MATERIALS CHEMISTRY AND PHYSICS
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2023
·
IF 4.6
Linbo Zhang,Haoyu Gao,Peng Zhang,Xianyu Jiang,Yujie Zhao,Liangjun Yin,Zhou Deng,Hanxuan Zhang,Jianliang Xie,Li Zhang,Haipeng Lu,Longjiang Deng
Magnetic metal absorbers are susceptible to strong corrosion in acid, alkali and salt fog environments, resulting in strong limitations of their applications. Therefore, it is urgent to develop magnetic absorber with enhanced anti-corrosion and microwave absorption. In this paper, carbonyl iron powder (CIP) coated with 2-methylimidazole/epoxy (2-MI/EP) composites were prepared by in-situ polymerization. The CIP@2-MI/EP composites showed better microwave absorption performance with a minimum reflection loss (RL min ) value of −54.11 dB at 9.69 GHz with 2 mm thickness. The electrochemical test results show that the corrosion current density of the composites decreases by two orders of magnitude and the corrosion potential is positively shifted to −0.1. In addition, the presence of 2-MI/EP layer can enhance the oxidation resistance of this composite. Considering the corrosion resistance , electromagnetic properties and oxidation resistance of this composite material, it provides an opportunity for valuable addition at commercial level.
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JOURNAL OF CRYSTAL GROWTH
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2023
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IF 1.8
Yi Yu,Chonghui Niu,Kai Shao,Mingjie Dan,Zhibin Wang,Yingying Wang,Jie Chen,Jiani Luo
A Ho 3+ :KBGM crystal with good quality and large size was successfully grown via TSSG method. The crystal’s structure, ambient-temperature polarized absorption and emission spectra and fluorescence lifetime were studied. The J-O theory was adopted to analyze the absorption spectra and results show that crystal exhibits relatively large intensity parameters Ω 2 and spectroscopic quality factor which is up to 3.12. At 453 nm, the absorption band is the strongest, and the corresponding cross-sections are 21.94 × 10 –20 cm 2 , 26.66 × 10 –20 cm 2 and 18.56 × 10 –20 cm 2 for the - X , - Y and - Z polarizations, respectively. The emission spectra also demonstrate the broad and strong emission band at 2030 nm. The FWHMs and cross-sections are 74 nm, 0.37 × 10 −20 cm 2 , 50 nm, 0.68 × 10 −20 cm 2 , and 49 nm 0.52 × 10 −20 cm 2 for the three polarizations, respectively. In addition, the crystal has a superior quantum efficiency which is as high as 97.1%. Taking all the analyses into account, it is reasonable to assert that the Ho 3+ :KBGM crystal an ideal candidate for ∼2 µm laser applications in many areas.
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CHEMICAL & PHARMACEUTICAL BULLETIN
·
2021
·Vol. 69
·期 11
·1054-1060
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IF 1.645
Yuqin Zhou,Weitong Hu,Xiangli Zhang,Yi Wang,Wenya Zhuang,Fengzhi Li,Qingyong Li
In the evaluation of the druggability of candidate compounds, it was vital to predict the oral bioavailability of compounds from apparent permeability (Papp) across Caco-2 cell-culture model of intestinal epithelium cultured on commercial transwell plate inserts. The study was to investigate the transport characteristics and permeability of FL118 (10, 11-Methylenedioxy-20(S)-camptothecin) derivatives 7-Q6 (7-(4-Ethylphenyl)-10, 11-methylenedioxy-20(S)-camptothecin) and 7-Q20 (7-(4-Trifluoromethylphenyl)-10, 11-methylenedioxy-20(S)-camptothecin). Transport characteristics and permeability of the tested compounds to the small intestine were assessed at different concentrations (0.5, 1 µM) via Caco-2 cell monolayers model in vitro. Uptake studies based on Caco-2 cells, including temperatures, concentrations, and the influence of efflux transporters, were combined to confirm the transport characteristics of the tested compounds. Furthermore, cytotoxicity results showed that the concentrations used in the experiments were non-toxic and harmless to cells. In addition, The Papp of 7-Q6 was (3.69 ± 1.07) × 10−6 cm/s with efflux ratio (ER) 0.98, while the Papp of 7-Q20 was (7.78 ± 0.89) × 10−6 cm/s with ER 1.05 for apical-to-basolateral (AP→BL) at 0.5 µM, suggesting that 7-Q20 might possess higher oral bioavailability in vivo. Furthermore, P-glycoprotein (P-gp) was proved to slightly affect the accumulations of 7-Q20, while the absorption of 7-Q6 was irrelevant with P-gp and breast cancer resistant protein (BCRP) based on the cellular uptake assays. Accordingly, 7-Q6 was completely absorbed by passive diffusion, and 7-Q20 was mainly dependent on passive diffusion with being effluxed by P-gp slightly. Meanwhile, both 7-Q6 and 7-Q20 were potential antitumor drugs that might exhibit high oral bioavailability in the body.
