Biomaterials Research
·
2026
·
IF 9.6
Bo Liu,Yaqin Tu,Xiangrui Li,Wenting Yu,Wenqing Zou,Wei Tang,Shimin Zong,Songwei Tan,Hongjun Xiao
Cisplatin (CDDP) is a widely used chemotherapeutic agent, but its clinical applications are constrained by ototoxic side effects. Currently, few effective strategies exist to prevent or mitigate CDDP-induced ototoxicity. Rutin is known for its cell-protective effects by reducing oxidative stress and inhibiting apoptosis. However, its limited water solubility and inefficient delivery to the inner ear pose substantial challenges. To address this, rutin is encapsulated in liposomes (Lip-Rutin) for nanoscale drug delivery, leveraging its antioxidant properties. Lip-Rutin markedly attenuates CDDP-induced oxidative stress damage and apoptosis, demonstrating a protective effect on OC-1 cells. The efficacy of Lip-Rutin in safeguarding against CDDP-induced ototoxicity is further validated through in vivo studies. Consequently, Lip-Rutin emerges as a promising novel therapeutic agent for combating CDDP-induced ototoxicity.
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PubMed
高影响因子
Heliyon
·
2023
·
IF 4
M.A. Khaleque,M.R. Ali,M.S. Bacchu,M.R.A. Mamun,M.I. Hossain,M.S. Hossain,Mohamed Aly Saad Aly,M.Z.H. Khan
In this work, a novel electrochemical detection strategy was developed based on a metal-organic framework of zinc oxide nanorod nanoparticles and rutin for selective screening of Thiourea as toxic chemicals. The zinc oxide nanorod were synthesized by following direct chemical precipitation methods and characterized by X-ray diffraction and X-ray photoelectron spectroscopy analysis. The surface of modified electrodes was also characterized by field emission scanning electron microscopes, energy-dispersive X-ray spectroscopy, and attenuated total reflectance flourier transform infrared spectroscopy. Furthermore, the electrochemical activity of the developed sensor was tested by cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy. The modified electrode showed outstanding electro-catalytic activity towards the detection of Thiourea in phosphate buffer saline at a high pH level of 12.0. The proposed sensor showed a linear range of linearity in a concentration ranging from 5.0 × 10 −6 - 900 × 10 −6 molL −1 and a detection limit of 2.0 × 10 −6 molL −1 . Moreover, the selectivity of the developed electrochemical sensor was investigated for the detection of Thiourea in the presence of organic compounds and a group of anions. Furthermore, the proposed strategy demonstrated an excellent recovery value in the spiked farmland water and fruit juice sample.
研究领域:
分析化学
·
环境科学
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PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Zuyue Li,Ran Yang,Mahmoud Abou-Elsoud,Peng Hu,Yijie Li,Long Sheng,Dong Uk Ahn,Xi Huang
This study aimed to overcome two inherent limitations of ovalbumin (OVA), specifically its high allergenicity and limited foaming properties, through the formulation of OVA-rutin complexes. Various modification levels of OVA-Rutin complexes were successfully produced, as confirmed by polyphenol binding equivalents and amino acid residues changes. Multispectral analyses collectively demonstrated that rutin promoted structural loosening in OVA and improved its molecular flexibility. At an OVA-Rutin ratio of 1:0.4, the IgE binding capacity diminished by 35.70%. Meanwhile, the system exhibited superior Fe 2+ chelation ability (50.88±0.31%), DPPH radical scavenging capability (67.18±2.25%) and ABTS radical scavenging ability (87.23±0.50%). The combination of rutin and OVA significantly increased foaming ability by 75.56-155.24% and foaming stability by up to 1.32-fold. This improved foam performance was attributed to the desirable air-water interfacial activity and rearrangement capacity of the OVA-Rutin complexes. These findings provide an effective strategy for simultaneously enhancing foaming properties of OVA and mitigating its allergenicity.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2024
·Vol. 25
·期 24
·13684
·
IF 4.9
Lankun Yi,Yubin Bai,Xu Chen,Weiwei Wang,Chao Zhang,Zixuan Shang,Zhijin Zhang,Jiajing Li,Mingze Cao,Zhen Zhu,Jiyu Zhang
Rutin is a widely known plant secondary metabolite that exhibits multiple physiological functions. The present study focused on screening for synergistic antibacterial combinations containing rutin, and further explored the mechanisms behind this synergy. In vitro antibacterial test results of rutin showed that the ranges of minimum inhibitory concentration (MIC) and Minimum bactericidal concentration (MBC) are 0.125–1 and 0.125–2 mg/mL, respectively. However, rutin and amikacin have a significant synergistic effect, with a fractional inhibitory concentration index (FICI) range of 0.1875–0.5. The time bactericidal curve proved that the combination of rutin and amikacin inhibited bacterial growth within 8 h. Scanning electron microscopy (SEM) revealed that a low-dose combination treatment could disrupt the cell membrane ofEscherichia coli(E. coli). A comprehensive analysis using alkaline phosphatase (AKP), K+, and a protein leakage assay revealed that co-treatment destroyed the cell membrane ofE. coli, resulting in the significant leakage of AKP, intracellular K+, and proteins. Moreover, confocal laser scanning microscopy (CLSM) and red–green cell ratio analysis indicated severe damage to theE. colicell membrane following the co-treatment of rutin and amikacin. This study indicates the remarkable potential of strategically selecting antibacterial agents with maximum synergistic effect, which could significantly control antibiotic resistance.
