Science Advances
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2025
·Vol. 11
·期 30
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IF 12.5
Caifeng Deng,Liukang Yu,Xuan Zhao,Yuxiao Chen,Jiabin Mei,Jie Wei,Xiaoyuan Chen,Guanghua Lei,Chao Zeng
Osteoarthritis (OA) is a multifactorial disease characterized by joint inflammation and cartilage degeneration, with no disease-modifying drugs available. The vicious cycle between the inflammatory microenvironment (inflamed soil) and dysfunctional chondrocytes (degeneration-related seeds) drives the chronic progressive deterioration of OA. Here, we report a genetically engineered chondrocyte-mimetic nanoplatform (termed HKL-GECM@MPNPs) comprising a honokiol (HKL)–loaded mitochondrion-targeting nanoparticle core coated with an interleukin-1 receptor type 2 (IL-1R2)–overexpressing chondrocyte membrane. HKL-GECM@MPNPs fuse with OA chondrocytes, transferring IL-1R2 onto the plasma membrane and reprogramming the inflamed microenvironment through IL-1β blockade. Mitochondrion-targeting cores then directly deliver HKL to restore mitochondrial sirtuin-3 in OA chondrocytes, reprogramming the cells’ pathological phenotype. Intra-articular injection of HKL-GECM@MPNPs in OA mice reduces inflammation, alleviates joint pain, and mitigates cartilage damage through a synergistic effect. Moreover, HKL-GECM@MPNPs effectively reverse cartilage degeneration in human OA cartilage explants. This approach highlights the potential of HKL-GECM@MPNPs to combine IL-1β blockade and mitochondrial sirtuin-3 restoration as a promising strategy for OA treatment.
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NEW JOURNAL OF CHEMISTRY
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2024
·
IF 2.7
Jiajie Xue,Lingjun Kong,Wei Lin,Jiasheng Zhang,Youzhi Zhu
The development of sensitive breast cancer biomarker (CA 15-3) measurement techniques is of great significance for the early diagnosis and therapeutic monitoring of breast cancer worldwide. Herein, we have designed a split-type photoelectrochemical (PEC) immunoassay platform for the ultrasensitive determination of CA 15-3 using In2O3/ZnIn2S4 heterojunctions with high photovoltaic conversion performance as a photoactive substrate. Efficient photocurrent-responsive In2O3/ZnIn2S4 was formed by surface loading narrow-bandgap ZnIn2S4 on MOF-derived wide bandgap In2O3 nanomaterials. Subsequently, a sandwich immunoreaction was performed using an alkaline phosphatase (ALP)-labeled secondary antibody as a signaling indicator to produce large amounts of ascorbic acid by enzymatic biocatalysis. Since ascorbic acid is an excellent electron donor capable of promoting photogenerated electron separation in semiconductor materials, it enhances the anodic photocurrent of In2O3/ZnIn2S4-modified electrodes. Under the optimal catalyst loading and immunoreaction time, the In2O3/ZnIn2S4-based PEC immunoassay showed a good photocurrent response to CA 15-3 over a wide detection range from 1.0 mU mL−1 to 10 000 mU mL−1 with a limit of detection of 0.45 mU mL−1. Owing to the excellent photocurrent response of In2O3/ZnIn2S4 to ascorbic acid and the split-type immunoassay protocol, the constructed PEC immunosensing platform has the advantages of high precision, anti-interference, and acceptable accuracy, and the results are equivalent to those of commercial enzyme-linked immunosorbent assay (ELISA) kits.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Xuhai Zhu,Xiaobing Li,Rongjun Lin,Rui Lu,Fang Lu
Designing efficient catalysts for the preferential hydrogenation of vinyl groups is a pivotal challenge in the production of pharmaceuticals, agrochemicals, fine chemicals, dyes, and other valuable compounds. Herein, we developed evenly dispersed bimetallic Pd–Co nanoparticles on mesoporous silica nanospheres (MSNs) for selective hydrogenation of a model compound 3-nitrostyrene. By tuning the Pd/Co molar ratio and solvents, the efficiency of 3-nitrostyrene hydrogenation to 3-ethylnitrobenzene with the Pd1–Co1/MSN-Nb catalyst was well optimized; while 3-nitrostyrene was converted entirely, the selectivity of 3-ethylnitrobenzene was up to 95%. Moreover, this catalyst was stable and compatible with styrene and its derivatives. Further characterization results indicated that the combined effect of Pd-based metal nanoparticles and MSN-Nb and the electronic interaction between Pd and Co components in the Pd1–Co1/MSN-Nb catalyst have significant importance in the hydrogenation of 3-nitrostyrene. The aforementioned catalytic system will prove invaluable in guiding the selective hydrogenation of vinyl groups.
