CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Yuhui Huang,Yehan Tao,Xifan Yuan,Jinwen Hu,Jian Du,Chenglong Fu,Jie Lu,Yanna Lv,Haisong Wang
Cobalt-based catalysts have demonstrated significant potential for the selective electrooxidation of biomass-derived 5-hydroxymethylfurfural (5-HMF) into high-value 2,5-furandicarboxylic acid (FDCA). However, monometallic systems suffer from sluggish redox kinetics of cobalt species and insufficient reactant adsorption. In this study, we address these limitations by constructing a niobium oxide-supported cobalt‑copper bimetallic catalyst (CoCu/Nb₂O₅), leveraging bimetallic synergy and interface engineering to enhance catalytic activity. The incorporation of copper species facilitates efficient electron transfer between cobalt species of different valence states, while the Nb₂O₅ support strengthens electronic interactions with 5-HMF molecules and enables lattice oxygen participation in the reaction. Furthermore, the porous structure of the support improves bimetallic dispersion and provides enhanced mass transport pathways. The optimized CoCu/Nb₂O₅ catalyst achieves complete 5-HMF conversion and a remarkable 98.3 % FDCA yield at 1.4 V vs RHE, alongside excellent stability and reusability. Additionally, the catalyst demonstrates versatility by efficiently converting furfural into furoic acid, another biomass-derived platform molecule. This work offers valuable insights for designing advanced cobalt-based electrocatalysts and promotes the valorization of biomass resources.
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Journal of Physical Chemistry C
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2025
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IF 3.2
Hao Yuan,Xiaoxue Han,Zhizheng Sheng,Jian Zhou,Zhendong Wang,Yingchun Ye,Yongfeng Hu,Weimin Yang
Zeolites have been widely employed in industrial catalysis, but the application of zeolites was often limited by their hydrothermal stability. As a successfully applied method for enhancing hydrothermal stability of zeolites, phosphorus (P) modification has been faced with issues such as polymerization and low utilization of P precursor. In this work, we developed a strategy for the P modification of zeolites via trimethylphosphine oxide (TMPO) selective adsorption. Thanks to its alkaline property, TMPO could be adsorbed selectively on the acid sites of zeolites and maintains strong interaction with framework aluminum during further redistribution and oxidation treatments. Extensive characterizations, such as 27Al and 31P MAS NMR, pyridine-FTIR, and P K-edge XANES, were employed to study the transformation of P–Al interaction in zeolites during hydrothermal treatment. It was revealed that the P species adsorbed on strong acid sites were beneficial to the production of a stronger P–Al interaction. Hydrothermal experimental results proved that the P-modified zeolites with a stronger P–Al interaction exhibited higher retention of Bro̷nsted acid sites, resulting from the greatly reduced polymerization of P to protect more framework aluminum. Our approach demonstrates the potential of TMPO modification in controlling P–Al interaction to enhance the hydrothermal stability of zeolites for the methanol to hydrocarbon reaction.
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MICROPOROUS AND MESOPOROUS MATERIALS
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2025
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IF 4.7
Zhang Yanting,Ding Yunlong,Guo Yunya,Wang Wenfeng,Li Xiaofeng,Dou Tao
The development of mesoporogen-free synthetic routes for hierarchical ZSM-5 zeolites is critical to advancing their application in diffusion-constrained catalytic processes such as heavy oil cracking. Here, we develop a mesoporogen-free strategy through synergistic control of seed solution temperature (70-170 °C) and addition amount (0.8-50 wt%). The synthesized zeolites were characterized using techniques such as X-ray Diffraction (XRD), Scanning electron microscope (SEM), Transmission electron microscopy (TEM), N 2 adsorption-desorption, ammonia temperature-programmed desorption (NH 3 -TPD), and pyridine-infrared (Py-IR). The results show that the sample is rich in mesopores and has well-preserved microporosity. Control experiments under TPAOH conditions equivalent to the seed solution addition amounts and with room-temperature-dried seed solids equivalent to the seed solution were conducted to highlight the critical role of seed solutions. Notably, seed solutions stored for three months retained their effectiveness in synthesizing phase-pure ZSM-5 zeolites, demonstrating exceptional stability. In tetralin (heavy oil model) cracking tests, the optimized zeolite (HZ-T100-A50) achieved 90 % conversion within 2 hours, which is 20 % higher than HZ-T100-A0.8, attributed to enhanced reactant accessibility. This study not only provides an eco-friendly method for synthesizing hierarchical ZSM-5 zeolites without mesoporous templates but also deepens the understanding of seed solution impacts, offering an important basis for optimizing zeolites synthesis and application.
