INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Qiu Fu,Ying Qin,Xinjia Zhang,Lijian Sun,Jiang Chang
The harms caused by ultraviolet (UV) and blue light to eyes are attracting momentous concern due to growing exposure to artificial illumination and modern IT devices. Herein, a simple and eco-friendly adsorption approach was employed to integrate curcumin, a natural bioactive compound, into the cellulose substrate for the development of flexible and biodegradable filters capable of blocking harmful light. The curcumin/cellulose films demonstrate excellent UV-screening competence and photostability, with UV-A and UV-B screening ratios ranging from 92.8 % to 100 % and 89.2 % to 100 %, respectively. The films could block >96 % of blue light in the wavelength range of 400–500 nm. Meanwhile, the films maintain high transmittance (85.2–89.4 %) and low haze (2.0–2.7 %). The films can efficiently block blue light emanated from sunlight, light-emitting diodes, lighting systems, computer and mobile phone screens. Encouragingly, the incorporation of curcumin led to a substantial increase in the water contact angle, elevating it from 41.6 to 81.3°. Furthermore, the films exhibit excellent antimicrobial properties, biodegradability, and tensile strength in excess of 72 MPa. Therefore, these films fabricated entirely from natural resources have the potential to achieve practical applications such as food packaging and spectacle lens, especially suitable for electronic screen protectors.
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REACTIVE & FUNCTIONAL POLYMERS
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2025
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IF 5.1
Mehrab Pourmadadi,Amir Reza Hafezi,Roya Yaghoobi,Aynaz Rahmaninodeh,Negin Hosseini,Afshin Alibabaie,Narges Ajalli,Elaheh Babajani Afrouzi,Mahdi Shirazi,Azam Ghadami
This research examines the formulation and characterization of a pH-sensitive nanocarrier for the targeted and controlled release of curcumin (Cur) in the treatment of brain cancer. The nanocarrier consists of gelatin (G), agarose (Aga), and magnesium-doped carbon quantum dots (Mg-CQD), produced by a water-in-oil-in-water (w/o/w) double emulsification method. These materials demonstrate pH responsiveness, biocompatibility, and biodegradability, crucial for addressing Cur's limitations, including inadequate solubility and fast metabolism. In vitro cytotoxicity assays on U-87 MG glioma cells showed a 49 % reduction in cell viability, whereas minimal toxicity was observed in L929 fibroblast cells, indicating selective anticancer potential. The nanocarrier exhibited a regulated and extended release of Cur under acidic conditions, achieving encapsulation and loading efficiencies of 45.75 % and 85.5 %, respectively, hence enhancing its bioavailability and therapeutic efficacy. Characterization confirmed uniform nanoparticle distribution (average size: 193.5 nm; zeta potential: −42 mV) and successful drug encapsulation. FTIR, XRD and FE-SEM tests validated the effective drug encapsulation, uniform distribution of nanoparticles, and stability. The findings underscore the nanocarrier's potential for targeted cancer therapy, providing both therapeutic efficacy and safety, with intriguing applications in nanomedicine.
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Materials Today Bio
·
2025
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IF 10.2
Juan Duan,Muxi Chen,Mengyan Wang,Rui He,Ke Li,Lei Shi
Radiation-induced oral mucositis (RIOM) substantially compromises the efficacy of cancer treatment and patient survival, while current therapeutic approaches exhibit limited efficacy in addressing its multifactorial pathogenesis. Curcumin possesses multi-targeted pharmacological properties relevant to RIOM, including antioxidative, anti-inflammatory, and mucosal repair effects, rendering it an ideal therapeutic agent. This study developed a curcumin-based intelligent-responsive integrated therapeutic platform (Cur-VE-Zn@gel) via a hierarchical assembly strategy. Specifically, curcumin was covalently bound to vitamin E to form the active center, while its coordination with Zn 2+ facilitates self-assembly into stable polymeric structures. This design not only significantly enhanced the biosecurity of curcumin but also amplified its antioxidant, anti-inflammatory, and tissue repair capabilities, while exhibited stable DNA repair characteristics, thus establishing a comprehensive radioprotective barrier. This bioactive complex was further incorporated into an adhesive thermosensitive hydrogel consisting of chitosan and poloxamer, which enabled targeted delivery to oral mucosa and bypassed the low systemic bioavailability of curcumin. Comprehensive in vitro and in vivo evaluations demonstrated that the Cur-VE-Zn@gel platform effectively modulated DNA damage repair, oxidative stress, inflammatory cascades, and epithelial regeneration, thereby achieving synergistic multi-targeted therapy for the suppression of RIOM. Ultimately, this biomaterial-based strategy successfully addresses the key pharmacological limitations of curcumin through structural modification and targeted delivery, providing a highly promising, safe, and effective approach for the clinically challenging management of RIOM.
