NANOTECHNOLOGY
·
2021
·Vol. 32
·期 37
·375712
·
IF 3.874
Bin Nie,Hong Wang,Chaohui Rao,Yanwei Zhang,Huifang Wang,Xiaojie Lian,Xianghua Gao,Baolong Niu,Wenfeng Li
Phosphate-stabilized amorphous calcium carbonate (ACCP) has excellent biocompatibility, bioactivity, and biodegradability, and can be easily synthesized and stored. However, unmodified ACCP, as a controlled drug release carrier, decomposes rapidly in an acidic environment and highly depends on the system's pH value, which can not meet the need for long-term release of active substances, thus limiting its application scope. To realize the specific pH responsiveness of ACCP nanoparticles, we designed and synthesized monodisperse sodium alginate/ACCP (Alginate/ACCP) composite nanoparticles in this paper. After ultrasonic treatment, nanoparticles with an average particle size less than 200 nm could form stable water dispersion that could be dispersed for up to 10 d. Based on the specific pH sensitivity of sodium alginate, the drug-controlled release performance of composite nanoparticles and the therapeutic effect of drug-loaded nanoparticles on A549 cancer cells were studied. The results indicated that under the same pH condition, the curcumin (Cur) release rate of composite nanoparticles gradually decreased with sodium alginate addition. When the dosage of sodium alginate was 1.0 mg ml−1, the cumulative drug release rate of nanoparticles in 40 h was only about 35%. Besides, the drug-loaded nanoparticles showed the excellent killing ability of cancer cells, and the survival rate of cancer cells decreased in a concentration-dependent manner. Therefore, through reasonable optimization design, we can synthesize composite nanoparticles with excellent sustained-release properties to provide a new strategy for cancer cells' long-term treatment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2019
·Vol. 24
·期 23
·4374
·
IF 3.06
Wenxiao Jiao,Wenxue Chen,Yuqi Mei,Yonghuan Yun,Boqiang Wang,Qiuping Zhong,Haiming Chen,Weijun Chen
The aim of this study was to prepare sodium alginates (SAs) with different molecular weight and G/M ratio, and characterize their rheological behaviors and emulsifying properties. The result of Fourier transform infrared (FTIR) showed that the chemical bonds among the β-d-mannuronic acid- (M-), α-l-guluronic acid- (G-), and MG-sequential blocks in the SA chains were not changed significantly by acid treatment. Meanwhile, the molecular weight and G/M ratio of the SA exhibited drastic variation after acid modification. The result of rheological analysis suggesting that the apparent viscosity of SA reduced from 30 to 16.4 mPa.s with the increase of shear rate, reveals that SA solution belongs to pseudoplastic liquid. Also, the apparent viscosity of acid-modified SA solution dropped rapidly with the decrease of the molecular weight. The properties of emulsions stabilized by SA, SA-Ms, and commercial SAs were evaluated via the interface tensiometry and determination of the zeta potential, droplet size, creaming index (CI), and Turbiscan stability index (TSI). Compared with the SA-stabilized emulsion, the interfacial tension of the emulsion stabilized by SA-M increased with the decrease of the molecular weight reduced at the similar M/G ratio. The decrease in zeta potential and the increase in TSI of the emulsion were observed with the decrease of molecular weight, indicating that molecular weight plays an important role on the emulsifying ability of SA. In addition, the SA with low G/M ratio can form emulsions with stable and fine droplets.Keywords:sodium alginate;rheological behavior;emulsifying property
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Tuo Yang,Xian Xiao,Xuewei Zhang,Yicheng Li,Xiao Liu,Xiafei Li,Xinyu Pan,Wentao Li,Hui Xu,Xiaolong Hao,Shuxia Duan,Baochun Li,Xianwei Wang,Wenbin Li,Liang Zhao
Removing free hemoglobin generated during extracorporeal circulation remains a challenge. Currently, there is no adsorbent with specificity and good biosafety for removing hemoglobin. In this study, a new chitosan/sodium alginate/carbon nitride (CS/SA/C 3 N 4 ) hydrogel adsorbent was prepared by blending SA with C 3 N 4 to drop into CS/CaCl 2 solution. The physicochemical properties of CS/SA/C 3 N 4 hydrogel were evaluated using some techniques, including scanning electron microscope, Zeta potential measurement, and thermogravimetric analysis. Hemoglobin adsorption in vitro, stability, hemocompatibility, cell compatibility, inflammatory reaction and blood extracorporeal circulation in vivo were also evaluated. The findings revealed that the CS/SA/C 3 N 4 -0.4 % hydrogel exhibited an impressive adsorption capacity of 142.35 mg/g for hemoglobin. The kinetic data of hemoglobin adsorption were well-described by pseudo second-order model, while the isothermal model data conformed to the Langmuir model. The hardness and modulus of CS/SA/C 3 N 4 -0.4 % was 11.7 KPa and 94.66 KPa respectively, which indicated robust resistance to breakage. CS/SA/C 3 N 4 demonstrated excellent hemocompatibility, biocompatibility and anti-inflammatory properties. In addition, the results of in vivo rabbit extracorporeal blood circulation experiment demonstrated that CS/SA/C 3 N 4 could adsorb free hemoglobin from blood while maintaining high biosafety standard. Consequently, CS/SA/C 3 N 4 hydrogel emerges as a promising candidate for use as a hemoglobin adsorbent in extracorporeal blood circulation system.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yu Miao,Jielu Wei,Xueqing Chen,Jingru Shi,Lingjiao Zhang,Liping Wang,Jialun Yang,Lili Ma,Jinyou Duan
