LANGMUIR
·
2022
·
IF 4.331
Bingying Jia,Liujie Bing,Bang Xu,Jihong Sun,Shiyang Bai
The amine (NH2)-functionalized UiO-66 was successfully anchored on disorderly layered clinoptilolite (CP) via surfactant (poly(ethylene glycol) (PEG) and poly(vinylpyrrolidone) (PVP))-assisted induction. The structural features and physicochemical parameters of the resultant UiO-66-on-CPs were characterized by powder X-ray diffraction (XRD) patterns, scanning/transmission electron microscopy (SEM/TEM) images, Fourier transform infrared (FT-IR) spectra, N2 sorption isotherms, and small-angle X-ray scattering (SAXS) patterns. The results demonstrated that the growth of UiO-66-NH2 nanoparticles facilitated the disorder degree of the crystal plane of CP along the a-axis, while the addition of PEG in the hydrothermal synthesis system of CP was conducive to the formation of a flower-like microstructure and the introduction of PVP was beneficial to the nucleation and growth of UiO-66-NH2 nanoparticles with a small size (40 nm) on the surfaces of the obtained CP-PEG lamellas. Finally, the gas-selective adsorption and separation performances of CO2 and CH4 were evaluated using the synthesized disorderly layered UiO-66-on-CP heterostructures as adsorbents, indicating that the NH2-functionalized UiO-66-on-CP exhibited a superior selective factor (3.66) of CO2/CH4. These results elucidated that the proposed approach is a promising strategy for constructing MOF-on-zeolite heterostructures, which may open an avenue to expand CP application and improve their performance.
✓ 已验证
DOI
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 4
·1-13
·
IF 5.3
Yang Peixun,Zhu Xiaoyan,Lan Hangzhen,Wu Yichun,Pan Daodong
A solid-phase microextraction (SPME) Arrow and high-performance liquid chromatography-UV detector (HPLC-UV, detection at 225 nm) based method was developed for the selective determination of nine alkylphenols (APs) in milk. The functionalized mesoporous UiO-66 (4-meso-UiO-66) was utilized as the new coating material, which was synthesized by post-modification of pore-expanded UiO-66-NH 2 by an esterification reaction with 4-pentylbenzoic acid. It was fully characterized by X-ray photoelectron spectroscopy (XPS), fourier transformation infrared spectrometry, nitrogen sorption-desorption test, scanning electron microscopy, transmission electron microscopy, and X-ray diffractometer. The characterization results showed the ester groups and benzene rings were introduced into the 4-meso-UiO-66, and the mesoporous structure was predominant in the 4-meso-UiO-66. The extraction mechanism of 4-meso-UiO-66 to APs is the synergistic effect of Zr-O electrostatic interaction and the size exclusion effect resulting from XPS, selectivity test, and nitrogen sorption-desorption test. The electrospinning technique was utilized to fabricate the 4-meso-UiO-66 coated SPME Arrow and polyacrylonitrile (PAN) was used as the adhesive. The mass rate of 4-meso-UiO-66 to PAN and the electrospinning time were evaluated. The extraction and desorption parameters were also studied. The linear range of this method was 0.2–1000 μg L –1 with a coefficient of determination greater than 0.9989 under the optimal conditions. The detection limits were 0.05–1 μg L –1 , the inter-day and intra-day precision (RSD) were 2.8–11.5%, and the recovery was 83.6%–112%. The reusability study showed that the extraction performance of this new SPME Arrow could be maintained after 80 adsorption-desorption cycles. This method showed excellent applicability for the selective determination of APs in milk. Graphical abstract
✓ 已验证
DOI
PubMed
高影响因子
MOLECULES
·
2025
·Vol. 30
·期 15
·3130
·
IF 4.6
Jun Li,Jianlan Deng,Qian Tao,Chenyu Yan,Yuxuan Liu,Jianxiao Yang,Zhong Cao
Luminescent metal–organic frameworks (MOFs) are used for the detection of organophosphorus pesticides (OPs) due to their large surface area and pore volume as well as their special optical properties. However, most self-luminescent MOFs are not only complex to synthesize and unstable in water but also feature a “turn-off” sensing system, which has highly restricted their practical applications in OP detection. Herein, a “turn-on” fluorescence sensor based on the guest-induced luminescence MOF Ru(bpy)32+@UiO-66 was constructed, which realized the sensitive detection of OPs through a dual-enzyme system for the first time. Compared with self-luminescent MOFs, Ru(bpy)32+@UiO-66 was not only more easily synthesized but also had higher chemical and photostability in water. In this strategy, by means of the hydrolysis of AChE and ChOx, H2O2will be produced, which can oxidize Fe2+to Fe3+, thereby quenching the fluorescence of Ru(bpy)32+@UiO-66. In the presence of OPs, the activity of AChE can be inhibited, resulting in the inability to generate H2O2and Fe3+, which will turn on the fluorescence signal of Ru(bpy)32+@UiO-66. As a result, the Ru(bpy)32+@UiO-66 sensing system not only had high sensitivity for OPs detection but also possessed a satisfactory detection recovery rate for parathion-methyl in real samples, which provides a new approach for OP detection in food safety as well as environmental monitoring.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2012
