Journal of Environmental Chemical Engineering
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2025
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IF 7.2
Jie Wang,Bingyan Yu,Keru Hou,Yating Ji,Xiaoyan Li,Chengcheng Li,Chengjian Yao,Zaisheng Cai
Membrane separation technology is widely used in separating oily wastewater, where pH-responsive membranes can cope with different conditions of oil-water separation. However, it is limited by membrane contamination during application. A multifunctional oil-water separation membrane (HATP@CN) with photocatalytic performance and pH response was prepared. The wettability of the membrane can be switched by adjusting the pH quickly, which has hydrophobicity when pH ≤ 7 and hydrophilicity when pH ＞7, and it has stable pH responsiveness. The separation effect of membrane on different kinds of oil-water mixtures under different response conditions was explored. The results showed that the separation efficiency of HATP@CN on heavy oil/water mixture and light oil/water mixture was higher than 96.3 % and 99.2 %, respectively, and the separation flux was higher than 6800 L·m −2 ·h −1 and 10000 L·m −2 ·h −1 , respectively. After 50 cycles of separation, HATP@CN still had good separation effects. At the same time, it can also separate water-in-oil emulsion and oil-in-water emulsion. The loading of TiO 2 endows the membrane with excellent photocatalytic performance, which has a high degradation ability of over 90 % within 6 min for various dye solutions. Even in dynamic filtration and separation, MB can be rapidly degraded to realize water purification. This study provided an effective strategy for applying membranes in complex oil-water separation.
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International Journal of Nanomedicine
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2024
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IF 6.6
Ling Wang,Fangqing Cai,Yixuan Li,Xiaolan Lin,Yuting Wang,Weijie Liang,Caiyu Liu,Cunze Wang,Junshan Ruan
Purpose Renal cell carcinoma (RCC) is the most common and lethal type of urogenital cancer, with one-third of new cases presenting as metastatic RCC (mRCC), which, being the seventh most common cancer in men and the ninth in women, poses a significant challenge. For patients with poor prognosis, temsirolimus (TEM) has been approved for first-line therapy, possessing pharmacodynamic activities that block cancer cell growth and inhibit proliferation-associated proteins. However, TEM suffers from poor water solubility, low bioavailability, and systemic side effects. This study aims to develop a novel drug formulation for the treatment of RCC.Methods In this study, amphiphilic block copolymer (poly(ethylene glycol) monomethyl ether-poly(beta-amino ester)) (mPEG-PBAE) was utilized as a drug delivery vehicle and TEM-loaded micelles were prepared by thin-film hydration method by loading TEM inside the nanoparticles. Then, the molecular weight of mPEG-PBAE was controlled to make it realize hydrophobic–hydrophilic transition in the corresponding pH range thereby constructing pH-responsive TEM-loaded micelles. Characterization of pH-responsive TEM-loaded nanomicelles particle size, potential and micromorphology while its determination of drug-loading properties, in vitro release properties. Finally, pharmacodynamics and hepatorenal toxicity were further evaluated.Results TEM loading in mPEG-PBAE increased the solubility of TEM in water from 2.6 μg/mL to more than 5 mg/mL. The pH-responsive TEM-loaded nanomicelles were in the form of spheres or spheroidal shapes with an average particle size of 43.83 nm and a Zeta potential of 1.79 mV. The entrapment efficiency (EE) of pH-responsive TEM nanomicelles with 12.5% drug loading reached 95.27%. Under the environment of pH 6.7, the TEM was released rapidly within 12 h, and the release rate could reach 73.12% with significant pH-dependent characteristics. In vitro experiments showed that mPEG-PBAE preparation of TEM-loaded micelles had non-hemolytic properties and had significant inhibitory effects on cancer cells. In vivo experiments demonstrated that pH-responsive TEM-loaded micelles had excellent antitumor effects with significantly reduced liver and kidney toxicity.Conclusion In conclusion, we successfully prepared pH-responsive TEM-loaded micelles. The results showed that pH-responsive TEM-loaded micelles can achieve passive tumor targeting of TEM, and take advantage of the acidic conditions in tumor tissues to achieve rapid drug release.
