ChemistrySelect
·
2024
·Vol. 9
·期 3
·e202304182
·
IF 1.9
Yiguo He,Mengxiang Li,Liming Peng,Tong Yang,Dong Zhang,Yadong Zhang
Graphical Atorvastatin calcium is a pivotal pharmaceutical for the treatment of primary hypercholesterolemia, with the reaction between isobutyl acetate and aniline being a crucial step. By employing continuous flow synthesis technology, we achieved a yield of 94 % within a residence time of 15 minutes. Simultaneously, kinetic studies and CFD calculations were conducted. Subsequently, we conducted further reaction investigations and designed a continuous system. 4-methyl-3-oxo-n-phenyl-pentanamide, as a crucial component of atorvastatin calcium, often generates a large amount of by-products in conventional synthesis. Here, we first developed a continuous microflow system for the continuous flow synthesis of 4-methyl-3-oxo-n-phenyl-pentanamide. Compared to traditional batch reactors, the reaction time was reduced by 1/12 in the microreactor. Using this device, the kinetic parameters of the reaction were determined, and a reaction kinetics model was established to investigate the effects of channel geometry and material inlet velocity on the entire reaction system. Furthermore, we studied the subsequent reactions and successfully established a fully continuous synthesis device, where the two-step continuous flow chemical reactions were achieved at 40 minutes and a total yield of 32 %.
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ORGANIC & BIOMOLECULAR CHEMISTRY
·
2024
·Vol. 22
·期 36
·7485-7491
·
IF 2.9
Zi-Xuan Hu,Shu-Rui Li,Qing-Jun Xia,Ting Wang,Josef Voglmeir,Göran Widmalm,Li Liu
Here we report an enzymatic approach to synthesize N-formylneuraminic acid (Neu5Fo) containing sialosides, through a five-enzyme cascade. This method stands as an alternative to traditional chemical syntheses, aiming for precision and efficiency in generating sialosides with a tailored N-formyl group generated directly from formic acid. The newly synthesized Neu5Fo was characterized using various NMR techniques revealing a conformational equilibrium at the amide bond of the formyl group in slow exchange on the NMR time scale with a trans : cis ratio of ∼2 : 1. This work not only suggests potential for exploring the biological roles of sialosides but also points to the possibility of developing novel therapeutic agents.
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CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Mengwen Zhang,Fanyu Meng,Binyang Jiang,Jinsheng Li,Lei Fan,Shoulei Yang
To further enhance the performance of Al 2 O 3 -Ti(C,N) composites, this study employed novel sinter forging and dynamic sinter forging techniques, comparing them with conventional hot pressing and oscillatory pressure sintering. The results revealed that the composites produced by all four processes exhibited high density and no phase transition or formation of new phases. However, the composites prepared by sinter forging and dynamic sinter forging exhibited significantly improved strength and hardness. The hardness of the composites produced by sinter forging increased to 23.39 GPa, while the strength reached 1142 MPa, representing a 61 % improvement compared to those sintered by hot pressing. This improvement can be attributed to the significant plastic deformation induced by the sinter-forging process, which results in a higher dislocation density at the grain boundaries and within certain grains, enhanced coordinated deformation between grains, and stronger grain boundary bonding. Furthermore, the average grain size was smaller. Therefore, sinter forging and dynamic sinter forging offer substantial advantages in the preparation of advanced ceramics.
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ACS Applied Polymer Materials
·
2025
·
IF 4.7
Jianglu Teng,Xibin Shen,Guohua Hang,Yuan Gao,Jiawei Hu,Sixun Zheng
The reaction of 4-(hydroxymethyl)phenylboronic acid with triethanolamine was carried out to synthesize a boronic ester diol featuring boron–nitrogen (B–N) coordination. This diol served as a chain extender, allowing B–N-coordinated boronic ester bonds to be introduced into polyurethane (PU) networks. Toward this end, we first synthesized a series of α,ω-dihydroxyl polyurethane telechelics with α,ω-dihydroxypropyl poly(dimethylsiloxane) as the polymeric diol. By varying the molar ratio of the boronic ester diol to 1,4-butane diol, the α,ω-dihydroxyl polyurethane telechelics were synthesized with variable contents of the dynamic covalent bonds. Thereafter, the reaction of α,ω-dihydroxyl PU telechelics with 3-isocyanatopropyl triethoxysilane was carried out to gain α,ω-ditriethoxysiloxane PU telechelics. The latter were readily cross-linked via the sol–gel process to afford the mechanically robust PU networks, with Young’s modulus and tensile strength as high as 302.7 and 35.4 MPa, respectively. More importantly, the reprocessing properties were imparted to the PU networks. Compared to the control PU network, the reprocessing temperature was depressed to 120 °C. In the meantime, the shape memory properties of PU networks were significantly improved through the introduction of dynamic covalent bonds. Furthermore, the shape memory networks featured reconfigurability with the introduction of B–N-coordinated boronic ester bonds.
