CARBOHYDRATE POLYMERS
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2026
·
IF 13.2
Qianqian Ouyang,Hongjiao Qu,Weiyan Quan,Yongkai Tang,Xufeng Zhu,Luming Deng,Xian Xie,Kefeng Wu
Microneedle patches have emerged as promising tools for wound repair. However, their clinical utility is limited by poor adhesion and insufficient interfacial stability, which often lead to secondary wound separation and inefficient drug delivery. Here, we report a seaweed-derived bioadhesive microneedle patch that integrates robust tissue adhesion with sustained drug release for effective skin regeneration. The hydrogel patch, composed of chitosan and poly(vinylpyrrolidone) (PVP), absorbs wound exudates and forms mechanically stable adhesion on tissue surfaces. As such, it maintains long-term fixation and protects the wound site. The microneedle array, fabricated via electrostatic interactions between seaweed-derived polysaccharides (contained α -D-Glcp-1→, →4,6)- α -D-Glcp-(1→, and →4)- α -D-Glcp-(1 → units, with a molecular weight of 27,476 Da, named SFP) and chitosan, exhibits rigid, sharp conical tips that enable efficient skin penetration while ensuring strong interfacial adhesion through conformal contact and hydrogen bonding. This intimate microneedle–tissue integration facilitates localized, continuous release of the antibacterial polysaccharide at the wound interface, thereby ensuring sustained therapeutic efficacy. Furthermore, in vivo studies demonstrated accelerated wound closure, enhanced collagen deposition, promoted angiogenesis, and reduced inflammation. Together, these findings establish the seaweed-derived microneedle patch as a multifunctional platform that stabilizes the wound interface, enhances therapeutic delivery, and holds broad potential for diverse biomedical applications.
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JOURNAL OF RARE EARTHS
·
2026
·
IF 9.6
Jingyang Shi,Xianbo Fang,Jieliang Wang,Zhao Cao,Jing Lv,Yongdan Cao,Xiaoping Wang,Na Luo,Fang Zhou,Aiqing Wang,Burdonov Alexander Evgenievich
In rare earth flotation, the separation of bastnaesite and parisite from fluorite is challenging by the similarity of their surface properties and solubility. This study utilized carboxymethyl chitosan (CTS) as a green organic inhibitor for the flotation separation of bastnaesite and parisite from fluorite. The inhibitory effect and mechanism of CTS on fluorite were studied through flotation tests and modern detection methods. The flotation tests results indicate that CTS can effectively inhibit fluorite under the conditions: CTS concentration of 20 mg/L, octyl hydroxamic acid (OHA) concentration of 1×10 –4 mol/L, and at pH 9.8, whereas it only slightly affects the flotation recovery of bastnaesite and parisite. The mechanism analysis results indicate that CTS selectively adsorbs on fluorite surface and reduces the contact angle from 27.25° to 20.38°, while significantly delaying the adhesion process of bubbles on the fluorite surface and reducing its ultimate adhesion angle. CTS undergoes strong chemical adsorption on the surface of fluorite, hindering the subsequent adsorption of OHA, but has weak adsorption on the rare earth minerals. CTS chelates with Ca 2+ on the fluorite surface through its –COO – molecule, forming a hydrophilic Ca(COOR) adsorption cover on the fluorite surface to increase its steric hindrance and inhibit fluorite flotation. Therefore, CTS can be used as a green, environmentally friendly, and highly selective inhibitor to achieve efficient flotation separation of bastnaesite and parisite from fluorite.
