CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Wen Xu,Shiwen Dong,Haijun Cheng,Stefanos Giannakis,Xiaohui Lu,Zhiqiao He,Da Wang,Shuang Song,Jun Ma
Mixed refractory organic wastewater containing both organic molecular and nanoparticle contrast agents poses a significant challenge for wastewater treatment. In this study, heterogeneous catalytic ozonation (HCO) technology was employed, creatively using the nanoparticle contrast agent Mn 3 O 4 /SiO 2 /C as a catalyst for the degradation of the organic molecular contrast agent iopamidol (IPM). This study aims to provide new insights and approaches to address the challenge of mixed contrast agent treatment in medical wastewater through a “treat-waste-with-waste” strategy. Mn 3 O 4 /SiO 2 /C exhibited an excellent IPM degradation efficiency, reaching 99.3 % within 30 min, compared with only 9.6 % IPM removal in the absence of catalyst ([cat] = 0.1 g L −1 , [IPM] 0 = 5 μM, [O 3 ] 0 = 3 mg L −1 , at pH 6.8 and 278 K). The Mn 3 O 4 , SiO 2 , and C in Mn 3 O 4 /SiO 2 /C were extensively integrated, and the proportion of Mn(II) in Mn 3 O 4 /SiO 2 /C was 39.9 %, as compared to 33.1 % in Mn 3 O 4 , which facilitated the generation of hydroxyl radicals. The siloxide and carbonaceous materials in Mn 3 O 4 /SiO 2 /C provided abundant sites for ozone adsorption and pollutant enrichment, promoting interfacial ozone contact with pollutants and subsequent catalytic reactions. The presence of structures such as Mn-O-Si and Mn-O-C in the material helps accelerate electron transfer, thus promoting electron capture and ozone decomposition. This strategy provides new insights for refractory pollutant elimination and serves as a guide for advancing green catalysis in water purification.
✓ 已验证
产品关联
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Zhuang Wang,Dongping Su,Ting Luo,Qiao Yu,Yiting Wang,Xingyue Liu,Xuanhao Huang,Songdong Ding
The separation of thorium from uranium and rare earths is of great significance for a thorium molten salt reactor nuclear energy system. Herein, a novel Aliquat 336@SiO2–P extraction resin, prepared by the in situ encapsulation of an amine-based ionic liquid (Aliquat 336) into a porous silica–polymer matrix at the same time as the polymerization, was developed for the highly selective separation of Th(IV) over U(VI) and rare earth ions. Batch adsorption studies showed that the prepared Aliquat 336@SiO2–P extraction resin has excellent selectivity, strong adsorption affinity, and high adsorption capacity for Th(IV). The adsorption process of Th(IV) follows pseudo-second-order kinetics and the Langmuir model, and the adsorption of Th(IV) is a monolayer-type, chemical, exothermic, and spontaneous process with increased entropy, achieving a maximum Th(IV) adsorption capacity (qmax) of 52.4 mg/g. Thorium is adsorbed as a complex anion in an HNO3 solution, and its adsorption conforms to the anion exchange mechanism. Furthermore, column experiments indicated that Th(IV) can be selectively separated from simulated monazite HNO3 leach liquor with a recovery rate as high as 97.7%, and the prepared extraction resin has good reusability. Compared to the conventional impregnation method, the Aliquat 336 extractant encapsulated in a porous silica–polymer matrix has significantly lower loss during the adsorption process. Overall, this new extraction resin demonstrates great application potential for the highly efficient separation and recovery of Th(IV) from monazite HNO3 leach liquor.
✓ 已验证
产品关联
DOI
高影响因子
Processes
·
2026
·Vol. 14
·期 2
·242
·
IF 3.4
Yu Guo,Qisong Liu,Li Liang,Guihong Lan,Ming Duan
Hydrogen sulfide (H2S) prevalent in fuel gases such as natural gas and biogas necessitates removal prior to utilization or pipeline distribution. Biological desulfurization is considered a green purification technology employing sulfur-oxidizing bacteria (SOB) under ambient conditions to eliminate sulfur compounds, offering advantages including high efficiency, simplified equipment, and minimal chemical consumption. A highly efficient SOB TYWJ-2 was isolated in this study. Genomic analysis revealed that strain TYWJ-2 possesses a complete set of sulfur metabolism genes, enabling the metabolism of various inorganic sulfides, along with salt-tolerance genes that support adaptation to high osmolarity environments. The optimal conditions for desulfurization were determined through single-factor experiments and Box–Behnken response surface methodology. Long-term desulfurization performance demonstrated stable operational efficiency, with H2S removal rates consistently reaching 99.72~99.87%. System performance remained robust under varying sulfur loads, elevated salinity, and intermittent operational shutdowns, with no significant decline in desulfurization efficiency observed. These findings indicate that strain TYWJ-2 holds considerable potential for the biological desulfurization of sulfur-containing biogas and natural gas.
