CHEMICAL PAPERS
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2026
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IF 2.7
Li Huaitao,Feng Yuexia,Wu Jun,Lu Jian,Hua Xueting,Li Feng
Biodegradable plastics, widely recognized as promising substitutes for conventional plastics, still face the challenge of microplastic contamination to require in-depth assessments of combined pollution scenarios. This study explored the adsorption of 1-chloronaphthalene (PCN-1) by biodegradable plastics including poly(butylene adipate-co-terephthalate) (PBAT) and polylactic acid (PLA) with polyethylene (PE) as a conventional plastic control in seawater. The maximum adsorption capacity of PCN-1 on PLA/PBAT/PE in seawater reached 131.22/323.59/301.80 μg g −1 . The desorption efficiency of PCN-1 from PLA and PBAT was substantially lower than that from PE, suggesting that biodegradable plastics might pose reduced environmental risks due to low pollutant release. Interaction between PCN-1 and biodegradable plastics could be regulated by pH, which was attributed to the modulation of π-π stacking interactions. Salinity exerted a positive effect on the adsorption capacity of PCN-1 by PLA, PBAT, and PE; the maximum capacities (131.22/323.59/301.80 μg g −1 , respectively) were achieved at a salinity of 30‰. Pseudo-second-order model obtained good fitting on adsorption kinetics of PCN-1 on PLA while PBAT and PE exhibited higher consistency with the pseudo-first-order model. Thermodynamic analysis based on enthalpy (ΔH) and Gibbs free energy (ΔG) changes revealed that PCN-1 adsorption on PLA was an endothermic process, while the adsorption on PBAT and PE was exothermic. Collectively, the capture of PCN-1 by biodegradable plastics is predominantly governed by three key factors: crystallinity of the plastic matrix, π-π interaction between the plastic and PCN-1, and hydrophobic interaction.
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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2026
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IF 2.5
Ming Li,Dong Ren,Haowei Hou,Jian Lu,Guowei Ren,Shuangquan Yao,Lindan Geng,Pengcheng Wang
Objective To investigate the role of endothelin receptor B (Ednrb/ETB) in tranexamic acid (TXA)-induced post-traumatic osteoarthritis (PTOA) and to elucidate the underlying molecular mechanisms. Methods Adult rats were assigned to four groups: control + TXA (T), cartilage scratch + TXA (CT), subchondral fracture + TXA (ST), and combined cartilage-subchondral fracture + TXA (CST). RNA sequencing combined with Venn analysis was used to identify candidate genes, including Ednrb . Molecular docking was performed to evaluate the binding affinity between TXA and ETB. Rats were subsequently regrouped for histological, immunohistochemical, and biochemical analyses of cartilage. ATDC5 chondrocytes were transfected with si-Ednrb-1/2 and co-treated with TXA to assess cell viability and pathway activation. Results RNA sequencing identified Ednrb as a core upregulated gene in the CT and CST groups. Molecular docking demonstrated strong binding between TXA and ETB (binding energy: –5.1 kcal/mol). In the rat PTOA model, TXA significantly increased OARSI scores in the NCT and NCST groups (P < 0.0001), upregulating the expression of ETB, matrix metalloproteinase 13 (MMP13), RXFP1, endothelin-1 (ET-1), phosphorylated nuclear factor-kappa B, and phosphorylated AKT, as well as the inflammatory mediators interleukin-1 beta, tumor necrosis factor alpha, and interleukin-6. In ATDC5 cells, Ednrb knockdown significantly increased cell viability, reduced apoptosis, and downregulated ETB, MMP13, and pathway-related signaling molecules, thereby attenuating inflammatory responses. TXA treatment significantly reversed these protective effects. Conclusion Ednrb functions as a key mediator in TXA-induced PTOA progression. The binding of TXA to ETB activates the relaxin and ET-1/ETB pathways, thereby promoting cartilage degradation and inflammation. Targeting Ednrb may represent a promising therapeutic strategy for preventing TXA-associated PTOA.
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CARBOHYDRATE POLYMERS
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2015
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IF 4.074
Yongjun Men,Xiyan Du,Jianan Shen,Leli Wang,Zhengping Liu
The copolymer of starch grafted with polystyrene (starch- g -PS) was synthesized with high grafting percentage by utilizing the ionic liquid 1-ethyl-3-methylimidazolium acetate ([EMIM]Ac) as solvent and potassium persulfate as initiator. The effect of various parameters upon the polymerization were studied including: initiator concentration, styrene:starch weight ratio, the reaction time and temperature. Grafting percentages were calculated using an FT-IR calibration method, with values up to 114%. The resulting copolymer was characterized using FT-IR, SEM, WAXD and TGA, which demonstrated that polystyrene side chains were evenly distributed on the starch backbone. Our results indicate that ionic liquid dissolution of starch, prior to polystyrene grafting, is a versatile methodology for the synthesis of amphiphilic, polysaccharide-based graft copolymers, having high grafting percent.