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FUEL
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2024
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IF 6.7
Jing Zhang,Xun Kuang,Linyu Zhu,Xintong Xiao,Zhongyue Zhou,Fei Qi
Despite the crucial roles of cyclohexanones across various industrial sectors, notably in the production of nylon and plastics, their conventional production heavily relies on fossil resources. The exploration of highly efficient routes to convert renewable biomass into cyclohexanones holds promise for advancing sustainable chemical processes, especially with the growing concerns in energy and the environment. Herein, we report the direct conversion of lignin-derived phenolic compounds to cyclohexanones through hydrodeoxygenation using PdFe/HZSM-5 catalysts. The successful achieved conversion of guaiacol was up to 97.27%, with a greatest selectivity of 90.59% to cyclohexanone on PdFe1.5/HZSM-5. Characterization of the catalysts further revealed that bimetallic catalyst promoted the dispersion of PdFe on HZSM-5 and facilitated the interactions between PdFe because of electron transfer, which collectively facilitated surprising outcomes. This work offers a promising strategy for improving lignin valorization within the context of producing sustainable chemicals and industrial materials.
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APPLIED CATALYSIS A-GENERAL
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2025
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IF 4.8
Ting Wu,Xiang Zhang,Hongju Liang,Quan Wang,Chun-Ling Liu,Wen-Sheng Dong
The design of highly efficient and cost-effective catalysts for the conversion of biomass-derived 5-hydroxymethylfurfural (5-HMF) into sustainable liquid fuel 2,5-dimethylfuran (DMF) is both important and challenging. In this study, we developed a non-noble Co catalyst supported on SBA-15 (25Co/SBA-15). Our results demonstrate that this catalyst exhibits remarkable efficiency in selectively hydrodeoxygenating 5-HMF to DMF, achieving a DMF yield of 96.3 % with complete conversion of 5-HMF under mild reaction conditions (150 °C, 2.0 MPa H 2 for 2 h). Notably, the productivity rate of DMF reached an exceptional value of 19.1 mmol·gcat −1 ·h −1 , surpassing most previously reported catalysts in literature. Additionally, by utilizing two distinct solvents - N,N-dimethylformamide (N,N-DMF) resulting in a high yield of 2,5-bis(hydroxymethyl)furan (BHMF) and tetrahydrofuran (THF) yielding an even higher yield of DMF - our approach enables facile switching between these two products during hydrogenation over the Co/SBA-15 catalyst. Furthermore, our catalyst demonstrates excellent reusability and can be easily regenerated through calcination in air. The exceptional catalytic performance of the catalyst can be ascribed to the synergistic effect between metallic Co and adjacent Lewis acidic Co 2+ in CoO dispersed on the surface of SBA-15. A dual-site Langmuir–Hinshelwood–Hougen–Watson (LHHW) model was proposed for the hydrodeoxygenating 5-HMF to DMF.
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BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
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2024
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IF 1.9
Liu Lilong,Wang Yexin,Dong Yanyan,Lin Shan,Guan Wenhui,Song Jia
The clinical application of 5-fluorouracil (5-Fu), a potent chemotherapeutic agent, is often hindered by its well-documented cardiotoxic effects. Nevertheless, natural polyphenolic compounds like resveratrol (RES), known for their dual anti-tumor and cardioprotective properties, are potential adjunct therapeutic agents. In this investigation, we examined the combined utilization of RES and 5-Fu for the inhibition of gastric cancer using both in vitro and in vivo models, as well as their combined impact on cardiac cytotoxicity. Our study revealed that the co-administration of RES and 5-Fu effectively suppressed MFC cell viability, migration, and invasion, while also reducing tumor weight and volume. Mechanistically, the combined treatment prompted p53-mediated apoptosis and autophagy, leading to a considerable anti-tumor effect. Notably, RES mitigated the heightened oxidative stress induced by 5-Fu in cardiomyocytes, suppressed p53 and Bax expression, and elevated Bcl-2 levels. This favorable influence enhanced primary cardiomyocyte viability, decreased apoptosis and autophagy, and mitigated 5-Fu-induced cardiotoxicity. In summary, our findings suggested that RES holds promise as an adjunct therapy to enhance the efficacy of gastric cancer treatment in combination with 5-Fu, while simultaneously mitigating cardiotoxicity.
