Journal of Functional Foods
·
2023
·
IF 5.6
Yeye Hu,Xueting Guan,Ziliang He,Yuan Xie,Zhiqiang Niu,Wei Zhang,Aoran Wang,Ji Zhang,Chuanling Si,Fu Li,Weicheng Hu
Apigenin-7-O-glucoside (AG), a flavonoid glycoside, has been shown in vitro anti-inflammatory activities. To date, the mechanism of AG against colitis has not been reported. In this study, we investigated the role of AG in relieving colitis and explored its potential mechanisms in dextran sulfate sodium (DSS)-induced colitis mice. The results indicated oral administration of AG increased colon length and improved colonic histopathology. Besides, it dramatically restored the colonic expression of pro-inflammatory and anti-inflammatory mediators, as well as enhanced the expression of intestinal barrier markers such as ZO-1, occludin, claudin-1, and claudin-3. The mitogen-activated protein kinases (MAPKs) including ERK, JNK, and p38 were significantly inhibited. Moreover, 16S rDNA sequencing revealed that AG improved the abundance of Akkermansia , and reduced that of Bacteroides and Desulfovibrio . Taken together, AG supplementation relieved DSS-induced colitis by protecting the intestinal barrier, inhibiting the MAPK pathway, and modulating gut microbiota, which indicated that AG may be a good candidate therapeutic compound for sustaining gut health to lower the risk of colitis.
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FOOD HYDROCOLLOIDS
·
2019
·
IF 5.839
Xingzhong Zhang,Yingli Liu,Yixiang Wang,Xiaogang Luo,Yan Li,Bin Li,Jing Wang,Shilin Liu
In order to enhance the surface hydrophobicity and emulsifying capacity of cellulose nanofibrils, a ‘green’ surface-modification with protein nanoparticles was conducted. The adsorption of soy protein isolate (SPI) nanoparticles on the bacterial cellulose oxidized by 2,2,6,6-tetramethylpiperidine-nitrogen-oxide (TEMPO) through electrostatic attraction at pH 3 was investigated. The experimental results demonstrated that the modification increased the surface hydrophobicity of TEMPO-oxidized bacterial cellulose (TOBC), and the complexes expressed the improved interfacial rheological properties. Accordingly, with the increasing contents of complexes, the Pickering emulsions exhibited the smaller droplets size, higher viscosity, and better physical stability. Moreover, the emulsions showed good anti-oxidative stability, where both primary (POVs) and secondary (TBARS) products of lipid oxidation were significantly lower than those of oil without coverage. The results of in vitro digestion indicated the improved anti-lipid hydrolysis performance of emulsions with tunable interfacial structure formed by complexes.
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CERAMICS INTERNATIONAL
·
2019
·
IF 3.45
Peiyao Lin,Jun Shen,Xiaohui Yu,Qinqin Liu,Dongsheng Li,Hua Tang
construction of the Schottky-junction is considered to be a valid route to boost the spatial charge separation and transfer of the photocatalytic system. Herein, two-dimensional (2D) O-doped g-C 3 N 4 nanosheets were prepared by an annealing route, and then a 2D/2D Ti 3 C 2 MXene/O-doped g-C 3 N 4 Schottky-junction was fabricated using an in-situ electrostatic assembly of negatively charged Ti 3 C 2 MXene and positively charged O-doped g-C 3 N 4 nanosheets. The as-prepared Ti 3 C 2 MXene/O-doped g-C 3 N 4 Schottky-junction exhibited almost two times enhanced hydrogen evolution (25124 μmol/g/h) in comparison to pristine O-doped g-C 3 N 4 (13745 μmol/g/h) and Ti 3 C 2 MXene/pristine C 3 N 4 (15573 μmol/g/h). Based on fully characterizations and theory calculation, the enhanced photocatalytic performance could be attributed to the synergy effect of intimate 2D/2D interfacial contact and the construction of Schottky-junction, which result in the short charge transport distance from HCN to Ti 3 C 2 MXene and efficient separation of the photo-generated charge. This study will provide new insight into developing 2D/2D Schottky-junction photocatalysts for the solution of the energy crisis.
