CHINESE SCIENCE BULLETIN
·
2013
·Vol. 59
·期 2
·147-153
·
IF 1.319
Wang Wei,Yan Xiao Li,Zhan Lei,Leng Fei,Yang Xiao Xi,Huang Cheng Zhi
A new type of highly selective aptamer-labeled fluorescent silica nanoparticles [Apt-tris(2,2′-bipyridyl)ruthenium(II)@SiO 2 NPs] were prepared through the reverse microemulsion method by using prolonged fluorescence lifetime ruthenium complexes of tris(2,2′-bipyridyl)ruthenium(II) (Ru(bpy)
2+ 3
) as the source of the fluorescence for cellular prion protein imaging. Investigations showed that the newly prepared Ru(bpy)
2+ 3
@SiO 2 NPs possessed superior advantages of strong fluorescence, low toxicity, and easy surface modification for bioconjugation. Cell imaging experiments indicated that Apt-Ru(bpy)
2+ 3
@SiO 2 NPs had great tendency to human bone marrow neuroblastoma cells (SK-N-SH cells), since they can express large amount of prion protein on the surface of the cell, while in HeLa cells this phenomenon disappeared for the reason that HeLa cells cannot express prion proteins.
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NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Yuan Zhou,Wenyue Jiao,Lei Tan,Yan Hao,Yicheng Wang,Tingrui Lin,Huazheng Sai
A superhydrophobic sponge (GO-g-PBA/APTES/MS) was fabricated through a facile and cost-effective dipping method. The as-prepared GO-g-PBA/APTES/MS adsorbed a broad variety of oils and organic solvents and exhibited high oil adsorption capacity (67.4–163.3 g g−1). The GO-g-PBA/APTES/MS could be utilized as an efficient filter for continuous oil/water separation with the assistance of a peristaltic pump. Meanwhile, this superhydrophobic sponge could be easily recovered by simple squeezing and reused for at least 70 cycles, maintaining a high adsorption capacity. Furthermore, GO-g-PBA/APTES/MS displayed superior stability in corrosive liquids such as acidic, alkaline, and salty environments. These results provided a useful avenue for utilization of the GO-g-PBA/APTES/MS, demonstrating the potential for applications in oil/water separation and oil spill collection.
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MOLECULAR MEDICINE
·
2023
·Vol. 29
·期 1
·1-13
·
IF 5.7
Zhuang Huangming,Ren Xunshan,Jiang Fuze,Zhou Panghu
Background Osteoarthritis (OA) is a common chronic disease characterized by chronic inflammation and extracellular matrix degradation. Indole-3-propionic acid (IPA) is a tryptophan metabolite secreted by intestinal flora, which can exert anti-inflammatory effects in a variety of diseases. In this study, we further investigated the potential therapeutic role of IPA in OA and the underlying mechanism.Methods IL-1β was utilized to induce chondrocyte inflammation. Then, the cytotoxicity of IPA on rat chondrocytes was assessed. Meanwhile, RT-qPCR, Griess reaction, ELISA, Western blot and immunofluorescence were performed to evaluate the expression of inflammatory factors and stromal proteins, and the NF-κB pathway in chondrocytes treated with IL-1β alone, with IPA or with aryl hydrocarbon receptor (AhR) knockdown. An OA rat model was established by anterior cruciate ligament transection, and hematoxylin-eosin staining, Safranin-O/Fast Green staining and immunochemistry were applied to estimate OA severity.Results IPA did not affect cellular viability at concentrations up to 80 µM. IPA significantly inhibited the IL-1β-induced expression of inflammatory factors (Nitric oxide, PGE2, TNF-α, IL-6, iNOS and COX-2) and matrix-degrading enzymes (MMP-3, MMP-13 and ADAMTS-5), upregulated the expression of anabolic markers (aggrecan and collagen-II) and inactivated the NF-κB pathway. However, AhR knockdown could abolish the above protection capabilities and the suppression of the NF-κB pathway induced by IPA. Furthermore, IPA significantly reduced serum inflammatory cytokines expression, cartilage destruction and synovitis in vivo, demonstrating its protective role in OA progression.Conclusion IPA improved IL-1β-induced chondrocyte inflammation and extracellular matrix degradation through the AhR/NF-κB axis, which provides an innovative therapeutic strategy for OA.