The enhancement of antimicrobial wound dressings is of utmost importance in light of the escalating risk of antibiotic resistance caused by excessive antibiotic usage. Conventional antimicrobial materials eradicate pathogenic bacteria while impeding the proliferation of beneficial bacteria during the management of wound infections, thereby disturbing the equilibrium of the skin micro-ecosystem and engendering recurrent cutaneous complications. Lactobacillus rhamnosus (L.rha) is a probiotic that can inhibit the growth of certain pathogenic bacteria by secreting a large number of metabolites. In this paper, we synthesized a cross-linker (SPBA) with a boric acid molecule from succinic acid and 4-(bromomethyl)phenylboronic acid, which formed a boric acid ester bond with a diol on the natural polysaccharide sodium alginate (SA), and obtained a pH/reactive oxygen species (ROS) dual-responsive hydrogel (SA-SPBA) for loading L.rha to treat wound infections. The SA-SPBA@L.rha hydrogel improves the survival of L.rha during storage and has good injectability as well as self-healing properties. The hydrogel showed good biocompatibility, the antimicrobial effect increases in a dose-dependent manner, and it has a certain antioxidant and anti-inflammatory capacity, accelerating wound repair. The use of SA-SPBA@L.rha hydrogel provides a safe and effective strategy for the repair of skin wound infections.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS
·
2025
·Vol. 25
·期 3
·920
·
IF 3.5
Ning Wang,Shiqi Liu,Liang Xu,Longjiao Wang,Ming He,Chuanjie Lei,Linyufan Xiao
This work proposes an optical fiber copper ion sensor, which is fabricated by an ion-imprinted sodium alginate/graphene oxide (SA/GO) hydrogel and single-mode fiber (SMF). This sensing Fabry–Perot Interferometer (FPI) achieves −1.98 nm/(mg/L) sensitivity with 0.998 linearity. To achieve higher sensitivity, we add a reference FPI to create a Vernier effect. We achieve 19.58 nm/mg/L sensitivity and 0.989 linearity at a concentration range of 0 mg/L–1.4 mg/L. It was 9.9 times higher than that of a single-sensing FPI. The experimental results also demonstrate that when the FSR values of two FPIs are closer, the higher response sensitivity is achieved. The sensor also has good measurement repeatability and dynamic response. In addition, the experimental results of response selectivity show that its response sensitivity to copper ions is significantly higher than other six types of ions, including iron ions, lead ions, magnesium ions, manganese ion, zinc ions, chromium ions. The copper ion is also mixed with six types of ions to deeply investigate the response selectivity. Good response selectivity and cross-responding are demonstrated by experimental results.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Jianing Zhang,Junjun Zhang,Xiaowei Huang,Xiaodong Zhai,Zhihua Li,Jiyong Shi,Remah Sobhy,Ibrahim Khalifa,Xiaobo Zou
Minimally processed fruits and vegetables (MPFVs) experience significant quality degradation during storage due to oxygen exposure, mechanical damage, and microbial contamination, which significantly reduces shelf life and leads to substantial economic waste. This research developed a cost-effective and environmentally active packaging by incorporating carbon quantum dots (CQDs) derived from lemons into guar gum (GG) and sodium alginate (SA) films. The CQDs were integrated into the biopolymer matrix via simple film-casting techniques. The CQDs exhibited exceptional antioxidant and antibacterial properties due to the abundant functional groups and unique quantum effects. The integration of CQDs into GG/SA films enhanced UV-blocking capabilities, mechanical strength (38.80 MPa), and antioxidant activity (43.45%). The release kinetics of CQDs from the films followed the Fickian diffusion kinetics. The use of CQDs offers several advantages over conventional methods including their biocompatibility, sustainability, and multifunctionality. Additionally, the films effectively delayed the browning of blanched asparagus. The mechanism of browning inhibition was attributed to the prevention of chlorophyll degradation and enzymatic browning. This approach offers a sustainable and effective solution for extending the shelf life and safety of MPFVs.