·
IF 4.531
Na Chang,Xiu-Ping Yan
Metal-organic frameworks (MOFs) which offer a variety of topologies, porous networks and high surface areas are promising and have potential for the applications of specific adsorption, isomerization, catalysis and separation. UIO-66 is the first MOF that has been observed to have reverse shape selectivity. However, such reverse shape selectivity of MOFs has never been explored for capillary gas chromatographic separation. Here we report the fabrication of MOF UIO-66 coated capillary column and exploration of the reverse shape selectivity and molecular sieving effect of such column for capillary gas chromatographic separation of alkane isomers and benzene homologues with excellent selectivity and precision. The adsorption enthalpies and entropies on the interaction between hydrocarbons and UIO-66 were measured to illustrate the energy effect on the separation of alkane isomers and benzene homologues on the UIO-66 coated capillary column. UIO-66 coated capillary column gave preferential retention of branched alkane isomers over their linear isomer, showing reverse shape selectivity, making UIO-66 coated capillary column attractive for capillary gas chromatographic separation of alkane isomers. iso -Propylbenzene (branched) eluted after n -propylbenzene on the UIO-66 coated capillary column again shows reverse shape selectivity. However, much bulkier 1,3,5-trimethylbenzene eluted earlier than n -propylbenzene and iso -propylbenzene on the UIO-66 coated capillary column, exhibiting molecular sieving effect. The combination of reverse shape selectivity with molecular sieving effect makes the UIO-66 coated capillary column promising for the separation of structural isomers.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Foods
·
2025
·Vol. 14
·期 18
·3264
·
IF 5.1
Yimeng Pang,Zehao Yang,Xiaohua Liu,Xing Shen,Hongtao Lei,Xiangmei Li
Gentamicin (GEN) is a broad-spectrum antibiotic widely used in livestock production, and its excessive residues in animal-derived foods pose potential health risks to consumers. However, conventional colloidal gold immunochromatographic assays (AuNPs-ICA) often suffer from low sensitivity and poor tolerance to sample matrices. Herein, a UiO-66-NH2framework decorated with gold nanoparticle (UiO-66-NH2@Au)-based ICA was employed to construct an ICA platform for GEN detection, combining the optical advantages of AuNPs with the protective and stable octahedral framework of the Metal-organic framework (MOF) to enhance antibody stability under extreme conditions. The method achieved limits of detection for GEN of 0.1 µg/kg in four tested matrices, with recoveries of 80.1–112.0% and coefficients of variation below 11.7%. Compared to traditional AuNPs-ICA, the sensitivity was improved by up to 30-fold, the pH tolerance range was expanded from 6–8 to 4–10, and the organic solvent tolerance to organic solvents expanded up to 40%. Verification with 40 real samples demonstrated excellent correlation (R2> 0.99) with results from commercial ELISA kits. This UiO-66-NH2@Au-ICA platform offers a new technical solution with high sensitivity, strong good anti-interference performance, and robustness for rapid field detection of GEN residues in products of animal origin and holds significant practical importance for advancing rapid food safety detection technologies.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biofabrication
·
2025
·Vol. 17
·期 3
·035012
·
IF 8
Mengyuan Li,Jiaming Ge,Jingwen Yao,Yuanhao Zhang,Lin Ma,Zheng Li,Xiangli Han,Ming Liu,Fei Tian,Jing Zhao
Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the head and neck. Due to low bioavailability and passive targetability of anticancer drugs show great limitations in cancer therapy, the treatment of OSCC faces major challenges. Folic acid (FA) targeting can deliver anticancer drugs efficiently into the tumor environment, further enhance the anti-cancer efficacy. Herein, the nanoplatform based on UiO-66 that encapsulated with an effective FA targeting ligands and the pH-responsive polyethylene glycol (PEG) layer for the targeted delivery of berberine (Ber) is constructed for fighting against OSCC. The FA modification and controlled pH-responsiveness enable the targeted delivery of UiO-66/PEG-FA, which promotes the release of Ber and increases the cumulative intracellular Ber concentration, which both promote consumption of glutathione (GSH) and induced generation of reactive oxygen species (ROS), further stimulate the secretion of inflammatory factors (TNF-α and IL-1β). A comprehensive evaluation of in vitro and in vivo experiments show that UiO-66@Ber/PEG-FA promote autophagy and apoptosis of tumor cells by regulating the expression of Beclin-1, ATG13, BAX and Bcl-2, and effectively inhibit tumor growth. Overall, UiO-66@Ber/PEG-FA exhibit superior pH-responsiveness and targeted therapeutic efficiencies in vitro and vivo, it can serve as an approach for OSCC therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2025
·
IF 6.1
Xueyun Wei,Baorong Zhang,Zhuomin Zhang,Gongke Li
Haloacetic acid (HAA) disinfection by-products (DBPs) with high polarity, low concentration and significant health hazard are widely present during disinfection processes, particularly iodinated and brominated acetic acids. Due to the lack of selective enrichment media, current sample preparation methods are insufficient for efficient enrichment of low concentrations of HAA DBPs in complex samples, which usually influences the analytical sensitivity and accuracy. In this study, a modulator-induced defect formation strategy was employed to prepare defective UiO-66-NH 2 (D-UiO) as a selective enrichment medium which was further fabricated as membrane solid-phase extraction (M-SPE) to efficiently enrich HAA DBPs. The structure and enrichment performance of the D-UiO medium was studied in detail. D-UiO exhibited good extraction selectivity for the five target DBPs in the presence of structural analogs as interfering compounds. Then, a sensitive quantification method by D-UiO based M-SPE was developed for trace brominated and iodinated acetic acid DBPs in tea drinks coupled with ultra-performance liquid chromatography-tandem mass spectrometry. The limits of detection of the method were in the range of 5.0-15.0 ng/L, and the recoveries were in the range of 78.3%-124%. By combining a ten-pass syringe pump with M-SPE technology, this method enabled batch sample processing and significantly reduced pre-treatment time. The method developed was efficient, selective, sensitive, and accurate for the analysis of hazardous HAA DBPs in complex tea drinks.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2021
·
IF 3.498
Meimei Zhou,Wei Zou,Xuemei Zhu,Huachen Ma,Pengbo Wang,Jiaxin Shang,Pingping Luo
UIO-66-NH 2 was successfully deposited on electrospun polyacrylonitrile (PAN) nanofibers treated by thermal oxidative stabilization (TOS) via a simple and effective in situ growth method. Owing to the formation of acridone rings, naphthyridinering rings and hydronaphthyridine rings during the TOS process, the thermally stabilized electrospun PAN (TSPAN) nanofibers were greatly improved in stability and heat resistance and could provide adequate nucleation points for MOFs growth, indicating an ideal MOFs deposition support without additional surface modifications. The results demonstrated that UIO-66-NH 2 crystals distributed relatively uniform and dense on the TSPAN nanofibers with mass loading up to 28.1 wt%. Compared with powdered UIO-66-NH 2 , the formed UIO-66-NH 2 @TSPAN nanofibers showed enhanced visible light driven photocatalytic activity towards reduction of Cr(VI) due to the improvement of visible light response, more excellent photothermal conversion ability and the increase of exposed active sites. The photocatalytic reduction rate of Cr(VI) over UIO-66-NH 2 @TSPAN was up to 93% within 180 min and the rate constant (k = 0.1362) was 2.3 times that of powdered UIO-66-NH 2 (k = 0.00576). Significantly, the mechanical flexibility and structural stability endowed the nanofibrous photocatalyst easy operation and outstanding reusable capability. The photocatalytic activity for Cr(VI) reduction still preserved 90% after five cycles. This work proposes a facile strategy for preparation of free-standing MOFs nanofibers and provides MOFs-based photocatalysts a new opportunitie for broad applications in water treatment.