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Carbon Energy
·
2025
·
IF 24.2
Pengcheng Wang,Xuqi Lin,Houlin Cheng,Ciqi Yuan,Yongping Zheng,Yingbin Lin,Zhigao Huang,Hao Chen,Jiaxin Li
Na 3 V 2 (PO 4 ) 3 (NVP) is a promising electrode material that exhibits magnetic anisotropy; however, the potential of this magnetic anisotropy to optimize battery performance has been largely unexplored. This study proposes a cost-effective and efficient method to induce the alignment of NVP along the (113) crystal plane by applying a vertical magnetic field during the slurry coating process, thereby enhancing its battery performance. Comprehensive structural characterizations and theoretical analysis elucidate the structure-activity relationship between the preferred crystal orientation and ion transport kinetics, facilitating the formation of more ordered Na + deintercalation pathways in NVP electrodes. This alignment reduces electrode tortuosity, enhances interfacial compatibility, and substantially improves battery performance, particularly in terms of high-rate cycling capability. As a result, the magnetic-field-modulated NVP (NVP−M⊥) electrode exhibits a high capacity retention of 85.1% after 500 cycles at 5 C, significantly surpassing that of the pristine electrode. The NVP−M⊥ electrode also demonstrates considerable reversible capacity at 40 C and maintains excellent stability under high temperature and prolonged cycling conditions. Furthermore, superior battery performance is observed in the assembled NVP−M⊥||hard−carbon pouch cell and commercial NVP electrode following magnetic-field modulation, thereby validating the efficacy of this method. Consequently, this magnetic-field-induced crystal-orientation optimization strategy provides an innovative approach for low-cost and high-throughput preparation of high-performance sodium-ion batteries.
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POLYMER BULLETIN
·
2025
·
IF 4
Zhao Xuan,Yang Liu,Sun Xinyu,Zhou Kun,Yuan Shuai
A novel class of 3-methylphenol alkoxy aluminum complexes was developed for the ring-opening polymerization (ROP) of ε-caprolactone (ε-CL) under mild conditions (60 °C, 30 min). Through systematic optimization of Al/CL molar ratios (5:1000 ~ 4:1000), monomer concentrations (1 mol/L), and reaction parameters, high polymer yield (99.9% ± 0.1%) was achieved, yielding polycaprolactone (PCL) with tunable molecular weights (M n up to 34 kg/mol) and narrow dispersity (PDI = 1.38). Structural characterization via 1 H NMR and FTIR confirmed successful PCL formation. GPC analysis validated controlled chain growth and uniformity (PDI < 1.5), while thermal properties were assessed via DSC and TGA, showing semicrystalline behavior and high thermal stability. Kinetic studies showed linear molecular weight progression with polymer yield, while sequential monomer feeding experiments confirmed living polymerization characteristics, with M n increasing proportionally and maintaining low PDI. Compared to conventional metal-based systems, this catalytic platform operates at lower temperatures with reduced toxicity risks, enabling energy-efficient synthesis of biodegradable polyester for biomedical and packaging applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xinglei Li,Yiyang Shen,Shengye You,Luxuan Shao,Rui Bao,Diya Zhang,Wei Dong,Jun Lin
Available remedies for diabetic oral mucosa wounds often prove inadequate, chiefly due to complications like bacterial infiltration, oxidative harm, and hindered angiogenesis throughout wound restoration. This study addresses the significant gap in effective therapeutic options by developing an injectable hydrogel, DCE1, designed to enhance healing in diabetic oral ulcers. Here, we present DCE1, composed of a polysaccharide matrix of dialdehyde xanthan gum and quaternary chitosan, integrated with epigallocatechin-3-gallate nanoparticles. DCE1 generates a shielding hydrogel barrier when administered locally, exhibiting potent sterilization and reactive oxygen species-clearing properties. Such benefits shift the wound healing process from an inflammatory to a proliferative stage. Notably, the DCE1 dressing is fully biodegradable post-treatment, ensuring complete absorption by the body after fulfilling its therapeutic role. In conclusion, our findings demonstrate that the DCE1 hydrogel significantly accelerates oral mucosa wound repair in both in vitro and in vivo models. This advancement represents a promising therapeutic strategy for diabetic oral ulcers, ultimately contributing to improved clinical outcomes in the management of this challenging condition.