研究领域:
微生物学
·
药理学
·
植物化学
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PubMed
高影响因子
JOURNAL OF FLUORESCENCE
·
2024
·
IF 2.6
Wang Xiaoyu,Hou Xingyu,Sun Na,Wang Yongqiang,Zhang Yiying,Lv Yuguang,Ding Lixin,Sun Xue
In this work, Waste pine nut shells were used as organic carbon source of biomass to synthesize carbon quantum dots. A highly responsive and selective fluorescent nanosensor (Si-doped biomass-derived carbon dots with molecular imprinted polymers, Si-CDs@MIPs) was designed for determination of Rutin (RT) in Chinese herbal substances like Sophora japonica L. . Not only was the synthesis method simple, environmentally friendly but also can selectively capture and specifically recognize the target compound RT, which was accomplished by a single-step hydrothermal process. The RT content in the real sample is 21%, with a recovery rate ranging from 89.7 to 106.3%, demonstrating excellent reproducibility. The nanosensor can selectively detect RT at a detection limit of 12.5 nmol/L. Therefore, it is showed that Si-CDs@MIPs will be feasible as a sensor for the rapid measurement of RT.
研究领域:
生物化学
·
环境科学
·
分析化学
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yajuan Qin,Xiaoai Chen,Fei Xu,Kexue Zhu,Ping Wang,Yutong Zhang,Yanjun Zhang
The human dietary system, which contains a variety of compounds such as polyphenols and polysaccharides, is very complex. Whether polysaccharides affect the inhibitory of polyphenol mixtures on α-amylase needs to be further investigated. The aim of this study was to analyze the effect and mechanism of pectin on the inhibition of α-amylase by a mixture of rutin and quercetin (R–Q). Results revealed that the inhibition and quenching affinity of R–Q for α-amylase was enhanced by pectin. The Stern-Volmer quenching constant of R–Q–α-amylase was increased by pectin from (6.08 ± 0.453) × 10 3 mL/mg to (9.80 ± 0.285) × 10 3 mL/mg. Pectin enhanced the ability of R–Q to inhibit α-amylase for two main reasons. On the one hand, it was owing to the binding of pectin to rutin, which increased the opportunity for quercetin to bind to the active center of α-amylase, thus enhancing the inhibitory effect of R–Q on α-amylase. On the other hand, pectin and quercetin simultaneously bound to different sites of α-amylase by noncovalent interactions to form the ternary complex of pectin–α-amylase–quercetin. The conformation of α-amylase and the hydrophobicity of amino acid residues were altered by the ternary complex, thereby enhancing the hydrogen bonding in the reaction system.