✓ 已验证
DOI
高影响因子
Nature Communications
·
2026
·
IF 18.1
Chu Aqiang,Zhang Xinke,Zhu Yuzhang,Yang Kai,Zhao Youjing,Zhou Teng,Zhang Shenxiang,Jin Jian,Jiang Lei
The growing demand for lithium has underscored the urgency of developing efficient extraction technologies from brines. Conventional methods suffer from low efficiency and high energy consumption. Inspired by the selective ion uptake and storage mechanisms of Salicornia , we designed an ion-selective hydrogel pump (ISHP) system to achieve ultra-high throughput lithium extraction. ISHP consists of a crosslinked polyvinyl alcohol (PVA) hydrogel block and an ultrathin ion-selective polyamide (PA) membrane grown in situ on its outer surface. The ultra-strong hydration capacity of the hydrogel enables the generation of an osmotic pressure of up to 47.86 bar inside it under sunlight, providing a powerful driving force for the efficient uptake of Li + ions from high-salinity brine. The Li + flux of ISHP reaches 1.20 g m −2 h −1 , which is over one order of magnitude higher than the current report. A device composed of multiple integrated ISHP units connected in series is designed to enable continuous lithium extraction under natural outdoor sunlight. A comprehensive techno-economic analysis is carried out on the full process of ISHP-based Li 2 CO 3 production technology. Compared with the conventional evaporation-precipitation method, this technology can shorten the production cycle by 90% and increase the annual economic benefits by eightfold.
✓ 已验证
产品关联
DOI
高影响因子
JOM
·
2026
·
IF 2.3
Jiang Cheng,Li Rui,Li Jing,Zhang Te
Chloride ions in zinc smelting accelerate electrode deterioration and corrosion of equipment, reducing the quality of zinc products. Conventional dechlorination technologies for copper slag pose significant challenges, including inefficient mass transfer due to solid-film barriers, limited reactivity due to the low activity of copper slag, and prolonged processing times. This paper proposes an ultrasonic-enhanced reduction deep-dechlorination technology based on rapid chemical reactions, establishing a liquid-phase mass transfer to completely break through the solid film barrier. The optimized parameters obtained for this technology are initial reaction solution pH 3.6, Cu 2+ :Cl⁻:H 2 A molar ratio = 1.5:1:0.75 reaction temperature is 20℃ (room temperature), ultrasonic power density of 26.7 W/L, reaction time of 3 min, achieving a 96.5% reduction in chloride ions, and fast decreasing from 1 g/L to 0.0353 g/L. As revealed by thermodynamic calculations, compared with the current dechlorination process for copper slag, this method improves reaction kinetics by 18.6%, reduces the thermodynamic potential by 59.3%, and increases the equilibrium constant by a factor of 6.7 × 10 9 . Dynamics calculations show that the calculated energy threshold (E a ) of the reaction in the ultrasound addition experiment is 37.82 kJ/mol. Ultrasound incorporation reduces the activation energy by 24.6%, accelerating the reaction and improving dechlorination efficiency.
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Shuai Gong,Yuxiang Zhang,Wei Du,Chong Zhang,Nai Wu,Xiuzhong Zhang,Zeqiang Ren,Yi Zhang,Pengbo Zhang,Chenyue Zhan,Xiaoyu Wu
Systemic chemotherapy for gastric cancer is frequently compromised by debilitating, dose-dependent toxicities, necessitating innovative adjunctive strategies that balance therapeutic efficacy with systemic safety. While natural products represent a promising source of candidates, their clinical translation is frequently hindered by intrinsic pharmacokinetic barriers. To address this, we developed the oral resident binary intestinal therapy (ORBIT) system, an excipient-free nanocapsule platform engineered for prolonged gut residency. Unlike conventional pharmaceutical formulations that depend on synthetic excipients, ORBIT is an excipient-free, self-assembled nanocapsule composed of a high-density dopamine-functionalized hyaluronic acid (hDAHA) shell encapsulating a berberine (BBR) core. This unique architecture provides a protective shield for BBR against premature degradation while utilizing the adhesive properties of the hDAHA shell to enhance gastrointestinal retention. ORBIT enables sustained, pH-responsive drug release, providing robust in situ shielding of the intestinal mucosa against oxaliplatin-induced injury and preserving epithelial barrier integrity. In preclinical gastric cancer models, the ORBIT regimen synergistically potentiates oxaliplatin-mediated tumor suppression while dramatically ameliorating systemic toxicity. Mechanistically, ORBIT administration profoundly remodels the microbiome-immune axis, specifically enriching beneficial commensals such as Akkermansia to drive increased intratumoral infiltration of CD8⁺ T cells. This study establishes a new oral nanotherapeutic paradigm for chemo-immunotherapy, presenting a compelling and clinically translatable strategy to optimize gastric cancer treatment outcomes.