✓ 已验证
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Wei-Guang Yang,Xin-He Feng,Xuwen Wu,Zhong-Zhen Yu,Dongzhi Yang
Two typical chemical warfare agents—nerve agents and blister agents—pose a serious threat to human life. Under atmospheric conditions devoid of free water, however, the rapid degradation and complete elimination of these agents using anhydrous catalysts remain significant challenges. To overcome this limitation, a LiCl+AC-MOF composite catalyst with moisture-induced wetting surface is prepared by in-situ growing UiO-66-NH 2 on the activated carbon particles, and then confining LiCl crystallization in the nanocavities of UiO-66-NH 2 . In humid atmosphere (RH = 90%), the confined LiCl undergoes deliquescence within the UiO-66-NH 2 nanocavities, thereby generating a continuous wetting surface. This mechanism yields an impressive water uptake of 1.61 g g −1 , which significantly enhances the equilibrium water content at the gas-solid boundary of the composite catalyst. Leveraging the abundance of free water to the Zr sites, the composite catalyst facilitates the rapid hydrolytic degradation of the nerve agent simulant dimethyl 4-nitrophenyl phosphate with a half-life of 1.9 h at RH = 90%. For the blister agent simulant 2-chloroethyl ethyl sulfide, the catalyst not only cleaves the C S and C Cl bonds but also utilizes its wetting surface to accelerate the recombination of intermediate into final products (half-life = 0.4 min at RH = 70%). In summary, the highly efficient catalyst designed in this work spontaneously harvests atmospheric moisture to create a self-wetting surface. This distinctive surface chemistry enhances both the mass transfer of chemical warfare agent simulants and their subsequent active degradation at Zr sites, thereby substantially broadening the design scope for advanced chemical protective materials applicable to next-generation respirators and gas masks.
✓ 已验证
DOI
高影响因子
FUEL
·
2026
·
IF 7.5
Muhammad Kashif Majeed,Rashid Iqbal,M.Umar Majeed,Muhammad Akram,M.Zeeshan Ashfaq,Adil Saleem
Heterogeneous catalysis is highly desirable for the self-condensation of cyclohexanone, an important step in producing intermediates for fine chemicals and polymers. Conventional methods often rely on toxic reagents and long reaction times, limiting their industrial viability. In this study, Zr- and Hf-based metal–organic frameworks (UiO-66 and NUS-6) were developed as efficient, environmentally friendly catalysts for the self-condensation of cyclohexanone. Their high surface area and hierarchical porosity, combined with bifunctional Brønsted and Lewis acid sites introduced through partial linker substitution, enable excellent catalytic performance. UiO-66(Zr) achieved 81 % conversion in 6 h and 98 % in 48 h, while NUS-6(Zr) reached 85 % and 86 % under the same conditions, with high selectivity toward the desired dimer products. The catalysts also showed strong thermal stability and reusability, maintaining activity at elevated temperatures. This work demonstrates a sustainable catalytic pathway for cyclohexanone dimerization, avoiding corrosive chemicals while offering both efficiency and selectivity.
