ENERGY & FUELS
·
2025
·
IF 5.3
Yong Chen,Bin Qin,Yanqiong Cheng,Hui Xu,Maocheng Liu
The energy density of biomass-derived porous carbon can be enhanced by the introduction of redox active molecules. Finding efficient materials for pseudocapacitive charge storage has become a grand challenge. Herein, using cyclic voltammetry, naphthol green B (NGB) for the first time is used as an organic redox active material in combination with biomass-based porous carbon (DS-2), which is produced from dandelion stems by precarbonization and KOH activation. The results demonstrate that DS-2/NGB50-5 exhibits a specific capacitance of 700 F g–1 at 1 A g–1 in 1 M H2SO4, which is almost 2.5 times greater than that of DS-2 (the specific capacitance of 249 F g–1). Even at 20 A g–1, 86% of the original capacitance is retained, indicating an excellent rate performance. The high specific capacitance mainly depends on the reversible reaction of −N═O groups of NGB molecules and H+ in the electrolyte at the charge and discharge durations. The symmetric capacitor based on DS-2/NGB50-5 delivers a high energy density of 36.6 Wh kg–1 at a power density of 650 W kg–1 and shows good cycling stability (capacitance retention of 78.4% after 10,000 cycles). This work has successfully developed a kind of redox active molecule with efficient energy storage, which opens a new avenue for the design of high-performance supercapacitors.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
·
IF 4.9
Ran Jiang,Dengjie Zhong,Yunlan Xu,Haixing Chang,Pengfei Liao,Yuanzhen He,Jiayou Zhang
How to improve the issues of ion agglomeration and metal ion leaching, and how to prepare cobalt-based catalysts with high reactivity and stability, are highly desired yet challenging. In this paper, MoS 2 modified Co-MOF derived nitrogen-doped carbon (Co/PCN/MoS 2 ) microspheres rich in active sites were prepared using a simple carbonation-hydrothermal method, with g-C 3 N 4 , MoS 2 and Co-MOF to overcome the aforementioned limitations. The flower-like nanostructure of MoS 2 contributed to exposing more marginal active sites, allowing the high dispersion of Co-MOF within its structure. Meanwhile, Mo 4+ /Mo 6+ and S species coexisted in MoS 2 , which promoted the valence cycle and electron transfer process, and improved the catalytic activity of the composite. The successful synthesis of Co/PCN/MoS 2 was proved by XRD , SEM and FTIR characterizations. The electrochemical performance analysis showed that Co/PCN/MoS 2 exhibited higher redox capacity than MoS 2 , and Co/PCN/MoS 2 /PMS system achieved the degradation rate of RhB as high as 97.19% within 30 min, which is higher than that of Co-MOF/g-C 3 N 4 /PMS (80.67%), Co-MOF/MoS 2 /PMS (78.08%), Co-MOF/PMS (77.00%), g-C 3 N 4 /PMS (53.68%) and MoS 2 /PMS (28.10%) systems. It had good anti-interference ability against coexisting substances, achieved good degradation performance in a wide pH range (pH 2.0–10.0), and possessed excellent stability and reusability with RhB degradation rate of 91.10% after 5 cycles. The quenching test confirmed that non free radical 1 O 2 is the main ROS for RhB degradation. This work is expected to provide a new idea and direction for the design and development of metal-doped heterogeneous catalysts with high activity and stability.