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JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
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2017
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IF 1.591
Liuchen Zhao,Hui Zhang,Wanxu Wang,Guoyong Wang
Surface tension, steady-shear viscosity, and antibacterial activity were investigated when salicylate 2-hydroxybenzoate (NaSal) was added to the micellar solution of N-hexadecane-N-methylpyrrolidinium bromide (C16MPB). It was found that for the mixed system, two flat portions appeared on the surface tension curve with the existence of NaSal in the low-concentration range. The equilibrium contact angle of droplets was decreased with the increase of NaSal concentration. In addition, the steady-shear viscosity abruptly increased with the increase of the concentration of mixture, even if the concentration of NaSal is low. However, this high-viscosity solution exhibited temperature-sensitive property, and white precipitate formation below 18°C. Moreover, the bactericidal capability of C16MPB was affected severely by the mixture of high concentration. All of these features could be attributed to the special interactions between C16MPB and NaSal molecules, among which intramolecular hydrogen bonding of NaSal plays a key role, which have been primely demonstrated by the package of Gaussian09 in this work.
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JOURNAL OF MOLECULAR STRUCTURE
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2022
·
IF 3.841
Jinyu Chang,Yuan Yao,Yangfeng Xia,Long Liu,Yanqiang Zhang
5-methyl-3,5-dipropyl-2-pyrazoline is an intermediate for the preparation of new high energy fuels. In this paper, chloroaluminate ionic liquids ([Bmim]Cl-xAlCl 3 , x = 1, 1.2, 1.4, 1.6, 1.8, 2.0) were applied as green catalysts for the synthesis of 5-methyl-3,5-dipropyl-2-pyrazoline through the intramolecular cyclization reaction of 2-pentyl ketazine. The effects of temperature, acidity and dosage of ionic liquids on the cyclization reaction were studied in detail and the highest catalytic performance was under the conditions as 110 °C, [Bmim]Cl-1.6AlCl 3 and 10% of 2-pentyl ketazine. With the theoretical simulations, the possible catalytic mechanism was proposed as the hydrogen-like interaction between Al ([Bmim] + AlCl 4 − ) and N1 atoms, which increases the charge of N2 atoms, thereby improving its nucleophilicity and further making it undergo intramolecular addition reaction with methyl. This study will provide guidance for the green preparation of 5-methyl-3,5-dipropyl-2-pyrazoline.