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International Journal of Polymeric Materials and Polymeric Biomaterials
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2026
·
IF 3.2
Xi Su,Wei Xu,Lulu Liu,Qingxiang You,Wenchang Yi,Siyu Chen,Zhenying Wan,Shuya Huang
A novel ethyl cellulose-sodium alginate/chitosan/curcumin (EC-SA/CS/Cur) composite microgel system was developed through a one-step emulsion method. Optimized homogenization at 1,300 rpm for 2 min enabled consistent fabrication of EC-SA/CS/Cur microgels with a mean particle size of 2.85 μm. The microstructural morphology, particle size distribution, and chemical composition of the optimized EC-SA/CS/Cur microgels were characterized by microscopy, laser particle size analysis, and Fourier-transform infrared spectroscopy. The microgels exhibited a curcumin encapsulation efficiency of 54.4 ± 6.8% and a drug loading capacity of 0.032 ± 0.004%. The microgels exhibited excellent stability under enzymatic and physiological pH environments while displaying a unique sustained-release profile in ethanol-containing media; under agitated conditions, a cumulative release of 3.2 μg/mL was achieved within 6 h, representing a 28.0% increase in cumulative release compared to static conditions. The minimum inhibitory concentration of EC-SA/CS/Cur microgels was determined as 675 μg/mL; after 3 h of exposure, their antimicrobial efficacy significantly outperformed free curcumin. These results confirm that the EC-SA/CS microgel system acts as an effective delivery vehicle, markedly enhancing curcumin’s antimicrobial performance. This study provides a promising strategy for developing stable, high-efficiency curcumin delivery systems with improved therapeutic potential, particularly for oral/throat protection against alcohol-induced irritation via on-site curcumin release to alleviate local inflammatory damage.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Chao Wang,Youfeng Guo,Siyi Xue,Cui Jin,Yufeng Huang,Lifeng Yan,Shidong Ji,Xiao Ma
Natural biomaterial-derived membranes show great potential for guided bone regeneration (GBR) and bone tissue engineering due to excellent biocompatibility and degradability. While incorporating inorganic nanoparticles like hydroxyapatite (HA) is a common strengthening strategy, the systematic impact of nanoparticle morphology on the integrated performance of composite membranes remains a critical, yet underexplored, knowledge gap. Here, we developed chitosan (CS)-based composite membranes incorporating hydroxyapatite (HA) nanoparticles of four morphologies: large lamellar (LHA), small lamellar (SHA), wire-like (WHA), and rod-like (RHA). Additionally, HA’s capacity as an ion carrier enabled the loading of silver (Ag) to impart antibacterial properties. High-aspect-ratio fillers (LHA, WHA) promoted crack deflection and energy dissipation, achieving tensile strengths up to 82.47 ± 4.10 MPa and toughness up to 28.61 ± 5.02 MJ·m −3 —significantly outperforming pure CS membranes. This reinforcement mechanism extended to other matrices, such as sodium alginate. Simultaneously, the Ag-loaded HA (Ag-HA) composite membranes synergistically enhanced osteogenic activity (alkaline phosphatase) and exhibited strong antibacterial efficacy. These findings elucidate morphology–size–performance correlations, providing a framework for designing multifunctional GBR biomaterials with enhanced mechanical properties, osteogenesis, and antimicrobial capabilities.
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CELLULOSE
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2026
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IF 4.6
Cheng Heli,Guo Zejiang,Chen Bingzhe,Gong Jiansheng,Luo Qipeng,Chen Xin,Wang Peng,Jiang Jungang
Hemicellulose-based hydrogels have attracted significant attention due to their inherent renewability, and tunable physicochemical properties. Overcoming their intrinsic mechanical weakness remains a persistent challenge. Here we present a robust and stretchable microgel-reinforced hemicellulose hydrogel made by embedding rigid chitosan microspheres (CMs) in the flexible hydrogel matrix formed by copolymerization of methacrylated hemicellulose and acrylamide. The compressive strength of the hydrogel achieves 3.52 MPa under a strain of 90%, which is 2.7 times that of the hydrogel without CMs. Meanwhile, the tensile strength reaches 44.09 kPa, with a strain of 413%. The toughness of the hydrogel is 91.1 kJ m −3 , nearly twice that of the hydrogel without CMs. Further incorporation of MXene endows the hydrogel with excellent electrical conductivity (0.56 S m −1 ), enabling pressure detection as low as 0.16 kPa, which makes it suitable for use as a sensor for real-time monitoring of physiological signals and human motion.