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ACS Applied Nano Materials
·
2025
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IF 5.5
Yue Cao,Xin Zhang,Bo Ren,Xiaodong Yang
Due to the complex physiological and pathological barriers in tumor tissues, the penetration depth of light is limited and the accumulation and distribution of photosensitizers in the tumor are insufficient, which seriously affects the therapeutic effect of photothermal therapy (PTT) on solid tumors. The preparation process of traditional photothermal agents is complicated, and their biosafety needs further improvement. Moreover, photothermal agents are difficult to rapidly excrete from the body after realizing the therapeutic function, which may cause long-term potential harm to the body. In this study, multifunctional nanoparticles (FeCNPs) consisting of iron(III), curcumin, and poly(ethylene glycol) grafted polyglutamate (PLG-g-mPEG) were obtained through a simple one-pot method. The synthesized FeCNPs exhibited an average hydrodynamic size of 125 nm and a polydispersion index (PDI) of 0.462. Furthermore, the nanoparticle has excellent biocompatibility and a photothermal effect. After the PPT, the FeCNPs break down into harmless elements via a dynamic disassembly mechanism triggered by deferoxamine mesylate (DFO), facilitating swift elimination and preventing possible long-term toxicity to major organs. The therapeutic synergies enable efficient tumor removal. In summary, this study demonstrates an approach for the dynamic disassembly of metal-polyphenol nanoparticles, effectively addressing the challenge of balancing the EPR effect and renal clearance.
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FOOD CHEMISTRY
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2025
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IF 9.8
Jiahao Ren,Yiting Fan,Ruoxin Chen,Yifang Cao,Xinglong Xiao,Fengsong Liu
Freshness deterioration of salmon during cold storage poses significant safety concerns, highlighting the need for real-time monitoring strategies. Herein, a novel starch-pectin film incorporating Nisin-A and curcumin nano-emulsion (SP-NC film) was developed for real-time monitoring of salmon freshness. FTIR, XRD, and molecular dynamics simulations confirmed strong molecular compatibility and stable hydrogen bonding among film components. The SP-NC film exhibited high mechanical strength, with a tensile strength of 4.51 MPa and elongation at break of 43.58 %, as well as outstanding barrier properties reflected by low water vapor permeability (6.82 × 10 −10 g·mm −1 ·s −1 ·Pa −1 ) and oxygen permeability (6.10 × 10 −9 g·mm·mm −2 ·s −1 ). Under blue light, the SP-NC film reduced S. aureus and Salmonella survival rates to 1.85 % and 3.79 %, respectively. When applied to 4 °C refrigerated salmon, the SP-NC film extended shelf life from 4 to 8 days and provided visual spoilage indication. Overall, this study offers a valuable reference for the design of intelligent food packaging.
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Scientific Reports
·
2025
·Vol. 15
·期 1
·1-13
·
IF 3.9
Chen Juanli,Wei Chuanfei,Zhang Yingchao,Chen Qingfa,Li Xuemei,Zhang Wei,Zhang Xiaoping,Han Fabin
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid beta (Aβ) plaques, leading to neuronal death. Notably, there are no therapeutically efficacious treatments for this disorder. This study investigates the neuroprotective mechanisms of curcumin. In vitro experiments demonstrated that curcumin significantly promoted the proliferation of neural stem cells (NSCs) derived from E16 mouse embryos. Additionally, in the APP/PS1 transgenic mouse model, curcumin improved cognitive function, as evidenced by a shorter escape latency and increased platform crossing frequency in the Morris water maze test and enhanced novel object recognition. Histological analysis showed that curcumin reduced Aβ accumulation in the hippocampal and cortical regions. Molecular studies revealed that curcumin upregulated the expression of BDNF and enhanced phosphorylation of CREB. Collectively, these findings indicate that curcumin exerts neuroprotective effects through multiple mechanisms, including promoting NSC proliferation, reducing Aβ accumulation, and the potential modulation of the BDNF-CREB signaling pathway.
