Materials Today Communications
·
2025
·
IF 4.5
Zichen Shi,Zongao Dou,Xiaopeng Sun,Xiao Wu,Zhiqiang Wang,Jing Sun,Qiang Fang
Based on our previous discovery that alkyl-side-chains in the aryl polymers have a positive effect on dielectric properties of the polymers, this work further investigates the side-chain effect by a hydrogenated bio-based cardanol monomer with a long pentadecyl alkyl side chain. The monomer was functionalized by introducing the thermocrosslinkable benzocyclobutene groups, and its cured product displayed a dielectric constant ( ε ) of 2.59 and a dielectric loss ( tan δ ) of 5×10 -4 at a high frequency of 10 GHz. In contrast, a controlling polymer with methyl side chain exhibited a ε of 2.84 and a tan δ of 1.4×10 -4 , respectively. Such data indicate that the long alkyl-side-chains can effectively improve the dielectric properties of the aryl polymers. Moreover, the cured hydrogenated bio-based cardanol also exhibited good hydrophilic properties with the water absorption of 0.16% even immersing it in boiling water for 96 h. These results imply that bio-based cardanol is a potential candidate for the preparation of the low- k materials used in microelectronic industry.
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2025
·
IF 5.9
Lidong Gong,Zichao Liang,Xianling Ning,Jianan He,Junjie Huang,Runtao Li,Yuxin Yin,Ridong Li,Zhiqiang Lin
A series of novel 2,4-diarylaminopyrimidine derivatives incorporating a 3-sulfamoylbenzamide moiety were designed and synthesized as potent focal adhesion kinase (FAK) inhibitors. Three compounds ( 5f, 10b , and 10c ) demonstrated FAK inhibitory activities comparable to the reference inhibitor TAE226 . In cellular assays, most analogues exhibited significant antiproliferative effects against four FAK-overexpressing tumor cell lines (HCT116, HeLa, MDA-MB-231, and A375), with IC 50 values below 1 μM. Notably, compound 10c displayed superior potency, showing IC 50 values ranging from 0.08 to 0.31 μM across the tested cell lines, and exhibited approximately 2-fold enhanced activity over TAE226 in inhibiting HCT116, MDA-MB-231, and A375 cell proliferation. Further mechanistic studies revealed that 10c effectively suppressed colony formation, migration, and adhesion of HCT116 cells, while inducing apoptosis via ROS elevation. Molecular docking analysis suggested that the enhanced activity of 10c may arise from an additional hydrogen bond interaction with the Arg426 residue of FAK, leading to stronger binding affinity compared to TAE226 . In vivo , 10c showed good oral bioavailability and significantly inhibited HCT116 xenograft tumor growth (TGI = 62.22 % at 50 mg/kg), outperforming TAE226 (50.98 %) without inducing weight loss or hepatorenal toxicity. These results highlight 10c as a promising FAK-targeted candidate worthy of further preclinical investigation.
✓ 已验证
DOI
PubMed
高影响因子
NANO
·
2024
·
IF 1
Jianchao Wang,Ziqi Wu,Huayong Peng
Ordered Ag@Au hybrid nanotube arrays were prepared by a galvanic replacement reaction and subsequently evaluated for their effectiveness as substrates for enhancing the fluorescence of poly(3-hexylthiophene) (P3HT). Ordered AgNWs arrays were assembled using a three-phase interface method, and ordered Ag@Au hybrid nanotube arrays were successfully prepared by a galvanic replacement reaction between a HAuCl 4 solution and ordered AgNWs arrays. The morphology of the ordered silver nanowires (AgNWs) arrays and Ag@Au nanotube arrays, as well as the influence of reaction time on the galvanic replacement reaction, were investigated. The fluorescence and laser-Raman properties of the conjugated polymer P3HT on various ordered Ag@Au nanotubes were analyzed. Gold (Au) particles grow on the surface of AgNWs, the diameter of the nanotubes gradually increases, and the ordered Ag@Au hybrid nanotubes form gradually. The surface plasmon resonance (SPR) peaks of Ag@Au hybrid nanotube arrays redshift and become wider as the reaction proceeds compared to AgNW arrays. The fluorescence properties of P3HT films on various ordered Ag@Au hybrid nanotubes were much higher than those on bare silicon substrates, but compared to the gold nanowire array, there is a decrease. As the galvanic displacement reaction progresses, the degree of reduction in fluorescence intensity increases. The unique aspect of this work was that the plasmon resonance wavelength of the ordered Ag@Au hybrid nanotube arrays showed a substantial redshift and broadening, which is much closer to biological samples. The ordered Ag@Au hybrid nanotube arrays can be used as ultra-sensitive fluorescence sensing platforms.