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JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2019
·
IF 4.978
Fekadu Tadesse Bekena,Hairus Abdullah,Dong-Hau Kuo,Misganaw Alemu Zeleke
Novel Mg-doped Zn(O,S) nanoparticles were synthesized by a chemical precipitation process at 90 ℃ and the prepared nanoparticles were characterized by XRD, SEM, HRTEM, XPS, UV–vis, DRS, PL, EIS, and photocurrent response. The photocatalytic reduction for the 4-nitrophenol using Na 2 SO 3 under UV light irradiation showed that Mg–Zn(O,S)-2.5 exhibited higher activity compared with other samples. 96.7% of 4-nitrophenolate ion reduced into 4-aminophenol within 45 min. Mg–Zn(O,S)-2.5 was also tested for hydrogen evolution, where the rates of 1035 μmol/g for the 4-NP-free sample and 705 μmol/g for the 4-NP-added one were achieved. Finally, the stability and reaction mechanism was mentioned.
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CARBOHYDRATE POLYMERS
·
2018
·
IF 5.158
Feng Cheng,Yadong Wu,Hongbin Li,Tingsheng Yan,Xinjing Wei,Guangyu Wu,Jinmei He,Yudong Huang
Tissue adhesion is one of the most common complications after surgery (especially after abdominal surgery), causing notable influences after the damaged tissue has healed. A physical barrier placed between the wound site and the adjacent tissues is a convenient and highly effective technique to minimize or prevent abdominal adhesions. In this work, the N , O -carboxymethyl chitosan/oxidized regenerated cellulose ( N, O-CS/ORC ) composite gauze was prepared. The N, O-CS/ORC composite gauze is degradable; in addition, the gauze exhibits excellent antimicrobial functionality against S. aureus and E. coli bacteria. Moreover, the notable hemostatic efficacy of the N, O-CS/ORC composite gauze was confirmed in rabbit livers/ears as models. The results showed that the N, O-CS/ORC composite gauze is nontoxic toward normal cells and can restrain the adhesion of fibroblast cells, thereby indicating its potential use in preventing tissue adhesion. In addition, the rat models for abdominal defect-cecum abrasion were used to evaluate the efficacy of N, O-CS/ORC composite gauze in preventing tissue adhesions after surgery. The results indicated that the N, O-CS/ORC composite gauze can significantly prevent postsurgical peritoneal adhesions. Finally, the potential anti-adhesion mechanism of the N, O-CS/ORC composite gauze, which may attribute to the combination of barrier function and instinct activity of N, O-CS and ORC, was investigated.
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高影响因子
CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Fan Du,Lei Zhang,Jiliang Ma,Xinwen Peng
Two kinds of xylan/palladium catalysts (PACMX-Pd and EDAX-Pd) were simply fabricated by integrating two N bidentate ligands into the skeleton of oxygen-rich xylan and followed with the in-situ reduction of palladium. The Pd loading in PACMX-Pd and EDAX-Pd nanocomposites was 0.353 mmol/g and 0.302 mmol/g, respectively. The catalysts exhibited an excellent catalytic activity for the Suzuki reaction with a yield of high up to 100% as well as a superior turnover frequency (TOF: 9626 h −1 ). Moreover, the catalysts showed outstanding stability and could be reused for at least 5 times without significant decrease in activity. Compared with other polymers and non-polymers supported palladium catalysts, the as-prepared biomass-based catalysts possess potential applications in a wide range of organic catalysis.
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PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2018
·Vol. 20
·期 16
·11285-11295
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IF 3.906
Shanshan Dai,Yuxin Suo,Dongfang Liu,Peiyao Zhu,Jihe Zhao,Jiang Tan,Hongsheng Lu
A series of CO2-responsive oil-in-water (O/W) emulsions were prepared by introducing hydrophobic tertiary amines (TAs) with varying alkane carbon numbers (ACNs) into the emulsion stabilized by sodium dodecyl benzene sulfonate (SDBS). TAs are converted to bicarbonate salts upon bubbling of CO2, which can form ion pairs with SDBS via electrostatic interaction, and then disrupt the stability of the emulsion. The reversible switch can be triggered by the removal of CO2. The ACN of TA, the concentration of SDBS/TA, the bubbling time of CO2, and the number of cycles are taken into account in order to study the controllable mechanism of these CO2-responsive emulsions. Because of the improved miscibility with oil, the ion pairs with TAs of larger ACNs can much more easily adhere to the oil phase, and then speed up the rupture rate of the oil droplets. The corresponding demulsification process is tracked by studying the interfacial tension, the zeta potential of the droplets, and microscope snapshots of all the systems. The UV-vis spectrophotometer analysis of the water phase and the 1H-nuclear magnetic resonance (1H NMR) test are further designed to comprehend the significance of ACNs and the solubility product of the formed ion pairs.