研究领域:
食品科学
·
生物化学
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高影响因子
Arabian Journal of Chemistry
·
2024
·
IF 5.3
Xiao-Lin Xie,Zhao Zhang,Wen Xiong,Jie Wang,Wei Gong,Wen Xu,Shuang Cai,Jing Li
Carbon dots (CDs) prepared from biomass usually produce poor quantum yield and reproducibility. A fine separation of raw materials may enhance the fluorescence performance. In this work, embryos of cumin seeds were precisely chosen as the carbon source to prepare (CDs) through hydrothermal method. The obtained product (CDs-E) possessed a higher quantum yield of 10.60 % than those synthesized with testas or whole seeds, which may be due to the relatively smaller particle size and more C-N functional groups. Rutin, as a common natural active component, could quench the fluorescence of CDs-E notably through internal filtering effect. Herein, a highly selective fluorescent sensor based on CDs-E for detecting rutin was proposed with a linearity range of 0.05 ∼ 30 μM and a detection limit of 0.015 μM obtained. Additionally, the developed method was successfully applied for the detection of rutin in Flos Sophorae , rutin tablets and capsules. This work showed the significance of fine classification for natural carbon source in preparation of CDs and provided a feasible method for quality monitoring of rutin-related pharmaceuticals, health care products and traditional Chinese medicinal materials.
研究领域:
分析化学
·
药物分析
·
生物医学工程
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DOI
高影响因子
Small
·
2024
·
IF 13
Jia Chen,Maoheng Fei,Meijun Ni,Yilin Wang,Zhifang Liu,Yixi Xie,Pengcheng Zhao,Zhiyong Zhang,Junjie Fei
In this work, multi-layer Ti 3 C 2 – carbon nanotubes – gold nanoparticles (Ti 3 C 2 -CNTs-Au) and cyclodextrin metal-organic framework – carbon nanotubes (CD-MOF-CNTs) have been prepared by in situ growth method and used to construct the ultra-sensitive rutin electrochemical sensor for the first time. Among them, the large number of metal active sites of Ti 3 C 2 , the high electron transfer efficiency of CNTS, and the good catalytic properties of AuNPs significantly enhance the electrochemical properties of the composite carbon nanomaterials. Interestingly, CD-MOF has a unique host–guest recognition and a large number of cavities, molecular gaps, and surface reactive groups, which gives the composite outstanding accumulation properties and selectivity for rutin. Under the optimized conditions, the constructed novel sensor has satisfactory detection performance for rutin in the range of 2 × 10 −9 to 8 × 10 −7 M with a limit of detection of 6.5 × 10 −10 M. In addition, the sensor exhibits amazing anti-interference performance against rutin in some flavonoid compounds and can be used to test natural plant samples (buckwheat, Cymbopogon distans , and flos sophorae immaturus). This work has promising applications in the field of environmental and food analysis, and exploring new directions for the application of Mxene-based composites.
研究领域:
材料科学
·
分析化学
·
纳米技术
·
环境科学
·
食品分析
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高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2020
·
IF 3.306
Zhifeng Cai,Siying Chen,Xinru Ma,Dang Na,Jie Zhao,Tianqi Wu,Caifeng Zhang
For the first time, we developed a facile, green and low-cost strategy to prepare blue-green emitting fluorescence copper nanoclusters (Cu NCs) by using tyrosine as a protecting agent and hydrazine hydrate as a reducing agent. The tyrosine-protected Cu NCs (Tyr-Cu NCs) were analyzed through fluorescence spectroscopy, UV–vis absorption spectroscopy, fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). The as-prepared Cu NCs was well dispersed and possessed good water solubility, excellent photostability and resistance to sodium chloride. The fluorescence intensity of Tyr-Cu NCs (around 480 nm under the excitation wavelength of 435 nm) was obviously quenched in the presence of rutin. According to this characteristic, a selective and sensitive fluorescence analytical method for the determination of rutin was established. The analytical method had a good linear relationship between F 0 /F and the concentrations of rutin (range from 0.1–60 μM) and the detection limit (LOD) was 0.016 μM. The possible mechanism of fluorescence quenching was caused by the IFE and static quenching. Meaningfully, the fluorescent probe was successfully employed to detect rutin in bovine serum samples.
研究领域:
分析化学
·
生物医学
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高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2016
·Vol. 21
·期 5
·1219-1228
·
IF 2.327
Xing Ruimin,Yang Haitang,Li Shengnan,Yang Jinghe,Zhao Xiaoyu,Wang Qinglong,Liu Shanhu,Liu Xiuhua
Fabrication of multicomponent nanocomposites as electrode-modified materials is an effective strategy to design highly active electrochemical sensors. Here, we present a facile strategy to fabricate the palladium phthalocyanine-multiwalled carbon nanotube (PdPc-MWCNTs) nanocomposite for the sensitive detection of rutin. Results showed that the prepared nanocomposites exhibited excellent electrocatalytic activity toward rutin due to the synergetic effects of PdPc and MWCNTs (excellent electric conductivity and catalytic activity) and the homogeneous dispersibility of Nafion. Under the optimized conditions, the developed sensor exhibited a linear response range from 0.10 to 51 μM for rutin with a low detectable limit of 75 nM and a fast response less than 3.0 s. The proposed method might offer a possibility for electrochemical analysis of rutin in Chinese medical analysis or serum monitoring owing to its low cost, simplicity, high sensitivity, good stability, and few interferences against common coexisting ions in real samples.