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Frontiers in Bioengineering and Biotechnology
·
2024
·
IF 4.3
Rongyi Wang,Hongsen Li,Lu Han,Boao Han,Yiting Bao,Hongwei Fan,Chaoyue Sun,Ruijie Qian,Liying Ma,Jiajing Zhang
The mitochondria act as the main producers of reactive oxygen species (ROS) within cells. Elevated levels of ROS can activate the mitochondrial apoptotic pathway, leading to cell apoptosis. In this study, we devised a molecular prodrug named CTT 2 P, demonstrating notable efficacy in facilitating mitochondrial apoptosis. To develop nanomedicine, we enveloped CTT 2 P within bovine serum albumin (BSA), resulting in the formulation known as CTT 2 P@B. The molecular prodrug CTT 2 P is achieved by covalently conjugating mitochondrial targeting triphenylphosphine (PPh 3 ), photosensitizer TPPOH 2 , ROS-sensitive thioketal (TK), and chemotherapeutic drug camptothecin (CPT). The prodrug, which is chemically bonded, prevents the escape of drugs while they circulate throughout the body, guaranteeing the coordinated dispersion of both medications inside the organism. Additionally, the concurrent integration of targeted photodynamic therapy and cascade chemotherapy synergistically enhances the therapeutic efficacy of pharmaceutical agents. Experimental results indicated that the covalently attached prodrug significantly mitigated CPT cytotoxicity under dark conditions. In contrast, TPPOH 2 , CTT 2 , CTT 2 P, and CTT 2 P@B nanoparticles exhibited increasing tumor cell-killing effects and suppressed tumor growth when exposed to light at 660 nm with an intensity of 280 mW cm −2 . Consequently, this laser-triggered, mitochondria-targeted, combined photodynamic therapy and chemotherapy nano drug delivery system, adept at efficiently promoting mitochondrial apoptosis, presents a promising and innovative approach to cancer treatment.
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DOI
PubMed
高影响因子
Carbohydrate Polymer Technologies and Applications
·
2024
·
IF 6.2
Chang Liu,Chao He,Qing Zeng,Dengqun Liao,Xianen Li
Urolithin B (UB) has significant health benefits, including a hypolipidemic effect, but its poor water solubility limits its bioavailability and pharmacological activities. In order to increase UB's water solubility, we used cyclodextrin complexation to prepare UB–methyl-β-cyclodextrin inclusion complex (UB–M-β-CD). Our result showed that water solubility of UB in inclusion complex was about 0.3 µg/mL, which was increased by 3875 folds than pure UB. In-vivo pharmacokinetic studies showed the enhanced UB content in rat plasma and the improved bioavailability with UB–M-β-CD. In hyperlipidemic hamsters, UB–M-β-CD reduced body weight and organ fat accumulation more effectively than UB alone. Both UB and UB–M-β-CD decreased serum lipid levels except that of high-density lipoprotein cholesterol. Meantime, UB–M-β-CD reversed hepatic bile acid dysregulation better than UB. Further comprehensive analysis revealed that UB–M-β-CD had the superior effects on hyperlipidemia, suggesting that cyclodextrin complexation enhances the therapeutic potential of UB in modulating liver lipid metabolism. Our results indicate that UB–M-β-CD has the great potentials in treatment of hyperlipidemia and related metabolic disorders.
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Nanomaterials
·
2025
·Vol. 15
·期 5
·410
·
IF 4.3
Yongxin Lu,Shangjie Gao,Teng Ma,Jie Zhang,Haixia Liu,Wei Zhou
The construction of heterojunctions can effectively inhibit the rapid recombination of photogenerated electrons and holes in photocatalysts and offers great potential for pollutant degradation. In this study, a Z-scheme heterojunction g-C3N4/WO3photocatalyst was synthesized using a combination of hydrothermal and calcination methods. The photocatalytic degradation performance was tested under visible light; the degradation efficiency of Rh B reached 97.9% within 15 min and that of TC-HCl reached 93.3% within 180 min. The excellent photocatalytic performance of g-C3N4/WO3composites can be attributed to the improved absorption of visible light, the increase in surface area, and the effective separation of photogenerated electron–hole pairs. In addition, after four cycles of experiments, the photocatalytic performance of g-C3N4/WO3did not decrease obviously, remaining at 97.8%, which proved that the g-C3N4/WO3heterojunction had high stability and reusability. The active radical capture experiment confirmed that h+and ·O2−played a leading role in the photocatalytic degradation. The Z-scheme heterojunction g-C3N4/WO3designed and synthesized in this study is expected to become an efficient photocatalyst suitable for environmental pollution control.
