JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
·
2019
·Vol. 56
·期 3
·1095-1103
·
IF 1.85
Zhang Baodong,Huang Chongxing,Zhang Linyun,Wang Jian,Huang Xingqiang,Zhao Yuan,Liu Ying,Li Cuicui
In this study, fresh mangos were packed using a custom-made antimicrobial film coated with sustained-release chlorine dioxide microcapsules. We then compared physical and chemical indexes, such as weight loss rate, firmness, chromatic aberrations, soluble solids, vitamin C, titratable acid, and other nutritional indicators, to examine changes in the mango and film during storage. Our findings revealed that control mango showed loss of edible value and commercial value after 21 days of storage, and the chlorine dioxide microcapsule antibacterial film group still retains food value and commercial value. Cross-sectional scanning electron microscopy images of the used film showed that the polylactic acid film was smooth and flat, whereas cross-sections of the antimicrobial film showed that the film was covered with voids due to deliberate release of chlorine dioxide gas during the packaging process. Thus, the antibacterial film exhibited erosion and degradation. These findings provided important insights into the use of antimicrobial films for the packaging of fruits during storage, which is essential for promoting the application of solid chlorine dioxide antimicrobial film in packaging preservation.
研究领域:
食品科学
·
生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2023
·
IF 5.9
Shushu Chao,Yiqiu Zhang,Shihong Cheng,Xinzhe Shao,Songlin Liu,Wenjuan Lu,Yanfeng Wang,Pingping Zhang,Qingqiang Yao
Based on the opportunities of ibuprofen administration innovation and challenges associated with the construction of transdermal drug delivery systems using medicated nanoparticles and electrospun nanofiber membranes, we developed a transdermal drug delivery system comprising ibuprofen-loaded ZnO nanoparticles/polyacrylonitrile electrospun nanofiber membranes (ZnO-ibuprofen/PAN), which was dual-stimulus responsive, wherein both pH and temperature triggered drug release. ZnO-ibuprofen nanoparticles with high drug loading capacity (17.7%) were prepared at room temperature by a one-step method involving 4,4′-((4-(4H-1,2,4-triazol-4-yl) phenyl) azanediyl)dibenzoic acid, Zn(NO3)2·6H2O, and ibuprofen, following which electrospinning was conducted to generate the ZnO-ibuprofen/PAN nanofibers. The transdermal drug release behavior of the ZnO-ibuprofen/PAN electrospun nanofiber membranes in the normal (pH = 7.4, 37 °C) and inflammatory (pH = 6.5, 42 °C) tissue environment exhibited increased drug release rate at higher ambient temperatures and decreased pH following 24 h of drug release. The cumulative drug release rate of ZnO-ibuprofen/PAN electrospun fibers through porcine skin under inflammatory conditions reached 71.35% ± 2.96% after 24 h, thereby demonstrating their favorable transdermal permeation behavior. The cytotoxicity assays revealed that the nanofibers possessed excellent biocompatibility. Thus, the dual stimulus-responsive ZnO-ibuprofen/PAN can be an effective transdermal drug delivery carrier.
研究领域:
药学
·
纳米技术
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材料科学
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药物递送系统
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2015
·
IF 2.752
Hui Li,Xiaohong Zhu,Hui Zhou,Shian Zhong
A novel hydrophobic organic–inorganic hybrid nanocomposite was prepared for sustained release of analgesic. Using enlarged halloysite nanotubes (EHNTs) as nanocontainer and organosilane (OS) as the hydrophobic layer, nanocomposite denote as EHNTs@OS was readily prepared with a mild reaction. Then the EHNTs@OS was characterized by Fourier transform infrared spectroscopy, transmission electron microscopy, energy dispersive X-ray analysis, and high-performance liquid chromatography. The hydrophobic layer composed of tetraethoxysilane and octyltriethoxysilane made a difference on the wettability of the EHNTs@OS. It was proved that the nanocomposite exhibited excellent hydrophobicity with a water contact angle of 132°. Moreover, an enhanced capacity for adsorption (25%) and the sustained-release performance (100 h) of the EHNTs@OS toward IBU were demonstrated and it followed the power law kinetic model. In conclusion, the drug-release platform explored in this work is suitable for other drugs and shows further comprehensive application prospect.
