INORGANIC CHEMISTRY
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2024
·
IF 4.3
Xing Liu,Ting Zhang,Lei Zhou,Ming Li,Rongxing He
A highly luminescent (C13H28N2)2Cu4I8 single crystal containing isolated γ-[Cu4I8]4– anionic cluster was synthesized without the use of unsaturated cations. To the best of our knowledge, compounds bearing such like anions are not dual-emitting under UV excitation. However, dual emission does occur in (C13H28N2)2Cu4I8. Moreover, the emission bands were found to be temperature-sensitive, allowing tuning of the emission colors from blue (0.19, 0.20) to green (0.33, 0.47) in the Commission International de L’ Eclairage (CIE) chromaticity coordinates. Remarkably, the color could be restored on returning to the initial temperature, confirming an efficient and reversible luminescent thermochromic effect in (C13H28N2)2Cu4I8. The origin of this excellent optical performance is discussed, and the difference in the mechanism with the dual-emissive Cu(I) halide complexes is also elucidated. Overall, our work provides a promising way to achieve efficient luminescent thermochromism. The developed (C13H28N2)2Cu4I8 represents one of the viable alternatives for eco-friendly luminescent thermochromic materials.
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高影响因子
CHEMOSPHERE
·
2024
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IF 8.1
Juan Qiao,Zhenyu Zhao,Zhengwei Zhou,Deli Wu
Palladized iron (Pd/Fe) represents one of the most common modification strategies for nanoscale zero-valent iron (nZVI). Most studies prepared Pd/Fe by reducing iron salts and depositing Pd species on the surface of pre-synthesized nZVI, which can be called the two-step method. In this study, we proposed a one-step method to obtain Pd/Fe by the concurrent formation of Fe 0 and Pd 0 and investigated the effects of these two methods on 4-chlorophenol (4-CP) removal, with carboxymethylcellulose (CMC) coated as a surface modifier. Results indicated that the one-step method, not only streamlined the synthesis process, but also Pd/Fe-CMC one-step , synthesized by it, exhibited a higher 4-CP removal rate (97.9%) compared to the two-step method material Pd/Fe-CMC two-step (82.4%). Electrochemical analyses revealed that the enhanced activity of Pd/Fe-CMC one-step was attributed to its higher electron transfer efficiency and more available reactive species, active adsorbed hydrogen species (H ads *). Detection of intermediate products demonstrated that, under the influence of Pd/Fe-CMC one-step , the main route of 4-CP was through hydrodechlorination (HDC) to form phenol and H* was the main active specie, supported by EPR tests, quenching experiments and product analysis. Additionally, the effects of initial 4-CP concentration, initial pH, O 2 concentration, anions such as Cl − , SO 4 2− , HCO 3 − , and humic acid (HA) were also investigated. In conclusion, the results of this study suggest that Pd/Fe-CMC one-step , synthesized through the one-step method, is a convenient and efficient nZVI-modifying material suitable for the HDC of chlorinated organic compounds.
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BIO-MEDICAL MATERIALS AND ENGINEERING
·
2024
·Vol. 35
·期 5
·475-485
·
IF 1
Bao Ronghua,Mao Yifan,Zhang Yuliang,Chai Junlei,Zhang Yuanbin,Luo Cheng,Zhang Kailong,Jiang Guohua,He Xiaodan
BACKGROUND:Osteoarthritis (OA) is a chronic and degenerative joint disease that remains a great challenge in treatment due to the lack of effective therapies. 4-octyl itaconate (4-OI) is a novel and potent modulator of inflammation for the treatment of inflammatory disease. However, the clinical usage of 4-OI is limited due to its poor solubility and low bioavailability. As a promising drug delivery strategy, injectable hydrogels offers an effective approach to address these limitations of 4-OI. OBJECTIVE:The aim of the study was to verify that the composite 4-OI/SA hydrogels could achieve a controlled release of 4-OI and reduce damage to articular cartilage in the group of osteoarthritic rats treated with the system. METHODS:In this study, an injectable composite hydrogel containing sodium alginate (SA) and 4-octyl itaconate (4-OI) has been developed for continuous intra-articular administration in the treatment of OA. RESULTS:After intra-articular injection in arthritic rats, the as-prepared 4-OI/SA hydrogel containing of 62.5 μM 4-OI effectively significantly reduced the expression of TNF-α, IL-1β, IL-6 and MMP3 in the ankle fluid. Most importantly, the as-prepared 4-OI/SA hydrogel system restored the morphological parameters of the ankle joints close to normal. CONCLUSION:4-OI/SA hydrogel shows a good anti-inflammatory activity and reverse cartilage disruption, which provide a new strategy for the clinical treatment of OA.