研究领域:
高分子化学
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材料科学
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绿色化学
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碳水化合物化学
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2019
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IF 3.375
Zheng Zhang,Rui Fang,Xiao-Xin Kong,Miao Feng,Gui-Ping Cao,Hui Lu,Shuang Ji,Peng Gao,Jia-Hao Zhang
In this paper, monolithic TS-1 (a zeolitic material containing both silicon and titanium) was successfully synthesized on polymer-modified carbon nanotubes/nickel foam (PMTS-1). PMTS-1 had high surface areas and aggregated pores (confined pores formed in an aggregated structure), and TS-1 could be evenly dispersed on the surface, which could facilitate reactant transport and improve dispersibility of TS-1. TS-1 strongly interacted with the polymer-modified CNTs/NF and is highly dispersed because the PDDA-modification could enhance the positivity of CNTs/NF. PMTS-1 was beneficial to the adsorption of the reactant propylene and the desorption of the product propylene oxide, which reduced the side reaction of the deep oxidation of propylene oxide, pore blocking, and coke formation. Also, the adsorption capacity of PMTS-1 to H2O2 was enhanced, which created a microenvironment conducive to the forward reaction. After the reaction, PMTS-1 was easily separated from the reactants, which offered an economical application prospect.
研究领域:
催化化学
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材料科学
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化学工程
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纳米复合材料
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沸石化学
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ChemistrySelect
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2022
·Vol. 7
·期 35
·e202202475
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IF 2.307
Zhiqiang Zhang,Qingyan Chu,Yuan Sun,Hao Wang,Deming Lu,Yuying Liu,Haibin Xiao,Ping Wang,Hongyou Cui,Ming Wang
Graphical The hierarchical TS-1 with abundant mesopores was prepared by TPAOH/TIPA treatment, which was applied to the reaction of the ammoximation-oxidation of acetone to 2-nitropropane. Hierarchical TS-1 catalyst performed excellent reusability and catalytic activity with 97.5 % conversion and 96.8 % selectivity. The novel technology for clean and mild synthesis of nitroalkanes has been developed. Modified TS-1 catalysts for the acetone ammoximation-oxidation reaction were prepared by post-treating TS-1 with different concentrations of TPAOH/TIPA, and the effects of alkali treatment on the catalytic performance were systematically investigated. The techniques such as XRD, SEM, TEM and N 2 sorption were used to characterize the catalyst samples, which exhibited that the introduction of alkali increased the volume and quantity of mesopores, while there was no obvious influence on the framework structure and titanium content in the framework. And the improvement in catalyst performance after alkali treatment was attributed to the increase of mesopores and the decrease in diffusion limitation. In addition, three common ammoximation catalysts (Ti-MOR, Ti- MWW and TS-1) were systematically investigated in this reaction. Ti-MOR showed superiority in the ammoximation to oxime, while TS-1 displayed the best catalytic performance in the ammoximation oxidation of ketones to nitroalkanes. It was indicated that modified TS-1 could be a promising catalyst for the ammoximation-oxidation reaction of acetone.
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CRYSTAL GROWTH & DESIGN
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2023
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IF 3.8
Zhenyuan Yang,Yanan Guan,Lei Xu,Yangtao Zhou,Xiaolei Fan,Yilai Jiao
This work presents the development and systematic study of a method to prepare hierarchical titanium silicalite-1 (TS-1) zeolites with high tetra-coordinated framework Ti species content. The new method involves (i) the synthesis of the aged dry gel by treating the zeolite precursor at 90 °C for 24 h; and (ii) the synthesis of hierarchical TS-1 by treating the aged dry gel using tetrapropylammonium hydroxide (TPAOH) solution under hydrothermal conditions. Systematic studies were conducted to understand the effect of the synthesis conditions (including the TPAOH concentration, liquid-to-solid ratio, and treatment time) on the physiochemical properties of the resulting TS-1 zeolites, and the results showed that the condition of a TPAOH concentration of 0.1 M, liquid-to-solid ratio of 1.0, and treatment time of 9 h was ideal to enable the synthesis of hierarchical TS-1 with a Si/Ti ratio of 44. Importantly, the aged dry gel was beneficial to the quick crystallization of zeolite and assembly of nanosized TS-1 crystals with a hierarchical structure (Sext = 315 m2 g–1 and Vmeso = 0.70 cm3 g–1, respectively) and high framework Ti Species content, making the accessible active sites ready for promoting oxidation catalysis.