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Regenerative Biomaterials
·
2026
·
IF 8.7
Lu Min,Sun Tong,Tang Chongxu,Zhang Xinmei,Hao Shuyue,Yang Mei,Xin Qiangwei,Zhu Zhongqiang,Ding Mingming,Weng Jie,Li Zhiqiang,Chen Xingyu,Li Jianshu
The healing of infected wounds is a formidable clinical challenge that demands advanced biomaterials capable of simultaneously eradicating pathogens and orchestrating the complex regenerative process. Herein, we engineered an immunomodulatory and angiogenic multifunctional hydrogel dressing by integrating choline phosphorylated chitosan (CS-MCP) with tetracycline-loaded polydopamine nanoparticles (PDA@TH NPs) for the programmed healing of infected wounds. This composite hydrogel demonstrates on-demand, spatiotemporally controlled therapeutic responses. Under near-infrared (NIR) irradiation, it enables synergistic bactericidal activity through photothermal effects and triggered antibiotic release. Moreover, the system exhibits pH-responsive drug release behavior, specifically targeting the acidic microenvironment of infected tissues. Beyond its potent antibacterial function, the hydrogel actively promotes regenerative processes. In vitro, CS-MCP markedly enhanced the adhesion, proliferation, and tube formation of human umbilical vein endothelial cells, demonstrating potent pro-angiogenic effects. Furthermore, the polydopamine nanoparticles effectively scavenged reactive oxygen species (ROS), attenuating oxidative stress and inducing M2 macrophage polarization to foster an immunoregulatory microenvironment conducive to tissue repair. In a rat model of Staphylococcus aureus-infected full-thickness skin defects, the hydrogel significantly accelerated wound healing by comprehensively modulating the entire regeneration cascade: eliminating infection, mitigating inflammation, promoting angiogenesis, and enhancing collagen deposition. This study presents a novel immune-engaging and pro-regenerative strategy, representing a highly promising platform for the treatment of refractory infected wounds.
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ACS Applied Nano Materials
·
2026
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IF 5.8
Minh Quan Ho,Nam-Son Dinh-Ngoc,Quynh-Anh Vu-Yen,Dang Nguyen Nha Khanh,Tan Anh Nguyen,Ngoc Thuy Trang Le
Abstract Pathogenic biofilms and complex biological environments significantly limit the therapeutic efficacy of antimicrobial peptides such as Nisin Z due to rapid degradation and poor penetration. In this study, we developed a Nisin Z-loaded chitosan-pectin coated liposome (LCPN) as a lipid-polymer hybrid nanosystem to overcome these limitations. The optimized LCP formulation exhibited an average particle size of 278.4 ± 3.1 nm, a polydispersity index of 0.229 ± 0.326, and a surface charge of −28.7 ± 0.8 mV. Furthermore, the nanosystem achieved a high encapsulation efficiency of 63.84% and demonstrated a sustained release profile, delivering 63.64% of Nisin Z over 72 h. In addition, LCPN exhibited a sustained release profile, contributing to prolonged antimicrobial activity. Functionally, the LCPN system demonstrated strong antibiofilm efficacy (88.13% at 350 μg/mL), effectively enhancing disruption of pre-formed biofilms and significantly reducing bacterial biomass compared to free Nisin Z. Notably, in vivo evaluation in a shrimp infection model showed enhanced antibacterial performance in hemolymph, resulting in improved survival rates (83.3% at 14 days post-infection) and growth performance following Vibrio challenge. These findings suggest that the chitosan-pectin coated liposomal platform is a highly stable and controlled-release delivery system for antimicrobial peptides, offering a promising and targeted strategy for disease management in aquaculture.