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Biomass Conversion and Biorefinery
·
2025
·
IF 4.1
Zhao Xiaoben,He Tao,Wang Shuainan,He Song
In this research, nitrogen-doped activated carbons (NACs) featuring a high specific surface area (3396 m 2 /g) and a certain amount of nitrogen doping (0.79–1.69%) were prepared by a combination of chemical activation and self-activation methods, and their CO 2 adsorption characteristics were comprehensively assessed. The experimental results showed that nitrogen doping not only significantly enhanced the specific surface area of the materials, but also significantly enhanced the CO 2 adsorption. The CO 2 adsorption capacity of the optimal sample, CMAC-0.5–3-700, reached 4.11 mmol/g and 2.32 mmol/g at 0 °C and 25 °C, respectively. In addition, the selectivity of NACs for CO 2 /N 2 was significantly improved, with a selectivity factor of up to 50.16, and the competitive adsorption experiments also demonstrated that NACs could still effectively adsorb CO 2 under the condition of CO 2 /N 2 = 15/85. Density-functional theory (DFT) calculations further revealed the interaction mechanism between NACs and CO 2 molecules, the enhanced CO 2 selectivity is attributed to electrostatic and π-electron interactions between nitrogen atoms and CO 2 . The findings indicate the significant potential of nitrogen-doped activated carbons (NACs) with high specific surface area and substantial nitrogen doping for post-combustion CO 2 capture.
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Yan Li,Huibin Liu,Mingyu Ma,Wenchao Peng,Yang Li,Xiaobin Fan
Vanadium-based oxides, known for their high capacity and low cost, have garnered significant attention as promising cathode candidates in aqueous zinc-ion batteries. Nonetheless, their poor rate performance and limited durability in aqueous electrolytes present a challenge to the realistic implementation of vanadium-based aqueous zinc-ion batteries. Here, we synthesized nitrogen-doped V2O3@C (N–V2O3@N–C) via ammonia treatment of V2O3@C derived from vanadium-based metal–organic framework (V-MOF), aiming to achieve outstanding rate and cycling performance. The N–V2O3@N–C electrode exhibits notable in situ self-transformation into an amorphous state. Density functional theory calculations reveal that the distorted N–V2O3 structure and uneven charge distribution result in the creation of an amorphous state. As expected, Zn/N–V2O3@N–C aqueous zinc-ion batteries can achieve remarkable specific capacity (349.0 mAh g–1 at 0.1 A g–1), along with impressive rate performance, showcasing a capacity of 253.5 mAh g–1 at 5 A g–1 and exceptional durability at 5 A g–1 (96.4% after 1350 cycles). The employed induced amorphization approach offers novel perspectives for designing high-performance cathodes that exhibit both sturdy structures and extended cycling lifespans.
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Nanoscale
·
2024
·
IF 5.8
Dongjie Zuo,Ayisha He,Hui Shen,Huifang Guo,Qinghua Xu,Zilin Li,Simin Li
N-heterocyclic carbene (NHC) ligands have emerged as highly effective surface ligands for the protection and functionalization of metal nanoclusters (NCs). However, research on NHC-stabilized metal NCs, including their synthesis, structure, properties, and applications, is still in its early stages. In this study, we present the first gold-copper alloy cluster protected by both NHC and alkyne ligands, denoted as Au3Cu(iPrNHCiPr)(PA)4 (abbreviated as Au3Cu, where iPrNHCiPr is a bidentate N-heterocyclic carbene ligand with isopropyl as the N-substituent, and PA is a phenylethynyl group). The precise composition of Au3Cu was confirmed through the utilization of electrospray ionization mass spectrometry (ESI-MS), and its structure was determined via X-ray single-crystal diffraction. It is worth noting that although the Au3Cu clusters do not display substantial light emission when exposed to UV lamps, they are capable of emitting green fluorescence subsequent to undergoing mechanical milling (
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INDUSTRIAL CROPS AND PRODUCTS
·
2024
·
IF 5.6
Wenwei Zhang,Tianjin Li,Xinping Ouyang,Xueqing Qiu
To cope with the challenge of insufficient interaction between lignin macromolecules and catalytic active sites in heterocatalysis systems which hindered the efficient hydrogenolysis of lignin, a lignin-derived N-doped macroporous carbon supported Ru catalyst (Ru/LNPC) was prepared via the pyrolysis of alkali lignin with potassium hydroxide as the activator and ammonium oxalate as the pore forming agent. The LNPC carrier featured a hierarchical porous structure with the diameter of macropores ranging from 50 nm to 10 μm, enhancing the adequately contact between the lignin macromolecules and Ru NPs. The doping nitrogen in the carbon carrier led to well dispersed Ru nanoparticles with average size of 1.08 nm, providing abundant active metallic centers. Therefore, Ru/LNPC exhibited excellent catalytic activity and stability to hydrogenolysis of lignin. Under the condition of 1.0 MPa H 2 at 280 ºC for 2 h, Ru/LNPC contributed to the yield of 45.6 % aromatic monomers from the depolymerization of lignin. After five recycling, Ru/LNPC still showed significant activity. This work provided a new strategy for designing catalysts for efficient hydrogenolysis of lignin and further facilitating its high-value utilization.