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CHEMICAL ENGINEERING JOURNAL
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2022
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IF 16.744
Jie Zhou,Hao Liu,Chao Xiong,Peng Hu,Hao Wang,Xuyu Wang,Hongbing Ji
Propane dehydrogenation (PDH) has been a promising method to satisfy the increasing demand for propylene, but Pt-based catalysts always suffer from sintering and coke formation. Developing stable and efficient catalysts for PDH is of great significance for the industry. Herein, the paper reports that a catalyst with potassium-promoted Pt-In bimetallic clusters encapsulated in silicalite-1 (S-1) zeolite works as an efficient and stable catalyst for PDH. The catalyst achieves a propane conversion of 43.73 % with 97.14 % selectivity of propene and an extremely high propylene productivity of 20.33 mol g Pt -1 h -1 with a weight hourly space velocity (WHSV) of 6.75 h −1 . No obvious deactivation occurs after 48 h on stream, affording an extremely low deactivation constant of 0.0025 h −1 . The introduction of indium species greatly improves the propene selectivity and restricts the coke formation. The introduction of K + into S-1 can significantly enhance the catalytic activity and the stability of the catalyst. The catalyst with excellent activity and stability is potential for industrial application.
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APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
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2023
·Vol. 107
·期 5
·1725-1736
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IF 5
Li Jing,Li Ziyi,Gong Hui,Ma Mengyi,Li Shuolei,Yang Huilin,Zhang Hailin,Liu Jianguo
Abstract In this study, a novel high-activity amylosucrase from Salinispirillum sp. LH10-3-1 (SaAS) was identified and characterized. The recombinant enzyme was determined as a monomer with a molecular mass of 75 kDa. SaAS protein exhibited the maximum total and polymerization activities at pH 9.0 and maximum hydrolysis activity at pH 8.0. The optimum temperature for total, polymerization, and hydrolysis activities were 40, 40, and 45 °C, respectively. Under the optimal pH and temperature, SaAS had a specific activity of 108.2 U/mg. SaAS also showed excellent salt tolerance and could retain 77.4% of its original total activity at 4.0 M NaCl. The addition of Mg 2+ , Ba 2+ , and Ca 2+ enhanced the total activity of SaAS. When the conversion of 0.1 M and 1.0 M sucrose was catalyzed at pH 9.0 and 40 °C for 24 h, the ratios of hydrolysis, polymerization, and isomerization reactions were 11.9:77.4:10.7 and 15.3:53.5:31.2, respectively. The α-arbutin yield of 60.3% was achieved from 20 mM sucrose and 5 mM hydroquinone catalyzed by SaAS. Key points
• A novel amylosucrase from Salinispirillum sp. LH10-3-1 (SaAS) was characterized.
• SaAS has the highest specific enzyme activity among all known amylosucrase.
• SaAS has hydrolysis, polymerization, isomerization, and glucosyltransferase activities.
Graphical Abstract
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ANALYTICAL CHEMISTRY
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2022
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IF 8.008
Zi-Tao Zhong,Ghazala Ashraf,Wei Chen,Bo Liu,Guo-Ping Wang,Yuan-Di Zhao
Matrix metalloproteinase (MMP) is closely correlated with tumorigenesis and progression. Establishing a low-cost, simple, rapid, and sensitive method for its detection is highly desired for the broad-spectrum screening of oral cancer. Herein, we combine the MMP-specific cleavage ability with magnetic separation technology and a commercial test strip to construct a sensitive biosensor to detect MMP-1 conveniently for the first time. The method involves two DNA probes, peptide–DNA1 and hCG–DNA2, where DNA1 and DNA2 are complementary sequences, and the peptide labeled with biotin can bind streptavidin-modified magnetic nanoparticles stably. The human chorionic gonadotropin (hCG) is the target of the pregnancy test strip. The cleavage reaction mediated by MMP-1 releases peptide–DNA1 and the hybridized hCG–DNA2 into the solution, and the hCG probe in the solution can develop color on the test strip for the determination of MMP-1 after magnetic separation. This method utilizes the high specificity of MMP-1’s proteolytic cleavage and the high sensitivity of the test strip to the target probe, achieving a sensitive detection of MMP-1 with a visual detection limit of 65.5 pg/mL. The method shows better anti-interference and sensitivity than the enzyme-linked immunosorbent assay in the application of a biological sample matrix, suggesting its great potential for clinical diagnosis, especially for broad-spectrum oral cancer screening.