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Journal of Superconductivity and Novel Magnetism
·
2025
·Vol. 38
·期 2
·112
·
IF 1.7
Li Xiaofeng,Gao Yuxia,Tian Zhaoming,Ren Weijie,Sun Xin,Wang Mingli
KNi(PO 3 ) 3 was successfully synthesized by solid-state method and the magnetic properties were characterized. The crystal structure of KNi(PO 3 ) 3 belongs to trigonal crystal system with space group R 3, where Ni 2+ ions form the distorted honeycomb-lattice within the ab-plane stacking in the “ABAB” type fashion along the c -axis. Magnetization measurements reveal the presence of antiferromagnetic (AFM) interaction with Curie Weiss (CW) temperature θ CW = − 12.905 K but without long-range magnetic order down to 2 K. Notably, the CW fitted effective moment µ eff = 3.35µ B and saturated magnetization M S = 2 μ B /Ni 2+ at 2 K support KNi(PO 3 ) 3 as an S = 1 spin system. Intriguingly, the zero-field specific heat exhibits a broad peak maximized at ~ 2.5 K indicating the onset of short-range spin correlation between Ni 2+ ions, while the integrated magnetic entropy ( S mag ) is close to the expected Rln3 for S = 1 system, indicative of large spin fluctuation below 2 K driven by spin frustration.
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POULTRY SCIENCE
·
2025
·
IF 4.2
Qiyue Zhang,Yue Wang,Yanwei Wang,Jielu Yuan,Yaru Wang,Yongqi Zeng,Haihua Zhang,Hui Yang,Qiugang Ma,Donghui Shi,Shimeng Huang
This study investigates the effects of 3-indoleacrylic acid (IAA), a bacterial metabolite of tryptophan, on LPS-induced liver injury in laying hens. The aim is to explore the potential hepatoprotective mechanisms of IAA, particularly through the modulation of inflammatory and antioxidant pathways. A total of 48, 24-week-old No. 6 Jingfen laying hens were randomly divided into four groups of 12 hens each: the CON group (basal diet), IAA group (basal diet + 150 mg/kg IAA), LPS group (basal diet), and IAA+LPS group (basal diet + 150 mg/kg IAA). The feeding period lasted 8 weeks, and at the end of the 8th week, the laying hens in the LPS and IAA+LPS groups were intraperitoneally injected with 0.5 mg/kg LPS. The four groups were uniformly slaughtered and sampled 12 hours after LPS injection. The expression of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6) was significantly alleviated ( P < 0.05), and antioxidant enzymes (T-SOD, CAT, GSH-PX) were significantly elevated ( P < 0.05) in the serum and liver of the IAA+LPS group. Histological analysis revealed reduced hepatocyte necrosis and inflammation in the IAA-treated groups ( P < 0.05). Additionally, the activation of MAPK and Toll-like receptor (TLR) signaling pathways was modulated through transcript analyses, thereby reducing inflammation and oxidative stress. In summary, IAA effectively mitigates liver inflammation and oxidative stress through the regulation of MAPK and TLR signaling pathways, providing a promising strategy for improving liver health in hens. This study represents the first report on the application of IAA in poultry, demonstrating its potential as a novel therapeutic agent for alleviating liver injury.
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ACS Applied Nano Materials
·
2021
·
IF 5.097
Ying Zheng,Mingqiang Cheng,Xinyan Wu,Shuang Zhang,Zhu Liu,Yanqiang Li,Weiquan Shao,Qing Lin,Jinshan Tan,Shouwu Gao,Yongcheng Zhang,Wanneng Ye
Mechanical energy can be directly transformed into chemical energy by piezoelectric materials, namely, piezocatalysis, which is a potential tactic for renewable clean energy collection and environmental purification. The piezocatalytic efficiency strongly relies on the piezoelectric property and free charge concentration of piezocatalysts. Here, four samarium-doped (1 – x)Pb(Mg1/3Nb2/3)O3-xPbTiO3 nanostructures were designed to investigate the correlation between the piezoelectric property and piezocatalytic performance. The diverse dye degradation efficiencies confirmed the high piezoelectric coefficient toward high catalytic activity. The degradation efficiency for acid orange 7 (AO7) was 100% within 20 min, while those for