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PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
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2024
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IF 4.2
Jiahao Lai,Bing Liu,Guihong Xiong,Qian Luo,Shuilin Song,Junxi Jiang,Hongyi Wei,Junwen Wang
Actinomycetes have emerged as significant biocontrol resources due to their rich array of bioactive natural products. While much research has historically focused on secondary metabolites isolated from their fermentation broth, there remains a dearth of reports on their volatile organic compounds (VOCs). Here, strain ML27, isolated from soil, was identified as Streptomyces albidoflavus based on morphological features, physiological, biochemical, and molecular characteristics ( 16S rRNA , atpD , recA , and rpoB gene sequences). VOCs from S. albidoflavus strain ML27 were effectively captured using solid-phase microextraction (SPME) and tentatively identified through gas chromatography–mass spectrometry (GC/MS). Among these compounds, 4-ethyl-1,2-dimethoxybenzene exhibited broad-spectrum antifungal activity and demonstrated efficacy in controlling citrus anthracnose, with a control efficacy of 86.67%. Furthermore, the inhibitory mechanism of 4-ethyl-1,2-dimethoxybenzene against Colletotrichum gloeosporioides was revealed. Results indicated that 4-ethyl-1,2-dimethoxybenzene induced swelling, deformity, and breakage in C . gloeosporioides mycelia, and significantly inhibited spore germination. Transcriptome analysis revealed that 4-ethyl-1,2-dimethoxybenzene inhibited the growth and development of C. gloeosporioides primarily by disrupting energy metabolism and the integrity of the cell wall and membrane. Based on these results, it is promising to develop 4-ethyl-1,2-dimethoxybenzene as a novel biopesticide for controlling citrus anthracnose.
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Food Chemistry-X
·
2024
·
IF 6.5
Binchen Wang,Shaohua Dou,Shang Wang,Yi Wang,Sufang Zhang,Xinping Lin,Yingxi Chen,Chaofan Ji,Yiwei Dai,Liang Dong
Unsaturated aliphatic aldehyde oxidation plays a significant role in the deep oxidation of fatty acids to produce volatile chemicals. Exposing the oxidation process of unsaturated aliphatic aldehydes is crucial to completely comprehend how food flavor forms. In this study, thermal desorption cryo-trapping in conjunction with gas chromatography-mass spectrometry was used to examine the volatile profile of (E)-4-decenal during heating, and 32 volatile compounds in all were detected and identified. Meanwhile, density functional theory (DFT) calculations were used, and 43 reactions were obtained in the 24 pathways, which were summarized into the peroxide reaction mechanism (ROOH), the peroxyl radical reaction mechanism (ROO·) and the alkoxy radical reaction mechanism (RO·). Moreover, the priority of these three oxidative mechanisms was the RO· mechanism > ROOH mechanism > ROO· mechanism. Furthermore, the DFT results and experimental results agreed well, and the oxidative mechanism of (E)-4-decenal was finally illuminated.
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Journal of Integrative Neuroscience
·
2024
·Vol. 23
·期 10
·185
·
IF 2.5
Yangzhi Xie,Hao Zhang,Jiacheng Chen,Sicong Xu,Yan Luo
Background: Luteolin is a natural flavonoid and its neuroprotective and anti-inflammatory effects have been confirmed to mitigate neurodegeneration. Despite these findings, the underlying mechanisms responsible for these effects remain unclear. Toll-like receptor 4 (TLR4) is widely distributed in microglia and plays a pivotal role in neuroinflammation and neurodegeneration. Here studies are outlined that aimed at determining the mechanisms responsible for the anti-inflammatory and neuroprotective actions of luteolin using a rodent model of Parkinson's disease (PD) and specifically focusing on the role of TLR4 in this process. Methods: The mouse model of PD used in this experiment was established through a single injection of lipopolysaccharide (LPS). Mice were then subsequently randomly allocated to either the luteolin or vehicle-treated group, then motor performance and dopaminergic neuronal injury were evaluated. BV2 microglial cells were treated with luteolin or vehicle saline prior to LPS challenge. MRNA expression of microglial specific marker ionized calcium-binding adapter molecule 1 (IBA-1) and M1/M2 polarization markers, as well as the abundance of indicated pro-inflammatory cytokines in the mesencephalic tissue and BV2 were quantified by real time-polymerase chain reaction (RT-PCR) and Enzyme-linked Immunosorbent Assay (ELISA), respectively. Cell viability and apoptosis of neuron-like PC12 cell line co-cultured with BV2 were detected. TLR4 RNA transcript and protein abundance in mesencephalic tissue and BV2 cells were detected. Nuclear factor kappa-gene binding (NF-κB) p65 subunit phosphorylation both in vitro and in vivo was evaluated by immunoblotting. Results: Luteolin treatment induced functional improvements and alleviated dopaminergic neuronal loss in the PD model. Luteolin inhibited apoptosis and promoted cell survival in PC12 cells. Luteolin treatment shifted microglial M1/M2 polarization towards an anti-inflammatory M2 phenotype both in vitro and in vivo. Finally, it was found that luteolin treatment significantly downregulated both TLR4 mRNA and protein expression as well as restraining NF-κB p65 subunit phosphorylation. Conclusions: Luteolin restrained dopaminergic degeneration in vitro and in vivo by blocking TLR4-mediated neuroinflammation.
