-8. In addition, the removal efficiency of the three FQs on MPN@ZIF-8 was still above 95 % after recycle for four times. The recoveries of the three FQs were in the range of 77.1–100.1 % with RSDs below 7.8 % in real sample analysis. Compared with the methods in preparation of MOF-based composite, the fabrication method mentioned in this study is versatile, very easy, environmental friendly and low cost, which has potential in large-scale production for application in environmental remediation.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
COMPOSITES COMMUNICATIONS
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2025
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IF 7.7
Ke Zhang,Minghui Ou,Yujie Xiao,Zhiwei Wei,Li Yang,Yi Xie,Changsheng Zhao
Copper-based nanozymes have emerged as promising therapeutic agents for oxidative stress-related diseases due to their enzyme-mimicking properties. However, their development is still limited by poor biocompatibility, insufficient broad-spectrum free radical scavenging ability, and potential toxicity from Cu 2+ leakage. To address these challenges, we developed Cu@EA-BTC, a broad-spectrum antioxidant material, by integrating ellagic acid (EA) into copper-based metal-organic frameworks (Cu@BTC). The Cu@BTC serves as a stable copper source, while the EA endows the Cu@EA-BTC with broad-spectrum ROS scavenging and enhanced catalase (CAT)-like activity via facilitating the reduction of Cu 2+ to Cu + . As a result, the Cu@EA-BTC exhibits superior antioxidant properties and excellent biocompatibility, including both cellular and blood compatibility. Meanwhile, the Cu@EA-BTC effectively protects immune cells from oxidative damage, which indicates its potential for oxidative stress-related therapies. This study provides a promising strategy for developing safe and efficient nanozyme-based antioxidant materials for biomedical applications.
研究领域:
生物医学
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材料科学
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药理学
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产品关联
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
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2024
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IF 7
Yuhan Cheng,Yuting Wang,Tongji Yuan,Jianhua Xie,Qiang Yu,Yi Chen
This research aims to evaluate the phenolic composition, antioxidant and enzyme inhibition activities of fermented Rubus chingii Hu wine, and explore the correlation between them. TPC (Total Phenolic content) and TFC (Total Flavonoid content) increased rapidly from 0 h to 72 h, followed by a slight decrease in TPC and a significant decrease in TFC. Fermentation could significantly increase the antioxidant activity and α-amylase/α-glucosidase enzyme inhibitory activity of Rubus chingii Hu . A total of 39 polyphenols and organic acids in fermented Rubus chingii Hu were identified by UPLC-ESI-Q-TOF-MS/MS and 11 of them were quantitatively analyzed. After fermentation, the contents of all the detected polyphenol compounds, except for quercetin and ellagic acid, significantly increased (p < 0.05). Correlation analysis showed that protocatechuic acid and catechin played an important role in the antioxidant activity of fermented Rubus chingii Hu , while protocatechuic acid and hypericin played an important role in the α-amylase inhibition activity. This study indicated that Rubus chingii Hu could be applided as a potential meterial for the wine production, and has the potential to be a functional food for promoting health.