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ACS Applied Nano Materials
·
2024
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IF 5.3
Yueyue Yang,Guojin Liu,Yang Tang,Yuqi Xu,Teng Ma,Wanbin Ma,Hailin Zhu,Jianyong Chen,Caihong Lei,Yin Wang
Wound dressings play a crucial role in wound treatment. Silk fibroin fiber membranes prepared via electrostatic spinning have generated medical wound dressings, exhibiting good biocompatibility with hemostatic, antimicrobial, and pro-healing properties. A pH-responsive ZnS/SF composite fiber membrane was prepared by loading zinc sulfide (ZnS) nanoparticles into a silk fibroin fiber membrane via in situ polymer matrix growth. The composite fiber membranes produced under the optimized conditions were successfully loaded with nanoscale ZnS particles. They had a dense reticular structure and high-water absorption with good biocompatibility and hemostatic properties. Upon exposure to an acidic microenvironment at the wound site, ZnS reacted with H+, giving a sustained release of hydrogen sulfide (H2S) and zinc ions (Zn2+), possessing strong bactericidal activity and pro-cell migration effects, facilitating angiogenesis. The composite fiber film is effective in helping to further promote wound healing when it is used as a wound dressing. This pH-responsive multifunctional ZnS/SF composite fiber membrane has potential applications in medical wound dressings.
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Journal of Materials Chemistry B
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2024
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IF 6.1
Nianlu Li,Gaorui Zhang,Jinhua Zhan,Dexin Yu
Fenton reaction–based chemodynamic therapy is a form of cancer therapy and its efficacy can be significantly improved by facilitating the iron ions involved catalytic reaction. In this work, iron-loaded carbonaceous nanoparticles (CNPs@Fe) with Fenton catalytic activity were fabricated and applied for chemodynamic therapy of cancer. The carbonaceous nanoparticles derived from glucose by a caramelization reaction demonstrated high biocompatibility. Besides, aromatic structures in the carbonaceous nanoparticles prefer accelerating electron transfer to enhance the catalytic decomposition of H2O2, resulting in the formation of highly reactive hydroxyl radicals (•OH). At pH 6.0 (representing the weak acidity in tumor microenvironment), the Fenton catalytic activity of CNPs@Fe for decomposition of H2O2 were 15.3 times higher than that of Fe2+ and 28.3 times higher than that of Fe3O4 by chromogenic reaction. The reasons for the enhancement were explained by analyzing the chemical composition of carbonaceous using high-resolution mass spectra. The developed Fenton agent also demonstrates a significant therapeutic effectiveness and little side effects by in vitro and in vivo anticancer studies. This work has put forward a novel approach to promote generation of reactive oxygen species (ROS) for chemodynamic therapy of cancer.
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Royal Society Open Science
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2024
·Vol. 11
·期 9
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IF 2.9
Xin-Rui Wang,Wei-Xiu Lin,Yi-Long Lu,Dietmar Kuck,Wen-Rong Xu
The water-soluble tribenzotriquinacene-based hexacarboxylic acid ammonium salt, TBTQ-C
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, acts as the host component (H) forming host–guest complexes with tetraphenylethylene (TPE)-functionalized monotopic and tetratopic quaternary ammonium derivatives, G1 and G2, to yield supra-amphiphiles. These supra-amphiphiles self-assemble to form pH-responsive fluorescent vesicles, which have allowed us to capitalize on the aggregation-induced emission (AIE) effect for imaging-guided drug delivery systems. These systems exhibit efficient drug loading and pH-responsive delivery capabilities. Upon encapsulation of the anticancer drug doxorubicin (DOX), both the TPE and DOX chromophores undergo dual-fluorescence deactivation due to the energy transfer relay (ETR) effect. Under acidic conditions, the release of DOX interrupts the ETR effect, resulting in the fluorescence recovery of TPE fluorogens and DOX, allowing for real-time visual monitoring of the drug release process. Cytotoxicity experiments confirmed the low toxicity of the unloaded vectors to normal cells, while the DOX-loaded vectors were found to significantly enhance the anticancer activity of DOX against cancer cells in vitro. The AIE-featured supramolecular vesicles presented in this research hold great potential for imaging-guided drug delivery systems.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2021
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IF 19.503
Mengtian Jin,Xian Zhang,Run Shi,Qing Lian,Shuzhang Niu,Ouwen Peng,Qun Wang,Chun Cheng
For large-scale implementation of electrochemical hydrogen production , it is essential to develop electrocatalysts that work well at high current densities over a wide pH range. Herein, we use a facile method to synthesize a hierarchical bimetal phosphide (CoP@Ni 2 P) on nickel foam, which requires very low overpotentials to achieve the benchmark 10 mA cm −2 (e.g., 16 mV in alkaline media). Furthermore, the CoP@Ni 2 P can deliver a high current density of 500 mA cm −2 at small overpotentials and show no obvious decay after the durability test for over 48 h at all pH levels. The outstanding catalytic performance is attributed to the superaerophobicity of the electrode surface, fast electron transport as well as the increased number of exposed active sites caused by the hierarchical structure and the synergistic effect of the heterostructures. Consequently, this work provides an advanced transition metal-based phosphide for large-scale hydrogen production in all pH ranges.