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PubMed
高影响因子
Journal of Water Process Engineering
·
2025
·
IF 6.7
Peng Xiang,Congming Tang,Kai Ma,Xinli Li
It is a key to disclose the structure-dependent adsorption capacity for design and optimization of adsorbent toward removal of dyestuff pollutants from wastewater. Due to this, the relationship between the crystal phase structure of MoS 2 and adsorption capacity for RhB (Rhodamine B) as a typical dyestuff contaminant was investigated. To compare with the commercial MoS 2 ( c MoS 2 ), the diffraction peak ascribed to (002) plane evidently moved toward low 2θ angle in 1T-MoS 2 , suggesting an enlarged interplanar spacing, which was confirmed by HRTEM characterization. 1T-phase displayed far higher adsorption capacity than 2H-phase, in which q t value of 1T-MoS 2 achieved 688.30 ± 10.1 mg/g at 500 mg/L RhB solution, and is 3.0 times larger than c MoS 2 containing 90 % 2H-MoS 2 . Besides, 1T-MoS 2 without sulfur vacancy also displays much higher adsorption capacity than the sulfur vacancy-rich ss MoS 2 , indicating that sulfur vacancy has no contribution to adsorption of RhB. On basis of R 2 criterion, the adsorptions for RhB over c MoS 2 , ss MoS 2 and 1T-MoS 2 well conformed to the pseudo-second order kinetics, indicating that chemical adsorption dominated during the adsorption process. Analysis of structure-dependent adsorption strongly demonstrated that 1T-MoS 2 had more excellent adsorption performance than c MoS 2 and ss MoS 2 due to the synergistic adsorptions of stronger coordination, electrostatic interaction and physisorption. To compare with other adsorbents, 1T-MoS 2 outperformed most of other adsorbents for adsorption of RhB. Cyclic adsorption experiments showed that 1T-MoS 2 possessed an excellent reusability. This work afforded an efficient strategy for crystal phase-mediated adsorption to achieve removal of RhB from wastewater.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2012
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IF 2.289
Peng Gao,Shaoqiang Yang,Zhu Xue,Guangbo Liu,Guoli Zhang,Longqiang Wang,Guobao Li,Yuzeng Sun,Yujin Chen
As a new type hydrogen storage material, Co–B hydrogen storage alloy was a hot research topic and has been paid increasing attention in recent years. In this work, a series of Co–B alloys with molar ratio of 1:1, 2:1 and 3:1 were synthesized by high energy ball-milling method. The phase, structure and morphology of the samples have been characterized by X-ray diffraction (XRD) and scanning electron microscope (SEM), which demonstrated that the samples ball-milled more than 5 h were mainly amorphous phase. Their electrochemical performance as electrochemical hydrogen storage material was investigated by galvanostatic charge–discharge process and cyclic voltammetry (CV) techniques. Electrochemical measurements showed that the Co–B alloys had excellent electrochemical hydrogen storage capacities and exhibited remarkable high rate discharge performance. Their electrochemical hydrogen storage capacity was 771 mAh/g, which was much higher than previous reports (238 mAh/g). Based on XRD and CV results, the exceptional electrochemical performances were suggested to arise from the electrochemical hydrogen storage reaction on the Co–B materials, which was brought about by the special amorphous structure and high chemical reactivity of the Co–B particles.