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TALANTA
·
2019
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IF 4.916
Tao Luo,Lingli Bu,Siyu Peng,Yaya Zhang,Zhi Zhou,Guorui Li,Jing Huang
Carbon quantum dots (CQDs), owing to its unique optical properties , have achieved tremendous progress for the detection of different metal ions , organic small molecules, macromolecules , etc. Here we synthesized fluorescent CQDs by a simple one-step microwave-assisted method using 3,4-Dihydroxy- l -phenylalanine (levodopa) as the carbon resource. The CQDs proved to be a multifunctional probe which can be used for detection of various species including copper ion , biothiols and curcumin , via different mechanisms. The selective detection of copper ion was obtained by fluorescence quenching and the mechanism was proved to be static quenching by electrostatic interaction . The fluorescence of levoCQDs-Cu 2+ system can be recovered by biothiols (GSH, Cys and Hcy), implying levoCQDs-Cu 2+ system can also be applied for biothiols detection. The excitation spectrum of levoCQDs had a good overlap with the absorption peak of curcumin, making it as a suitable curcumin probe by fluorescence quenching via inner filter effect (IFE). Furthermore, the levoCQDs can also track the formation of Cu 2+ -Curcumin complexes by restoring the fluorescence of the CQDs in levoCQDs and Cu 2+ -Curcumin system, and this feature may be exploited in the mechanism study of Cu 2+ -Curcumin in the treatment of Alzheimer's disease. The fluorescent levoCQDs were finally used for Cu 2+ and curcumin detection in some real samples including different types of environmental water samples and human serum samples, providing a convenient strategy to monitor Cu 2+ and curcumin in environmental and biological samples.
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ACS Applied Materials & Interfaces
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2021
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IF 9.229
Cuiping Qi,Di Wang,Xue Gong,Qiyang Zhou,Xinxin Yue,Chenglei Li,Zhipeng Li,Guixiang Tian,Bo Zhang,Qing Wang,Xiuhong Wei,Jingliang Wu
Recent research studies have shown that the low survival rate of liver cancer is due to drug resistance and metastasis. In the tumor microenvironment (TME), activated hepatic stellate cells (aHSCs) have been proven to favor the development of liver cancer. Hence, the combination therapy dual-targeting aHSCs and tumor cells might be an effective strategy for treatment of liver cancer. In this study, the novel multifunctional liposomes (CAPS-CUR/GA&Gal-Lip) were prepared for co-delivery of curcumin (CUR) and capsaicin (CAPS), in which glycyrrhetinic acid (GA) and galactose (Gal) were chosen as targeting ligands to modify the liposomes (Lip) for dual-targeting liver cancer. To mimic TME, a novel HSCs+HepG2 (human hepatoma cell line) cocultured model was established for the antitumor effect in vitro. The results showed that, compared to HepG2 cells alone, the cocultured model promoted drug resistance and migration by upregulating the expression of P-glycoprotein (P-gp) and Vimentin, which were effectively inhibited by CAPS-CUR/GA&Gal-Lip. The efficacy of the in vivo antitumor was evaluated by three mice models: subcutaneous H22 (mouse hepatoma cell line) tumor-bearing mice, H22+m-HSC (mouse hepatic stellate cell) tumor-bearing mice, and orthotopic H22 cells-bearing mice. The results showed that CAPS-CUR/GA&Gal-Lip exhibited lesser extracellular matrix (ECM) deposition, lesser tumor angiogenesis, and superior antitumor effect compared with the no- and/or Gal-modified Lip, which was attributed to the simultaneous blocking of the activation of HSCs and inhibition of the metastasis of tumor cells. The dual-targeting method using Lip is thus a potential strategy for liver cancer treatment.
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ACTA PHARMACOLOGICA SINICA
·
2013
·Vol. 34
·期 7
·939-950
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IF 2.354
Peng Yan-min,Zheng Jian-bin,Zhou Yu-bo,Li Jia
Aim: Curcumin has shown promising anticancer activity, which relies on its inhibition on NF-κB pathway. In this study, we characterized the pharmacological profile of a novel curcumin analog P1 and elucidate the related mechanisms. Methods: HEK293/NF-κB cells, stably transfected with an NF-κB-responsive luciferase reporter plasmid, were generated for high-throughput screen (HTS). Eight cancer cell lines, including PC3, COLO 205, HeLa cells etc . were tested. Cell viability was assessed using the sulforhodamine B (SRB) assays. Cell apoptosis was evaluated using FACS, immunocytochemistry, and Western blotting. H 2 -DCFDA and MitoSOX Red were used to detect cellular and mitochondrial reactive oxygen species (ROS). The mitochondrial function was evaluated using mitochondrial oxygen consumption assay. Results: P1, a tropinone curcumin, was found in HTS targeting the NF-κB pathway. Its IC 50 value in inhibition of TNF-α-induced NF-κB activation was 0.8 μmol/L, whereas its IC 50 values in inhibiting the growth of A549 and HeLa cells were 1.24 and 0.69 μmol/L, respectively, which was 20- to 30-fold more potent than curcumin. The inhibition of P1 on the NF-κB pathway was further addressed in HeLa cells. The compound up to 10 μmol/L did not affect the binding of NF-κB to DNA, but markedly inhibited NF-κB nuclear translocation, IκB degradation and IκB kinase phosphorylation. The compound (1 and 3 μmol/L) concentration-dependently induced ROS generation, whereas curcumin up to 20 μmol/L had no effect. P1-induced ROS generation was mainly localized in mitochondria, and reversed by NAC. Moreover, the compound significantly enhanced TNF-α-induced apoptosis. Conclusion: P1 is a novel curcumin analog with potent anticancer activities, which exerts a distinct inhibition on the NF-κB pathway.
