Journal of Future Foods
·
2026
·
IF 10.6
Yaoyao Xu,Yi Qin,Xiao Feng,Chengcheng Gao,Weiwei Cheng,Zhenjiong Wang,Yan Zhang,Xiaozhi Tang
Lauric arginate (LAE) has potent antimicrobial activity; however, it exhibits inadequate stability and antimicrobial efficacy due to interactions with anionic constituents. This study developed a novel LAE/hydroxypropyl-β-cyclodextrin inclusion complex (LAE/HP-β-CD IC), the structure of which was examined using various analytical techniques. The results showed that the non-polar tail of LAE likely penetrated the HP-β-CD cavity through its larger opening and exited through the narrower end, forming a partially included structure. The LAE/HP-β-CD IC effectively enhanced the thermal stability and emulsifying properties of LAE, extending its pH-stable range (1–9) and enabling stable storage for at least 35 d (4°C, pH 3–9). Moreover, it hindered the interactions between anionic components and LAE, enhancing its antimicrobial activity. The LAE/HP-β-CD IC significantly amplified the inhibition zone against Staphylococcus aureus from 15.54 to 31.64 mm and reduced the minimum inhibitory concentration of LAE against Escherichia coli from 0.038 to 0.020 mg/mL. This LAE/HP-β-CD IC is a promising novel emulsifying antimicrobial agent that could expand the application of LAE.
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ACS Applied Nano Materials
·
2026
·
IF 5.5
Shao-Ye Su,Liu-Liu Yang,Xin-Rui Shi,Fa-Wen Wu
The practical application of metal–organic frameworks (MOFs) in water remediation is often hindered by their powdery nature, which causes aggregation, difficult recovery, and potential secondary pollution. To address this, we pioneer an integrated strategy of chemical bonding and in situ epitaxial growth to fabricate, for the first time, a robust and substrate-anchored cyclodextrin-based MOF (CD-MOF) composite. The innovation centers on using ethylenediamine-modified β-cyclodextrin (EDA-β-CD) as chemically grafted nucleation sites on aldehyde-functionalized polystyrene to guide the oriented growth of CD-MOF, yielding a well-adhered PS-CD-MOF composite. This novel material exhibits excellent adsorption of sulfonamide antibiotics (e.g., 5.55 μg·mg–1 for sulfadimethoxine) with rapid kinetics. More importantly, it demonstrates outstanding reusability over multiple cycles while maintaining structural integrity, thereby overcoming a key limitation of powder MOFs. Its versatile adsorption across different sulfonamides confirms the success of the synthesis strategy and highlights its potential as a stable, recyclable platform for waste liquid.
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JOURNAL OF CLINICAL INVESTIGATION
·
2026
·
IF 14.3
Gengmiao Xiao,Aijun Qian,Zhuo Gao,Tingting Dai,Hui Liang,Shuai Wang,Mulan Deng,Yunjing Yan,Xindan Zhang,Xuedi Zhang,Yunping Mu,Jiqiu Wang,Aibo Gao,Huijie Zhang,Fanghong Li,Allan Zijian Zhao
Aging commonly causes decline of testosterone or estrogen, leading to overaccumulation of fatness in males or females, respectively. Although such phenomenon can be readily explained by estrogen’s direct action on adipocytes in females, accumulative evidence does not support the direct action of testosterone in adipocyte lipid metabolism, suggesting that there is a missing intermediary link. Herein, we propose that glycoprotein hormone β5 (GPHB5) is the intermediary linkage between testosterone and the regulation of adiposity. In clinical samples, blood levels of GPHB5 were correlated negatively with men’s ages, and positively with circulating testosterone. Testosterone directly stimulated the expression of GPHB5 in cultured cells, pharmacological blockade of androgen receptor (AR) functions abrogated such effect. Knockout of AR led to not only development of obesity but also reduction of GPHB5 expression. Genetic ablation of GPHB5 in the males, but not in the females, lowered the browning of white adipose tissue, diminished energy expenditure and caused severe obesity. Importantly, elevated blood testosterone didn’t exert its catabolic actions in GPHB5 null mice, and yet, recombinant GPHB5 protein was able to stimulate energy expenditure and reduce adiposity. Taken together, these results provided the strong proof that GPHB5 is the “missing” intermediary hormone linking testosterone (and aging) and its well-known catabolic effect on adipose tissue.