研究领域:
材料科学
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药学
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF NEUROSCIENCE
·
2017
·Vol. 45
·期 10
·1258-1267
·
IF 2.941
Dan Lv,Lijuan Zhou,Xianyu Zheng,Yongcheng Hu
Although the peripheral nervous system has an intrinsic ability for repair and regeneration after injury, bridging long peripheral nerve defects remains a challenge. Functional nerve regeneration depends on interactions among axons, Schwann cells, fibroblasts and immune cells. Macrophages, as immune cells recruited early in this process, show polarization toward phenotypes that are detrimental or beneficial to tissue remodeling depending on the microenvironment of the scaffolds. In this study, we investigated the effects of macrophage phenotypes modulated by collagen VI on axonal regeneration and functional recovery by bridging a 15-mm-long sciatic nerve defect in rats. Our results showed that local delivery of collagen VI within a polycaprolactone (PCL) electrospun conduit increased the recruitment of macrophages and their polarization toward the pro-healing (M2) phenotype. In addition, the axonal regeneration and neurologic functional recovery in the PCL/collagen VI conduit group are equivalent to that of an autograft. In conclusion, the present study confirmed that PCL/collagen VI conduits with sustained release of collagen VI in the local microenvironment may, through triggering macrophage M2 polarization to enhance the nerve regeneration, suggest that our combined biomaterial-immunomodulatory system may be an attractive candidate for peripheral nerve regeneration.
研究领域:
神经科学
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组织工程
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免疫学
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生物材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2017
·
IF 3.154
Dongliang Zhang,Yanfei Cao,Chengye Ma,Shanfeng Chen,Hongjun Li
There is a paradox when incorporating enzyme into an edible chitosan film that chitosan is dissolved in acid solution and enzyme activity is maintained under mild conditions. A method for maintaining the pH of the chitosan solution at 4–6 to prepare a chitosan film containing β-cyclodextrin, resveratrol−β-cyclodextrin inclusion (RCI), was developed, using glucamylase and acetic acid. A considerable amount of resveratrol was released by the glucamylase-incorporated film within 15 days, and the maximum amount released was 46% of the total resveratrol content. The highest resveratrol release ratio (released resveratrol/total resveratrol) was obtained in the film with 6 mL of RCI. Scratches and spores were generated on the surface of the glucamylase-added film immersed in water (GAFW) for 7 days because of β-cyclodextrin hydrolysis during film drying and water immersion. RCI and β-cyclodextrin were extruded from the film surface and formed teardrops, which were erased by water on the GAFW surface but appeared on the glucamylase-added film without water immersion (GAF). The bubbles generated by the reaction of acetic acid and residual sodium bicarbonate were observed in both glucamylase-free films immersed in water (GFFW) for 7 days and without water immersion (GFF). The FT-IR spectra illustrated that the covalent bond was not generated during water immersion and β-cyclodextrin hydrolysis. The crystal structure of chitosan was destroyed by water immersion and β-cyclodextrin hydrolysis, resulting in the lowest chitosan crystallization peak at 22°. The increasing of water holding capacity determined by EDX presented the following order: GAF, GFFW, GFF, and GAFW.
研究领域:
食品科学
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生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Mofei Shen,Xinyu Liao,Yunlei Xianyu,Donghong Liu,Tian Ding
Cyclodextrin metal–organic frameworks (CD-MOFs) possess great potential in environmental applications due to their high specific surface area and good biocompatibility properties. However, the hydrophilicity of the CD-MOF hinders its ability to maintain a sustained release in water as a carrier. In this study, we prepared a CD-MOF that has codelivery ability for both phytochemicals [caffeic acid (CA)] and silver nanoparticles (Ag NPs) and further incorporated this material (CA@Ag@CD-MOF) into the polydimethylsiloxane (PDMS) matrix to construct a hybrid membrane. This hybrid membrane could effectively maintain the release capacity of the CD-MOF in water, while endowing PDMS with swelling ability in water. The hybrid membrane can achieve a sustained release for up to 48 h in water. In addition, the elastic modulus of the hybrid membrane increases by nearly 100%, and the swelling degree of the hybrid membrane in water increases by 42% compared with that of the pure PDMS membrane, indicating better mechanical properties. The hybrid membrane exhibits excellent antibacterial effects on Escherichia coli O157:H7 (E. coli O157:H7) and Staphylococcus aureus (S. aureus). We expect that this work will be beneficial to the delivery research of the CD-MOF in more environmental scenarios, especially in water treatment.