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ACS Applied Nano Materials
·
2021
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IF 5.097
Ying Zheng,Mingqiang Cheng,Xinyan Wu,Shuang Zhang,Zhu Liu,Yanqiang Li,Weiquan Shao,Qing Lin,Jinshan Tan,Shouwu Gao,Yongcheng Zhang,Wanneng Ye
Mechanical energy can be directly transformed into chemical energy by piezoelectric materials, namely, piezocatalysis, which is a potential tactic for renewable clean energy collection and environmental purification. The piezocatalytic efficiency strongly relies on the piezoelectric property and free charge concentration of piezocatalysts. Here, four samarium-doped (1 – x)Pb(Mg1/3Nb2/3)O3-xPbTiO3 nanostructures were designed to investigate the correlation between the piezoelectric property and piezocatalytic performance. The diverse dye degradation efficiencies confirmed the high piezoelectric coefficient toward high catalytic activity. The degradation efficiency for acid orange 7 (AO7) was 100% within 20 min, while those for methyl orange (MO), methylene blue, and rhodamine B dyes were 97, 78, and 72%, respectively, within 40 min under ultrasonic vibration only. Furthermore, high catalytic efficiency of 96% was still maintained for AO7 degradation after 10 consecutive degradation cycles for samarium-doped 0.70Pb(Mg1/3Nb2/3)O3-0.30PbTiO3 due to its high piezoelectric coefficient. The investigation of the catalytic mechanism demonstrated that hole and superoxide radicals were the primary active species toward AO7 degradation, whereas hydroxyl and hole radicals were for MO degradation. This work not only demonstrates the highly efficient catalytic activity of samarium-doped (1 – x)Pb(Mg1/3Nb2/3)O3-xPbTiO3 nanostructures but also gives a deep comprehension of the correlation between the piezoelectric property and catalytic performance of piezocatalysts.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2018
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IF 3.779
Zhi Zhou,Simin Gu,Yongli Zhang,Fangfang Wu,Nan Zhou
NASICON-type NaTi 2 (PO 4 ) 3 has been acknowledged as a promising anode for energy storage due to high ion conductivity and low cost. Nevertheless, intrinsic low electrical conductivity of NaTi 2 (PO 4 ) 3 and low stability in aqueous electrolyte limit its further applications in aqueous lithium rechargeable battery. In this paper, polyaniline as carbon and nitrogen sources was employed to synthesize nitrogen-doped carbon coated NaTi 2 (PO 4 ) 3 (NTP-P) composite by sol-gel approach and following calcination treatment. The loose and carbon-coated structure endows NTP-P with good structure stability and improved electrochemical kinetics . Compared with glucose-derived carbon-coated NaTi 2 (PO 4 ) 3 composite, NTP-P exhibits superior rate and cycling performance. NTP-P with proper carbon content delivers the discharge capacity of 119.4 and 83.4 mAh g −1 at rate of 0.2 and 15 C, and its capacity retention can maintain 85.8% after 1000 cycles at 5 C. This research reveals that the integration of carbon coating and nitrogen doping by using polyaniline give an excellent method to enhance the electrochemical properties of electrode materials.
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APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Keyi Sun,Yuxuan Liu,Wenbin Fei,Yian Wang,Huazhang Guo,Kexin Rao,Mengting Deng,Yulei Sui,Ling Wu
Na 4 MnCr(PO 4 ) 3 , a manganese-based NASICON-type phosphate cathode material, is attracted considerable attention due to its high voltage and energy density. However, its practical application is hindered by poor electronic conductivity and inferior sodium ion diffusion kinetics. In this study, trace La 3+ is utilized to optimize the lattice structure of Na 4 MnCr(PO 4 ) 3 due to its unique energy level structure. La 3+ doping significantly enhances the local environment of the Mn-O bond and stabilizes the lattice structure by improving covalency, thereby mitigating Mn dissolution during charge–discharge cycles. Additionally, the large ionic radius of La 3+ promotes the sodium ion transport kinetics by expanding the cell volume and facilitating rapid sodium storage. As a result, the optimal Na 4 MnCr 0.995 La 0.005 (PO 4 ) 3 /C sample demonstrates an impressive initial discharge specific capacity of 124.5 mAh g −1 at 0.1C and superior cycling stability with a capacity retention of 70.2 % after 500 cycles at 5C. Furthermore, density functional theory calculations indicate that La 3+ doping can enhance conductivity and reduce the energy barrier for sodium ion diffusion. This study presents an effective and cost-efficient doping strategy for modifying high-energy density NASICON-type phosphate cathode materials, showing promising potential in the field of sodium ion batteries.
