Materials Science & Engineering C-Materials for Biological Applications
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2017
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IF 4.164
Yongli Shi,Zhaomin Liu,Yaxing Yang,Xiaojie Xu,Yan Li,Tong Li
To enhance the therapeutic effects of meloxicam (MLX), we developed an oral MLX-loaded poly(ethylene glycol)-b-poly(ε-caprolactone) nanoparticles@hydrogel (MLX-NPs@hydrogel) preparation. The MLX-NPs were fabricated via a solvent evaporation method, and their morphologies were observed by a JEM-1011 transmission electron microscope (TEM). The poly(mPEGMA- co -MAA) hydrogels were synthesized, and studies on their pH sensibilities were carried out in pH 1.2, 6.8, and 7.4 buffers. The final MLX-NPs@hydrogel preparation was obtained by immersing the hydrogels in the MLX-NPs suspensions (pH 7.4) for 48 h. The thermodynamic properties and cytotoxicity of the MLX-NPs@hydrogel preparation were also studied. TEM images illustrated that mPEG-b-PCL NPs had a uniform size distribution. The poly(mPEGMA- co -MAA) hydrogels showed an excellent pH-sensibility. Thermal gravity analysis (TGA) data suggested that the protection of hydrogels improved the stability of mPEG-b-PCL NPs. The release studies revealed that MLX-NPs@hydrogel could deliver the MLX-NPs into alkalescent environment ( e.g. intestinal tract). Then, the medicated NPs released MLX at a sustained release profile. Such preparation could overcome the drawbacks of oral MLX, and enhance its therapeutic effects. Therefore, the NPs@hydrogel was a promising sustained-controlled release matrix.
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RSC Advances
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2017
·Vol. 7
·期 21
·12518-12523
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IF 3.108
Pengfei Zhou,Xuping Wang,Bo Yang,Frank Hollmann,Yonghua Wang
Epoxides are important synthetic intermediates for the synthesis of a broad range of industrial products. This study presents a promising solution to the current limitation of enzyme instability. By using simple deep eutectic solvents such as choline chloride/sorbitol, significant stabilization of the biocatalyst has been achieved leading to more robust reactions while using environmentally more acceptable solvents as compared to ionic liquids.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2017
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IF 2.843
Jianhua Liu,Junzhi Li,Liqun Xu,Yajuan Qiao,Jiucun Chen
In this work, multifunctional B,N codoped carbon dots (B/N–C-dots) were synthesized from a facile hydrothermal treatment of branched polyethylenimine and 4-formylphenylboronic acid. The obtained B/N–C-dots had a very narrow size distribution and showed excitation-wavelength-dependent photoluminescence properties with a high fluorescence quantum yield (QY) of 15.85%. The B/N–C-dots showed temperature and pH (3–13) dual responses. Additionally, the B/N–C-dots showed a good sensitivity and selectivity to Fe3+ with a detection limit of 1.62 μM. What is more, the as-prepared B/N–C-dots exhibited low toxicity and good biocompatibility and could be used for cell imaging. Considering these good properties, the obtained B/N–C-dots have good potential for temperature, pH, and ion sensors and cellular imaging.
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ACS Applied Polymer Materials
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2024
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IF 4.4
Yanbo Liu,Tianyi Zhang,Bo Yang,Ming Hao,Xiaodong Hu,Xiaoxiao Wang
Piezoelectric devices are becoming increasingly attractive in areas such as wearable electronics, mobile environmental sensors, and health monitoring due to their unique capability to harvest discrete mechanical energy. Nevertheless, most piezoelectric materials are fabricated into low-dimensional products, which limits the performance breakthroughs and application prospects of these devices. Here, a series of polyvinylidenefluoride (PVDF) doped with dopamine hydrochloride@BaTiO3/MXene/chitosan (PVDF-B/MXene/CS) composite aerogel piezoelectric devices with outstanding output performance were fabricated by combining electrospinning and freeze-drying techniques. Among them, the PVDF-B/MXene/CS composite aerogel-based piezoelectric devices with electrodes exhibited rather better output performance compared to those without electrodes, while the electrodeless piezoelectric devices demonstrated excellent piezoelectric response under various stress modes. The electrodeless piezoelectric devices maintained a stable voltage over 1800 cycles and achieved the maximum power output of 4.25 nW with an external resistance of 100 MΩ. Furthermore, the electrodeless piezoelectric device was capable of charging capacitors with varying capacities and could easily illuminate a small light emitting diode (LED) light by manual tapping. These piezoelectric devices showed tangible and stable signals regarding mechanical stimuli monitoring, such as wrist bending, finger tapping, and pedal movements. This work not only expands the range of aerogel-based piezoelectric materials but also showcases their immense potential in the field of piezoelectric devices.