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CARBOHYDRATE POLYMERS
·
2026
·
IF 13.2
Peiying Chen,Haihan Liu,Haoming Li,Yumeng Meng,Jingru Chen,Yunkun Zhao,Xingxing Zeng,Jing Wen,Chuanzhi Kang,Qi Hu
Swelling programs pore in hemicellulose/chitosan porous networks. • DHC cryogels absorb water in 1 s. • DHC-240 achieves an OG adsorption capacity of 785.64 mg/g. • DHC-240 reaches the OG/MB selectivity coefficient of up to 3319. • Molecular simulations reveal selective dye–network interfacial affinity. The sustainable porous materials are highly desirable for achieving rapid and selective ionic separation in water purification, yet the relationship between swelling-induced pore evolution and transport behavior remains insufficiently understood. Here, a swelling-mediated porous transport strategy is reported for biomass-derived cryogels. By regulating the swelling state of hydrogel precursors before freeze-drying, dialdehyde hemicellulose/chitosan cryogels (DHC) with programmable interconnected pores were constructed. The optimized cryogels showed ultrafast water uptake (<1 s), reversible compressibility under 80% strain, and stable porous transport during repeated operation. Swelling-programmed pore architectures accelerated dye diffusion and adsorption kinetics, enabling DHC-240 to reach a maximum Orange G (OG) adsorption capacity of 785.64 mg/g and rapid separation within 1 min. In mixed dye systems, DHC-240 showed high ionic selectivity, with selectivity coefficients up to 3319. Molecular simulation revealed charge-dependent adsorption. Anionic OG and fluorescein sodium (FS) maintained stable binding distances of 5.64 and 7.13 Å, whereas cationic dyes showed unstable, energetically unfavorable interactions. Energy decomposition highlighted docking interaction energy as the dominant contribution (−33.8 kcal/mol), and free-energy analysis confirmed favorable OG binding (−2.1 kcal/mol) versus unfavorable methylene blue binding (+1.6 kcal/mol). This work establishes swelling-regulated pore programming for transport-controlled molecular separation. Download: Download high-res image (317KB) Download: Download full-size image
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EUROPEAN POLYMER JOURNAL
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2026
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IF 6.8
Heng Wang,Xin-Yuan Guo,Jin-Ping Guan,Ying-Jun Gao,Xian-Wei Cheng
A multifunctional aerogel with ultralow thermal conductivity, high flame retardancy, hydrophobicity, and robust mechanical properties was developed. The aerogel’s support skeleton comprised amidoxime-functionalized polyacrylonitrile and silica nanofibers. Under acidic conditions, chitosan and montmorillonite formed an electrostatically driven network, with positively charged chitosan and negatively charged montmorillonite interweaving into the nanofiber matrix to create a three-dimensional, interpenetrating, multivariate cross-linked structure. The incorporation of montmorillonite nanosheets into the flexible nanofiber network significantly enhanced the aerogel’s mechanical properties, facilitating triple cross-linking with chitosan. The resulting aerogel exhibited a porosity of 98.58%, an ultralow density of 27 mg/cm 3 , and a mechanical strength of 428.89 kPa, comparable to or better than some reported aerogels under similar conditions. Additionally, it demonstrated superior thermal insulation (0.0299 W/(m·K)), exceptional flame retardancy with a limiting oxygen index exceeding 50%, and hydrophobicity with a water contact angle of 146.2°. Notably, the aerogel maintained over 96.95% of its initial adsorption efficiency after 10 cycles, highlighting its excellent reusability. These findings establish a provide a useful reference for the development of multifunctional aerogel materials for building insulation, meeting stringent fire safety standard.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Na-won Baek,Shin-hee Lee