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Journal of Materials Chemistry A
·
2022
·Vol. 10
·期 21
·11340-11353
·
IF 14.511
Shiqi Sun,Yanjun Chen,Qiang Bai,Que Huang,Changcheng Liu,Shengnan He,Yaxiong Yang,Yanzhong Wang,Li Guo
The emergence of three-dimensional Na3V2(PO4)3 (NVP) has attracted a lot of attention due to its high reversible capacity and long voltage platform. Unfortunately, its popularization and application are limited by its poor intrinsic conductivity. Herein, a convenient sol–gel method is proposed to synthesize potassium/lanthanum/silicon co-substituted NVP. The potassium ions are responsible for extension along the c axis while the other two ions facilitate the expansion of the crystal structure along the other directions. Accordingly, the ternary substitution reduces the resistance existing in the neighboring coordination environment and improves the stability of the crystal framework by enlarging the migration channels for Na+. Significantly, with the simultaneous function of ternary substitution, slight lattice distortions occur in the bulk and more active sites for reversible de-intercalation of Na+ emerge, favorably supplementing the discharge capacity during the period of structural phase transition. Moreover, first-principles calculations demonstrate that the introduction of three heteroatoms could decrease the gap between the conductive and valence bands and reduce the energy barrier for sodium migration. The optimized Na3.03V1.93La0.07(PO4)2.9(SiO4)0.1 possesses a superior sodium storage property in both half- and full-cells. This work reveals the distinctive advantages of ternary substitution on the NVP system through theoretical and experimental methods, contributing to further exploration of other cathode materials.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2023
·
IF 4.5
Qi Qi,Xiaodong Li,Jianquan Liang,Kangyi Chen,Mingxuan Zong,Xinghai Li,Li Zhao,Changsong Dai
NASICON structural materials have the advantages of structural stability, high ion conductivity, and high working potential, which have attracted widespread attention as cathode for sodium-ion batteries. Although the three-electron reaction in the NASICON structure Na 3 MnTi(PO 4 ) 3 increases the specific capacity of the material, poor electronic conductivity remains a key factor restricting its practical application. Herein, Na 3 Mn 1-x Zr x Ti(PO 4 ) 3 /C (x = 0, 0.01, 0.03, 0.05, 0.07 and 0.1), a typical three-dimensional NASICON structure cathode material for sodium-ion batteries, was synthesized by the sol-gel method. Through powder X-ray diffraction, the Zr 4+ doping in the Na 3 MnTi(PO 4 ) 3 (NMTP) structure was verified. It was found that doping trace amounts of Zr at the Mn site can not only reduce the Jahn-Teller effect caused by Mn 3+ , but also strengthen the Zr-O bond compared to the Mn-O bond, making the crystal structure more stable by reducing the proportion of Mn. According to the findings of the EIS test, a suitable amount of Zr doping can enhance the electronic conductivity and Na ion diffusion coefficient of NMTP/C electrode materials, weaken polarization phenomena, increase electrode reaction rate, and significantly improve the rate performance and cycling performance of Na 3 Mn 1-x Zr x Ti(PO 4 ) 3 material. The Na 3 Mn 1-x Zr x Ti(PO 4 ) 3 /C sample prepared has high initial capacity of 124mAh/g, a capacity retention rate of 86 % after 200 cycles at 0.2C, and a capacity retention rate of 84 % after 500 cycles at 1C. This proves that the material still exhibits excellent cycling stability and structural stability after high current cycling. More importantly, the Na 3 Mn 0.95 Zr 0.05 Ti(PO 4 ) 3 (Zr5-NMTP)//Hard carbon full battery also exhibits ideal electrochemical performance.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2019
·
IF 4.833
Wen-Jing Zhu,Ben-Wen Cui,Hui Min Wang,Ji-Xing Nan,Hu-Ri Piao,Li-Hua Lian,Cheng Hua Jin
Six series of 4-(benzo[ c ][1,2,5]thiadiazol-5-yl)-3(5)-(6-methylpyridin-2-yl)- pyrazoles 18a – d , 19a – d , 22a – d and 3(5)-(6-methylpyridin-2-yl)-4-(thieno[3,2,- c ]- pyridin-2-yl)pyrazoles 20a – d , 21a – d , 23c , 23d have been synthesized and evaluated for their activin receptor-like kinase 5 (ALK5) and p38α mitogen activated protein (MAP) kinase inhibitory activities in enzymatic assays. Among these compounds, the most active compound, 22c , inhibited ALK5 phosphorylation with an IC 50 value of 0.030 μM in the enzymatic assay. Compound 22c showed four-fold more potent activity against ALK5 kinase than the clinical candidate, compound LY-2157299 . The selectivity index of 22c against p38α MAP kinase is 235, which is much higher than that of LY-2157299 (4) and equally selective to that of EW-7197 (218). Compound 22c effectively suppressed protein and mRNA expression of collagen I and α-SMA in TGF-β-induced LX-2 human hepatic stellate cell (HSC), this result shows that compound 22c has the ability to inhibit the activation of HSC. Compound 22c is expected to be a preclinical candidate for the treatment of hepatic fibrosis .
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