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JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2018
·Vol. 102
·期 5
·2415-2425
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IF 2.956
Jingyuan Chu,Yue Zhao,Guangyu Jiang,Wei Wu,Zhiwei Zhang,Zhiyong Hong,Zhijian Jin
Tuning substrate properties is an effective methodology to modulate the texture development of MgO films deposited by ion beam-assisted deposition (IBAD) process for epitaxial oxide films. Herein, a solution deposition planarization (SDP) technique is employed to deposit Gd-Zr-O layer for engineering surface properties of the flexible metal substrate. The correlation between the Gd-Zr-O thin film microstructure and the IBAD-MgO texture is investigated. The coordinated study on atomic force microscopy (AFM) and reflection high-energy electron diffraction (RHEED) reveal that the grain coarsening during high-temperature sintering negatively influences the texture formation of IBAD-MgO. Moreover, the chemical environment of the atoms on the surface of Gd-Zr-O seed layer also plays a critical role, which is normally overlooked. The X-ray photoelectron spectroscopy (XPS) analysis indicates that the carbon residue and intermediate phase result in the poor texture of the IBAD-MgO. This phenomenon is related to the partial decomposition and synthesis reactions due to the lower sintering temperature or reduced surface to volume ratio. We demonstrate the high-quality texture of IBAD-MgO layer, deposited on mono-coated thick Gd-Zr-O film, by using optimal heat-treatment conditions. The cross-sectional TEM images present the dense Gd-Zr-O film with Gd 2 Zr 2 O 7 nanograins. The multifunctionalities, such as planarization, a barrier layer, and seed layer, of Gd-Zr-O layers are realized in full-stacked CeO 2 /LaMnO 3 /IBAD-MgO/SDP-Gd-Zr-O/C276 samples. This work demonstrates a route for simplifying the architecture of 2G-HTS using Gd-Zr-O layer and explores the effect of the surface properties on texture formation in IBAD-MgO layer.
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Inorganic Chemistry Frontiers
·
2017
·Vol. 5
·期 3
·635-642
·
IF 4.036
Di Tian,Xiaofeng Lu,Guangdi Nie,Mu Gao,Ce Wang
Currently, the search for the fabrication of inexpensive and efficient binder-free electrodes for high performance supercapacitor applications is still a great challenge. In this work, different nanostructures of Ni–Mn oxide (Ni–Mn–O) are directly grown on the surface of flexible electrospun carbon nanofibers (ECNFs) and further used as binder-free electrodes for supercapacitors. Among three typical nanostructures, Ni–Mn–O nanosheets on ECNFs show superior electrochemical properties with a good specific capacitance (368.6 F g−1) and excellent rate properties (88.6% retention at 20 times initial current density) in a three-electrode system. Furthermore, an aqueous symmetry cell and a solid-state symmetry supercapacitor are assembled using two pieces of flexible ECNFs@Ni–Mn–O nanosheets. The maximum energy density and power density based on the solid-state supercapacitor are up to 20.4 W h kg−1 and 5.2 kW kg−1, respectively, indicating that the flexible ECNFs@Ni–Mn–O nanosheets present a fairly promising future for practical applications in the field of energy storage.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2017
·
IF 2.323
Yüfang Wu,Xiaolu Zhang,Yanchao Di,Yu Kang,Li Bai
The solubility of p-toluenesulfonamide and o-toluenesulfonamide in seven monosolvents of methanol, ethanol, n-propanol, isopropanol, n-butanol, acetonitrile, and ethyl acetate were measured by using the isothermal saturation method at temperatures ranging from 283.15 to 318.15 K under 101.3 kPa. The mole fraction solubility of p-toluenesulfonamide and o-toluenesulfonamide in those selected monosolvents increased with the increase in temperature. The maximum mole fraction solubility of o-toluenesulfonamide was observed in ethyl acetate (0.07748 at 318.15 K), followed by that in acetonitrile (0.07368 at 318.15K), methanol (0.05790 at 318.15 K), ethanol (0.04564 at 318.15 K), n-propanol (0.04271 at 318.15 K), isopropanol (0.04142 at 318.15 K), and n-butanol (0.03879 at 318.15 K). For p-toluenesulfonamide + solvents systems, the maximum mole fraction solubility was observed in acetonitrile (0.1588 at 318.15 K), followed by that in ethyl acetate (0.1329 at 318.15K), methanol (0.1043 at 318.15 K), ethanol (0.09142 at 318.15 K), n-propanol (0.06888 at 318.15 K), isopropanol (0.05092 at 318.15 K) and n-butanol (0.05645 at 318.15 K). The measured solubility data were correlated and calculated by using the modified Apelblat equation, Buchowski–Ksiazaczak λh equation, Wilson model, and NRTL model. The largest values of relative average deviations (RAD) and the root-mean-square deviations (RMSD) between the experimental and calculated solubility were 0.87 × 10–2 and 8.46 × 10–4, respectively. On the basis of the obtained solubility, the standard enthalpy of solution (ΔHsolo), the standard Gibbs energy (ΔGsolo) of solution, and the standard entropy of solution (ΔSsolo) of p-toluenesulfonamide and o-toluenesulfonamide dissolved in monosolvents were calculated. The results show that the dissolution of p-toluenesulfonamide and o-toluenesulfonamide in these monosolvents is a spontaneous process. The correlation and curve fitting results indicated good correlation of the experimental solubility data of p-toluenesulfonamide and o-toluenesulfonamide with the modified Apelblat model. Therefore, the experimental solubility and correlation equations established in this study can be useful in the crystallization, purification in laboratories, and related industries.