✓ 已验证
DOI
PubMed
高影响因子
Foods
·
2024
·Vol. 13
·期 4
·622
·
IF 4.7
Qian Li,Rui Li,Fanxing Yong,Qiaoli Zhao,Jing Chen,Xing Lin,Ziyu Li,Zhuo Wang,Baojun Xu,Saiyi Zhong
Pickering emulsions (PEs) have been regarded as an effective approach to sustaining and preserving the bioactivities of essential oils. The aim of this research is to prepare a PE stabilized by chitosan/alginate nanoparticles (CS-SA NPs) for the encapsulation and stabilization of D-limonene. In this work, the influence of calcium ions (Ca2+) on the morphology and interaction of nanoparticles was studied, and then the preparation technology of CS-SA/Ca2+NPs was optimized. The results showed that the presence of Ca2+reduced the size of the nanoparticles and made them assume a spherical structure. In addition, under the conditions of 0.2 mg/mL CaCl2, 0.6 mg/mL SA, and 0.4 mg/mL CS, the CS-SA/Ca2+NPs had the smallest size (274 ± 2.51 nm) and high stability (−49 ± 0.69 mV). Secondly, the PE was prepared by emulsifying D-limonene with CS-SA/Ca2+NPs, and the NP concentrations and homogenization speeds were optimized. The results showed that the small droplet size PE could be prepared with 2 mg/mL NP and a homogenization speed of 20,000 r/min, and it had excellent antibacterial and antioxidant activities. Most importantly, the emulsion showed higher activity, higher resistance to ultraviolet (UV) and a higher temperature than free D-limonene. This research provides a feasible solution for the encapsulation, protection and delivery of essential oils.Keywords:homogenization speed;thermal stability;ultraviolet stability;antibacterial activity;antioxidant activity
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Qi Zhang,Gang Lin,Huainian Wang,Ming Chao Jin,Haoming Dang,Jie Zhang,Ruijie Guo,Hong Yan,Baolong Niu,Huifang Wang
This study focused on the preparation, functionality, and application of smart food packaging films based on polyvinyl alcohol (PVA) and anthocyanins (ACNs) -loaded sodium alginate-chitosan quaternary ammonium salt (HACC-SA) nanocomplexes. The average encapsulation rate of anthocyanins-loaded nanocomplexes reached 62.51 %, which improved the hydrophobicity and water vapor barrier of the PVA film. FTIR confirmed that the nanocomplexes were immobilized in the PVA film matrix by hydrogen bonding, which improved the mechanical properties of the film. The SEM and XRD results demonstrated that the HACC-SA-ACNs nanocomplexes were uniformly distributed in the film matrix and the crystallinity of PVA was decreased. The P/HACC-SA-ACNs film showed a significant response to buffers of pH 2–13 and high color stability after 21 days of storage compared to the P/ACNs film. Furthermore, the color of the composite film changed from purple to red as the milk freshness decreased during 72 h of milk freshness monitoring, indicating that the P/HACC-SA-ACNs films were suitable and promising for application as smart packaging materials.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Li Yang,Yichen Yang,Ying Yang,Kaiwen He,Guangyang Jiang,Yongqiang Tian
In this work, a straightforward approach utilizing distillers' grains (DG) waste and sodium alginate (SA) was developed to prepare functional and bioactive packaging films. Deep eutectic solvents (DESs) were initially synthesized from choline chloride (CO), betaine (BO), glycerol (GO), and oxalic acid . Composite films were then prepared from DES-treated DG slurry and SA at different ratios. Characterization and analysis revealed that adding 75 % CO-treated DG slurry reduced the water vapor permeability (WVP) by over 66 % compared to that of the SA film. Composite films containing CO/BO-treated DG slurry had an ultraviolet light barrier rate exceeding 99 %, while those with 75 % DES-treated DG slurry demonstrated excellent antioxidant activity , with a 2,2′-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) free radical scavenging rate of 80.14 %–88.35 %, representing a 322.45 %–365.73 % increase compared to that of the pure SA film. These composite films also exhibited favorable mechanical properties (31.58 MPa, 5.53 % EB), thermal stability , and biodegradability , extending the shelf life of grapes by 1.8 times. In conclusion, bioactive composite films derived from DES-treated DG are expected to replace petroleum-based plastics, enhancing sustainable biomass use and environmental responsibility.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2024
·
IF 6.5
Hong Yang,Yao Chen,Yongwei Cai,Jianxiang Li,Lei Qiu,Yimeng Wang,Yuanju Li,Danni Qu,Ruru Wang,Qi Zhao
Catheter-associated urinary tract infections (CAUTIs) pose a significant clinical challenge, potentially resulting in complications such as bacteriuria and mortality. Developing coatings with antibacterial and antiadhesive properties for urinary catheters is essential to address these issues. In this study, a novel hydrogel coating composed of silver nanoparticles (Ag NPs), sodium alginate (SA), polyacrylamide (PAAm), and polyvinyl alcohol (PVA) was prepared on polydopamine (PDA)-modified latex urinary catheters using a simple dipping method. The Ag NPs were synthesized via an in-situ reduction of AgNO 3 with SA, eliminating the need for additional chemical reductants. The Ag NPs-SA-PAAm-PVA hydrogel-coated urinary catheter demonstrated superior antibacterial and antiadhesive characteristics compared to the bare urinary catheter. The antiadhesive properties of the hydrogel-coated urinary catheter were attributed to its hydrophilicity and lubricity, while the antibacterial effects were linked to the penetration of Ag NPs and Ag + ions into bacterial structures, disrupting bacterial metabolism through the generation of reactive oxygen species (ROS) and free radicals upon attachment of Ag + ions to cell walls and membranes. Furthermore, the hydrogel coatings exhibited remarkable mechanical properties, along with good biocompatibility and hemocompatibility. The exceptional antibacterial and antiadhesive properties of the hydrogel-coated urinary catheter hold promise for reducing CAUTIs.