methyl orange (MO), methylene blue, and rhodamine B dyes were 97, 78, and 72%, respectively, within 40 min under ultrasonic vibration only. Furthermore, high catalytic efficiency of 96% was still maintained for AO7 degradation after 10 consecutive degradation cycles for samarium-doped 0.70Pb(Mg1/3Nb2/3)O3-0.30PbTiO3 due to its high piezoelectric coefficient. The investigation of the catalytic mechanism demonstrated that hole and superoxide radicals were the primary active species toward AO7 degradation, whereas hydroxyl and hole radicals were for MO degradation. This work not only demonstrates the highly efficient catalytic activity of samarium-doped (1 – x)Pb(Mg1/3Nb2/3)O3-xPbTiO3 nanostructures but also gives a deep comprehension of the correlation between the piezoelectric property and catalytic performance of piezocatalysts.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2023
·
IF 4.5
Qi Qi,Xiaodong Li,Jianquan Liang,Kangyi Chen,Mingxuan Zong,Xinghai Li,Li Zhao,Changsong Dai
NASICON structural materials have the advantages of structural stability, high ion conductivity, and high working potential, which have attracted widespread attention as cathode for sodium-ion batteries. Although the three-electron reaction in the NASICON structure Na 3 MnTi(PO 4 ) 3 increases the specific capacity of the material, poor electronic conductivity remains a key factor restricting its practical application. Herein, Na 3 Mn 1-x Zr x Ti(PO 4 ) 3 /C (x = 0, 0.01, 0.03, 0.05, 0.07 and 0.1), a typical three-dimensional NASICON structure cathode material for sodium-ion batteries, was synthesized by the sol-gel method. Through powder X-ray diffraction, the Zr 4+ doping in the Na 3 MnTi(PO 4 ) 3 (NMTP) structure was verified. It was found that doping trace amounts of Zr at the Mn site can not only reduce the Jahn-Teller effect caused by Mn 3+ , but also strengthen the Zr-O bond compared to the Mn-O bond, making the crystal structure more stable by reducing the proportion of Mn. According to the findings of the EIS test, a suitable amount of Zr doping can enhance the electronic conductivity and Na ion diffusion coefficient of NMTP/C electrode materials, weaken polarization phenomena, increase electrode reaction rate, and significantly improve the rate performance and cycling performance of Na 3 Mn 1-x Zr x Ti(PO 4 ) 3 material. The Na 3 Mn 1-x Zr x Ti(PO 4 ) 3 /C sample prepared has high initial capacity of 124mAh/g, a capacity retention rate of 86 % after 200 cycles at 0.2C, and a capacity retention rate of 84 % after 500 cycles at 1C. This proves that the material still exhibits excellent cycling stability and structural stability after high current cycling. More importantly, the Na 3 Mn 0.95 Zr 0.05 Ti(PO 4 ) 3 (Zr5-NMTP)//Hard carbon full battery also exhibits ideal electrochemical performance.
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OPTICAL MATERIALS
·
2022
·
IF 3.754
Yuanjie Wang,Tengfei Cao,Zhihuang Xu,Liwang Ye,Xinxin Zhuang
Organic-inorganic hybrid halides (OIHs) have attracted widespread attention because of their exceptional optoelectronic properties. In particular, Mn 2+ -based hybrid halides show intense green or red emission, which benefit from distinct d-d optical transition in Mn 2+ . This work deals with the dual-emission in two novel hybrid single-crystals (N-AEP)[MnCl 3 (H 2 O) 3 ] 2 ·Cl ( 1 ) and [(N-AEP) 2 MnCl 6 ]·2Cl ( 2 ) (N-AEP 3+ = C 6 H 18 N 3 3+ ). Luminescence properties studies indicate that the low-energy emission is assigned to the Mn 2+ -based octahedron , while the high-energy emission ascribes to the organic cation [N-AEP] 3+ . Inorganic polyhedron transformation ([MnCl 3 (H 2 O) 3 ] - to [MnCl 6 ] 4- ) increased the luminescent intensity, which benefited from the weaker nonradiative transition in [MnCl 6 ] 4- octahedron. Significantly, by finely adjusting the excitation wavelength, complex 2 showed tunable emission properties, realizing the transition from “warm” white light (0.40, 0.33) to “cold” white light (0.28, 0.28). This paper offers a new example on the effective design of dual-emission materials.