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Materials Today Bio
·
2025
·
IF 10.2
Nuo Cheng,Qianqian Zhou,Zongfang Jia,Yang Mu,Sheng Zhang,Lei Wang,Yunna Chen
The therapeutic effect of immune checkpoint inhibitors (ICIs) in triple-negative breast cancer (TNBC) is unsatisfactory. The immune "cold" microenvironment caused by tumor-associated fibroblasts (TAFs) has an adverse effect on the antitumor response. Therefore, in this study, mixed cell membrane-coated porous magnetic nanoparticles (PMNPs) were constructed to deliver salvianolic acid B (SAB) to induce an antitumor immune response, facilitating the transition from a "cold" to a "hot" tumor and ultimately enhancing the therapeutic efficacy of immune checkpoint inhibitors. PMNP-SAB, which is based on a mixed coating of red blood cell membrane and TAF membrane (named PMNP-SAB@RTM), can simultaneously achieve the dual effects of "immune escape" and "homologous targeting". Under the influence of an external magnetic field (MF), SAB can be targeted and concentrated at the tumor site. The SAB released in tumors can effectively inhibit the production of extracellular matrix (ECM) by TAFs, promote T-cell infiltration, and induce antitumor immune responses. Ultimately, the combination of PMNP-SAB@RTM and BMS-1 (PD-1/PD-L1 inhibitor 1) effectively inhibited tumor growth. Finally, this study presents a precise and effective new strategy for TNBC immunotherapy on the basis of the differentiation of "cold" and "hot" microenvironments.
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Energy Storage Materials
·
2024
·
IF 18.9
Caiyun Sun,Guangsheng Huang,Chaohe Xu,Lingjie Li,Aitao Tang,Xiaoyuan Zhou,Jingfeng Wang,Fusheng Pan
Aqueous rechargeable Mg-ion batteries (ARMIBs) are promising for large-scale energy storage due to the aqueous electrolyte's high safety and low cost. However, the aqueous electrolyte's narrow electrochemical stability window (ESW) significantly hinders the development of ARMIBs, especially the compatibility of electrolytes with anode materials . We first report a TiO 2 (B) anode for ARMIBs that has high compatibility with wide potential aqueous electrolytes (ESW: ∼3.66 V), thus resulting in a low magnesiated potential (∼0.95 V vs. Mg 2+ /Mg), highest capacity (50 mA g −1 : 247.7 mAh g −1 ) reported for Ti-based oxide anodes in aqueous metal-ion batteries thus far, and fast Mg 2+ diffusion kinetics (∼3.49 × 10 −11 cm 2 s −1 ). When the magnesiated TiO 2 (B) (Mg x TiO 2 (B)) anode is paired with V 2 O 5 , the Mg x TiO 2 (B)||V 2 O 5 full cell can deliver high voltage (2.5 V), high capacity (100 mA g −1 : 64.4 mAh g −1 , based on the total electrode mass) and high cycling stability with no capacity decay after 200 cycles at 100 mA g −1 . The versatile intercalation chemistry of TiO 2 (B) observed here is expected to spur the development of high-voltage ARMIBs.