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2026
·
IF 6.7
Wanyi Zhang,Chenyu Zhou,Hanbo Wang,Yuhan Chen,Tingting Xia,Xingguang Su
Quercetin, a potent natural antioxidant, is gaining widespread attention for its remarkable health benefits, including the prevention of cardiovascular diseases, allergies, diabetes, and cancer. As a promising functional food ingredient, there is an urgent need for fast, sensitive, and portable methods to monitor quercetin levels in various products. In this study, we present a portable dual-mode nanozyme-driven sensor based on cerium dioxide nanoparticle-anchored metal-organic framework (CeO 2 @UiO-66-NH 2 ) nanocomposite. This nanocomposite exhibits impressive oxidase-like activity and intrinsic fluorescence properties, enabling it to catalyze the oxidation of colorless N, N-diethyl-p-phenylenediamine to a pink product, which in turn quenches the fluorescence of CeO 2 @UiO-66-NH 2 at 458 nm via an inner filter effect (IFE). The presence of quercetin inhibits reactive oxygen species generation, thus attenuating the oxidation and restoring fluorescence. A paper-based fluorescent-colorimetric dual-mode sensing platform was established for quercetin detection, enabling rapid and visual evaluation without complex instruments. The proposed method exhibited a broad linear response range of 1-60 μM. The limits of detection for the colorimetric/fluorescent and paper-based colorimetric/fluorescent were 0.35, 0.27, 0.37, and 0.29 μM, respectively. This dual-mode sensor demonstrates excellent analytical sensitivity and selectivity, with successful application in real vegetable and juice samples, offering a reliable, efficient tool for quercetin monitoring in food and functional food ingredients.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Xinru Liang,Yali Liu,Changde Song,Jinliang Ning,Chuanfang Zhao,Jiawen Li,Baiyi Zu,Xincun Dou
CNF biomacromolecules were developed as green MOF modulators. • Defective nanosized MOF with enhanced fluorescence activity was successfully prepared. • ICT effect modulation enables sensitive organophosphorus pesticide detection. • Food-grade multifunctional fruit coating was constructed via cellulose self-assembly. • The work offers new insight into cellulose high-value use in food & agricultural safety. Biomass-derived polysaccharide macromolecules have emerged as sustainable, biocompatible functional materials for green agricultural and food applications, owing to their tunable surface groups, self-assembly properties and environmental friendliness. MOFs hold great sensing potential for their superior structural properties, while pure MOFs have critical flaws (severe agglomeration, low mass transfer, poor specificity/stability) in practice, limiting their broader deployment. To address this challenge, a general strategy for structural regulation of UiO-66-OH using green and sustainable carboxylated cellulose nanofibrils (CNFs, a typical linear polysaccharide biomacromolecule) as the sole biogenic modulator and nano-template was proposed. Driven by the competitive coordination and nano-templating effects of CNFs, the defective nanosized UiO-66-OH features abundant active sites and amplified fluorescence signals, modulating the intramolecular charge transfer (ICT) effect for sensitive pesticide detection. In the presence of the target analyte, a distinct fluorescence enhancement was achieved, with an LOD of 1.40 μg/kg (far below the international glyphosate MRL of 0.1 mg/kg in grains) and robust anti-interference against 17 common interferents. Additionally, leveraging the self-assembly properties of CNFs polysaccharide, a food-grade multifunctional fruit coating was fabricated via spray coating, enabling in-situ visual monitoring of pesticide residues and fruit freshness, pesticide degradation, and long-acting fruit preservation. This work offers a rational material design insight and technical support for high-value utilization of cellulose-based biomacromolecules, as well as the green governance of agricultural pesticide residues and high-efficiency fruit preservation. Download: Download high-res image (179KB) Download: Download full-size image
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）