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Journal of Materials Chemistry A
·
2022
·Vol. 10
·期 21
·11340-11353
·
IF 14.511
Shiqi Sun,Yanjun Chen,Qiang Bai,Que Huang,Changcheng Liu,Shengnan He,Yaxiong Yang,Yanzhong Wang,Li Guo
The emergence of three-dimensional Na3V2(PO4)3 (NVP) has attracted a lot of attention due to its high reversible capacity and long voltage platform. Unfortunately, its popularization and application are limited by its poor intrinsic conductivity. Herein, a convenient sol–gel method is proposed to synthesize potassium/lanthanum/silicon co-substituted NVP. The potassium ions are responsible for extension along the c axis while the other two ions facilitate the expansion of the crystal structure along the other directions. Accordingly, the ternary substitution reduces the resistance existing in the neighboring coordination environment and improves the stability of the crystal framework by enlarging the migration channels for Na+. Significantly, with the simultaneous function of ternary substitution, slight lattice distortions occur in the bulk and more active sites for reversible de-intercalation of Na+ emerge, favorably supplementing the discharge capacity during the period of structural phase transition. Moreover, first-principles calculations demonstrate that the introduction of three heteroatoms could decrease the gap between the conductive and valence bands and reduce the energy barrier for sodium migration. The optimized Na3.03V1.93La0.07(PO4)2.9(SiO4)0.1 possesses a superior sodium storage property in both half- and full-cells. This work reveals the distinctive advantages of ternary substitution on the NVP system through theoretical and experimental methods, contributing to further exploration of other cathode materials.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2014
·
IF 2.129
Ke Zhang,Zheng-yin Yang,Bao-dui Wang,Shao-Bo Sun,Ying-Dong Li,Tian-rong Li,Zeng-chen Liu,Jun-mei An
A new Schiff-base ligand ( 1 ) with good fluorescence response to Al 3+ , derived from 2-oxo-quinoline-3-carbaldehyde and nicotinic hydrazide, had been synthesized and investigated in this paper. Spectroscopic investigation revealed that the compound 1 exhibited a high selectivity and sensitivity toward Al(III) ions over other commonly coexisting metal ions in ethanol, and the detection limit of Al 3+ ions is at the parts per billion level. The mass spectra and Job’s plot confirmed the 1:1 stoichiometry between 1 and Al 3+ . Potential utilization of 1 as intracellular sensors of Al 3+ ions in human cancer (HeLa) cells was also examined by confocal fluorescence microscopy.
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JOURNAL OF PHYSICAL CHEMISTRY B
·
2011
·
IF 3.603
Jianji Wang,Lamei Zhang,Huiyong Wang,Changzeng Wu
Material preparation in ionic liquids and environmental pollution control by ionic liquids are often closely dependent on the aggregation behavior of ionic liquids in solution. In the present work, conductivity, fluorescence probe, and dynamic light scattering techniques have been used to study the effect of organic solvents on the aggregation behavior of 1-dodecyl-3-methylimidazolium bromide in water. It was shown that the critical aggregation concentration (CAC), the ionization degree of the aggregates (α), and the standard Gibbs energy of aggregation (ΔGm°) of the ionic liquid increase, while its aggregation number (Nagg) and aggregates’ size decrease with increasing concentration of organic additives in water. These results have been discussed from the favorable interactions of alkyl chain of the ionic liquid with the mixed solvents. It is suggested that the solvophobic parameter, characterized quantitatively by Gibbs energy of transfer of hydrocarbon from gas into a given solvent, can be used to account for the effect of organic additives on the formation and growth of the ionic liquid aggregates in water. Aggregation behavior of ionic liquids in aqueous organic solutions can be modulated simply by the solvophobic parameters of hydrocarbon in the mixed solvents.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2019
·
IF 4.833
Wen-Jing Zhu,Ben-Wen Cui,Hui Min Wang,Ji-Xing Nan,Hu-Ri Piao,Li-Hua Lian,Cheng Hua Jin
Six series of 4-(benzo[ c ][1,2,5]thiadiazol-5-yl)-3(5)-(6-methylpyridin-2-yl)- pyrazoles 18a – d , 19a – d , 22a – d and 3(5)-(6-methylpyridin-2-yl)-4-(thieno[3,2,- c ]- pyridin-2-yl)pyrazoles 20a – d , 21a – d , 23c , 23d have been synthesized and evaluated for their activin receptor-like kinase 5 (ALK5) and p38α mitogen activated protein (MAP) kinase inhibitory activities in enzymatic assays. Among these compounds, the most active compound, 22c , inhibited ALK5 phosphorylation with an IC 50 value of 0.030 μM in the enzymatic assay. Compound 22c showed four-fold more potent activity against ALK5 kinase than the clinical candidate, compound LY-2157299 . The selectivity index of 22c against p38α MAP kinase is 235, which is much higher than that of LY-2157299 (4) and equally selective to that of EW-7197 (218). Compound 22c effectively suppressed protein and mRNA expression of collagen I and α-SMA in TGF-β-induced LX-2 human hepatic stellate cell (HSC), this result shows that compound 22c has the ability to inhibit the activation of HSC. Compound 22c is expected to be a preclinical candidate for the treatment of hepatic fibrosis .
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