Asian Journal of Pharmaceutical Sciences
·
2025
·
IF 11.9
Zhiyuan Tang,Yuening Sun,Quanhua Yi,Qian Ding,Yang Ding,Jianfei Huang
The effective intracellular accumulation of doxorubicin (DOX) is crucial for improving antitumor efficacy, which is severely impeded by limited drug penetration, uncontrollable drug release, and drug resistance. In this study, a thermal-deformative polymer embedding ultrasmall ceria (CeO 2 ) was rationally designed for deep tumor drug shuttling and hypoxia reversal to improve chemotherapy. Structurally, the CeO 2 nanozyme was covalently grafted with a polymer of p(NIPAM-co-AM) that could sharply shrink for DOX loading, which was consolidated with polydopamine (PDA) film encapsulation. Thereafter, a tumor penetration guide of apolipoprotein A-I (apoA-I) conjugated iRGD peptide (apoA-I-iRGD) was further decorated onto the PDA shell via Michael addition for preparing CeO 2 P/DOX@iAPDA. With the aid of apoA-I-iRGD, CeO 2 P/DOX@iAPDA penetrated both the tumor spheroids (∼78 μm) and the tumors of the mouse model deeply. After internalization by tumor cells and triggering by low pH in lysosomes, rapid DOX release was achieved by peeling off the PDA shell and thermosensitive deformation of p(NIPAM-co-AM). CeO 2 P/DOX@iAPDA provided 66.4% tumor suppression in 4T1-derived tumor spheroids and 63.2% in 4T1-tumor-bearing mice, respectively. Preliminary mechanistic research involving western blotting and immunohistochemistry revealed that CeO 2 P/DOX@iAPDA reversed resistance through the through HIF-1α-P-gp/lipid axis. Collectively, this study intelligently integrated CeO 2 nanozymes, temperature-sensitive polymers, and imitated biochemical modifications to improve chemotherapy for breast cancer.
研究领域:
纳米技术
·
癌症治疗
·
药学科学
·
生物医学工程
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Jiahui Jiang,Bingbing Gong,Guancheng Xu,Ting Zhao,Hui Ding,Yuying Feng,Yixuan Li,Li Zhang
CeO 2 has been identified as a significant cocatalyst to enhance the electrocatalytic activity of transition metal phosphides (TMPs). However, the electrocatalytic mechanism by which CeO 2 enhances the catalytic activity of TMP remains unclear. In this study, we have successfully developed a unique CeO 2 -CoP-1–4 multishell microsphere heterostructure catalyst through a simple hydrothermal and calcination process. CeO 2 -CoP-1–4 exhibits great potential for electrocatalytic oxygen evolution reaction (OER), requiring only an overpotential of 254 mV to achieve a current density of 10 mA cm −2 . Moreover, CeO 2 -CoP-1–4 demonstrates excellent operating durability lasting for 55 h. The presence of CeO 2 as a cocatalyst can regulate the microsphere structure of CoP, the resulting multishell microsphere structure can shorten the mass transfer distance, and improve the utilization rate of the active site. Furthermore, in situ Raman and ex situ characterizations, and DFT theoretical calculation results reveal that CeO 2 can effectively regulates the electronic structure of Co species, reduces the reaction free energy of rate-limiting step, thus increase the reaction kinetic. Overall, this study provides experimental and theoretical evidence to better comprehend the mechanism and structure evolution of CeO 2 in enhancing the OER performance of CoP, offering a unique design inspiration for the development of efficient hollow heterojunction electrocatalysts.