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International Journal of Food Science
·
2026
·Vol. 2026
·期 1
·9991306
·
IF 3.1
Zhenlin Zhang,Weiwei Cheng,Meihua Hu,Xin Yao,Yixuan Zhu,Zhichao Yin,Dong Liu
To explore the potential application of sweet potato peel polyphenols (SPPPs) in dairy products, this study investigated the effects of thermal processing and storage on their stability in yogurt and evaluated the role of β -cyclodextrin ( β -CD) in mitigating degradation. Our results demonstrated that different thermal processing conditions significantly affected the total polyphenol content (TPC) of yogurt. The combination of fermentation at 40°C for 10 h followed by sterilization at 120°C for 3 min preserved up to 90.9% of the TPC, with corresponding changes in antioxidant capacity. During storage, a gradual decline in TPC was observed, although individual phenolic compounds remained relatively stable, and antioxidant activity fluctuated or decreased. The addition of β -CD effectively reduced polyphenol loss and improved their stability under both thermal and storage conditions. For instance, yogurt treated at 120°C with β -CD showed higher TPC and superior antioxidant properties compared to samples without β -CD. Furthermore, the cohesiveness, viscosity, and thickness of SPPP-enriched yogurt were positively correlated, while storage time influenced flowability, firmness, homogeneity, and mouthfeel. In conclusion, optimizing thermal processing parameters and incorporating β -CD can significantly enhance the stability of SPPPs in dairy matrices, offering theoretical support for the development of functional dairy products.
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CELL BIOLOGY INTERNATIONAL
·
2026
·Vol. 50
·期 2
·e70136
·
IF 3.1
Guansheng Hu,Laiai Fang,Xiang Ding,Qingjun Zeng,Youwu Wen,Dongyang Cheng,Yonggui Zhou
Replication factor C (RFC), a multimeric protein with ATPase activity, plays a crucial role in DNA replication and repair. RFC4, one of its subunits, is aberrantly expressed in various malignant tumors, including colorectal cancer (CRC). Nevertheless, the impact of RFC4 on CRC metastasis remains to be elucidated. In this study, we systematically examined the effects of RFC4 silencing on the proliferation, migration, invasion, epithelial-mesenchymal transition (EMT), and Wnt/β-catenin signaling pathway in CRC cells in vitro. Additionally, we further explored the regulatory role of RFC4 in liver metastasis of CRC cells in vivo. Finally, BML-284, a known activator of the Wnt/β-catenin signaling pathway, was employed to validate the underlying mechanism by which RFC4 modulates the invasive phenotype of CRC cells. The results demonstrated that RFC4 was significantly overexpressed in CRC cell lines. Upon silencing of RFC4, the proliferation, migration, and invasion capabilities of CRC cells were markedly attenuated, and the EMT process as well as Wnt/β-catenin signaling pathway activity were effectively suppressed. Notably, RFC4 silencing significantly reduced liver metastasis of CRC cells in a nude mouse model. However, the inhibitory effects of RFC4 silencing on CRC cells proliferation, migration, invasion, and EMT were partially reversed by the intervention of the Wnt/β-catenin signaling pathway activator BML-284. Altogether, these results indicate that RFC4 plays a critical role in promoting CRC metastasis, and its mechanism of action may involve the regulation of Wnt/β-catenin signaling pathway activation to facilitate EMT.
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BIOLOGICAL & PHARMACEUTICAL BULLETIN
·
2025
·Vol. 48
·期 10
·1503-1513
·
IF 1.7
Xinyue Zhou,Wei Zhou,Changhong Qu,Yisha Jiang,Wenzhu Liu,Lipeng Pei
Endometriosis, a prevalent gynecological disorder marked by ectopic growth of endometrial-like tissue, demonstrates malignant tumor-like properties including aggressive adhesion and invasiveness. Emerging evidence implicates roundabout guidance receptor 3 (ROBO3) in cellular pathophysiology, yet its role in endometriosis remains unexplored. In this study, we first found abnormally high ROBO3 expression in endometriosis by bioinformatics analysis. Next, functional assays revealed that ROBO3 is a key regulator promoting the invasion and migration of endometriotic stromal cells (ESCs) in vitro. Mechanistically, ROBO3 activates the Wnt/β-catenin signaling pathway, evidenced by increased phosphorylation of glycogen synthase kinase 3β, nuclear β-catenin accumulation, and upregulated c-myc expression. Pharmacological inhibition of Wnt/β-catenin with MSAB (5 μM) reversed ROBO3-mediated pro-invasive and pro-migratory effects. Furthermore, we discovered that ROBO3 enhances the secretion of chemokines CCL2 and CCL5 in ESCs, which subsequently promote macrophage polarization toward the M2 phenotype, as indicated through elevated expression of interleukin-10 and Arg-1. Collectively, our findings elucidate a dual mechanism whereby ROBO3 drives endometriosis progression through both intrinsic activation of Wnt/β-catenin signaling and extrinsic modulation of tumor-associated macrophages, underscoring ROBO3 as a promising therapeutic target for endometriosis.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2017
·
IF 3.133
Yue Ben,Le Zhang,Shuai Wei,Tianyuan Zhou,Zheng Li,Hao Yang,Yun Wang,Farida A. Selim,Chingping Wong,Hao Chen
Monodispersed and spherical β-TCP granules for 3D printing were prepared by spray drying with the surface modification of PVB . Modifier PVB attached to the particle surface to form the crosslinked network structure and keep them combine with each other into aggregates. The morphology, size, forming performance and crushing behavior of granules as well as the microstructure and density of as-fabricated β-TCP ceramics were used to optimize the PVB contents. Promising results could be expected that PVB contents were 1.0 wt.% and the average particle size of granules was 37.36 μm. The modified granules exhibited excellent forming performance with monodispersed and spherical aggregates for 3D printing . They could be completely crushed under 80 MPa without obvious inter-granules void. These granules with 1.0 wt.% PVB had defined strengths for ceramic forming. The good dispersity and flowability assured the high density and uniform porous structure of β-TCP ceramics, which were used as biological ceramic materials and completely met the standard for bone tissue engineering .
