Nano Research
·
2023
·Vol. 16
·期 5
·6290-6297
·
IF 9.9
Cai Jiahao,Song Shizheng,Zhu Lijie,Lu Qipeng,Lu Zong,Wei Yanying,Wang Haihui
A kind of two-dimensional (2D) metal-organic framework (MOF) material, Cu-meso-tetrakis (4-carboxyphenyl) porphine (Cu-TCPP) nanosheets with wrinkled and flat morphologies are used as building blocks to assemble membranes by vacuum filtration (VF) and electrophoretic deposition (EPD) as energy-efficient nanofiltration (NF) membranes to remove dyes from water. Since the nanosheets with wrinkled structure can provide additional water transport channels, thereby increasing the water permeance, in the premise of a high rejection (> 97.0%) for the dye brilliant blue G (BBG) (1.60 nm × 1.90 nm), the water permeance of the membrane assembled by the wrinkled nanosheets (∼ 1170 nm) is about 4 times that of the membrane assembled by the flat nanosheets (∼ 530 nm), reaching 16.39 L·m −2 ·h −1 ·bar −1 . Additionally, the use of the relatively flat nanosheets and the membrane preparation method of electrophoretic deposition is more conducive to stack nanosheets orderly and reduce defects. Therefore, the water permeance of the membrane prepared by EPD (∼ 1170 nm) with flat nanosheets is about twice that of the membrane prepared by VF (∼ 530 nm), achieving 9.40 L·m −2 ·h −1 ·bar −1 with similar rejection (> 97.0%) of dye evans blue (EB) (3.10 nm × 1.20 nm). Furthermore, these membranes still exhibit good separation performance at high pressure of 0.6 MPa. Nanosheets with diverse structures and various membrane fabrication processes provide new directions for the separation performance optimization of 2D MOF materials for water purification.
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Advanced Composites and Hybrid Materials
·
2023
·Vol. 6
·期 2
·1-13
·
IF 20.1
Lian Peng,Yan Ruihan,Wu Zhiguo,Wang Zhibin,Chen Ying,Zhang Li,Sheng Xinxin
Inorganic hydrated salt phase change materials (PCMs) have received great attention due to their capabilities to reduce building energy consumption and improve building thermal comfort. In this work, a modified PCM (DHPD-STP) with a low supercooling degree was first prepared by using disodium hydrogen phosphate dodecahydrate (Na 2 HPO 4 ·12H 2 O, DHPD) as the matrix and sodium thiosulfate pentahydrate (Na 2 S 2 O 3 ·5H 2 O, STP) as a nucleating agent. Then expanded graphite (EG) was added to DHPD-STP to afford a novel form-stable composite phase change material (CPCM). The novel CPCM obtained had a phase transition temperature (34.74 °C) appropriate for building thermal management, an excellent phase change enthalpy (184.39 J/g), and an extremely low supercooling degree (1.1 °C). The addition of EG greatly improved the form stability and cycle stability of the CPCM. Even after 200 cycles, the CPCM prepared still had a high enthalpy of phase changes (164.54 J/g). More importantly, the use of CPCM-loaded roofs effectively mitigated the variation of room temperature and improved indoor thermal comfort. The above results demonstrate the great potential of the CPCM prepared for passive building thermal management. Graphical Abstract
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-11
·
IF 16.6
Fan Wenjun,Duan Zhiyao,Liu Wei,Mehmood Rashid,Qu Jiating,Cao Yucheng,Guo Xiangyang,Zhong Jun,Zhang Fuxiang
Single-atom catalysts supported on solid substrates have inspired extensive interest, but the rational design of high-efficiency single-atom catalysts is still plagued by ambiguous structure determination of active sites and its local support effect. Here, we report hybrid single-atom catalysts by an axial coordination linkage of molecular cobalt phthalocyanine with carbon nanotubes for selective oxygen reduction reaction by screening from a series of metal phthalocyanines via preferential density-functional theory calculations. Different from conventional heterogeneous single-atom catalysts, the hybrid single-atom catalysts are proven to facilitate rational screening of target catalysts as well as understanding of its underlying oxygen reduction reaction mechanism due to its well-defined active site structure and clear coordination linkage in the hybrid single-atom catalysts. Consequently, the optimized Co hybrid single-atom catalysts exhibit improved 2e − oxygen reduction reaction performance compared to the corresponding homogeneous molecular catalyst in terms of activity and selectivity. When prepared as an air cathode in an air-breathing flow cell device, the optimized hybrid catalysts enable the oxygen reduction reaction at 300 mA cm −2 exhibiting a stable Faradaic efficiency exceeding 90% for 25 h.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2023
·Vol. 415
·期 10
·1889-1896
·
IF 4.3
Li Shuofan,Wu Jianxun,Zhang Weilai,Jiang Yue,Hu Miao,Chung Keng H.,Shi Quan