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MOLECULAR PHARMACEUTICS
·
2016
·
IF 4.342
Meirong Huo,Yao Liu,Lei Wang,Tingjie Yin,Chen Qin,Yanyu Xiao,Lifang Yin,Jiyong Liu,Jianping Zhou
A redox-sensitive micellar system constructed from an O,N-hydroxyethyl chitosan–octylamine (HECS-ss-OA) conjugate with disulfide linkages between the hydrophobic alkyl chains and hydrophilic chitosan backbone was synthesized for triggered intracellular delivery of hydrophobic paclitaxel (PTX). In aqueous environments, conjugates formed micelles with high PTX loading (>30%). Mechanistically, the sensitivity of HECS-ss-OA micelles to reducing environments was investigated using the parameters of in vitro release and particle size. Intracellular release of nile red fluorescence alongside cytotoxicity studies further confirmed the potency of redox-sensitive micelles for intracellular drug delivery compared with redox-insensitive micelles. Additionally, an in vivo study confirmed the efficacy of PTX-loaded micelles in tumor-bearing mice with superior antitumor efficacy and diminished systemic toxicity when compared with the redox-insensitive micelles and a PTX solution. These results demonstrate the potential of redox-sensitive HECS-ss-OA micelles for intracellular trafficking of lipophilic anticancer drugs.
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BIOMEDICINE & PHARMACOTHERAPY
·
2017
·
IF 2.759
Yanyan Zhu,Yameng Jiang,Lei Shi,Linying Du,Xiaodong Xu,Enxia Wang,Yong Sun,Xin Guo,Boyang Zou,Huaxin Wang,Changyuan Wang,Lidan Sun,Yuhong Zhen
7- O -Geranylquercetin (GQ) is a novel O -alkylated derivate of quercetin . In this study, we evaluated its apoptosis induction effects in human gastric cancer cell lines SGC-7901 and MGC-803 and explored the potential molecular mechanisms. The results demonstrated that GQ lowered viability of SGC-7901 and MGC-803 cells in a dose- and time-dependent manner without apparent cytotoxicity to human gastric epithelial cell line GES-1. GQ could induce apoptosis in SGC-7901 and MGC-803cells, and arrest the gastric cancer cells at G2/M phase. Mechanism study showed that GQ triggered generation of reactive oxygen species (ROS), then activated p38 and JNK signaling pathways , subsequently led to mitochondrial impairment by regulating the expression of Bcl-2, Bcl-xl and Bax, and finally promoted the release of cytochrome c and the activation of caspases to induce apoptosis. In addition, Z-VAD-FMK (caspase inhibitor) could reverse GQ-induced apoptosis. SB203580 (p38 inhibitor) and SP600125 (JNK inhibitor) could rescue GQ-induced cell death and attenuate mitochondrial signal pathway activation. Furthermore, NAC (ROS inhibitor) could rescue GQ-induced cell death, reduce ROS generation, decrease the phosphorylation of p38 and JNK, and then attenuate the activation of mitochondrial signal pathway. Taken together, GQ induces caspase-dependent apoptosis in gastric cancer cells through activating ROS-MAPK mediated mitochondrial signal pathway. This study highlights the potential use of GQ as a gastric cancer therapeutic agent.
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危险品化学品经营许可证（带存储）