✓ 已验证
DOI
高影响因子
JOURNAL OF POWER SOURCES
·
2024
·
IF 8.1
Zihao Zheng,Zhiyuan Ma,Xuelin Tao,Teng Hui,Hanqi Yu,Hua Qian,Honghua Huang,Lidong Che,Fengli Bei
The poor cycling performance of Li-rich manganese-based (LMR) cathodes is one of the challenges that need to be urgently overcome. Enhancing the stability of the layered structure responsible for lithium-ion diffusion is an effective way to improve the cycling performance. Layered structures are mainly formed during the high-temperature solid-phase reaction, whereas the prolonged and constant-high-temperature calcination conditions in conventional calcination procedure may pose a threat to the layered structural stability. Thus, in order to optimize the formation environment of layered structures under high-temperature solid-phase reaction, we have designed suitable temperature-controlled strategies for each stage of layered structure formation, gradual maturation, and post-treatment, respectively, referred to as the 3-stage calcination strategy. This calcination strategy contributes to the formation of a more ordered and stable layered structure, which significantly improves the cycling performance of LMR cathodes (capacity retention rate of 85.2 % after 200 cycles at 1C). The shortening of the constant high temperature calcination time helps to further reduce the production cost of the batteries . The design concept of this work is to regulate the formation process of layered structures in stages, which provides inspiration for the efficient and controllable synthesis of electrode materials with excellent structural stability at low production cost.
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2018
·
IF 3.779
Beibei Zong,Wuyou Fu,Huijing Liu,Liwen Huang,Hari Bala,Xiaodong Wang,Guang Sun,Jianliang Cao,Zhanying Zhang
In this work, high stable perovskite solar cells (PSCs) based carbon counter electrode were fabricated in the air environment with 30% of humidity, in which the perovskite CH 3 NH 3 Pb(I 1- x Br x ) 3 were used as the absorber. We investigated the effect of the different Br-doping ( x = 0.00, 0.10, 0.15, 0.20, 0.25, 0.30) on the devices performance and found that the appropriate amount of Br-doping could effectively improve crystallinity of the perovskite film and enhance the light absorption. When the doping-ration x was 0.25, the device exhibited the best performance with the efficiency of 9.99% with active area of 0.2 cm 2 under the irradiation of 100 mW/cm 2 air mass 1.5 global (AM1.5G) sunlight. By electrochemical impedance spectroscopy (EIS) measurement, we found that the introducing of Br − into the perovskite film could reduce the carrier recombination loss . Finally, the stability test of the PSCs was carried out and the result showed that the device still keep 96.23% of the initial efficiency after being stored in the air for 56 days (1344 h), which show an excellent stability.
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Jiahong Xie,Xin Hao,Yiqiu Shang,Wei Chen
Dicarboxylic acids derived acylated-anthocyanins are common in nature, which can also be obtained by enzymatic acylation of anthocyanins. However, little research have focused on the properties of anthocyanins with dicarboxylic acid derivatives due to the complexity of isolation, detection, and identification. In this work, pelargonidin-3-glucoside (Pg3G) was acylated with various dicarboxylic acids. The conversion yields of acylated Pg3G were positively associated with carbon chain lengths of dicarboxylic acids. The primary acylated products were identified as pelargonidin- 3 -(6″-malonyl) glucoside, pelargonidin- 3 -(6″-succinyl) glucoside, and pelargonidin- 3 -(6″-glutaryl) glucoside using LC-MS and NMR. Furthermore, the three acylated Pg3G derivatives exhibited improved thermostability and enhanced lipophilicity compared with Pg3G. The improved thermostability was attributed to the influence of dicarboxylic acids substituent on the distribution of flavylium cation, quinoidal base, hemiketal, cis -chalcone, and trans -chalcone at the equilibrium condition. Overall, our research provided insights about the improved stability and lipophilicity of pelargonidin-3-glucoside following enzymatic acylation with aliphatic dicarboxylic acids.
✓ 已验证
DOI
高影响因子
Materials Science and Engineering B-Advanced Functional Solid-State Materials
·
2015
·
IF 2.169
Xinghao Lin,Yanming Zhao,Youzhong Dong,Quan Kuang,Zhiyong Liang,Danlin Yan,Xudong Liu
A metaphosphate NaFe(PO 3 ) 3 compound has been obtained by solid state method here. This title compound belongs to the orthorhombic structure with the space group of P 2 1 2 1 2 1 (No. 19) and lattice parameters of a = 14.3390(3) Å, b = 14.3374(2) Å, c = 14.3642(1) Å. Its structure can be described as made up of infinite (PO 3 ) 1− chains connected by FeO 6 octahedra, while the monovalent Na cations are located in the tunnels determined by the connection of PO 4 tetrahedrons and FeO 6 octahedrons. Besides, the morphology, vibrational spectra, magnetic and sodium deinsertion/insertion properties of NaFe(PO 3 ) 3 compound are also presented and discussed here for the first time, which can provide more information about the physicochemical properties of this metaphosphate compound.