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JOURNAL OF POWER SOURCES
·
2026
·
IF 8.4
Qian-Yu Wang,Sian-Hong Ong,Zi-Ye Liu,Zhong-Wei Zhang,Quan-De Li,Ji-Ming Hu
Conductive graphene nanosheets boost oxygen evolution electrocatalysis. • Electrochemically assisted deposition forms porous Ni(OH) 2 /NiO onto freestanding graphene. • Low overpotential of 260 mV at 10 mA cm −2 and Tafel slope of 41 mV dec −1 . • Macroscopic model indicates faster *OOH formation with transfer coefficient of 0.74 Developing low-cost oxygen evolution reaction (OER) catalysts with efficient charge transport and accessible active sites is essential for alkaline water electrolysis. Here we report an electrochemically assisted technique (EAT) to deposit highly dispersed Ni(OH) 2 species on the surface of freestanding graphene (Gr) without deliberate surface functionalization, where a transient SiO 2 -derived framework assists the deposition process of Ni(OH) 2 , followed by heat treatment and alkaline etching to form an intimately contacted Gr@eNi(OH) 2 -NiO composite. On one hand, Gr enables the highly dispersed distribution of Ni(OH) 2 /NiO species and improves the accessibility of active sites for the OER. On the other hand, Gr provides good electrical conductivity and rapid charge-transfer kinetic, leading to high catalytic activity. In 1 M KOH, Gr@eNi(OH) 2 -NiO delivers an overpotential of 260 mV at 10 mA cm −2 and Tafel slope of 41 mV dec −1 , together with stable operation in alkaline electrolyte. Macroscopic kinetics analysis based on current-overpotential fitting further suggests an enhanced potential response of the *OOH-forming step, consistent with improved OER kinetics enabled by Gr-deposit coupling. This work provides a practical route to integrate Ni hydroxide/oxide phases with Gr scaffolds for efficient alkaline water oxidation. Download: Download high-res image (334KB) Download: Download full-size image
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JOURNAL OF LUMINESCENCE
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2022
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IF 4.171
Jing Zhang,Bo Ye,Rong-Rong Wang,Xiao-Ma Tao,Ge-Mei Cai
The luminescence behavior of rare earth Eu as the famous fluorescent probe not only depends on its chemical valence, but also on the concentration and occupation in the lattice, except for the interaction with the host. Herein, previously reported monoclinic BaIn 2 (P 2 O 7 ) 2 (BIP) phosphate acts as the host, and part of In atoms have been experimentally designed to be replaced by Eu. The lattice occupation and luminescence behavior of Eu in BIP were discussed. In the PL spectra , the intrinsic emission of BIP and the emission of Eu 2+ were observed in addition to the characteristic emission of Eu 3+ , all of which were also emerged in the cathodoluminescence spectrum. EPR analysis confirmed the existence of Eu 2+ , that is, Eu 3+ is spontaneously reduced in the BIP lattice. The red/orange ratio of Eu 3+ characteristic emission changes with the change of concentration, indicating the evolution of lattice occupation. The charge density before and after Eu doped BIP was analyzed by DFT calculation. From the perspective of charge exchange, it was further confirmed that partially Eu 3+ was reduced to Eu 2+ at different In or Ba crystallographic sites. The present work demonstrates a unique case of mixed occupation, double valence and tunable emission of Eu in phosphate.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2023
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IF 4.2
Lujie Liu,Lu Liu,Kaidi Zhang,Mingyang Qin,Huimin Luan,Zhaochi Feng,Jiexun Chen,Liang Wang,Feng-Shou Xiao
Selective transformation of olefins is an important route to produce cyclic monoether glycol products, but the current catalysts still suffer from insufficient activity, selectivity, and durability. Herein, we reported that molybdenum oxide on siliceous beta zeolite was highly efficient for the selective conversion of cyclohexene with a trans-2-methoxycyclohexanol yield as high as 95% in the presence of methanol and tert-butyl hydroperoxide as an oxidant. This reaction included the epoxidation of cyclohexene and subsequent solvolysis. Mechanistic studies revealed that the siliceous beta zeolite benefited the formation of abundant monomeric MoOx species, which was efficient for both the epoxidation of cyclohexene and subsequent solvolysis. Furthermore, this catalyst was also active for the conversion of other olefins, achieving the corresponding β-alkoxyalcohols.