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MACROMOLECULAR RESEARCH
·
2011
·Vol. 19
·期 12
·1287-1295
·
IF 1.639
Xu Feng,Yan Ting-Ting,Luo Yan-Ling
The thermo-sensitive amphiphilic block copolymer poly( N -isopropylacrylamide)- block -poly( D,L -lactide) (PNIPAAm- b -PLA) was synthesized using a simple free radical copolymerization route based on a bifunctional initiator, 2,2-azobis(2-methylpropion amidine) dihydrochloride followed by the ring-opening polymerization of D,L -actide in the presence of a Sn(Oct) 2 catalyst. The chemical structure of the PNIPAAm- b -PLA copolymers was verified using Fourier transform-infrared spectrophotometry and nuclear magnetic resonance, and the molecular weight and polydispersity index were examined using gel permeation chromatography. The amphiphilic PNIPAAm- b -PLA block copolymers could self-assemble into spherically shaped micelles in an aqueous solution with a transmission electron microscopy diameter range of 40–56 nm and a dynamic laser scattering hydrodynamic diameter of 90–200 nm. This behavior depends on the environmental temperature, the hydrophobic interactions among PNIPAAm molecular chains, the intermolecular hydrogen bonding between the PNIPAAm chains and water molecules, and the intramolecular hydrogen bonding between the -CONH 2 groups. The copolymers held a critical micellization concentration of 4.93–7.21 mg·L −1 and a low critical solution temperature of 31.15–32.62 °C being more or less affected by their compositions, PLA or PNIPAAm block length, and polymerization temperature. The as-prepared PNIPAAm- b -PLA block polymers are anticipated to be applied as candidate drug release carriers.
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Small Methods
·
2025
·
IF 9.1
Xiaoying Han,Juxin Yin,Yu Wang,Jianjian Zhuang,Kai Hu,Yehong Gui,Haohua Mei,Jizhi Tong,Ying Mu
The rapid, precise, and automated diagnosis of infectious diseases is crucial for effective disease management and control. Herein, the integrated portable and automatic digital detection system (IPADS), a novel diagnostic platform for nucleic acid detection is introduced. The device employs the hybrid magnetic system (HMS), which uses an electromagnet and a movable permanent magnet to modulate the magnetic field and control bead movement, increasing nucleic acid extraction efficiency to over 80%, while simplifying the traditional labor-intensive process and enabling quick, low-risk sample processing. Additionally, a disposable cartridge is designed for integrated HMS based preprocessing, with detection performed using digital RPA-Cas12a, enabling rapid, enclosed, and automation-friendly detection across a dynamic range spanning five orders of magnitude, with a sensitivity as low as 100 copies mL −1 in serum samples. An automated platform further optimizes workflow. As a proof of concept, IPADS is applied to detect hepatitis B virus (HBV) DNA in 20 clinical serum samples, demonstrating high concordance with gold-standard quantitative PCR (qPCR) methods. These results validate the potential of IPADS as a reliable point-of-care testing solution.
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PubMed
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Nano Research
·
2024
·
IF 9.5
Liu Fang,Zou Lingyun,Chen Yongcheng,Liu Zuolong,Huang Yue,Jin Qiao,Ji Jian
Biofilm-associated bacterial infection brings serious threats to global public health owing to serious antibiotic resistance. It is urgently needed to develop innovative strategies to combat biofilm-associated bacterial infections. Polymyxins stand out as the last line of defense against Gram-negative bacteria. However, serious nephrotoxicity of polymyxins severely limits their clinical utility. Herein, a hypoxia-responsive liposome is designed as the nanocarrier of polymyxin B (PMB) to combat biofilms developed by Gram-negative bacteria. A metronidazole modified lipid (hypoxia-responsive lipid (HRLipid)) is synthesized to fabricate hypoxia-responsive liposomes (HRLip). PMB loaded hypoxia-responsive liposomes (HRL-PMB) is then prepared to mitigate the nephrotoxicity of PMB while preserving its excellent bactericidal activity. HRL-PMB shows very low hemolysis and cytotoxicity due to liposomal encapsulation of PMB. PMB can be readily released from HRL-PMB in response to hypoxic biofilm microenvironment, exerting its bactericidal activity to realize biofilm eradication. The excellent in vivo antibiofilm ability of HRL-PMB is confirmed by a Pseudomonas aeruginosa infected zebrafish model and a P. aeruginosa pneumonia infection model. Meanwhile, HRL-PMB can greatly reduce the nephrotoxicity of PMB after intravenous injection. The hypoxia-sensitive liposomes held great promise to improve the biosafety of highly toxic antibiotics while preserving their intrinsic bactericidal ability, which may provide an innovative strategy for combating biofilm-associated infections.