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Journal of the Taiwan Institute of Chemical Engineers
·
2024
·
IF 5.5
Song Zou,Yimu Wang,Yu Wan,Zhenxing Wang,Shuang Gao,Qingsong Luo,Yanting Wang,Changhao Feng
Background It is imperative to monitor the levels of n-butanol in the environment for the preservation of ecosystems and safeguarding human health. As a potential substitute for n-butanol sensors, the LaFeO 3 nanofibers show encouraging promise. Methods We have used the electrospinning method to successfully construct a series of Fe doping LaFe 1+x O 3 ( x = 0, 0.03, 0.05, 0.07) nanotubes. Through the use of XRD, FESEM, TEM, and EDS, the sample's morphological structure and composition were examined. Significant findings With a quick response/recovery time of 9/15 s, the gas sensor based on LF 1.05 O 3 nanotubes showed a staggering response of 33.6 at 150 °C toward 100 ppm n-butanol. Compared to the other test gases, this sensor demonstrated remarkable n-butanol selectivity. Furthermore, a methodical examination of the sensing mechanism was carried out.
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VACUUM
·
2024
·
IF 3.8
Xiaoying Yu,Chunhong Gao,Jinjia Liu,Jiang Wang,Meilin Jia,Gala Sa,Aiju Xu
Photocatalytic technology has good stability and ecological friendliness which is used to treat organic pollutants in wastewater. In this paper, TiO 2 , 1.5%V–TiO 2 and N, V co-doped TiO 2 were synthesized by hydrothermal method for photocatalytic degradation of tetracycline. Meanwhile, XRD , HRTEM , SEM, FT-IR, XPS, UV–Vis DRS , PL and electrochemistry tests were used to characterize the catalysts. The results showed that the appropriate amount of N, V co-doped can cause structural changes of TiO 2 . The co-doped of N and V enhanced the photocurrent response of TiO 2 , increased the specific surface area, reduced the band gap, and improved the efficiency of photodegradation of tetracycline. Accordingly, the tetracycline photocatalytic degradation path was proposed. 6%N-1.5%V–TiO 2 completely degraded tetracycline into CO 2 , H 2 O and NO 3 − . The calculation results show that an appropriate amount of N, V co-doped TiO 2 decreased bandgap, improved the optical absorption performance of TiO 2 . This work demonstrated the potential of N, V co-doped to design efficient photocatalysts .
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MICROPOROUS AND MESOPOROUS MATERIALS
·
2025
·
IF 4.7
Zehong Zhu,Qingxin Wu,Xueying Wang,Haiyang Zhang,Jian Li,Yanzhao Dong,Yongsheng Xu,Yunsheng Dai,Jinli Zhang
Here, the spiral mesoporous hydrothermal carbonaceous nanospheres (SMHNs) were designed and fabricated from pentose precursors to enhance gas diffusion in acetylene hydrochlorination. Through the optimization of hydrothermal conditions, the optimized SMCNs-800 material showcased the highest catalytic activity with an acetylene conversion of 77 % under the condition of GHSV (C 2 H 2 ) = 30 h −1 . The structural analysis indicated that the material with helical structure could provide larger pore sizes and abundant defect sites, exposing more active sites. The structure-activity relationship among acid-base properties of the catalyst surface, the adsorption-desorption capacity for the reactants and the catalytic activity jointly demonstrated that pyridine-N and -C=O could provide abundant basic sites for the adsorption and activation of H-Cl, thus accelerating the process of acetylene hydrochlorination reaction.
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APPLIED ORGANOMETALLIC CHEMISTRY
·
2012
·Vol. 26
·期 11
·600-603
·
IF 2.061
Dongsheng Bai,Huanwang Jing,Guangjian Wang
The synthesis of cyclic carbonates from epoxides and carbon dioxide catalyzed by cyanocobalamin and n -Bu 4 NI system was achieved under 0.8 MPa CO 2 pressure at 140°C without organic solvents. Propylene carbonate was obtained in 99% yield within 6 h under the optimized reaction conditions. The cyanocobalamin catalyst could be recycled with water and retained moderate catalytic activity. Copyright © 2012 John Wiley & Sons, Ltd.
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