研究领域:
无机化学
·
材料科学
·
固体化学
·
电化学
·
能源材料
✓ 已验证
DOI
高影响因子
Journal of Chemistry
·
2021
·Vol. 2021
·期 1
·5685596
·
IF 2.506
Jia Ma,Jianer Wang,Yuping He,Yiwei Huang,Yejun Chen
Solvothermal reaction of 4,4’,4’-nitrilotribenzoic acid (H 3 TCA) with Ca(NO 3 ) 2 ·4H 2 O and Cd(NO 3 ) 2 ·4H 2 O successfully afforded a heterometallic compound, that is, [Cd 2 Ca(TCA) 2 (DMA) 2 (H 2 O) 3 ] n ·2n(DMA) ( 1 , DMA = N,N’-dimethylacetamide). The structure of 1 was further characterized through EA, diffraction of single crystal X-ray, and thermogravimetric analysis (TGA) together with powder X-ray diffraction (PXRD). Moreover, complex 1 ’s luminescent performance in solid state was also discussed at environmental temperature. The applications on the ischemic cerebral infarction therapy were evaluated, and the specific mechanism was investigated at the same time. Firstly, the hypersensitivity C-reactive protein (hs-CRP) content in human brain microvascular endothelial cell (HBMEC) was measured with real-time reverse transcription-polymerase chain reaction (RT-PCR). Then, interleukin-18 and interleukin-1 β content released through the HBMEC was detected with enzyme-linked immunosorbent assay (ELISA).
研究领域:
生物无机化学
·
神经药理学
·
炎症生物学
·
转化医学
·
分子影像学
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2017
·Vol. 43
·期 12
·9327-9333
·
IF 2.986
Nan Zhou,Shengxiong Huang,Tao Hong,Wei Luo,Yun Tian,Xiangyang Lu,Zhi Zhou
In this paper, LiTi 2 (PO 4 ) 3 @carbon composite as anode for aqueous lithium ion battery has been successfully synthesized by in-situ carbon coating method using oxalic acid and glucose as double carbon sources. XRD results confirm the rhombohedral NASICON-type LiTi 2 (PO 4 ) 3 structure of the as-prepared composite. The LiTi 2 (PO 4 ) 3 @carbon composite using double carbon sources (LTP-OG-10) disperses well, and the coated carbon layer has the appropriate thickness of 3–7 nm, which result in proper balance of the good electrical conductivity and the fast kinetics of diffusion of lithium ions . LTP-OG-10 exhibits better electrochemical performance compared with those using oxalic acid (LTP-O) or glucose (LTP-G) single carbon source. LTP-OG-10 anode delivers the discharge capacity of 112.5 mA h g −1 , 96.8 mA h g −1 , and 54.2 mA h g −1 at 0.2 C, 5 C and 20 C, respectively, much larger than that of LTP-O and LTP-G. Moreover, LTP-OG-10 demonstrated excellent cycling performance, with the capacity retention of 71.1% after 400 cycles at 0.2 C, 22.9% higher than that of LTP-G. The good electrochemical properties of LTP-OG-10 is mainly ascribed to the increase of defects, high-quality and appropriate thickness of carbon layer. Our study reveals that preparing LiTi 2 (PO 4 ) 3 @carbon composite using double carbon sources is an efficient approach to enhance its electrochemical properties.