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Journal of Environmental Chemical Engineering
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2025
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IF 7.2
Xuanjun Li,Xiaojing Su,Junping Liao,Pingping Deng,Zeyuan Lu,Shengye Chen,Kunquan Li,Hongqiang Li,Wenjian Wu
pH-Responsive superwetting materials have found increasingly extensive applications in oil-water separation. To broaden the response range of such materials, researchers have proposed dual pH-responsive materials for this application. While these materials exhibit wettability transitions under both acidic and alkaline conditions, they are still limited by poor recovery of superhydrophobicity. To address this limitation, a conductive superhydrophobic fabric with alkaline-responsive properties was fabricated by introducing silver nanowires onto the textile substrate followed by grafting hydrophobic and pH-responsive functional chemicals. The CG/Ag-S fabric exhibited excellent superhydrophobicity (water contact angle at 153.7°), and presented dual-induced pH response to both alkaline conditions and electric field. Notably, the fabric maintained its superhydrophobicity and stable responsiveness after 13 response cycles, with alkaline droplets (pH at 13) fully permeating through it within 30 s. Additionally, electrolysis-induced surface alkalization enabled water to wet and permeate through the fabric within 60 s for effective light oil-water separation. In oil-water separation tests, the CG/Ag-S fabric achieved a separation efficiency of 95.4 % for heavy oil-water mixtures with a flux of 1.68 × 10 4 L·m −2 ·h −1 before pH response, and a separation efficiency of 97.8 % for light oil-water mixtures with a flux of 1.72 × 10 4 L·m −2 ·h −1 after pH response. The design of dual-induced pH-mono-responsiveness solves the superwettability recovery challenge of pH-dual-responsiveness materials, and the dual-induced response capability also broadens the response range of pH-responsive materials.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2025
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IF 6.6
Zhenjia Chen,Jiaqi Li,Xingyu Mu,Qiongling Chen,Xiaowen Wang
This study investigates investigated the mechanisms and variations in physicochemical properties and microstructures of potato protein gels at different pH levels under freezing conditions. Potato protein gels with a 15% protein concentration were prepared at pH 2, pH 7, and pH 10. The results showed that at pH 7, the gel exhibited roughness, pronounced granularity, a uniform pore size distribution, and a water-holding capacity of 97.12%. After freezing, the enthalpy was -228.13 J/g, leading to significant changes in moisture distribution and a reduction in water-holding capacity to 80.43%. At pH 10, increased hydrogen bonding (8.58%) and ionic bonding (2.03%) contributed to a denser, more ordered mesh structure with an enhanced water-holding capacity ( of 97.88%). The enthalpy was -227.85 J/g, which minimized moisture distribution changes and preserved a high water-holding capacity after freezing. In contrast, at pH 2, the gel exhibited a coarse and non-uniform structure, with a reduced water-holding capacity of 67.55%, increased enthalpy of -243.45 J/g, and elongated relaxation time. The freezing process led to ice crystal formation, which disrupted the protein network, particularly at lower pH levels. These findings offer a theoretical basis for optimizing potato protein gel structures and advancing the development of innovative potato-based products.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Shun Liu,Chengjian Yao,Yinjie Chen,Yumei Wang,Lihui Xu,Hong Pan,Qun Yang,Kaikai Chen,Zaisheng Cai
Janus membrane materials have demonstrated significant potential in oil–water separation applications, particularly for treating standard oil–water mixtures. However, their inability to effectively demulsify complex oil–water emulsions, especially industrial wastewater emulsions, remains a critical limitation. This study presents an innovative pH-responsive smart Janus fabric developed through Atom Transfer Radical Polymerisation (ARGET-ATRP) technology. Poly(2-(dimethylamino)ethyl methacrylate (PDMAEMA) was precisely grafted onto the surface of bilayer Janus textiles, enabling intelligent regulation of surface wettability by pH-induced chain extension/contraction transitions. Under acidic conditions (pH 4.0), the smart Janus fabric exhibited exceptional oil-in-water emulsion separation performance, achieving 99.2 ± 0.4 % separation efficiency with a maximum permeation flux of 5403.4 L/m 2 ·h·bar, while effectively intercepting oil droplets larger than 600 nm. The material maintained over 97.00 % separation efficiency after 10 operational cycles, demonstrating remarkable stability. The design of intelligent Janus fabrics with pH adjustment to achieve separation performance provides innovative ideas for industrial complex oily wastewater treatment.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Xinghai Huang,Jingjin He,Lu Yao,Ziqi Zhu,Jianwei Luo,Peiyuan Li,Jianhua Wei,Haiyi Zhong