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Analytical Methods
·
2016
·Vol. 8
·期 24
·4888-4894
·
IF 1.915
Lu Wang,Qinqin Wang,Kai Sheng,Lina Zou,Baoxian Ye
In this study, the electrochemical properties of astilbin were investigated for the first time and an electroanalytical method was established synchronously, which was based on a β-cyclodextrin–graphene nanocomposite modified electrode (β-CD–GNs/GCE). The electrode process of astilbin was investigated in detail, and some dynamic parameters were calculated. The detecting sensitivity of astilbin was greatly enhanced at this voltammetric sensor. Under optimum conditions, a lower detection limit (1 × 10−8 mol L−1) and wider linear range (3.0 × 10−8 mol L−1 to 2.0 × 10−6 mol L−1) were achieved by the proposed sensor. Finally, the proposed method was applied to the analysis of a real sample, and the results showed that the method was applicable and reliable.
研究领域:
电分析化学
·
纳米材料
·
传感技术
·
药物分析
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JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2016
·Vol. 16
·期 3
·3115-3121
·
IF 1.338
Yu Fan,Tang Xinhui
Long-circulating liposome is an effective formulation in field of cancer treatment. However, high expenditure of formulation and high dose of cholesterol severely restrict its application. In this paper, we developed a method by grafting polyethylene glycol 2000 on β-sitosterol
succinic anhydride ester to obtain relatively cheap polyethylene glycol-β-sitosterol conjugates, which were used to prepare long-circulating liposome without cholesterol. Gambogic acid which is an effective antitumor ingredient with very short half-life, was used as a model drug
to prepare long-circulating liposome in this research. Meanwhile, the characteristics, pharmacokinetics and distribution of this novel long-circulating liposome were also investigated in comparison with other gambogic acid formulations. Polyethylene glycol-β-sitosterol conjugates
were synthesized, different liposomal formulations were also prepared by ethanol injection method, and the obtained nanoparticles were characterized by dynamic light scattering and transmission electron microscope. The long-circulating effect, pharmacokinetics and distribution of gambogic
acid in rats were also explored. 1HNMR confirmed that polyethylene glycol-β-sitosterol conjugates were synthesized successfully. Novel long-circulating liposome was successfully prepared by ethanol injection method attaining a entrapment efficiency of 89.4%, exhibiting
a homogeneous particle size of 245.2 nm and −24.3 mV zeta potential with smooth continuous surface. This novel long-circulating liposome demonstrated better long-circulating effect than ordinary long-circulating liposome. The novel long-circulating liposome as-prepared not only could
reduce cost of grafting polyethylene glycol on macromolecular phospholipid, but also no cholestrol in preparation was applied, expanding the application of liposome as a formulation in the field of lowering blood lipid. Therefore, polyethylene glycol-β-sitosterol conjugates are
recommended substitute for polyethylene glycol modified phospholipid to prepare long-circulating liposomes.
研究领域:
药剂学
·
药物递送系统
·
癌症治疗
·
纳米医学
·
药代动力学
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JOURNAL OF SEPARATION SCIENCE
·
2013
·Vol. 36
·期 15
·2441-2449
·
IF 2.591
Jialiang Guo,Qiaoxuan Zhang,Yongbo Peng,Zhenghua Liu,Longyi Rao,Teng He,Jacques Crommen,Pinghua Sun,Zhengjin Jiang
A novel, facile, and efficient one-step copolymerization strategy was developed for the preparation of β-cyclodextrin (β-CD) methacrylate monolithic columns using click chemistry. The novel mono-(1H-1,2,3-triazol-4-ylmethyl)-2-methylacryl-β-CD monomer was synthesized by a click reaction between propargyl methacrylate and mono-6-azido-β-CD, and then monolithic columns were prepared through a one-step in situ copolymerization of the mono-(1H-1,2,3-triazol-4-ylmethyl)-2-methylacryl-β-CD monomer and ethylene dimethacrylate. The physicochemical properties and column performance of the fabricated monolithic columns were characterized by elemental analysis, SEM, and micro-HPLC. Satisfactory column permeability, efficiency, and separation performance were obtained for the optimized poly(mono-(1H-1,2,3-triazol-4-ylmethyl)-2-methylacryl-β-CD-co-ethylene dimethacrylate) monolithic columns. Additionally, typical hydrophilic interaction chromatography retention behavior was observed on the monoliths at high acetonitrile content in the mobile phase. Although the enantioselectivity of our monolithic columns did not meet the level of other reported β-CD monolithic columns, this one-step strategy based on click chemistry still provides an interesting and effective model as it offers the possibility to easily prepare related novel CD methacrylate monoliths through a one-step copolymerization strategy.