研究领域:
分析化学
·
材料科学
·
药物分析
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高影响因子
ANALYST
·
2023
·Vol. 148
·期 9
·2100-2109
·
IF 4.2
Yanxue Xu,Guihua Chen,Yunting Qin,Dan Xiao
A glassy carbon electrode (GCE) was modified with graphite powder (G/GCE), and then treated with a solution of sodium peroxide for several minutes to prepare an oxidized G/GCE (OG/GCE). The OG/GCE has prominently improved responses toward dopamine (DA), rutin (RT) and acetamidophenol (APAP), of which the anodic peak current was increased by 2.4, 4.0 and 2.6 fold compared with that obtained using the G/GCE. The redox peaks of DA, RT and APAP on the OG/GCE could be separated sufficiently. The corresponding redox processes were confirmed as diffusion-controlled and parameters such as the charge transfer coefficients (α), saturating adsorption capacity (Γ*) and catalytic rate constant (kcat) were estimated. In individual detection, the linear ranges for DA, RT and APAP were 10 nM–10 μM, 1.00 nM–150 nM and 20 nM–30 μM, respectively, and the LODs for DA, RT and APAP were estimated as 6.23 nM, 0.36 nM and 13.1 nM with 3σ/S, respectively. The contents of RT and APAP in drugs were determined and agreed with the labeled contents. The recoveries of DA in serum and sweat were in the range of 91–107%, indicating that the determination results achieved by the OG/GCE are reliable. The practical use of the method was verified with a graphite-modified screen-printed carbon electrode (G/SPCE), which was also activated by Na2O2 to prepare OG/SPCE. The recovery of DA in sweat achieved using the OG/SPCE was 91.26%.
研究领域:
电化学
·
分析化学
·
材料科学
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DOI
PubMed
高影响因子
Chemosensors
·
2023
·Vol. 11
·期 3
·171
·
IF 4.2
Xin Meng,Bao-Lin Xiao,Xin-Yan Song,Xin-Xin Ma,Yang-Yang Li,Lin-Lin Ma,Yu-Jie Chen,Yu-Ying Li,Ke-Xin Xu,Jian-She Wei,Tao Hong,Ali Akbar Moosavi-Movahedi,Jun Hong
Rutin is a natural antioxidant flavonoid compound with anti-inflammatory, antioxidant, and antiviral effects that is used to prepare drugs with wide application in clinical treatment. Therefore, the quantitative detection of rutin has important practical significance. In this work, a novel electrochemical sensor based on glassy carbon electrodes (GCEs) modified with sodium carboxymethylcellulose (CMC), multi-walled carbon nanotubes (MWCNTs), and 1-butyl-3-methylimid (ionic liquid, IL) was developed for the super-sensitive detection of the flavonoid rutin. The properties of these modified materials were analyzed by transmission electron microscope (TEM), cyclic voltammograms (CVs), and electrochemical-impedance spectroscopy (EIS). CMC was used to disperse MWCNTs to further enhance their hydrophilicity and biocompatibility. The modified MWCNTs improved the sensitivity of rutin detection. The square-wave voltammetry (SWV) technique showed that the linear range of rutin concentration determination was 0.01 μM to 1 µM and 1 µM to 10 µM. The minimum concentration detection of rutin was 0.83 nM and 6.6 nM, respectively. The proposed sensor presented good selectivity for rutin and successfully analyzed rutin content in the pharmaceutical rutin tablets. These results are consistent with those measured by ultra-high-performance liquid chromatography (UHPLC). Therefore, this sensor has latent application value in the analysis of rutin in food and drug tablets and nutraceutical samples.Keywords:sensor;multi-walled carbon nanotubes;ionic liquid;sodium carboxymethylcellulose;rutin
研究领域:
电化学
·
纳米技术
·
分析化学
·
药学
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高影响因子
危险品化学品经营许可证（带存储）