研究领域:
材料科学
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环境科学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2022
·Vol. 10
·期 19
·5583-5595
·
IF 7.59
Han Li,Jiming Xu,Jun-Feng Hu,Qing-Yun Hu,Xiaolin Fang,Zhi-Jun Sun,Zhigang Xu,Lu Zhang
Periodontitis is a prevalent chronic inflammatory disease that destroys the periodontal supporting tissues, impinges on oral health, and is correlated with an increased risk of systemic disease. Currently, the main drug treatment is antibiotic therapy; however, systemic antibiotic therapy still has various drawbacks such as bacterial resistance, low bioavailability and burst release. It is noteworthy that the local use of non-antibiotic drugs with sustained release characteristics can effectively overcome these problems. It has been documented that chlorogenic acid (CGA) has good anti-inflammatory and antioxidant properties. To achieve the sustained release of CGA, we synthesized CGA–PLGA@PVP nanomicelles by loading CGA onto poly(D,L-lactide-co-glycolide) (PLGA) and modified them with polyvinylpyrrolidone (PVP) for better dispersion. The results demonstrated that CGA–PLGA@PVP nanomicelles could prolong the release time of CGA, and could not only effectively remove reactive oxygen species (ROS) but also downregulate the overexpression of proinflammatory cytokines in lipopolysaccharide (LPS)-treated RAW264.7 cells. Moreover, CGA–PLGA@PVP nanomicelles could remain in gingival tissue for more than 24 hours after local injection, inhibit alveolar bone resorption and prevent the progression of periodontitis in a mouse model, showing good biocompatibility. Therefore, CGA–PLGA@PVP nanomicelles have great properties and are expected to be a novel therapeutic strategy for periodontitis.
研究领域:
药剂学
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牙科学
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材料科学
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药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DRUG DELIVERY
·
2022
·
IF 6.819
Yujin Zhao,Chang Huang,Zhutian Zhang,Jiaxu Hong,Jianjiang Xu,Xinghuai Sun,Jianguo Sun
Glaucoma is the leading cause of irreversible vision loss worldwide, and reduction of intraocular pressure (IOP) is the only factor that can be interfered to delay disease progression. As the first line and preferred method to treat glaucoma, eye drops have many shortcomings, such as low bioavailability, poor patient compliance, and unsustainable therapeutic effect. In this study, a highly efficient brimonidine (BRI) silicone rubber implant (BRI@SR@TPU implant) has been designed, prepared, characterized, and administrated for sustained relief of IOP to treat glaucoma. The in vitro BRI release from BRI@SR@TPU implants shows a sustainable release profile for up to 35 d, with decreased burst release and increased immediate drug concentration. The carrier materials are not cytotoxic to human corneal epithelial cells and conjunctival epithelial cells, and show good biocompatibility, which can be safely administrated into rabbit’s conjunctival sac. The BRI@SR@TPU implant sustainably released BRI and effectively reduced IOP for 18 d (72 times) compared to the commercial BRI eye drops (6 h). The BRI@SR@TPU implant is thus a promising noninvasive platform product for long-term IOP-reducing in patients with glaucoma and ocular hypertension.
研究领域:
药剂学
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眼科医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2022
·
IF 5.589
Zhe Wang,Xin Chen,Duanxiu Li,Enhe Bai,Hailu Zhang,Yanwen Duan,Yong Huang
Co-amorphous technology is an emerging approach for pharmaceutical engineering of drugs and drug leads with improved physicochemical properties and bioavailability. Platensimycin (PTM) is a promising natural antibiotic lead that acts on bacterial fatty acid synthase and exhibits excellent antibacterial activity . Despite great strides to improve its poor pharmacokinetics by medicinal chemistry and nanotechnology, there are no convenient oral delivery systems developed. Here, a co-amorphous system of PTM and berberine chloride (BCL) was developed for oral delivery of PTM. Co-amorphous PTM-BCL was prepared by rotary vacuum evaporation method, and systematically characterized by powder X-ray diffraction, temperature modulated differential scanning calorimetry , Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). Compared with PTM or BCL alone, the equilibrium solubility and dissolution rate of both of them in the co-amorphous systems decreased significantly, showing the characteristics of sustained release . The molecular interactions between PTM and BCL were mediated by strong charged-mediated hydrogen bonds , based on FTIR, XPS, and NMR-based techniques. The co-amorphous PTM-BCL system showed excellent physiochemical stability at room and elevated (40 °C) temperature under dry conditions. The combination of PTM and BCL showed increased killing of a clinical isolated methicillin-resistant Staphylococcus aureus strain in killing checkerboard assays. Finally, co-amorphous PTM-BCL exhibited 2- or 3-fold longer half-life in rats than that of crystalline and amorphous PTM upon oral administration, respectively. Our study suggests a rational approach to realize the full potential of potent antibiotic PTM, which may be conveniently adapted for engineering of other important pharmaceutics.