研究领域:
食品科学
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药理学
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生物化学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Yubin Xiang,Jie Li,Tao Deng,Xue Lu,Yongming Guo
A pesticide carrier was fabricated via Fe 3+ -mediated co-crosslinking strategy. • Metal-polyphenol-functionalized carriers enabled pH-triggered controlled release. • The release was governed by synergistic effects of diffusion and hydrogel relaxation. • The carrier was non-toxic to murine fibroblast cells and showed good biosafety. Hydrogel-based controlled release systems are widely used in pharmaceutical and agricultural fields. To achieve controlled release of hydrophilic drugs, which otherwise release rapidly through hydrated polymer networks, we develop a facile ferric ion co-crosslinking strategy to fabricate composite hydrogel beads. The highly porous composite hydrogel beads were prepared by blending recycled household formaldehyde adsorbent (RFA) with sodium alginate (Alg) at a 1:1 ( w /w) ratio, followed by Fe 3+ -induced crosslinking and subsequent surface functionalization with tannic acid (TA). Through altering the Alg hydrogel structure, RFA enabled the hydrogel to synergistically restrict drug molecules, and coupled with the blocking function of metal-polyphenol complexes (MPC), this composite structure provided effective regulation of water-soluble drug molecule release. The carrier demonstrated pronounced swelling and disassembly of the metal-polyphenol microfilm, resulting in rapid gentian violet (GV) release under alkaline pH conditions. In acidic environments, the conversion of ternary metal-polyphenol complexes into double or single complexes weakened the “on-off” effect, thereby accelerating GV release compared with neutral conditions. The release of GV was governed by a combination of diffusion-controlled processes and progressive hydrogel bead relaxation. Additionally, the carrier exhibited no detectable toxicity in murine fibroblast cells and during rice seed germination, indicating its favorable biosafety. These findings demonstrated that the controlled-release system had the potential to be further explored for environmental protection and hazardous substances management.
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产品关联
DOI
PubMed
高影响因子
ChemSusChem
·
2026
·Vol. 19
·期 13
·e70855
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IF 5.9
Long Li,Yuntong Li,Fei Jing,Qianqian Shang,Zheng Pan,Meng Zhang,Caiying Bo,Yonghong Zhou,Xiaohui Yang,Xuejun Pan
Lignin is an abundant, renewable biopolymer, but its structural complexity and low reactivity have hindered its effective valorization. Herein, we report an integrated strategy combining depolymerization, demethylation, and phenolation of lignin in an acidic lithium bromide molten salt hydrate system. Spectroscopic analyses (FTIR, 1 H NMR, and 2D-HSQC NMR) confirmed efficient cleavage of major ether linkages, yielding structurally simplified lignin derivatives with enhanced functionalities. Demethylation increased phenolic hydroxyl (Ar–OH) content by 1.36–2.49 mmol/g, while subsequent phenolation further elevated Ar–OH levels to 6.77–7.71 mmol/g, more than doubling those of native lignin. These structural changes translated into enhanced bioactivity: The modified lignins exhibited strong antioxidant activity (>90% DPPH⋅ scavenging), high antimicrobial efficacy (>87% bacterial inhibition), and favorable safety profiles (IC 50 > 80 mg/L). In vivo feeding trials demonstrated that the modified lignins significantly improved growth performance and provided robust antiviral protection in mice. Overall, this integrated strategy enables efficient conversion of technical lignin into high-value bioactive polyphenols with performance comparable to or exceeding commercial tannins, while retaining clear economic advantages, highlighting their potential for sustainable applications in feed additives, cosmeceuticals, and nutraceuticals. Graphical Low-cost lignin was upgraded in an acidic lithium bromide (LiBr) solution via integrated depolymerization, demethylation, and phenolation to yield bioactive polyphenols with enhanced phenolic hydroxyl content. The resulting polyphenols exhibited strong antioxidant and antibacterial activities, along with low cytotoxicity and promising in vivo performance, including improved growth and anti-influenza efficacy in mice.