✓ 已验证
产品关联
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Wenzhi Lei,Maodong Qi,Jiangling Song,Hongcai Li,Xingnan Wang,Yue Ma,Zhenpeng Gao
Starch nanoparticles (SNPs) have been recognized as potentially efficient adsorbents for polyphenols. However, their actual adsorption in complex systems such as fruit pomace extract is significantly lower than theoretical predictions and their adsorption capacity is inferior to traditional materials such as macroporous adsorbent resins, which limits their industrial application. Aiming to enhance the adsorption of apple pomace polyphenols, this study used sodium alginate (SA) modifies SNPs to create a cornstarch-based composite system (SA-SNPs). The optimal modified addition of sodium alginate was 0.3 g (g starch) −1 , under this condition, the nanoparticles obtained exhibited the smallest particle size (154.60 nm) and the best adsorption performance (33.97 mg g −1 in 90 min). The SA-SNPs reached the adsorption equilibrium at 180 min, which significantly enhanced the equilibrium adsorption amount of the polyphenols (from 2.68 to 37.02 mg g −1 ). The adsorption process was found to follow the pseudo-second- order kinetic model and the Langmuir isotherm model, which included membrane diffusion, intra-particle diffusion, and equilibrium phases. The adsorption amount initially increased and then continued to decrease with the increase in temperature, and the whole process was exothermic and spontaneous (ΔH° = −52.394 kJ mol −1 , ΔG° < 0 kJ mol −1 ). Additionally, SA-SNPs loaded with polyphenols demonstrated better protection of polyphenol DPPH radical-scavenging activity during storage, enhanced stability, and optimal colon-targeted sustained-release properties in complex physiological environments. This work presents a new approach to improving the adsorption capacity of SNPs and developing high-performance natural edible separation materials.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Mengmeng Zhang,Zhihui Sui,Lijian Sun,Qi Zhang,Wenjing Zhao,Longyu He,Shuzhen Gao,Fang Hu
In this study, a assembly technique based on phosphorylated sodium alginate (PSA) and fluorosilicone waterborne polyurethane (FSiWPU) was developed, and a multifunctional hemp cellulose fabric system which integrates flame retardant, hydrophobic and UV resistant properties was successfully constructed. Stable multilayer structures are formed by utilizing the hydrogen bonding between the phosphate group/carboxylic acid group of PSA and the carbamate group (-NHCOO-) of FSiWPU. The phosphorylation of sodium alginate significantly improves its thermal stability and generates a dense carbon layer with polyurethane decomposition products at high temperatures, resulting in a limiting oxygen index (LOI) of 32.7 % for hemp cellulose fabric, which achieves a UL-94 V-0 rating. Compared with the original fabric, the peak and total heat release rates of phosphorylated sodium alginate/fluorosilicone waterborne polyurethane (PSA/FSiWPU) coated hemp cellulose fabric decreased by 75.2 % and 90.1 %, respectively. Meanwhile, the fluorosilicon component in FSiWPU is enriched on the fabric surface and the water contact angle of the coated fabric reaches 136.05°, which endows the fabric with excellent hydrophobicity and self-cleaning properties. Encouragingly, the functional coating is universal and suitable for a variety of substrates. Moreover, the coated fabric shows excellent UV resistance, with a UV protection factor of 91.26 and a UVA transmission rate of <5 %. Not only that, coated fabrics also have good mechanical properties and washability. Therefore, this work not only opens up new idea for the multifunctional finishing of hemp cellulose fabrics, but also has great potential in practical applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）