Thiophenes and sulfides are the dominant sulfur-containing compounds in petroleum and have been widely of concern in the fields of petroleum refining and geochemistry. In this study, a novel approach was developed for selective separation and characterization of petroleum-derived thiophenic and sulfide compounds. Thiophenic compounds were selectively converted to sulfonates in the presence of vitriolic acid and can be characterized by negative ion electrospray mass spectrometry. Thiophenic sulfonates were further separated from the oil by silica chromatography and enabled the molecular characterization of sulfides in the residual oil. Various model sulfur compounds and a vacuum gas oil were used to validate the method; thiophenic and sulfide biomarker compounds in a well-documented crude oil were selectively characterized. The results indicate that the approach is feasible for molecular characterization of thiophenic and sulfide compounds, which is complementary to recently developed methods for separation and/or ionization of sulfur compounds in petroleum. Graphical Abstract
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Journal of Biological Engineering
·
2023
·Vol. 17
·期 1
·1-14
·
IF 5.6
Yuan Shan,Xu Chao,Jin Miaomiao,Xian Mo,Liu Wei
Background Aromatic primary amines (APAs) are key intermediates in the chemical industry with numerous applications. Efficient and mild biocatalytic synthesis is an excellent complement to traditional chemical synthesis. Our lab previously reported a whole-cell catalytic system for the synthesis of APAs catalyzed by carboxylic acid reductase from Neurospora crassa (ncCAR) and ω-transaminase from Ochrobactrum anthropi (OATA). However, the accumulation of toxic intermediates (aromatic aldehydes) during biocatalytic synthesis affected yields of APAs due to metabolic imbalance. Results In this work, the biocatalytic synthesis of APAs (taking cinnamylamine as an example) was metabolically regulated by the overexpression or knockout of five native global transcription factors (TFs), the overexpression of eight native resistance genes, and optimization of promoters. Transcriptome analysis showed that knockout of the TF arcA increased the fluxes of NADPH and ATP in E. coli , while the rate of pyruvate metabolism was accelerated. In addition, the genes related to stress and detoxification were upregulated with the overexpression of resistance gene marA , which reduced the NADPH level in E. coli . Then, the expression level of soluble OATA increased by promoter optimization. Overall, arcA and marA could regulate the catalytic rate of NADPH- dependent ncCAR, while arcA and optimized promoter could regulate the catalytic rate of OATA. Lastly, the cinnamylamine yield of the best metabolically engineered strain S020 was increased to 90% (9 mM, 1.2 g/L), and the accumulation of cinnamaldehyde was below 0.9 mM. This work reported the highest production of cinnamylamine by biocatalytic synthesis. Conclusion This regulatory process provides a common strategy for regulating the biocatalytic synthesis of other APAs. Being entirely biocatalytic, our one-pot procedure provides considerable advantages in terms of environmental and safety impacts over reported chemical methods.
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FIBERS AND POLYMERS
·
2023
·Vol. 24
·期 2
·469-482
·
IF 2.5
Hu Qingxi,Wang Qi,Liu Suihong,Lu Ye,Zeng Zhaoxiang,Feng Jiaxuan,Feng Rui,Zhang Haiguang
Nowadays, many studies focus on the preparation of small-diameter vascular scaffolds, but some issues still existed that need to be urgently solved, but there are still problems such as slow endothelialization and failure to keep the vessels open for a long time that need to be solved. In this paper, a composite process of preparing triple-layer vascular scaffolds with microchannel structure in the inner layer is proposed to guide cell growth and accelerate the endothelialization process. The PCL pattern was printed as the intermediate layer of the vascular scaffold by 3D printing method, and the width of the microchannel in the inner layer of the scaffold was controlled by the printing spacing. The inner and outer layers were prepared by electrospinning. Heparin is often used as an anticoagulant in vascular tissue engineering to improve the problem of thrombosis and blockage of vascular scaffold after transplantation into the body. Here, the inner layer carries heparin immobilized with silk fibroin by coaxial electrospinning, so that heparin can be released slowly. The addition of silk fibroin also improved the hydrophilicity of PCL electrospinning film by water contact angle test. The mechanical properties of vascular scaffolds with double intermediate layers (DIL) are better than those with single intermediate layers (SIL) and also better than pure electrospinning scaffolds. In vitro cell experiments showed that cells grow directionally on microchannel structures of inner layer and randomly on electrospinning film without microchannel structure. The results showed that the microchannels were more conducive to cell growth and proliferation at a diameter of 0.25 mm. The composite electrospinning films with silk fibroin and heparin facilitated cell adhesion and proliferation compared to the pure PCL films. All these results indicate that the vascular scaffolds have potential applications in clinic for vascular tissue regeneration.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 17