✓ 已验证
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2026
·
IF 5.9
Yuhan Yan,Xuehua Deng,Sunting Xuan,Zhengbiao Zhang
The synthesis of disubstituted polypeptoids, or N-substituted polypeptides, remains challenging due to steric hindrance. Here, a synthetic platform, with orthogonal functional side chains, was developed for the construction of structurally diverse disubstituted polypeptoids. Poly(N-allyl S-methyl cysteine) was synthesized by acetic acid-catalyzed controlled ring-opening polymerization. Subsequent methylation yielded the sulfonium-pendant polymer, which underwent base-catalyzed elimination of sulfonium groups to generate well-defined poly(N-allyl dehydroalanine). This polymer features two orthogonal reactive sites, electrophilic α,β-unsaturated carbons and N-allyl groups, which could undergo selective modification through sequential orthogonal reactions. Michael addition reaction preferentially functionalized the α,β-unsaturated sites while preserving allyl groups for subsequent thiol-ene click chemistry. This strategy enabled precise installation of alternating functional side chains, yielding structurally diverse disubstituted polypeptoids with high functional group density and programmable side-chain sequences. The combination of efficient orthogonal functionalization, tunable side-chain arrangement, and dense functionality establishes these disubstituted polypeptoids as versatile scaffolds for different applications.
✓ 已验证
DOI
PubMed
高影响因子
Innovative Food Science & Emerging Technologies
·
2026
·
IF 6.9
Minbo Li,Xianbing Xu,Min Fan,Junjie Yi,Ming Du
Clean-label clarification of polysaccharide-rich mushroom hydrolysates is critical for producing high-quality natural seasonings. In this study, we developed a green polysaccharide-targeted clarification strategy termed cryo-induced molecular flocculation (CIMF), which offers a remarkable advantage of being additive-free and highly efficient compared with conventional clarification methods such as natural sedimentation, ethanol-assisted flocculation, and chitosan-assisted flocculation for clarifying Termitomyces albuminosus hydrolysates (TAH). CIMF achieved a high clarification efficiency (60.41%) without the use of external flocculants by selectively aggregating and removing insoluble polysaccharides (41.25%) while efficiently retaining peptides (96.15%). Structural analyses and molecular dynamics simulations further revealed that low temperature facilitated monosaccharide aggregation by reducing the solvent-accessible surface area and enhancing sugar–sugar interactions leading to compact cluster formation. In summary, CIMF represents a clean-label and polysaccharide-oriented clarification strategy that provides a sustainable and green approach for the manufacture of high-quality functional food ingredients.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
·
2026
·
IF 2
Haichao Yu,Yan Xu,Jinfeng Zhao,Jiayue Huang
This study presents a label-free optical biosensor based on fully spherical liquid crystal (LC) microdroplets for the simple and sensitive pesticide detection. The LC–water interface was modified with myristoylcholine chloride (Myr), a cationic surfactant, resulting in a radial molecular configuration of the LC microdroplets, in which LC molecules orient perpendicularly to the droplet surface. Upon the introduction of acetylcholinesterase (AChE), enzymatic hydrolysis of Myr is triggered, inducing a transition to a bipolar configuration, where LC molecules align parallel to the droplet interface. Conversely, the presence of AChE inhibitors, such as dimethoate and fenobucarb, suppresses this hydrolysis, thereby preserving or restoring the droplets to a radial configuration. Experimental results reveal that the detection limits for fenobucarb and dimethoate reach 1 × 10−8 mg/mL and 1 × 10−9 mg/mL, respectively, both well below the maximum permissible levels specified by water quality regulations. This platform exhibits a sensitivity improvement of approximately two orders of magnitude compared to systems utilizing hemispherical LC microdroplets. Additionally, successful application to real water samples from Heilongjiang River validates its practical utility. Overall, this label-free, simple, and highly sensitive LC microdroplet-based biosensor represents a promising approach for environmental pesticide monitoring.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Catalysis
·
2026
·
IF 13.6
Yong Tang,Yongqi Zeng,Chunyu Wang,Chuang Du,Fengxi Li,Lei Wang
The stereoselective cross-dehydrogenative coupling (CDC) reaction represents a highly promising approach for the direct synthesis of high-value non-natural amino acids. The photoenzyme cascade strategy synergistically integrates the reactivity of photocatalysts with the selectivity of enzymes, demonstrating attractive potential for eco-friendly asymmetric synthesis. In this study, we report a photoartificial CDCase cascade method for the asymmetric CDC reaction between N-aryl glycine esters and cycloketones. The optimal artificial CDCase was constructed by anchoring the biotinylated Cu-phenanthroline cofactor (5-NH2Phen-biotin*Cu(OAc)2) within the double mutant (S112H–K121M) of streptavidin obtained through genetic engineering optimization. In a mild aqueous medium, the resulting artificial CDCase cooperates with photocatalysis, efficiently catalyzing the asymmetric CDC reaction at a low enzyme loading (0.5 mol %), yielding a series of α-cycloketone-substituted N-aryl glycine esters with good yields and stereoselectivities. Comprehensive molecular docking and molecular dynamics (MD) simulations provided insights into the critical complex intermediates involved in the proposed reaction mechanism and clarified the interactions between the artificial CDCase and its substrates. Furthermore, through analysis of interatomic distances between pivotal reactive carbon centers and probable nucleophilic attack directions, we have deciphered the structural foundation underlying the formation of the predominant conformation, concurrently rationalizing the enhanced reactivity and stereoselectivity observed for the S112H–K121 M mutant.