研究领域:
分析化学
·
高分子科学
·
色谱学
·
超分子化学
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高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2015
·
IF 2.679
Na Kong,Hui-Hui Zhang,Jie Wang,Zhi-Hong Liu
Two pure dehydrated borogermanates with microporous structure, β -K 2 [B 2 Ge 3 O 10 ] and NH 4 [BGe 3 O 8 ], have been synthesized and characterized by XRD, FT-IR, TG techniques. The molar enthalpies of solution of 2.51 mg of GeO 2 (s)/0.99 mg of H 3 BO 3 (s)/1.98 mg of H 3 BO 3 (s) in 2.00 cm 3 of 1 mol · dm −3 NaOH (aq) were measured, respectively. The molar enthalpies of solution of 2.44 mg of K 2 B 4 O 7 · 4H 2 O (s) and 2.18 mg of NH 4 B 5 O 8 · 4H 2 O (s) in the mixture solvent of 2.00 cm 3 of 1 mol · dm −3 NaOH (aq) which contains 2.51 mg of GeO 2 (s) were measured, respectively. The molar enthalpies of solution of 3.82 mg of β -K 2 [B 2 Ge 3 O 10 ] (s) in the mixture solvent of 2.00 cm 3 of 1 mol · dm −3 NaOH (aq) which contains 0.99 mg of H 3 BO 3 (s), and 3.00 mg of NH 4 [BGe 3 O 8 ] (s) in the mixture solvent of 2.00 cm 3 of 1 mol · dm −3 NaOH (aq) which contains 1.98 mg of H 3 BO 3 ) (s) were also measured, respectively. With the use of standard molar enthalpies of formation for NH 4 B 5 O 8 · 4H 2 O (s), K 2 B 4 O 7 · 4H 2 O (s), GeO 2 (s), H 3 BO 3 (s) and H 2 O (l), the standard molar enthalpies of formation of – (3937.1 ± 4.7) kJ · mol −1 for β -K 2 [B 2 Ge 3 O 10 ] and – (2713.7 ± 6.0) kJ · mol −1 for NH 4 [BGe 3 O 8 ] at T = 298.15 K were obtained on the basis of the appropriate thermochemical cycles, respectively.
研究领域:
无机化学
·
物理化学
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ACS Applied Bio Materials
·
2026
·
IF 4.7
Lei Kang,Chunquan Ma,Xiajie Hu,Xudong Wu,Rong Shan,Fuxiang Song
Bone tissue engineering scaffolds are used to repair dimensional alveolar crest defects resulting from etiologies such as trauma, infection, or tumor resection, thereby enabling a more accurate, efficient, and predictable dental diagnosis and treatment. In this study, cone beam computed tomography (CBCT) data from patients with alveolar crest defects were utilized to design a personalized scaffold. Subsequently, the 3D PCL/β-TCP scaffold was successfully fabricated based on this design using 3D printing technology. In parallel, a comprehensive series of assays were conducted to evaluate the properties of the 3D PCL/β-TCP scaffold, including its ability to promote MC3T3-E1 cell adhesion and proliferation in vitro. Furthermore, its capacity to induce bone formation was assessed in an in vivo animal model. The results demonstrated that the scaffold exhibited excellent biocompatibility, as evidenced by CCK-8 and live/dead (AM/PI) fluorescence staining assays, and significantly facilitated the adhesion and proliferation of MC3T3-E1 cells. Additionally, ALP and Alizarin Red staining experiments indicated that the 3D PCL/β-TCP scaffold significantly enhanced ALP expression and calcified nodule formation. Finally, the in vivo experiments in rats with skull defects confirmed that the 3D PCL/β-TCP scaffold contributed to accelerated bone formation. In summary, owing to numerous favorable properties such as personalized customization, biomimetic porous architecture, and excellent osteogenic ability, the 3D PCL/β-TCP scaffold was confirmed to be an advantageous candidate, offering ideas and effective methods for the precise repair of the alveolar crest.
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