研究领域:
材料科学
·
电化学
·
催化
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2018
·
IF 5.116
Di Zhu,Huiyuan Ma,Haijun Pang,Lichao Tan,Jia Jiao,Tao Chen
A non-enzymatic nanocomposite of 12-heteropolyacids and CeO 2 @Pt alloy nanoparticles decorated by reduced graphene oxide (RGO), was successfully developed by a facile and eco-friendly route for simultaneous determination of xanthine (XA) and uric acid (UA). The surface morphology and structure of the nanocomposite were investigated by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS) and fourier transform infrared spectroscopy (FT-IR), respectively. And then, the electrochemical properties of the nanocomposite were further examined by differential pulse voltammetry (DPV), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The as-prepared nanocomposite exhibited excellent sensing performance towards the determination of UA and XA simultaneously with a widely linear range from 4.43 × 10 −7 M to 4.52 × 10 −4 M and 1.25 × 10 −7 M to 5.73 × 10 −4 M, respectively, along with a relatively low detection limit of 5.13 × 10 −8 M and 1.34 × 10 −8 M, mainly because of the synergistic effect of the active components. Meanwhile, the nanocomposite also revealed a superb anti-interference property, as well as good stability and reproducibility. What's more, the nanocomposite was applied in detecting XA and UA in real samples with satisfactory results, demonstrating that the nanocomposite of PMo 6 W 6 /RGO-CeO 2 @Pt would be a good potential candidate sensor for practical detecting xanthine and uric acid.
研究领域:
分析化学
·
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 11
·1-17
·
IF 5.3
Liang Jintao,Liang Jianlu,Xiao Xinkai,Guo Fei,Zhan Yulian,Zhou Xueqing,Zhou Zhide,Li Guiyin
A sandwich-type electrochemical aptasensor for ultrasensitive detection of glypican-3 (GPC3) was constructed using GPC3 aptamer (GPC3 Apt ) labelled reduced graphene oxide-cerium oxide-gold nanoparticles (RGO-CeO 2 -Au NPs) as the signal probe and the same GPC3 Apt as the capture probe. The electrochemical redox properties of CeO 2 (Ce 3+ /Ce 4+ ) in the RGO-CeO 2 -Au NPs indicate the electrochemical signals. When the target GPC3 was present, an “aptamer-protein-aptamer” sandwich structure was formed on the sensing interface due to the specific binding between the protein and aptamers, resulting in an increased electrochemical redox signal detected by differential pulse voltammetry (DPV) technique. Under optimal conditions, the established aptasensor exhibited a logarithmic linear relationship between the current response and GPC3 concentration in the range 0.001–100.0 ng/mL, with a minimum detection limit of 0.74 pg/mL. Using the spike-recovery tests for measurement of the human serum samples, the recovery was from 99.26 to 114.01%, and the RSD range was 3.04 to 5.34%. Furthermore, the sandwich-type electrochemical aptasensor exhibited excellent performance characteristics such as good stability, high specificity, and high sensitivity, demonstrating effective detection of GPC3 in human serum samples and can be used as a clinical detection tool for GPC3. Graphical Abstract
研究领域:
电化学
·
纳米技术
·
生物传感器
·
癌症诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POWER SOURCES
·
2023
·
IF 9.2
Lanying Lu,Debo He,Rong Fang,Chengsheng Ni,John T.S. Irvine
The valorization of the CO 2 greenhouse gas is important in decarbonization using the renewable energies. Intermediate temperature solid oxide electrolysis cells (SOEC) working at around 800 °C can be useful in activating the strong C O bond (799 kJ mol −1 ) in CO 2 for the production of CO and decreasing the precious electricity by partially using the heat instead. Ceria/Co doping on the stable chromite is employed to design a composite oxide/metal cathode with a unique ceria decorating Co 0 for the direct CO 2 electrolysis. The in situ outgrowth of Co 0 from the B site activates the ceria exsolution from the A site, or vice versa , producing a well-adhered heterojunction for the activation of CO 2 . A high current and stable density above 1 Acm −2 for 300 h is obtained at a bias of 1.3 V for the CO 2 at a Faraday efficiency close to unity. The higher electrochemical performance of the cell with Ce/Co 0 codoped cathode is explained by the oxygen storage property of the ceria rather than the direct activation of CO 2 over ceria. This work presents a novel method of constructing metal/oxide cathode for efficient CO 2 analysis and in-depth mechanistic explanation for the metal/oxide hetero-structure in CO 2 activation.