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ANALYTICA CHIMICA ACTA
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2019
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IF 5.256
Qi-Xuan Sun,Xing Wei,Shang-Qing Zhang,Ming-Li Chen,Ting Yang,Jian-Hua Wang
It is of great importance to elucidate the fate of drugs, e.g., their cellular uptake, transport and metabolism/excretion at single cell level. In the present work, cellular uptake and excretion of curcumin in HepG2 and MCF-7 cells were investigated by measuring 59 Co in a curcumin cobalt complex ([Co(tpa)(cur)](ClO 4 ) 2 ) with inductively coupled plasma mass spectrometry (ICPMS). The uptake and distribution pattern of the metal drug complex in single cells were thoroughly studied, demonstrating extremely large discrepancy of uptake behavior among individual cells. The complex concentration-dependent uptake and excretion behavior is observed for both HepG2 and MCF-7 cells. The uptake of ([Co(tpa)(cur)](ClO 4 ) 2 ) by HepG2 cells is firstly increased with the concentration of the complex followed by level-off at certain level. On the other hand, however, the uptake by MCF-7 cells increases exponentially with the complex concentration within a same concentration range. The present study provides important information on the transport process of the metal drug complex at single cell level, it may be promising for further applications in the elucidation of metal drug effectiveness in vivo.
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Food Bioscience
·
2024
·
IF 4.8
Yue Pan,Lu Liu,Jiayu Li,Bin Zhu,Xiaodong Li,Jinju Cheng,Muhammad Muneeb,Kouadio Jean Eric-parfait Kouame,Xin Jiang
Inspired by the milk fat globule membrane composition, we investigated the interaction between whey protein isolate (WPI) and soybean lecithin (SL) at various mass ratios (10:0, 10:1, 10:2, 10:5, 10:10, and 10:15) and their effects on curcumin emulsions. Our results demonstrated that SL interacted with WPI through hydrophobic interactions and hydrogen bond restructuring. The WPI–SL complex effectively enveloped oil droplets, resembling natural milk fat globules. Notably, the 10:10 sample exhibited the smallest droplet size (217.33 nm), lowest polydispersity index (0.202), and lowest zeta potential (−43.56 mV). After heat treatment at 90 °C for 1 h, the 10:10 sample exhibited the highest thermal stability , and its polydispersity index (0.236) was significantly lower than at other mass ratio (0.332–0.268). During in vitro digestion, emulsions stabilized by the WPI–SL complex exhibited less oil droplet aggregation, resulting in enhanced curcumin bioaccessibility (58.73–66.32 %) compared to pure WPI-stabilized emulsions (57.45 %). These findings signify the potential of WPI–SL complexes in constructing effective delivery systems mimicking natural fat globule structures, thereby improving curcumin bioavailability. The systematic investigation of different WPI–SL mass ratios in this study provides valuable insights for optimizing emulsifier compositions in the food industry.
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ULTRASONICS SONOCHEMISTRY
·
2024
·
IF 8.7
Dan Yang,Lili Wang,Linxuan Zhang,Mengqi Wang,Dan Li,Ning Liu,Dechun Liu,Mouming Zhao,Xiaolin Yao
Curcumin (Cur) as a natural pigment and biological component, can be widely used in food and beverages. However, the water insolubility of Cur significantly limits its applications. In this study, we prepared a series of nanocrystals via ultrasound-assisted method to improve the solubility and availability of Cur. The results showed artemisia sphaerocephala krasch polysaccharide (ASKP), gum arabic (GA) and wheat protein (WP) were outstanding stabilizers for nanocryatals except traditional agent, poloxamer 188 (F68). The obtained curcumin nanocrystals (Cur-NC) displayed a rod-shaped, crystal- and nanosized structure, and extremely high loading capacity (more over 80 %, w/w). Compared with raw powder, Cur-NC greatly improved the water solubility and dispersibility, and the slow and complete release of Cur of Cur-NC also endowed them excellent antioxidant capacities even at 10 μg/mL. Importantly, as functional factor additive in beverages (e.g. water and emulsion), Cur-NC could increase the content of Cur to at least 600 μg/mL and retain a good stability. Overall, we provided an effective improvement method for the liposoluble active molecules (e.g. Cur) based on the nanocrystals, which not only tremendously enhanced its water solubility, but also strengthened its bioactivity. Notably, our findings broadened the application of water-insoluble compounds.
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