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INTERNATIONAL IMMUNOPHARMACOLOGY
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2022
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IF 5.714
Jian-Bing Xiong,Jia-Xi Duan,Nan Jiang,Chen-Yu Zhang,Wen-Jing Zhong,Jin-Tong Yang,Yu-Biao Liu,Feng Su,Yong Zhou,Dai Li,Hui-Hui Yang,Cha-Xiang Guan
Our previous study showed that triggering receptors expressed on myeloid cell-1 (TREM-1) was upregulated in bleomycin (BLM)-induced pulmonary fibrosis (PF) mouse model. However, the role of TREM-1 in the development of PF and its underlying mechanism remain unclear. Herein, we report that the prophylactical blockade of TREM-1 using a decoy peptide dodecapeptide (LR12) exerted protective effects against BLM-induced PF in mice, with a higher survival rate, attenuated tissue injury, and less extracellular matrix deposition. Interestingly, therapeutic blockade of TREM-1 at the early stage of fibrosis also attenuated BLM-induced PF, suggesting a non-inflammatory effect. More importantly, we observed that TREM-1 blockade with LR12 significantly reduced the expression of the senescence-relative protein, including p16, p21, p53, and γ-H2AX in the lungs of PF mice. Notably, TREM-1 was upregulated in alveolar epithelial cells (AECs) and correlated with the levels of senescence markers in BLM-treated mice. In vitro , activating TREM-1 with an agonistic antibody exacerbated BLM-induced senescence in MLE12 cells, a murine AEC cell line. Furthermore, prophylactic or therapeutic blockade of TREM-1 protected MLE12 cells from senescence induced by BLM or H 2 O 2 . In conclusion, our findings elucidate a pro-fibrotic effect of TREM-1 by inducing AECs senescence in PF, providing a potential strategy for fibrotic disease treatment.
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CANCER SCIENCE
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2022
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IF 6.518
Jie Liu,Huxia Wang,Miao Zhang,Yazhao Li,Ruiqi Wang,He Chen,Bo Wang,Xiaoqian Gao,Shaoran Song,Yaochun Wang,Yu Ren,Juan Li,Peijun Liu
Multiple cancers have been reported to be associated with angiogenesis and are sensitive to anti‐angiogenic therapies. Vascular normalization, by restoring proper tumor perfusion and oxygenation, could limit tumor cell invasiveness and improve the effectiveness of anticancer treatments. However, the underlying anticancer mechanisms of antiangiogenic drugs are still unknown. Metformin (MET) and simvastatin (SVA), two metabolic‐related drugs, have been shown to play important roles in modulating the hypoxic tumor microenvironment and angiogenesis. Whether the combination of MET and SVA could exert a more effective antitumor effect than individual treatments has not been examined. The antitumor effect of the synergism of SVA and MET was detected in mouse models, breast cancer patient‐derived organoids, and multiple tumor cell lines compared with untreated, SVA, or MET alone. RNA sequencing revealed that the combination of MET and SVA (but not MET or SVA alone) inhibited the expression of endothelin 1 (ET‐1), an important regulator of angiogenesis and the hypoxia‐related pathway. We demonstrate that the MET and SVA combination showed synergistic effects on inhibiting tumor cell proliferation, promoting apoptosis, alleviating hypoxia, decreasing angiogenesis, and increasing vessel normalization compared with the use of a single agent alone. The MET and SVA combination suppressed ET‐1‐induced hypoxia‐inducible factor 1α expression by increasing prolyl hydroxylase 2 (PHD2) expression. Furthermore, the MET and SVA combination showed a more potent anticancer effect compared with bosentan. Together, our findings suggest the potential application of the MET and SVA combination in antitumor therapy.
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JOURNAL OF COMPARATIVE NEUROLOGY
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2022
·Vol. 531
·期 2
·294-313
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IF 3.028
Xulin Li,Gaoyang Zhao,Hongren Huang,Jialin Ye,Junfeng Xu,Yuan Zhou,Xiaojuan Zhu,Liping Wang,Feng Wang
Many brain functions that underlie behavior, cognition, and emotions vary with age, as does susceptibility to neuropsychological disorders. The expression of specific genes that are involved in these functions, such as the genes encoding for oxytocin, its receptors, and apolipoprotein D, varies with age across different brain regions. The cannabinoid 1 receptor (CB 1 R) is one of the most widely spread G-protein coupled receptors in the central nervous system and is increasingly recognized for its important contribution to various brain functions. Although changes in CB 1 R expression with age have been reported in the male mouse brain, they have not been well investigated in the female brain. Here, we used fluorescence in situ hybridization to target CB 1 R mRNA in the whole brains of female C57BL/6J mice aged 4, 6, 12, 52 (12 months) and 86 weeks (20 months), and quantified CB 1 R-positive cells in 36 brain regions across the whole brain. The results showed that CB 1 R-positive cells number changed with age. Specifically, CB 1 R expression increased with age in some subregions of the cortex, decreased with age in the lateral septal area, and reached its lowest level at 52 weeks in the thalamus, hypothalamus, and hindbrain subregions. Cluster analysis revealed that some brain regions shared similar temporal characteristics in CB 1 R-positive cell number across the lifespan. Our results provide evidence that investigation of the neural basis of age-related characteristics of female brain functions is not only warranted but required.
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