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高影响因子
ACTA HISTOCHEMICA
·
2023
·
IF 2.5
Yan Wu,Jun Zhang,Xintian Wang,Yuncong Xu,Jinxu Zheng
Objective Idiopathic pulmonary fibrosis (IPF) is considered as a chronic interstitial lung disease with underlying mechanism of IPF remaining unclear, while there are no definitive treatment options. In recent years, scientists have gradually paid attention to the influence of angiogenesis on IPF. Because IPF is a progressive with microvascular remodeling disorder, scientists have postulated that angiogenesis may also be one of the initiating and contributing factors of the disease. Bupleurum is a common natural Chinese herbal medicine with antibacterial, anti-inflammatory, anti-tumor and other pharmacological effects. As the most important active monomer of Bupleurum, Saikosaponin-d (SSd) is a new discovery with anti-pulmonary fibrosis (PF) activity. This study attempts to investigate the role of SSd in the interference of PF through regulation of angiogenesis in IPF through Angiopoietin (Angpt) /Tie receptor 2 (Tie2) pathway. Methods Randomly, we allocated C57BL/6 mice into four groups (n = 20 in each group). Afterwards, establishment of IPF model was accomplished via intratracheal administration of bleomycin (BLM, 5 mg/kg), while corresponding drug intervention was given accordingly. On 3rd, 7th, 14th and 28th days after modeling, we performed histopathological examination through staining. Meanwhile, immunohistochemistry (IHC) of PF and the expression of related factors were observed, while Ang/Tie2 pathway was assessed by ELISA with the effect of SSd on angiogenesis related proteins in IPF being explored with IHC and Western Blot technique. Results Our results showed that SSd could reduce inflammation and PF levels in lung tissue of experimental mice, while levels of angiogenesis-related factors, namely Tie-2, Ang-1 and ANGPT2 (Ang-2), fibrosis- associated factors like Alpha-smooth muscle actin (α-SMA), collagen-I and hydroxyproline in SSd and dexamethasone (DXM) mice were significantly reduced at each time point compared to BLM (p < 0.01). Additionally, we discovered substantial decreased expressions of Ang-1, Ang-2, Tie-2, α-SMA and collagen-I at protein level in SSd and DXM mice at each time point compared to BLM (p < 0.05). Besides, insignificant differences were observed between SSd and DXM groups (p > 0.05). Conclusion This study has demonstrated that SSd could down-regulate the expression of ANG-1, Ang-2 and Tie2 in the Ang/Tie2 pathway, and may reduce lung inflammation and PF in BLM-induced mice via inhibition of angiogenesis.
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PubMed
高影响因子
WORLD JOURNAL OF GASTROENTEROLOGY
·
2023
·
IF 4.3
Heng Shi,Xin-Hai Zhao,Qin Peng,Xian-Ling Zhou,Si-Si Liu,Chuan-Chuan Sun,Qiu-Yu Cao,Shi-Ping Zhu,Sheng-Yun Sun
BACKGROUND Di (2-ethylhexyl) phthalate (DEHP) is a common plasticizer known to cause liver injury. Green tea is reported to exert therapeutic effects on heavy metal exposure-induced organ damage. However, limited studies have examined the therapeutic effects of green tea polyphenols (GTPs) on DEHP-induced liver damage. AIM To evaluate the molecular mechanism underlying the therapeutic effects of GTPs on DEHP-induced liver damage. METHODS C57BL/6J mice were divided into the following five groups: Control, model [DEHP (1500 mg/kg bodyweight)], treatment [DEHP (1500 mg/kg bodyweight) + GTP (70 mg/kg bodyweight), oil, and GTP (70 mg/kg bodyweight)] groups. After 8 wk, the liver function, blood lipid profile, and liver histopathology were examined. Differentially expressed micro RNAs (miRNAs) and mRNAs in the liver tissues were examined using high-throughput sequencing. Additionally, functional enrichment analysis and immune infiltration prediction were performed. The miRNA-mRNA regulatory axis was elucidated using the starBase database. Protein expression was evaluated using immunohistochemistry. RESULTS GTPs alleviated DHEP-induced liver dysfunction, blood lipid dysregulation, fatty liver disease, liver fibrosis, and mitochondrial and endoplasmic reticulum lesions in mice. The infiltration of macrophages, mast cells, and natural killer cells varied between the model and treatment groups. mmu-miR-141-3p (a differentially expressed miRNA), Zcchc24 (a differentially expressed mRNA), and Zcchc24 (a differentially expressed protein) constituted the miRNA-mRNA-protein regulatory axis involved in mediating the therapeutic effects of GTPs on DEHP-induced liver damage in mice. CONCLUSION This study demonstrated that GTPs mitigate DEHP-induced liver dysfunction, blood lipid dysregulation, fatty liver disease, and partial liver fibrosis, and regulate immune cell infiltration. Additionally, an important miRNA-mRNA-protein molecular regulatory axis involved in mediating the therapeutic effects of GTPs on DEHP-induced liver damage was elucidated.