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
·
IF 8.7
Qian Liang,Haoqing Cheng,Fuzhi Yan,Xiaomin Hu,Fen Zhu,Huabo Huang,Xianghua Yu,Yulan Liu,Jiayou Ji,Liang Li
A green route is developed for Fe₃O₄/FeN/N co-doped porous carbon aerogels from sodium carboxymethyl cellulose, tea polyphenols and polypyrrole. • Tea polyphenol−Fe 3+ coordination mitigates pyrolysis-induced framework shrinkage and enables uniform polypyrrole dispersion. • The CTP2-700 aerogel exhibits a minimum reflection loss of −58.4 dB (3.1 mm) and effective bandwidth of 5.3 GHz at 2.1 mm (20 wt% loading). • RCS simulations demonstrate good radar stealth; this work guides the design of lightweight biomass carbon-based electromagnetic absorbers. In recent years, the fabrication of lightweight porous carbon aerogels from biomass precursors has attracted considerable attention in the field of electromagnetic wave absorption. Herein, novel Fe 3 O 4 /FeN/N porous carbon aerogels were successfully synthesized using sodium carboxymethyl cellulose as the carbon source, with metal-phenolic networks constructed through the coordination of tea polyphenols and Fe 3+ . These networks not only enable homogeneous dispersion of polypyrrole but also mitigate the shrinkage of carbon frameworks during high-temperature pyrolysis, thereby maintaining the structural integrity of the aerogel products. The as-prepared carbon aerogels possess a hierarchical porous structure and well-developed conductive networks. Electromagnetic parameter tests revealed that the materials achieved a minimum reflection loss of −58.4 dB at a matching thickness of 3.1 mm, together with a broad effective absorption bandwidth of 5.3 GHz at a thickness of 2.1 mm. This work offers an innovative strategy for the green and efficient utilization of cellulose-based materials and demonstrates their potential for developing lightweight, high-performance electromagnetic wave absorbers.
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DOI
高影响因子
FOOD CHEMISTRY
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2026
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IF 10.4
Tuo Leng,Yuting Wang,Xiaoyi Hu,Qiang Yu,Yi Chen
Polyphenol and phytosterol networks were constructed during Camellia seed development. • Early seeds showed active carbohydrate-driven secondary metabolism. • The 127 and 13 DEGs were linked to polyphenol and phytosterol biosynthesis. • Polyphenol and phytosterol biosynthesis declined during oil accumulation. Camellia oil is rich in polyphenols and phytosterols, whose accumulation during seed development influences both nutritional and functional quality. To understand how these compounds are biosynthesized and coordinated with primary metabolism, we profiled dynamic changes in polyphenols, phytosterols, and primary metabolites across four developmental stages of Camellia seeds. Early stages exhibited active carbohydrate metabolism, providing carbon precursors for polyphenol and phytosterol production to support seed coat formation and stress defense. During maturation, carbon flux shifted from secondary metabolites toward storage lipids, accompanied by increasing triacylglycerol and oleic acid levels. Metabolomic analysis identified 43 polyphenols and 2 phytosterols, while transcriptome data revealed 127 differentially expressed genes in polyphenol pathways and 13 genes in steroid biosynthesis. These results reveal the coordinated gene and metabolite networks underlying secondary metabolite biosynthesis and carbon flux transitions, providing molecular targets for improving oil quality and bioactive compound content in Camellia seeds. Download: Download high-res image (139KB) Download: Download full-size image
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DOI
高影响因子
Nanoscale
·
2025
·
IF 5.1
Yue Hong,Zhiliang Gao,Ziyu Chen,Qiang Li,Jiwei Cui,Mingdong Dong
Colorimetric sensors based on nanozymes hold significant potentials in the fields of analysis and sensing. However, most nanozymes have poor selectivity and relatively low catalytic activity, which limits their practical applicability. Herein, Fe–N–C single-atom nanozyme (Fe-SAzyme) with excellent catalytic activity was synthesized through a ZIF-templated and pyrolytic strategy. The as-synthesized Fe-SAzyme can mimics oxidase-like activity by catalyzing the oxidation of 3,3’,5,5’-tetramethylbenzidine to generate distinctive color reactions. Additionally, the Fe-SAzyme was successfully utilized in colorimetric detection and discrimination of various polyphenols based on nanozyme inhibition. Furthermore, a colorimetric sensor with a detection limit of 0.04 μg/mL was developed for the quantitative detection of pyrogallol. This work provided a new sensing technique for detecting polyphenolic compounds using single-atom iron nanozymes, demonstrating promising potential in the fields of food safety and environment protection.
研究领域:
分析化学
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纳米生物技术
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食品科学
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环境监测
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分子诊断
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）