研究领域:
材料科学
·
电化学
·
能源存储
·
无机非金属材料
·
功能材料
✓ 已验证
DOI
高影响因子
CELLULOSE
·
2014
·Vol. 21
·期 5
·3311-3322
·
IF 3.033
Zhang Min,Ding Cuicui,Huang Liulian,Chen Lihui,Yang Haiyang
Collagen/cellulose blended solutions with collagen/cellulose mass ratio (Col/Cel) of 0, 1/40, 1/20, 1/10 and 1/5 were prepared using [Emim]Ac as solvent. The interactions between the two polymers before and after regeneration were investigated. In steady shear flow, all of the experimental viscosity values were greater than those of the estimated values calculated from the log-additivity rule for each sample, suggesting interactions between the two polymers in solutions. All solutions exhibited shear thinning behavior and the flow curves could be described by Cross model. Zero shear viscosity ( η
0 ) versus Col/Cel was examined and a linear increase (from 8.73 to 16.39 Pa·s) can be observed for η
0 as Col/Cel ≤ 1/10, while there was only a slight increase (from 16.39 to 18.42 Pa·s) in η
0 as Col/Cel increased to 1/5. Dynamic rheology results suggested the existence of aggregates in solution with Col/Cel = 1/10. Furthermore, the activation energy of solution was 84.5 kJ mol −1 as Col/Cel = 1/10, higher than that of cellulose solution (44.2 kJ mol −1 ). Regenerated films were prepared and characterized to trace back the interactions between the two polymers in [Emim]Ac. Fourier transform infrared spectroscopy indicated the hydrogen-bond interaction between collagen and cellulose in films. The denaturation temperature of collagen in films with Col/Cel ≤ 1/10 could be improved, but it was decreased with the increase of collagen content, and finally was reduced to be close to that of collagen as Col/Cel = 1/5. The features of dynamic mechanical analysis for films were indicative of the lack of homogeneity between collagen and cellulose as Col/Cel = 1/5. Atomic force microscopy images further confirmed the phase-separation when Col/Cel = 1/5.
研究领域:
高分子科学
·
材料化学
·
流变学
·
生物材料
·
可持续材料
✓ 已验证
DOI
高影响因子
Gut Microbes
·
2026
·
IF 11
Xueli Qiu,Lijun Wu,Fengxian Jiang,Huajian Shan,Lei Sheng,Bo Tian,Heng Wang,Hao Cui,Lide Tao,Chenyang Wu,Yuqian Yao,Chao Wang,Xiaozhong Zhou,Yingzi Zhang,Jinyu Bai
Postmenopausal osteoporosis (PMOP) has a high incidence in middle-aged and elderly women, leading to an increased risk of fractures and elevated rates of disability and mortality. In this work, we identified the reduction of indole-3-propionic acid (IPA) as a potential key factor contributing to the decline in bone mass observed in postmenopausal women. Mechanistically, IPA activates AhR, leading to the stabilization of key proteins in Wnt and NF-κB pathways that regulate bone formation and resorption. We evaluated efficacy in vivo using eight-week-old female C57BL/6 mice subjected to bilateral ovariectomy (OVX), with treatments initiated one week postsurgery, and performed complementary in vitro assays. Intraperitoneal IPA (20 mg/kg, 3× per week for 8 weeks) increased the trabecular bone mineral density (Tb.BMD) by ~68% versus OVX controls, whereas engineered Clostridium sporogenes that enhances IPA biosynthesis led to an even greater increase of ~118%. Together, these findings highlight the gut–bone axis as a central framework linking microbiota-derived IPA to skeletal remodeling and provide preclinical proof-of-concept for an engineered C. sporogenes–IPA strategy with therapeutic potential in PMOP.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Energy Materials
·
2026
·
IF 5.5
Jiaoyang Shen,Hehe Ren,Jian Zou,Xin Guo,Yuanjie Wei,Quancai Li,Jing Liang,Wei Wu
Aqueous symmetric sodium-ion batteries (ASSIBs) are gaining attention as attractive energy storage devices for flexible and wearable electronics due to their excellent structural stability, inherent safety, environmental friendliness, and the abundant sodium resources. NASICON-structured Na2VTi(PO4)3 (NVTP) features a three-dimensional framework structure; Ti4+/Ti3+ and V4+/V3+ redox couples can be used to fabricate symmetrical sodium-ion batteries as both the anode and the cathode. However, poor cycle stability and irreversible dissolution in aqueous solutions limit the application of NVTP in flexible ASSIBs. Herein, the Na1.9K0.1VTi(PO4)3-10% GNP (NKVTP-GNP) composite was synthesized by partially substituting Na+ in Na2VTi(PO4)3 with K+ and coating graphene nanoplatelets (GNP). The K+ doping and GNP coating successfully promoted the conversion of V4+ to V5+ and enhanced the cycling stability of the materials. The capacity retention rate of the NKVTP-GNP cathode is 99% after 1000 cycles, while the anode maintains 81% of its capacity after 500 cycles. Additionally, a flexible symmetric battery NKVTP-GNP//NKVTP-GNP was fabricated via a screen-printing technique, which delivered a wide voltage window of 1.8 V, an energy density of 63 Wh kg−1, and excellent cycling stability, retaining 90% of its capacity after 2000 cycles at 10 C. More importantly, the battery shows high flexibility, adjustable shapes, and high-throughput manufacturing. This work provides insights into the development of high-performance flexible ASSIBs.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）