✓ 已验证
DOI
高影响因子
CELL
·
2026
·
IF 42.5
Xiao-Yan Ge,Jie Cheng,Li-Jun Zhang,Lu-Lu Guo,Rui Xiang,Yan Lu,Shang-Lei Ning,Kai-Yu Wang,Kong-Kai Zhu,Ming-Xin Gao,Yue Li,Yu-Song Zhang,Nai-Kang Rong,Xiang Han,Ming-Hui Zhang,Le Fang,Yun-Fei Xu,Su-Wen Zhao,Qian Li,Fan Yang,Yong Hao,Ren-Jie Chai,Xiao Yu,Ji-Chun Yang,Jin-Peng Sun
Oxylipins are important metabolic messengers for normal life activities, and olfactory receptors (ORs) are known for their low affinity for odor and are not considered oxylipin receptors. By developing the “anonymous receptor identification by reverse-G-protein pull-down” (ARIG) method, we identify orphan OR Or5v1/Olfr110 as an oxylipin 12(S)-hydroxyeicosapentaenoic acid (12(S)-HEPE) receptor. The serum from obese patients with increased BMI showed lower Or5v1/Olfr110-Gs activation compared with normal people. Systemic Or5v1/Olfr110 deficiency or liver-specific Or5v1/Olfr110 deficiency impaired glucose homeostasis, even after stimulation with 12(S)-HEPE. Engagement of 12(S)-HEPE with Olfr110 activated Gs-PKA-pATF2-Cpt1α signaling to reduce obesity through promotion of fatty acid oxidation in liver. Structural aided development of synthetic agonist HOR1-C59 improved glucose homeostasis, which is dependent on Or5v1/Olfr110 expression. Overall, we revealed that a high-affinity oxylipin-sensing OR plays key roles in metabolism. The beneficial effects of HOR1-C59 underscore the therapeutic value of small synthetic compounds that target ORs for disease treatment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Anzhuo Weng,Dongxu Jia,Xin Chen,Xinyan Zheng,Wei Yang,Yujuan Jia,Tongtong Yin,Yanxia Zhang,Qian Yu
Biofilm-associated infections remain a major challenge, as the inherent recalcitrance of the extracellular polymeric substance matrix renders conventional antibiotics ineffective, further driving antimicrobial resistance. To address this, combination therapies have emerged as a potent strategy to enhance therapeutic outcomes. In this study, a dual-functional, antibiotic-free nanoplatform was designed to eradicate biofilms through combined quorum sensing (QS) inhibition and chemodynamic therapy (CDT). This nanoplatform consists of calcium peroxide (CaO2) nanoparticles coated with a quercetin/copper ion (Qe/Cu2+) complex. Upon exposure to the acidic biofilm microenvironment, the Qe/Cu2+ complex dissociates, releasing Qe and Cu2+ while exposing the CaO2 core. The subsequent reaction of CaO2 with water generates hydrogen peroxide, which is then catalyzed by Cu2+ via a Fenton-like reaction to produce highly bactericidal hydroxyl radicals. Simultaneously, Qe disrupts bacterial QS pathways, attenuating pathogenicity and sensitizing the biofilm-embedded bacteria to oxidative damage. This antibiotic-free nanoplatform demonstrated robust in vitro antibiofilm activity against Pseudomonas aeruginosa and Staphylococcus aureus, while significantly reducing bacterial colonization and accelerating wound healing in an infected mouse model, suggesting that the synergetic integration of QS inhibition and CDT represents a promising strategy for combating biofilm-associated infections.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）