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PubMed
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CATALYSIS LETTERS
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2024
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IF 2.3
Xu Xian,Lan Ling,Xu Jiangong,Liang Zheng,Tan Jin,Wang Haiyong,Qiu Songbai
The development of biodegradable materials from biomass is a crucial strategy for leveraging biomass resources. A key component in this process is 2,5-bis(hydroxymethyl)furan (BHMF), a significant biomass-derived platform chemical. However, producing BHMF with high selectivity through the selective hydrogenation of 5-hydroxymethylfurfural, while avoiding the creation of unwanted byproducts, is a complex challenge. In our research, we have developed a novel catalyst featuring a magnetic core. This catalyst, which consists of platinum loaded onto a graphene-like shell, has been applied to the catalytic hydrogenation of HMF in an aqueous environment. Under the optimized conditions of 373 K, 3 MPa H 2 , and 1 h reaction time, a BHMF yield exceeding 99% was achieved. This method presents a promising and effective approach for the high-value conversion of biomass waste into polymer materials and pharmaceutical chemicals. Graphical Abstract
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JOURNAL OF MOLECULAR LIQUIDS
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2024
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IF 5.3
Xiao-Ping Zheng,Xin-Yu Tian,Yu Chai,Ya-Peng Du,Yu-Cang Zhang,Yan-Zhen Zheng
This study explores an efficient catalytic system for the conversion of chitosan into 5-hydroxymethylfurfural (5-HMF) under hydrothermal conditions. The catalysts used are deep eutectic solvents (DESs) comprising choline chloride (ChCl) as the hydrogen bond acceptor (HBA) and various organic acids as the hydrogen bond donor (HBD). Among the DESs tested, the ChCl: oxalic acid (OA) combination exhibits the highest catalytic activity, resulting in a yield of 27.5% 5-HMF employed the optimized conditions. To elucidate the interaction between ChCl and OA, various analytical techniques were employed, including quantum chemical calculations, nuclear magnetic resonance (NMR), and Fourier transform infrared spectroscopy (FTIR). These investigations confirmed the formation of strong hydrogen-bonds between ChCl and OA. Furthermore, the solid residues obtained during the conversion process were characterized using FTIR, X-ray diffraction (XRD), and scanning electron microscopy (SEM). These analyses provide insights into the chemical structures and morphologies of the residues, revealing the gradual conversion of chitosan, along with the formation of humin by-products.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2024
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IF 3.8
Hongyu Qu,Xiangcheng Li,Xiao Han,Junjie Li,Xinqiang Feng,Chuang Liu,Zhendong Wang,Weimin Yang
Rational design of highly efficient non-noble-metal catalysts for the selective hydrogenolysis of biomass platform compounds to produce fuels and fine chemicals is a key pursuit for the sustainable chemical industry. In this work, we report for the first time the synthesis of a Ni-supported germanosilicate zeolite (Ni-SCM-14) catalyst by a simple grinding method, showing both satisfactory yield (90.3%) and good stability in eight cycles for the hydrogenolysis of 5-hydroxymethylfurfural (HMF) to 2,5-dimethylfuran (DMF). Characterization revealed that Ni nanoparticles were highly dispersed on the SCM-14 zeolite with strong interactions. The synergistic effect of highly dispersed Ni hydrogenation sites and the weak acidity activation of the C–O bond provided by SCM-14 is considered to be the key to the efficient hydrogenolysis of HMF. This discovery opens up a new avenue for germanosilicate zeolite to activate the C–O bond.