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INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
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2024
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IF 2.6
Jia Yin,Xiaoxia Peng,Aijun Yang,Mudi Lin,Kunfa Ji,Xiaohui Dai,Juan Huang,Li Li,Like Feng
Summary From recent literature and research studies, it has been found that some bacterial strains have abilities with probiotic activities to produce B vitamins, which play essential roles in maintaining human health. Oligosaccharides can promote the beneficial microbes, however, the specific effects of oligosaccharides on B vitamins-producing ability of probiotic strains have not been clarified. This study evaluated the effect of different oligosaccharides on the probiotic properties and B vitamin-producing ability of 21 selected probiotic strains. The obtained results suggested that the strains could utilise oligosaccharides as the sole carbon source, and the hydrophobicity, auto-aggregation, and biofilm formation of probiotic strains were specific regulated after fermentation with different oligosaccharides. In particular, the oligosaccharides had different influences on the levels of extracellular B vitamins produced by probiotic strains. These findings provide the foundation for studies on the B vitamins-producing probiotic strains and their application in functional foods to prevent B vitamins deficiency.
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Surfaces and Interfaces
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2024
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IF 5.7
Ranfeng Li,Zhenhua Dai,Taiyu Huang,Qianqian Zhang,Xunfu Zhou,Zhongli Peng,Zuotao Liu,Yueping Fang
CdS with a visible light response and energy band location suitable for CO 2 photoreduction has received extensive attention. However, low product selectivity and photocatalytic efficiency limit its application. Here, NaBH 4 is used as a reducing agent to generate Cd metal on the surface of CdS nanorods in situ. This leads to the construction of a B-CdS/Cd metal cocatalyst/semiconductor structure. This configuration significantly enhanced the CdS's activity of photocatalytic CO 2 reduction. The Cd metal which is on the surface of CdS nanorods promoted the separation and transfer of photogenerated charges and increased both light photosensitivity and CO 2 adsorption capabilities. The improved B-CdS/Cd catalyst shows excellent CO 2 reduction capabilities by generating CO at a rate of 323.39 μmol g − 1 h − 1 , which is 2.01 times more than pure CdS, owing to the synergistic enhancements. Simultaneously, Cd acts as an active site inhibiting H 2 production during the CO 2 reduction reaction. This work demonstrates the potential of Cd metal as a metal cocatalyst in photocatalytic CO 2 reduction.
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PROCESS BIOCHEMISTRY
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2024
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IF 3.7
Shihao Liang,Wei Zhuang,Zhenfu Wang
In this work, isocyanate-based strategy was developed for efficient immobilization of Candida antarctica lipase B (CALB). Of 41 commercial resins, EP109 was chosen and hydrophobized with hydroxyl-terminated polydimethylsiloxane (HTPDMS) for tert-butyl isocyanate (tBIC)-based CALB immobilization due to high loading amount and specific activity. The tBIC-based strategy exhibited shorter immobilization time, higher loading and activity than adsorption strategy by hydrophobic interaction. When compared with free CALB, EP109-HTPDMS-tBIC@CALB owned improved stability (against acid, alkali, and heat) and storability. Subsequently, EP109-HTPDMS-tBIC@CALB was employed in the bio-synthesis of 1,3-diacylglycerol in a solvent-free system with a yield of 76.31%, which was higher than commercial Novozym 435 (53.93%). EP109-HTPDMS-tBIC@CALB exhibited 76.34% of residual activity after 20 repeat uses.
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PHYTOCHEMISTRY
·
2024
·
IF 3.2
Ying Gao,Juan Chen,Junjun Liu,Zijian Huang,Xiaogang Peng,Wanpeng Li,Chunlun Qin,Hanli Ruan
In this study, incartrilactones A ( 1 ) and B ( 2 ), two previously undescribed schinortriterpenoids (SNTs) possessing an unprecedented 5/5/6/5/7/5-fused hexacyclic skeleton, together with one previously undescribed ( 3 ) and one known ( 4 ) analogues, were isolated from the stems of Schisandra incarnata Stapf. Their structures with absolute configurations were determined by comprehensive spectroscopic analysis, X-ray crystallography and electronic circular dichroism calculation. Compounds 1 and 2 represent the first class of 14,15-seco-15,17-cyclolancifoartane-type SNTs containing the unusual linkage of ‒C14‒C16‒C13‒C17‒C15. The hypothetical biogenetic pathway of compounds 1 and 2 was postulated. Compounds 1 and 2 exhibited potent α -glucosidase inhibitory activity with IC 50 values of 133.1 and 165.3 μM, representing that they were more active than the positive control, acarbose (IC 50 = 232.8 μM). Compound 4 showed moderate in vitro immunosuppressive effect against ConA-induced T cell and LPS-induced B cell proliferation, with IC 50 values of 35.3 ± 0.9 μM and 24.9 ± 0.6 μM, respectively. The cytotoxicity of compounds 1 − 4 against three human cancer cell lines was also tested, with no obvious cytotoxicity being observed.