研究领域:
材料科学
·
电化学
·
能源转换与存储
·
环境科学
✓ 已验证
DOI
高影响因子
APPLIED CATALYSIS A-GENERAL
·
2019
·
IF 4.63
Li Cao,Xiaodong Wu,Ze Chen,Yue Ma,Ziran Ma,Rui Ran,Zhichun Si,Duan Weng,Baodong Wang
CeO 2 /WO 3 -TiO 2 (CeWTi) and Nb 2 O 5 -CeO 2 /WO 3 -TiO 2 (NbCeWTi) catalysts were prepared by a sol-gel precipitation method. Both the catalysts exhibit high selective catalytic reduction of NO x with NH 3 (NH 3 -SCR) activities at 270–500 °C. The sulfur tolerances of the catalysts were evaluated at 270 °C by adding H 2 O and SO 2 in the feeding gas and NbCeWTi exhibited a significantly improved resistance. The thermogravimetric (TG) and mass spectrographic (MS) results indicated that much less sulfates formed on NbCeWTi and existed mainly in the form of ammonium hydrogen sulfate species which protected Ce x+ active sites effectively from attacking of SO 2 . According to the results of temperature-programmed desorption of ammonia (NH 3 -TPD), H 2 temperature-programmed reduction (H 2 -TPR) and SO 2 oxidation , loading niobia on CeWTi inhibited the SO 2 oxidative adsorption and SO 3 production which basically reduced sulfur poisoning of the catalyst. Additionally, the niobia modification ensured the formation of nitrates from the competitive adsorption of SO 2 and hereby facilitated the nitrate SCR route based on the in situ diffuse reflectance infrared Fourier transform spectra (DRIFTS).
研究领域:
催化
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Qi Zhong,Kangdong Wang,Gao Pan,Shuping Peng,Cijun Shuai
CeO2 nanozymes have demonstrated the potential to enhance biological scaffolds with chemodynamic therapy. However, their catalytic efficacy is limited by the slow conversion of Ce4+ to Ce3+ and the lack of substrates like H2O2 and H+. To address these challenges, we adopted a dual-pronged strategy that utilized the plasmonic resonance of Au nanoparticles and their glucose-oxidase mimicry to boost electron and hydrogen transfer. Specifically, we integrated Au/CeO2 nanozymes into poly-l-lactic acid scaffolds via selective laser sintering. This conversion of Ce3+ to Ce4+ in the scaffolds enhanced the reduction of H2O2 to a hydroxyl radical, inducing oxidative stress in tumor cells. The Au nanoparticles played a crucial role in boosting the Ce3+/Ce4+ catalytic cycle by providing both the energy and the catalytic substrates. They recycled Ce4+ back to Ce3+ by exploiting plasmonic-induced hot electrons and catalyzed glucose oxidation to supply H2O2 and H+. Our nanoscale and atomic-scale simulations confirmed that the Au/CeO2 hybrid structure utilized near-field coupling to amplify the plasmonic resonance and the Au–O–Ce bridge reduced the electron transfer barrier. Consequently, the Au/CeO2 scaffold decreased the activation energy from 22.57 to 9.92 kJ/mol. These findings highlight the significant promise of the Au/CeO2 nanozyme scaffold for NIR-enhanced chemodynamic therapy.
研究领域:
纳米技术
·
癌症治疗
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2021
·Vol. 14
·期 2
·361-372
·
IF 7.79
Ruoxi Zhao,Rui Zhang,Lili Feng,Yushan Dong,Jialing Zhou,Songnan Qu,Shili Gai,Dan Yang,He Ding,Piaoping Yang
The construction of nanoplatforms with combined photothermal properties and cascading enzymatic activities has become an active area of anticancer research. However, the overheating of photothermal therapy (PTT) and the specific properties of tumor microenvironment (TME) greatly impaired the therapeutic efficiency. Herein, we rationally fabricated a virus-like SiOx/CeO2/VOx (SCV) nanoplatform for 1064 nm near-infrared (NIR) triggered mild-temperature PTT and nanozyme catalytic therapy. Firstly, the virus-like shape of SiOx/CeO2/VOx made it favorable for cell adhesion and improved its phagocytosis in cells, and the SCV generated an effective PTT effect upon 1064 nm laser irradiation. Particularly, the produced VO2+ in TME could be used as a heat shock protein inhibitor to inhibit the expression of heat shock protein 60 (HSP60) to enhance the PTT efficiency. Moreover, the SCV nanozyme exhibited obvious peroxidase-mimic (POD) catalytic activity, which could generate highly toxic free radical ions (˙OH) under acidic conditions. The mild-temperature heat and ˙OH produced by enzymatic catalysis effectively blocked the tumor growth, as verified firmly by in vitro and in vivo tests. Our designed virus-like SCV nanozyme with POD mimic enzyme activity and a mild photothermal effect may provide a new way of thinking about the combination therapy model.