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Minerals
·
2024
·Vol. 14
·期 12
·1255
·
IF 2.2
Chenglong Du,Jiang Yu,Guangyi Liu
Iron ore is the main raw material of the iron and steel metallurgy industry, but quartz in iron ore reduces metallurgical efficiency and increases metallurgical costs. Therefore, iron ore desiliconization by flotation plays an important role in the iron and steel metallurgy industry. In this study, 4-tert-butyl-catechol (TBC) was designed as a collector to directly float out hematite from quartz. The micro-flotation tests demonstrated that under pH ~9.0, 1 × 10−5mol·L−1TBC recovered 98% hematite from its mixture with quartz, while the recovery of quartz was only about 17%. Zeta potential and contact angle results inferred that the adsorption affinity of TBC toward hematite was greater than that to quartz. The results of FTIR and XPS inferred that TBC adsorbed on the Fe3+sites of hematite interfaced via the O atom of its two adjacent hydroxyl groups to form a stable five-membered chelating ring at pH 9.0. This study offered new research insight on the development of novel collectors for hematite flotation through bionics technology.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Xiangming Li,Bo Sun,Qingpeng Chen,Hiang Kwee Lee,Bo Shi,Hegang Ren,Haitao Li,Zequn Ma,Meng Fu
The reduction of 4-nitrophenol (4-NP) into 4-aminophenol (4-AP) is an important reaction in both chemical manufacturing and environmental protection. The design of a highly active, multifunctional and reusable catalyst for efficient 4-NP decontamination/valorization is therefore crucial to bring in economic and societal benefits. Herein, we achieve an efficient plasmonic-photothermal catalyst of Pd nanoparticles by growing them on graphene-polyelectrolytes self-assembly nanolayers via an in situ green reduction approach using polyelectrolyte as the reductant. The as-fabricated catalyst shows high catalytic behaviors and good stability (maintained over 92.5 % conversion efficiency after ten successive cycles) for 4-NP reduction under ultra-low catalyst dose. The rate constant and turnover frequency were calculated at 0.197 min −1 and 7.79 mmol g −1 min −1 , respectively, which were much higher than those of most reported catalysts. Moreover, the as-prepared catalyst exhibited excellent photothermal conversion efficiency of ∼77 % and boosted 4-NP reduction by ∼2-fold under near-infrared irradiation (NIR). This study provides valuable insights into the design of greener catalytic materials and facilitates the development of multifunctional plasmonic-photothermal catalysts for diverse environmental, chemical, and energy applications using NIR.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Jing Lv,Guangyu Liu,Huimin Gao,Yutao He,Xiaorong Tang,Ziqi Wang,Kaikai Sun,Kulbaram Bayazitova,Zhongliang Jiang
Trehalose, as a food and feed additive, can regulate physiological and pathological processes by activating autophagy, yet the molecular mechanism of trehalose dominated a rise in autophagy has not been elucidated. This study investigated the mechanisms of trehalose-induced autophagy in porcine granulosa cells (PGCs). Trehalose was internalized into PGCs by endocytosis and caused a temporary change of the lysosome pH, ultimately inducing autophagy. Furthermore, miRNA-seq analysis of PGCs indicated that trehalose upregulated the expression of miR-221-5p_R-4, which can target nuclear receptor binding factor 2 (NRBF2) to induce autophagy of PGCs. In summary, this study reveals that miR-221-5p_R-4 targeting NRBF2 was involved in the autophagy of PGCs challenged by trehalose, which was taken up by PGCs through endocytosis.