·51356-51367
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IF 5.8
Zhang Junshan,Mao Xisong,Lan Yuanpei,Li Junqi,Chen Chaoyi,Yang Jian,Zhang Wei,Murali Arun,Liu Li,Wang Qin
Chemical reducing or rare earth cations (RE) doping was normally employed to promote the photocatalytic performance of ceria, aimed to evaluate their cooperation influences, ceria was obtained by decomposing homogenously RE (RE = La, Sm, and Y)-doped CeCO 3 OH in H 2 . XPS and EPR results evidenced that the excess oxygen vacancies (OVs) were formed in RE-doped CeO 2 compared to the un-doped ceria. However, all the RE-doped ceria unexpectedly showed an impeded photocatalytic activity towards to methylene blue (MB) photodegradation. The 5% Sm-doped ceria had the best MB photodegradation ratio of 81.47% after 2-h reaction in all RE-doped samples, which was lower than that of 87.24% for the un-doped ceria. After doping RE cations and chemical reducing, the band gap of ceria were almost narrowed, while the PL spectra and photo-electro characterizations indicated that the separation efficiency of photo-excited e − / h + (electrons/holes) was reduced. The RE dopants and formed excess OVs including inner and surface OVs was proposed to promote the recombination of e − / h + which further hindered the generation of active species of · O 2 − and · OH, and finally weakened the photocatalytic activity of ceria.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 17
·51125-51142
·
IF 5.8
Lu Mang,Wu Xue-jiao,Wan Chu-xing,Gong Qiu-ping,Li Jia-xin,Liao Shuang-shuang,Wang Yu-an,Yuan Shu-hao
A reduced graphene oxide (RGO) supported Fe 3 O 4 -MnO 2 nanocomposite (Fe 3 O 4 -MnO 2 @RGO) was successfully prepared for catalytic degradation of oxytetracycline (20 mg/L) by potassium persulfate (PS) and adsorption removal of mixture of Pb 2+ , Cu 2+ , and Cd 2+ ions (each 0.2 mM) in the synchronous scenario. The removal efficiencies of oxytetracycline, Pb 2+ , Cu 2+ , and Cd 2+ ions were observed as high as 100%, 99.9%, 99.8%, and 99.8%, respectively, under the conditions of [PS] 0 = 4 mM, pH 0 = 7.0, Fe 3 O 4 -MnO 2 @RGO dosage = 0.8 g/L, reaction time = 90 min. The ternary composite exhibited higher oxytetracycline degradation/mineralization efficiency, greater metal adsorption capacity (Cd 2+ 104.1 mg/g, Pb 2+ 206.8 mg/g, Cu 2+ 70.2 mg/g), and better PS utilization (62.6%) than its unary and binary counterparts including RGO, Fe 3 O 4 , Fe 3 O 4 @RGO, and Fe 3 O 4 -MnO 2 . More importantly, the ternary composite had good magnetic recoverability and excellent reusability. Notably, Fe, Mn, and RGO could play a synergistic role in the improvement of pollutant removal. Quenching results indicate that surface bounded SO 4 •– was the major contributor to oxytetracycline decomposition, and the -OH groups on the composite surface shouldered a significant role in PS activation. The results indicate that the magnetic Fe 3 O 4 -MnO 2 @RGO nanocomposite has a good potential for removing organic-metal co-contaminants in waterbody. Graphical Abstract
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CANCER GENE THERAPY
·
2023
·
IF 6.4
Ma Jia,Zhou Wenyang,Yuan Yifeng,Wang Baosheng,Meng Xiangpeng
Proteasome 26S subunit, non-ATPase 12 (PSMD12) genes have been implicated in several types of malignancies but the role of PSMD12 in pancreatic cancer (PC) remains elusive. Bioinformatics analysis showed that PSMD12 was highly expressed in PC patients and was associated with shorter overall survival. PSMD12 was also shown to be highly expressed in PC tissues and cell lines. Upregulated PSMD12 showed enhanced cell viability, increased colony formation rate and upregulated levels of PCNA and c-Myc, while the inhibition of PSMD12 abated these levels. PSMD12 knockdown promoted cell apoptosis. The results of xenografts in nude mice confirmed that PSMD12 promoted PC tumor growth in vivo. Protein ‒ protein interaction network and functional enrichment analyses implied that PSMD12 may have a connection with cyclin-dependent kinase inhibitor 3 (CDKN3). Co‑immunoprecipitation and western blot results confirmed that PSMD12 could interact with and abate the ubiquitination level of CDKN3, thus stabilizing the CDKN3 protein. Rescue assays showed that PSMD12 overexpression caused cell proliferation and that knockdown-induced cell apoptosis could be reversed by CDKN3 regulation. This work reveals the essential roles of PSMD12 in the proliferation and apoptosis of PC development. PSMD12 may regulate CDKN3 expression by interacting with and abating the ubiquitination level of CDKN3, thereby participating in the malignant behavior of PC.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 7