This study reports the first application of horseradish peroxidase (HRP)-mediated oxidative coloration to bio-based nylon 5,10 using natural phenolics, and clarifies the performance-enhancing role of chitosan as a dyeing template. Mass spectrometric analysis confirmed that the incorporation of chitosan significantly increases oligomer growth during pigment formation. Comparative process evaluation revealed that in-situ chitosan templating causes excessive surface polymerization, uneven coloration, and reduced K/S values, which is attributed to the formation of loosely bound pigment aggregates that are easily removed during washing, leading to significant pigment loss from the fiber surface, whereas ex-situ chitosan-templated bio-dyeing yields the highest color depth and superior shade uniformity. In addition, chitosan templating transforms the weak or selective antibacterial activity of pristine phenolics into strong broad-spectrum inhibition against both E. coli and S. aureus. Although washing and rubbing fastness were generally acceptable, light fastness remained insufficient. Overall, this study provides the first empirical demonstration that nylon 5,10 is a suitable substrate for enzymatic oxidative coloration, and establishes ex-situ chitosan-templated bio-dyeing as an optimal strategy to simultaneously achieve deep coloration, uniformity, and antibacterial functionality. The integration of a bio-based polyamide substrate with a bio-based enzymatic coloration system highlights a promising low-carbon and energy-efficient route toward industrially scalable sustainable textile production. Download: Download high-res image (181KB) Download: Download full-size image
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2026
·Vol. 143
·期 22
·e70714
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IF 3.1
Ting-Ting Li,Yanping Zhang,Kelei Zang,Xiaomeng Wang,Hongli Liu,Jia-Horng Lin,Ching-Wen Lou
In the process of noise pollution control, the limitation of simply relying on increasing the thickness of the sound-absorbing layer has been recognized. Aerogel, due to its lightweight and multifunctional characteristics, has become a research hotspot. However, how to optimize the structure of aerogels to balance sound-absorption performance with other key characteristics remains an important research direction. In this study, by in situ combining zinc borate (ZB) nanoparticles and directional freezing technology, the optimal incorporation amount of nanocellulose (CNC) was explored, and CNC/ZB/carboxymethyl chitosan aerogel with honeycomb pore structure and excellent sound absorption effect was prepared. In order to expand its application in complex scenes, its antibacterial and flame retardant properties were further studied. The experiments demonstrated that the optimized incorporation of CNC not only enhanced the sound-absorbing performance (with the peak of sound absorption coefficient in the 500–1500 Hz frequency band approaching 1), but also maintained an antibacterial rate of over 97% and a combustion rate as low as 0.76 mm s −1 . This sound-absorbing aerogel integrates efficient sound absorption, mechanical strength and toughness, as well as antibacterial and flame-retardant properties, providing a new material design concept for addressing environmental noise and health and safety issues.
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APPLIED ORGANOMETALLIC CHEMISTRY
·
2026
·Vol. 40
·期 4
·e70549
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IF 4.3
Linjun Shao,Zheng Yin,Ke Long,Faliang Gou,Guiying Xing,Peng Yang,Xianman Zhang
Chitosan (CS) is a widely distributed and abundant biopolymer in nature. In this study, CS was blended with poly(methacrylic acid) (PMAA) to prepare stable chitosan composite nanofibers (CS/PMAA) via electrospinning, followed by annealing. The nanofibers were then functionalized through Schiff base reactions between CS amino groups and aldehydes and used to support palladium catalysts. Their catalytic performance was evaluated by the Heck reactions. Notably, the Pd 2+ ions anchored on the CS/PMAA nanofibers exhibited higher activity than those on the 2-pyridylimino-functionalized chitosan nanofibers (2PyCS/PMAA). In contrast, the Pd 0 species supported on the 2PyCS/PMAA nanofibers showed outstanding catalytic activity and remarkable reusability. HR-TEM was utilized to monitor the morphological changes and Pd 0 nanoparticle contents on the CS/PMAA and 2PyCS/PMAA nanofibers during reuse. Chelating interactions between the nanofibers and Pd 2+ ions were studied by FT-IR, adsorption distribution analysis, XRD, and HR-TEM. The strong nucleophilic affinity of Pd 2+ ions for the CS nanofibers was further verified by PALS. In conclusion, this work presents an effective and straightforward approach for preparing highly active and stable supported palladium catalysts.
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危险品化学品经营许可证（带存储）