研究领域:
纳米医学
·
癌症治疗
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2023
·
IF 22.1
Ning Luo,Fengyu Gao,Hengheng Liu,Tingkai Xiong,Jiajun Wen,Erhong Duan,Chengzhi Wang,Shunzheng Zhao,Honghong Yi,Xiaolong Tang
Developing effective and stable catalysts for low-temperature selective catalytic reduction (SCR) of NO x remains challenging. Herein, we constructed a hierarchical structure by loading CoMn 2 O 4 onto Ti-doped CeO 2 , that CoMn 2 O 4 /CeTiO x catalyst has shown superior deNO x activity (>95% at 100–225 °C), prominent reaction activation energy (28.8 ± 0.9 kJ mol −1 ) and outstanding stability (>75% at 100–200 °C within H 2 O and SO 2 ). The “low-temperature active sites” and “dual anti-poisoning sites” contribute to excellent activity and stability. Firstly, the hierarchical structure boosts generation of active metal-support interface, which is conducive to oxygen migration (including adsorbed oxygen (O ads ), lattice oxygen (O lat ) and oxygen vacancy (O v )) and metal charge transfer (Mn 2+/3+ +Ce 4+ ↔Mn 3+/4+ +Ce 3+ , Ti 4+ +Ce 3+ ↔Ce 4+ +Ti 3+ ). This is the key to breaking through the limits of catalytic activity stability. Secondly, enhanced surface acidity favors NH 3 adsorption and activation, which accelerates -NH 2 /-NH concatenate with NO x through Eley-Rideal mechanism to generate N 2 and H 2 O. Thirdly, the dual strong SO 2 affinity sites by Ti-induced CeO 2 crystal reconstruction retard the active center affected by the sulfate species, which contributes to striking stability. This work highlights the importance of design of isolated active sites to improve SO 2 and H 2 O endurance.
研究领域:
催化
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2024
·
IF 4.1
Yanan Li,Yuqi Wang,Jinlei Wu,Shuqin Gao,Binjing Zhu,Junqian Wang,Jing Zhao,Le Wu,Lan Zheng,Xiaoli Zhang
Dry reforming of methane (DRM) is considered one of the most efficient methods for carbon utilization, as it can transform greenhouse gases (CH 4 and CO 2 ) into syngas (CO and H 2 ) which could be widely used in the production of high-value hydrocarbons. The synergistic effect between Ni and Co is leveraged to enhance the coke resistance and stability of Ni-based catalyst during the DRM process, building upon the surface spatial confinement provided by honeycomb-lantern-like CeO 2 support. The enhanced catalytic performance of Ni 0.9 Co 0.1 catalyst can be attributed primarily to the addition of cobalt, which facilitates CO 2 adsorption and activation, further promotes the Boudouard reaction and aids in the elimination of coke. This phenomenon is supported by evidence from CO 2 -TPD, XPS, SEM, TGA, XRD, and CO 2 -TPO analyses. Furthermore, the kinetics of Ni 0.9 Co 0.1 are examined using Power-Law (PL) and Langmuir-Hinshelwood (LH) mechanisms, obtaining the explicit equations for the rate constants ( k and k r ), reaction orders of the reactants (α and β), and adsorption equilibrium constants ( K CH 4 and K CO 2 ). The comparison of the predicted CH 4 consumption rates with the experimental rates suggests that the LH mechanism is notably more precise than PL mechanism for Ni 0.9 Co 0.1 catalyst. Moreover, the relevant kinetic parameters (the activation energy and pre-exponential factor), pertinent to coke gasification process for the spent Ni 0.9 Co 0.1 and Ni 1.0 , are determined and calculated through CO 2 -TPO characterization and the modified Wigner-Polanyi equation.