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Materials Today Bio
·
2025
·
IF 10.2
Ziling Li,Huiling Lei,Jiannan Hu,Tong Zhou,Shuaiqi Yuan,Xinyue Ma,Yunfei Zhu,Chao Liu,Decai Wang,Yuzhou Wu,Shuyun Xu
The pneumonia induced by carbapenem resistant Klebsiella pneumoniae (CRKP) has high morbidity and mortality. Among the antibiotics currently available, polymyxin B (PMB) is considered to be the last line of defense. Routine intravenous administration of PMB has many problems, such as severe neurotoxicity and nephrotoxicity. In this study, a novel inhaled PMB-loaded albumin nanoparticles (PEG-pHSA@PMB) capable of penetrating airway mucus and responding to the infection microenvironment is constructed. An acid-responsive functional molecule (PEBA) and NH 2 -PEG-SH are linked to the surface of human serum albumin (HSA) via the conjugation reaction. Subsequently, PMB is loaded through electrostatic interactions to yield PEG-pHSA@PMB. The sulfhydryl groups of PEG-pHSA@PMB interact with mucins to help penetrate mucus after inhaled. In an acidic environment, the protonation of the tertiary amino groups within PEG-pHSA@PMB causes the charge alteration, which leads to the release of PMB. It demonstrated excellent mucus permeability, potent bactericidal activity, and superior bacteriostatic effects compared to sole PMB. Inhalation of PEG-pHSA@PMB significantly reduced the bacterial load in the lungs of mice with CRKP pneumonia, alleviating inflammatory response. Moreover, PEG-pHSA@PMB exhibited good cytocompatibility and biosafety. The novel strategy of the inhalation drug delivery system is promising for the treatment of pneumonia caused by drug-resistant bacteria.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2025
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IF 5.2
Yubo Wang,Yong Zhou,Jinling Wang,Lu Zhang,Chen Liu,Ding Guo,Yanlin Yu,Roumei Ye,Yun Wang,Bing Xu,Yiming Luo,Dengyue Chen
The limited selectivity and high systemic toxicity of traditional chemotherapy hinder its efficacy in treating diffuse large B-cell lymphoma (DLBCL). The combination of sonodynamic therapy (SDT) with chemotherapy has emerged as a novel strategy for cancer treatment, aiming to improve therapeutic outcomes and reduce systemic toxicity. However, challenges such as elevated drug clearance rates and non-selecitivity remain to be resolved. This study has developed a biocompatible nanomedicine delivery system, PA-HM@DOX/ICG, employing hollow mesoporous silica nanoparticles (HMSNs) as the nanocarrier. The nanomedicine incorporates the chemotherapeutic agent doxorubicin (DOX) along with the sonosensitizer indocyanine green (ICG) within its encapsulation, and undergoes additional surface modification using lipid-nucleic acid conjugates (DSPE-PEG-AS1411) to facilitate active targeted delivery. In vitro cellular experiments have validated that PA-HM@DOX/ICG can specifically recognize and be internalized by SU-DHL-4 lymphoma cells due to the overexpression of nucleolin on their surface. The synergistic effects of DOX-induced DNA damage and reactive oxygen species (ROS) generated by ultrasound-activated ICG induce apoptosis in these cells. Furthermore, PA-HM@DOX/ICG displays minimal toxicity towards LO2 normal hepatocytes, indicating a favorable biosafety profile. In vivo animal studies have shown that PA-HM@DOX/ICG effectively accumulates in tumor sites in mice through both the enhanced permeability and retention (EPR) effect and nucleolin-mediated targeting. Under ultrasound irradiation, PA-HM@DOX/ICG significantly inhibits tumor growth. This study introduces a nanoplatform that integrates chemotherapy with sonodynamic therapy, offering a novel approach for the efficient treatment of DLBCL.
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