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高影响因子
WATER AIR AND SOIL POLLUTION
·
2024
·Vol. 236
·期 1
·1-16
·
IF 3.8
Zheng Lijia,Cao Shoutao,Tang Meng,Ge Ming
A solvothermal route was used to synthesize manganese ferrite/multi-wall carbon nanotubes (MnFe 2 O 4 /MWCNT) composite catalyst, which was firstly employed to activate peroxymonosulfate (PMS) to eliminate rhodamine B (RhB) from water. The catalytic activity of the as-obtained MnFe 2 O 4 /MWCNT for PMS activation and RhB degradation was higher than that of MnFe 2 O 4 and MWCNT. The optimal MnFe 2 O 4 /MWCNT-10 catalyst (0.3 g/L) can remove 98.1% of RhB (20 mg/L) from water by activating PMS (1.0 g/L) after 100 min of reaction, and this catalyst remained stable in the oxidation process. Quenching experiments, X-ray photoelectron spectroscopy (XPS) and electrochemical analysis demonstrated that RhB elimination in the MnFe 2 O 4 /MWCNT-PMS system was accomplished by the non-radical ( 1 O 2 and electron transfer) and free radical (O 2 •− , SO 4 •‒ and •OH) oxidation pathways, and 1 O 2 played a leading role. The influence of operational factors (PMS dosage, initial solution pH, catalyst dosage, reaction temperature, common inorganic anions and water matrix) on RhB removal by MnFe 2 O 4 /MWCNT-10 activated PMS was investigated in detail. The presence of Cl ‒ ions significantly boosted RhB degradation due to the production of more 1 O 2 .
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高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2025
·
IF 4.7
Qi Wang,Yuqi Liu,Han Chen,Tong Yan,Xinying Wang,Yusi He,Baizhuang Li,Biao Li,Yuebin Feng,Huilong Luo,Wei Li
Cobalt-based materials have been proved to be effective heterogeneous catalysts for the activation of peroxymonosulfate (PMS) to degrade many refractory organic dyes. Herein, a novel Co-based complex was prepared by hydrothermal method using py (pyridine) and pda (pyridine-2,3-dicarboxylic acid) as mixed ligands and Co(NO 3 ) 2 ·6H 2 O as Co 2+ ion source and characterized by techniques of Single-crystal X-ray diffraction (SC-XRD), Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TG), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET). Then the prepared Co-based complex was utilized as a peroxymonosulfate (PSM) activator for the efficient degradation of Rhodamine B (Rh B). It was found that the degradation efficiency of Rh B by the system was as high as 98.34 % within 10 min. Meanwhile, the effects of Rh B concentration, catalyst dosage, PMS dosage, and reaction temperature on the degrading process were investigated. Free radical capture experiments confirmed that sulfate radical (SO 4 ˙ˉ) and hydroxyl radical ( ˙ OH ) were the main free radicals that played a role in the degradation of Rh B dye, and the possible degradation mechanism of the reaction was proposed. The recyclability test demonstrated that the catalytic efficiency of the prepared Co-based complex was still higher than 95 % after four cycles, and the characteristic peaks of PXRD spectrum match the simulated pattern. The present results indicated that the prepared Co-based complex can be serve as a stable and effective catalyst for generating free radicals (such as SO 4 • − , • OH) to further treat organic dyes and provide more options for future wastewater remediation.
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危险品化学品经营许可证（带存储）