Intelligent food packaging, as an innovative direction for enhancing food quality monitoring capabilities, has garnered extensive attention among consumers and in the research community in recent years. This study constructed composite film materials using sodium alginate (SA) and polyvinyl alcohol (PVA) as the matrix, loaded with the natural active ingredient curcumin to evaluate the potential of the composite film as an indicator of shrimp freshness. The results revealed that the composite film had a thickness of less than 0.1 mm and could effectively block ultraviolet-visible light. Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR) analyses indicated that curcumin was uniformly distributed within the film matrix. This composite film exhibited strong antioxidant activity (ABTS scavenging rate: 82 %; DPPH scavenging rate: 47.9 %) and reliable pH-responsive characteristics, turning purple or reddish-brown when the pH exceeded 10. This property provides a simple and intuitive method for detecting changes in food quality. In terms of monitoring shrimp freshness, the composite film effectively indicated spoilage. The SA-PVA-CUR30 film changed from light yellow to purple on the fourth day, with a significant increase in the ΔE value (from 34.52 to 51.89), demonstrating optimal indicating performance. In conclusion, this pH-sensitive composite film offers new insights for innovation in food packaging and lays a foundation for the precise control of food quality.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Shilong Zhang,Shuyang Tan,Yajun Deng,Bo Wu,Yanling Yang,Jiangfan Chang,Xianhui Zhang,Baiyi Chen,Jianhua Wu
Traditional antifouling coatings often lack the combined capabilities of static antifouling and dynamic fouling-release, which are critical for marine propellers. This study addresses this limitation by developing pH-sensitive polysiloxane coatings that integrate both functionalities. Two coating systems, PS-Levo and PS-PLL, were synthesized by incorporating levofloxacin (Levo) and polylysine (PLL) as antifouling agents, respectively. PS-Levo was synthesized via an epoxy-carboxylic acid ring-opening reaction, while PS-PLL was obtained through an amine-hydrosilylation reaction, using APTES as the curing agent. A key innovation of these coatings is their pH-triggered hydrolysis. Marine microorganisms that form biofilms on the coating surface can alter the microenvironmental pH through their metabolic activities, either lowering or raising it, thereby promoting the release of antifouling agents. The coatings exhibited remarkable antifouling efficacy, achieving bactericidal and anti-algal rates of over 99% and 97%, respectively. Following a 180-day immersion of the coated panels in natural seawater, minimal marine biofouling adhered to the coated surfaces and could be effortlessly removed by simple rinsing, thereby demonstrating excellent static antifouling and dynamic fouling-release performance. Moreover, the PS-Levo and PS-PLL coatings exhibited outstanding adhesion, mechanical properties, and corrosion resistance. This research introduces an innovative strategy for combating biofouling on marine propellers and presents significant potential for practical applications in the marine antifouling industry.
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Journal of Macromolecular Science Part A-Pure and Applied Chemistry
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2022
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IF 2.216
Feifei Shao,Tao Xue,Yijing Wang,Yesheng Xu,Xinjie Wang,Xinxin Li
The smart responsive materials have become one of the hottest areas of research in oil/water separation field and there are various studies on preparation technologies. However, most of the materials reported were prepared by coating or coupling to attach functional polymer to substrates, which generally had unstable physical and chemical properties and were difficult to be applied in harsh environments. In this work, we fabricated a smart and durable oil/water separation material by one-step foaming method to graft pH-responsive copolymer onto a polyurethane foam (PUF) substrate. The foam exhibited reversible wettability under different pH environments, had excellent oil adsorption capacity (24.78–64.27g/g) and high oil/water separation efficiency (above 98%). Besides, the foam also showed stable performance and excellent recyclability in a series of durability experiments, including mechanical abrasion, light radiation and chemical immersion. The foam with simple preparation process and excellent stability will have promising application prospects in the field of oil/water separation.
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