·1-13
·
IF 2.8
Guo Yitong,Du Jingyang,Hu Meihua,Wei Bin,Su Taichao,Zhou Aiguo
In this paper, the thermoelectric (TE) performance of Bi 2 Te 3 was improved by the incorporation of Mo 2 C MXene, which is a novel two-dimensional material with moderate TE performance. The TE properties of Mo 2 C MXene were characterized from bulk samples bonded with 5 wt% Al sintered by spark plasma sintering (SPS) at 623 K for 6 min. Due to the very weak TE performance of Al, the performance of Mo 2 C MXene/Al composite reflects that of Mo 2 C MXene. It is an N-type conductor with the Seebeck coefficient of − 9.25 µV/K at 600 K. This is the first report to characterize the TE performance of Mo 2 C MXene bulk samples. Thereafter, Bi 2 Te 3 /Mo 2 C MXene composite powders were prepared from Mo 2 C MXene powers and precursors of Bi 2 Te 3 by hydrothermal method at 453 K for 24 h. The bulk samples of Bi 2 Te 3 incorporated with Mo 2 C MXene was obtained by SPS at 523 K for 7 min. The composites are N-type conductors. The electrical conductivity was remarkably increased with the content of Mo 2 C MXene, while the thermal conductivity slightly decreased. The sample with 5 vol% Mo 2 C MXene showed the optimal thermoelectric properties, and its ZT value was 0.26 at 473 K. At 450 K, the ZT value (~ 0.25) of that sample was 78.6% higher than that of Bi 2 Te 3 (~ 0.14). This is the first report on regulating TE performance by the incorporation of Mo 2 C MXene, a 2D material with intrinsic TE performance.
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Journal of Orthopaedic Surgery and Research
·
2023
·Vol. 18
·期 1
·1-12
·
IF 2.6
Huang Jun,Zhou Hongxiang,He Liang,Zhong Lin,Zhou Ding,Yin Zongsheng
Background Nonunion is a failure of fracture healing and a major complication after fractures. Ubiquitin-specific protease 1 (USP1) is a deubiquitinase that involved in cell differentiation and cell response to DNA damage. Herein we investigated the expression, function and mechanism of USP1 in nonunion. Methods and results Clinical samples were used to detect the USP1 expression in nonunion. ML323 was selected to inhibit USP1 expression throughout the study. Rat models and mouse embryonic osteoblasts cells (MC3T3-E1) were used to investigate the effects of USP1 inhibition on fracture healing and osteogenesis in vivo and in vitro, respectively. Histological changes were examined by micro-computerized tomography (Micro-CT), hematoxylin & eosin (H&E) staining and Masson staining. Alkaline phosphatase (ALP) activity detection and alizarin red staining were used for osteogenic differentiation observation. The expression of related factors was detected by quantitative real-time PCR, western blot or immunohistochemistry (IHC). It was shown that USP1 was highly expressed in nonunion patients and nonunion rats. USP1 inhibition by ML323 promoted fracture healing in nonunion rats and facilitated the expression of osteogenesis-related factors and the signaling of PI3K/Akt pathway. In addition, USP1 inhibition accelerated osteogenic differentiation and promoting PI3K/Akt signaling in MC3T3-E1 cells. Conclusions USP1 inhibition plays a promotive role in coordinating osteogenic differentiation and fracture healing during nonunion. PI3K/Akt may be the downstream pathway of USP1.
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Food Biophysics
·
2023
·Vol. 18
·期 3
·402-410
·
IF 3
Ren Cong,Xiong Wenfei,Li Bin
Understanding the effects of typical unit operations on the structure and properties of protein/polyphenol complexes has important guiding value for the design and development of two-component functional foods. Therefore, the effects of high-pressure homogenization (HPH) on the structure, physicochemical properties, and in vitro digestive characteristics of soy protein isolate (SPI)-black soybean coat extract (BE) complexes were investigated. UV-Vis and intrinsic fluorescence spectra manifested that the tertiary conformation of protein was partially unfolded after HPH treatment. In addition, with the enhancement of HPH pressure, the zeta-potential magnitude and average particle size of SPI-BE complexes increased and decreased, respectively. On the other hand, HPH had no significant effect on in vitro digestion, anthocyanin content, and free radical scavenging ability of SPI-BE complexes. These findings can provide new insights and guidance for the optimization and regulation of protein-polyphenol co-existing food systems, and provide reference for their application in food industry.
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