研究领域:
催化
·
化学工程
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2024
·
IF 8.1
Fei Duan,Yunqin Hu,Junfeng Lin,Mingyue Li,Hao Wu,Zhiqing Cui,Caihong Fang
To develop non-noble electrocatalysts with high activity and stability for oxygen evolution reaction (OER)/urea oxidation reaction (UOR) is crucial to boost the efficiency of overall water/urea splitting reaction (OWS/OUS) for H 2 production. Herein, we synthesized novel CeO 2 /Co(OH) 2 /FeS nanosheet arrays on nickel foam (CeO 2 /Co(OH) 2 /FeS@NF) through a simple two-step hydrothermal and following solvothermal routine. In this special structure, the ultra-thin 2D nanosheet morphology can adequately offer large contact area and thus abundant of active sites, facilitating significantly the mass transfer. Furthermore, the incorporation of FeS into CeO 2 /Co(OH) 2 will not only modify the electron structure but also provide a number of phase interfaces, which can improve the inherent electron conductivity and promote the electron transport. More importantly, the rich oxygen vacancies (O v ) sites can vary the coordination of metal centers, modulating both the charge distribution and M−O bonding strength. As results, the CeO 2 /Co(OH) 2 /FeS@NF shows superior low overpotentials of 178 mV/1.30 V at 10 mA cm −2 to OER/UOR. The activity keeps its low value of 232 mV/1.375 V even when the current density was increased to as high as 300 mA cm −2 . More importantly, the electrode of CeO 2 /Co(OH) 2 /FeS@NF//CeO 2 /Co(OH) 2 /FeS@NF just requires a low cell voltage of 1.41 V to realize OUS at a current density of 10 mA cm −2 . Specifically, we also realized solar-driven H 2 production. Plenty of H 2 bubbles were continuously generated with a high speed of 600 L h −1 m −2 on the working electrode surface once the solar panel was placed under the natural sunlight.
研究领域:
材料科学
·
电化学
·
能量转换与存储
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ELECTRONIC MATERIALS
·
2022
·Vol. 51
·期 7
·3831-3842
·
IF 2.047
Zhang Baozhong,He Jintao,Tian Panpan,Lv Lina,Zhu Huina,Xie Lingling,Liu Xiaolong,He Baoshan
In this study, based on the specific binding of nucleic acid aptamers (Apts) to 3,3′,4,4′-tetrachlorobiphenyl (PCB77), an ultrasensitive electrochemical aptasensor was constructed for the detection of PCB77. The Apts were captured by hairpin (HP) deoxyribonucleic acid capture probes through complementary base pairing. The large surface area of reduced graphene oxide (rGO) combined with Ag-Cu 2 O significantly improved the efficiency of electron transfer on the electrode surface and provided a large number of binding sites for HP capture probes. Streptavidin (SA)-modified CeO 2 /AuPt was used as signal-generating material to amplify electrical signals cooperatively with Ag-Cu 2 O/rGO, and it was also combined with biotin-modified nucleic acid Apts via the SA-biotin system to form signal labels, which significantly improved the sensitivity of the aptasensor. The morphology and size of the synthesized materials were characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The internal structure and composition of the materials were further analyzed by x-ray photoelectron spectroscopy (XPS), x-ray diffraction (XRD), and Fourier transform infrared (FT-IR) spectroscopy. The sensor assembly process was confirmed by electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). Differential pulse voltammetry (DPV) was used to optimize the experimental conditions and evaluate the performance of the sensor. Under optimal conditions, the detection limit of the aptasensor was 0.069 ng/L, and the dynamic range was 0.1–10 3 ng/L, providing a high-quality platform for PCB77 detection. Graphical Abstract
研究领域:
分析化学
·
环境科学
·
纳米技术
·
电化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）