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Journal of Fungi
·
2023
·Vol. 9
·期 9
·930
·
IF 4.7
Qiuli Ouyang,Shiwei Shi,Yangmei Liu,Yanqin Yang,Yonghua Zhang,Xingxing Yuan,Nengguo Tao,Lu Li
Geotrichum citri-aurantii(G. citri-aurantii) is one of the most important postharvest pathogens leading to a postharvest loss of citrus by causing sour rot. In this study, the antifungal activity oftrans-2-hexenal, a natural component of essential oil, againstG. citri-aurantiiwas evaluated.Trans-2-hexenal treatment inhibited the mycelia growth ofG. citri-aurantiiwith a minimum inhibitory concentration and minimum fungicidal concentration oftrans-2-hexenal at 0.50 and 1.00 μL/mL, respectively. Moreover,trans-2-hexenal efficiently reduced the incidence of sour rot of Satsuma fruit inoculated withG. citri-aurantii. Ultrastructural observations and Fourier transform infrared (FT−IR) results showed thattrans-2-hexenal treatment affected the cell wall and cell membrane instructions ofG. citri-aurantii. The content ofβ-1,3-glucan was significantly decreased aftertrans-2-hexenal treatment, but the cell wall permeability was not changed. The decrease in lipid and ergosterol contents might be responsible for this antifungal activity. Several important genes,FKS1,ERG1,ERG7, andERG11, showed decreasing expression levels aftertrans-2-hexenal treatment. Molecule-docking results also indicated thattrans-2-hexenal could join with the protein of FKS1, ERG1, ERG7, and ERG11 to impact enzyme activities. These results demonstrated thattrans-2-hexenal is a promising fungicide for controlling sour rot of harvested citrus fruit by damaging the membrane integrity ofG. citri-aurantii.Keywords:G. citri-aurantii;trans-2-hexeanl;antifungal mechanism;cell wall;cell membrane
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Journal of Materials Chemistry A
·
2021
·Vol. 9
·期 29
·15948-15954
·
IF 12.732
Yani Ding,Wei Zhou,Liang Xie,Shuai Chen,Jihui Gao,Fei Sun,Guangbo Zhao,Yukun Qin
Hydrogen peroxide (H2O2) electrosynthesis through 2-electron oxygen reduction reaction (ORR) is an attractive alternative to the industrial anthraquinone oxidation method. Conventional H2O2 electrosynthesis processes usually operate under galvanostatic or potentiostatic conditions that occasionally result in unsatisfactory selectivity and efficiency. Herein, we applied pulsed electrocatalysis to achieve synergy between reactant adsorption, electrochemical reaction, and product diffusion by regulating the pulsed potential, pulsed width, and duty cycle, which could increase H2O2 production by 138.12%. For the first time, we revealed that pulsed electrocatalysis could regulate the adsorption of ORR intermediates by affecting the charge and discharge process of the electric double layer (EDL) based on density functional theory (DFT) calculations. Finally, we provided a new perspective on the mechanism of pulsed electrocatalysis to promote the production of H2O2via 2-electron ORR, thereby offering guidance for the precise control and efficient conduction of electrochemical reactions in the future.
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