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CATALYSIS TODAY
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2024
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IF 5.2
Chengfeng Yi,Jingwen Li,Zhigang Liu
NiS X stands out in the electrochemical oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA) due to the favorable conductivity and diverse chemical composition. However, NiS X usually exhibits few exposed active sites and poor charge transfer kinetics. Moreover, during the electrochemical oxidation of HMF, the conductivity of the catalyst would decrease rapidly with the formation of oxidized Ni species, leading to a rapid decline in catalytic performance. Therefore, a series of NiS X /carbon black (CB) hybrids (NiS X /CB-n) were synthesized via a one-step solvent hydrothermal method in which NiS X displayed a large cubic block structure assembled from small nanosheets. Among the prepared catalysts, NiS X /CB-2, with the optimal amount of introduced CB, exhibited superior electrocatalytic activity for the oxidation of HMF, achieving 100% HMF conversion, 98% FDCA yield, and 100% Faradaic efficiency at 1.45 V (vs. RHE). The outstanding electrocatalytic activity of NiS X /CB-2 was attributed to the suitable CB doping, which not only enhanced the conductivity of catalyst but also separated the small nanosheets, preventing the formation of densely packed NiS X structure and increasing the specific surface area of catalyst, thereby exposing more active sites and improving the availability of material. Furthermore, the formation of C-S bonds facilitated charge interactions between NiS X and CB, promoting the transfer of charges during the electrolysis process and enhancing electrocatalytic kinetics. Open circuit potential tests demonstrated that the introduction of CB also strengthened the adsorption capacity of catalyst for HMF, further benefiting its electrocatalytic activity.
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BIOORGANIC CHEMISTRY
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2021
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IF 5.275
Fang Guo,Tao Xia,Ping Xiao,Qingyue Wang,Zhitong Deng,Wang Zhang,Guowang Diao
Pillar[5]arene complexes of the naturally occurring compound bisdemethoxycurcumin (BDMC) were acquired for improving the water solubility and stability of BDMC. As a family member of curcuminoid compounds, BDMC has many interesting therapeutic properties. However, its low aqueous solubility and stability resulted in poor availability and restricted the clinical efficacy. Pillar[5]arenes with hydrophilic ends and a hydrophobic cavity could include with BDMC based on size matching. The synthesized hydrazide-pillar[5]arene (HP5A) and BDMC had a strong host–guest interaction with a 1:1 binding stoichiometry. Furthermore, the HP5A ⊃ BDMC complex could self-assemble into well-defined fibers in water/ethanol solution. This supramolecular complex worked well in vitro for inhibiting the proliferation of hepatoma carcinoma cells HepG2. Remarkably, this method of complexation with pillar[5]arenes visibly reduced the undesirable side effects on normal cells without weakening the anti-cancer activity of the drugs. We expected that the obtained host–guest complex and fibrous assembly would provide a promising platform for delivering drugs with low water solubility.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2021
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IF 5.279
Hua Yang,Leqiong Jin,Dengqi Zhao,Zhifeng Lian,Manikandan Appu,Jianying Huang,Zibin Zhang
An omnipresent pathogenic bacterium, Pseudomonas aeruginosa (P. aeruginosa PAO1), is easy to contaminate environmental water or foods, causing daily food spoilage and infections. The biofilm-forming ability and bacterial resistance of P. aeruginosa PAO1 make it difficult to be eradicated by traditional bacteriostatic agents. In this work, we designed and synthesized a pyridinium-based pillar[5]arene (PP5), while trimethylammonium-based pillar[5]arene (TP5) was used as a control compound. After clear characterization, the antibacterial and antibiofilm activities as well as the microbial resistance of TP5 and PP5 against P. aeruginosa PAO1 were extensively examined. It was revealed that PP5 exhibited good inhibition activity with the minimum inhibitory concentration (MIC) of 0.051 mmol/L, while no significant antibacterial and biofilm formation activity for TP5 against P. aeruginosa PAO1 was observed. More importantly, PP5 had negligible antimicrobial resistance even after 18th passages. A transmission electron microscope (TEM) showed that PP5 could physically disrupt the cell membranes, causing the leakage of internal constituents, which is possibly ascribed to the synergistic penetrability and π–π interactions of strain, thus greatly reduced the development of bacterial resistance. Overall, the presented studies indicated that pyridinium moieties could facilitate the cationic pillar[5]arene to generate surprising antibacterial and antibiofilm formation ability against P. aeruginosa PAO1.
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PubMed
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