研究领域:
药学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Chengbin Guo,Yubo Lian,Chen Huang,Zhenyu Chen
A novel sustained-release system was designed on the basis of metal–organic framework-5 (MOF-5) as a nanocontainer to load benzotriazole (BTA). Furthermore, the fabricated BTA/MOF-5 (BTA@MOF-5) was doped to the epoxy coating to improve the anticorrosion performance of copper. UV spectrophotometry proved the sustained-release behavior of BTA@MOF-5. Salt spray tests and electrochemical measurements demonstrated the self-healing ability of the composite coating . This novel sustained-release system provides a new strategy for metal protection.
研究领域:
材料科学
·
化学工程
·
腐蚀科学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Environmental Sciences
·
2022
·
IF 6.796
Mei Du,Jingzhang Liu,Fengbang Wang,Lei Bi,Chunyan Ma,Maoyong Song,Guibin Jiang
Bacterial infections have become a great threat to public health in recent years. A primary lysozyme is a natural antimicrobial protein; however, its widespread application is limited by its instability. Here, we present a poly (N-isopropylacrylamide) hydrogel inverse opal particle (PHIOP) as a microcarrier of lysozyme to prolong and enhance the efficiency against bacteria. This PHIOP-based lysozyme (PHIOP-Lys) formulation is temperature-responsive and exhibits long-term sustained release of lysozyme for up to 16 days. It shows a potent antibacterial effect toward both Escherichia coli and Staphylococcus aureus , which is even higher than that of free lysozyme in solution at the same concentration. PHIOPs-Lys were demonstrated to effectively inhibit bacterial infections and enhance wound healing in a full-thickness skin wound rat model. This study provides a novel pathway for prolonging the enzymatic activity and antibacterial effects of lysozyme.
研究领域:
生物材料学
·
微生物学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2022
·
IF 5.999
Wu Di,Yang Shuai,Wang Bo,Tan Wei,He Jinpeng,Guowen Qian,Youwen Deng
It is of great challenges to repair bone defect and prevent tumor recurrence in bone tumors postoperative treatment. Bone scaffolds loaded with zoledronate (ZOL) are expected to solve these issues due to its osteogenesis and anti-tumor ability. Furthermore, ZOL needs to be sustained release to meet the requirement of long-term therapy. In this study, ZOL was loaded into amination functionalized mesoporous silicon (SBA15NH 2 ), and then incorporated into poly ( L -lactic acid) to prepare PLLA/SBA15NH 2 -ZOL scaffold via selective laser sintering technology. On one hand, ZOL of local release not only can inhibit growth and proliferation of bone tumor cells but also inhibit osteoclast differentiation through competitive binding of receptor activator of nuclear factor (NF)-kB (RANK) in osteoclast precursors. On the other hand, amination function could change the surface charge of mesoporous silica to positive charge to enhance the absorption of ZOL, mesoporous structure and abundant amino groups of SBA15NH 2 play a barrier role and form hydrogen bond with phosphate groups of ZOL, respectively, thereby achieving its sustained release. The results showed that the loading amount of ZOL was 236.53 mg/g, and the scaffold could sustainedly release ZOL for more than 6 weeks. The scaffold inhibited proliferation of osteosarcoma cells through inducing apoptosis and cell cycle arrest . TRAP staining and F-actin ring formation experiment showed the scaffold inhibited differentiation and mature of osteoclast. Pit formation assay indicated that bone resorption activity was inhibited strongly.
研究领域:
生物医学工程
·
药剂学
·
组织工程
·
癌症治疗
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）