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BIOCHEMICAL PHARMACOLOGY
·
2018
·
IF 4.235
Binbin Sun,Zeyu Zhong,Fan Wang,Jiong Xu,Feng Xu,Weimin Kong,Zhaoli Ling,Nan Shu,Ying Li,Tong Wu,Mian Zhang,Liang Zhu,Xiaodong Liu,Li Liu
Skeletal muscle accounts for approximately 75% of glucose disposal in body and statins impair glucose metabolism. We aimed to investigate the effect of atorvastatin on glucose metabolism in C2C12 cells. Glucose metabolism and expression of glucose transporter 4 (GLUT4) and hexokinase II (HXKII) were measured following incubation with atorvastatin or pravastatin . Roles of cholesterol in atorvastatin-induced glucose metabolism impairment were investigated via adding cholesterol or mevalonic acid and confirmed by cholesterol depletion with methyl-β-cyclodextrin. Hypercholesterolemia mice induced by high fat diet (HFD) feeding, orally received atorvastatin (6 and 12 mg/kg) or pravastatin (12 mg/kg) for 22 days. Results showed that atorvastatin not pravastatin concentration-dependently impaired glucose consumption, glucose uptake and GLUT4 membrane translocation in C2C12 cells without affecting expression of HXKII or total GLUT4 protein. The atorvastatin-induced alterations were reversed by cholesterol or mevalonic acid. Cholesterol depletion exerted similar impact to atorvastatin, which could be alleviated by cholesterol supplement. Glucose consumption or GLUT4 translocation was positively associated with cellular cholesterol levels. In HFD mice, atorvastatin not pravastatin significantly increased blood glucose levels following glucose or insulin dose and decreased expression of membrane not total GLUT4 protein in muscle. Glucose exposure following glucose or insulin dose was negatively correlated to muscular free cholesterol concentration. Expression of membrane GLUT4 protein was positively related to free cholesterol in muscle. In conclusion, atorvastatin impaired glucose utilization in muscle cells partly via inhibiting GLUT4 membrane translocation due to inhibition of cholesterol synthesis by atorvastatin, at least, partly contributing to glucose intolerance in HFD mice.
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SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2017
·
IF 4.784
Xiaoming Chen,Qishu Qu
A new magenta-to-transmissive electrochromic polymer, poly(3,4-bis(3-bromopropoxy)thiophene) (PBBrPOT) was synthesized by electrochemical polymerization and its electrochromic properties were characterized in detail. Compared with the representative “large-volume alkyl substituents” strategy, herein we use bromines as the end-capping groups of two propoxyl substituents on the 3- and 4- position of the thiophene ring to introduce more steric repulsion within the polymer chains, and therefore obtain a magenta neutral state of the polymer. The PBBrPOT film shows a set of reasonable electrochromic features, including low driving potentials (−0.1 V and 0.9 V), appropriate transmittance change (38% at 556 nm), but a relatively longer response time in bleaching process ( t 95 = 6.5 s).
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CHEMISTRY & BIODIVERSITY
·
2024
·
IF 2.3
Huafeng Yang,Hui Liu,Yuan Zheng,Bo Li,Shujing Wang,Jun Zhang,Jiandong Wang
Cornus officinalis total glycosides (COTG) derived from the traditional Chinese medicine Cornus officinalis, is a natural immunosuppressant and has been extensively studied in immunomodulation and immunosuppression. This study aimed to explore the effects of COTG on granulomatous lobular mastitis (GLM) and its associated mechanisms. Compared to the model group, COTG effectively ameliorated histopathological damage to breast tissue, reduced mammary gland suppuration, and enhanced the blood-milk barrier. Additionally, COTG treatment reduced the total number of T cells and B cells in GLM rats, significantly improving clinical indicators such as P-selectin, E-selectin, and intercellular cell adhesion molecule-1. We also observed downregulation of CD28 and B7 expression levels, an upregulation of cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) expression, and a significant decrease in inflammatory marker levels in the COTG group. COTG exerts an anti-inflammatory effect in GLM by stimulating CTLA-4, inhibiting the B7-CD28 signaling pathway affecting T cell activation, and promoting the blood-milk barrier. These findings suggest that COTG could be a promising therapeutic option for managing GLM, potentially improving patient outcomes by modulating immune responses and reinforcing the blood-milk barrier.
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