TALANTA
·
2015
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IF 3.545
Ganghui Chu,Wensheng Cai,Xueguang Shao
Ring-opening reaction with synchronous hydrolysis was used to prepare 4-butylaniline-modified attapulgite (abbreviated as BA-ATP) for pre-concentration of bisphenol A (BPA) in trace quantity. The preparation was achieved under mild condition, and the material was characterized by Fourier transform infrared spectroscopy (FT-IR), elemental analysis , nuclear magnetic resonance (NMR) and scanning electron microscopy. BA-ATP was used in solid phase extraction (SPE), and SPE was performed in a neutral condition without regard to ionic strength . The results indicate that BA-ATP has high affinity to BPA with a maximum adsorption amount of 44 mg g −1 , and the adsorption can be described by Langmuir isotherm model. The content of bisphenol A in water samples was analyzed by HPLC method with the pre-concentration using BA-ATP. The limit of detection (LOD) can be as low as 3.9 ng mL −1 , and the average recoveries are in a range of 93–97% with relative standard deviation (RSD) of less than 2%.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2017
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IF 6.198
Shenyu Lan,Jinxi Feng,Ya Xiong,Shuanghong Tian,Shengwei Liu,Lingjun Kong
Piezo-catalysis was first used to degrade a nondye pollutant, 4-chlorophenol (4-CP). In this process, hydrothermally synthesized tetragonal BaTiO3 nano/micrometer-sized particles were used as the piezo-catalyst, and the ultrasonic irradiation with low frequency was selected as the vibration energy to cause the deformation of tetragonal BaTiO3. It was found that the piezoelectric potential from the deformation could not only successfully degrade 4-chlorophenol but also effectively dechlorinate it at the same time, and five kinds of dechlorinated intermediates, hydroquinone, benzoquinone, phenol, cyclohexanone, and cyclohexanol, were determined. This is the first sample of piezo-dechlorination. Although various active species, including h+, e–, •H, •OH, •O2–, 1O2, and H2O2, were generated in the piezoelectric process, it was confirmed by ESR, scavenger studies, and LC-MS that the degradation and dechlorination were mainly attributed to •OH radicals. These •OH radicals were chiefly derived from the electron reduction of O2, partly from the hole oxidation of H2O. These results indicated that the piezo-catalysis was an emerging and effective advanced oxidation technology for degradation and dechlorination of organic pollutants.
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FOOD CHEMISTRY
·
2024
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IF 8.5
Chuanxiang Cheng,Yujie Lei,Tiantian Min,Yushan Zhang,Jin Yue
4-Terpineol (4-TA), a typical monocyclic monoterpene essential oil compound with important biological activities, poor stability and solubility severely hamper its biological activities. To date, β-cyclodextrin (β-CD) encapsulating essential oil to form inclusion complexes (ICs) is considered as a satisfactory treatment. Nevertheless, the detailed inclusion mechanism of β-CD for 4-TA especially the behavior of 4-TA during inclusion formation have not available yet. Herein, 4-TA/β-CD ICs were successfully synthesized by the co-precipitation method, and hydrogen bonds and hydrophobic interactions played a key role in the formation of ICs, and the isopropyl of 4-TA entered the cavity through the wide rim of β-CD. Moreover, the release profile demonstrated that high RH (85 % and 99 %) triggered the release of TA from ICs. This study suggests the great potential of cyclodextrin inclusion strategy for improving the stability and sustained release of 4-TA in food preservation application.
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Catalysts
·
2025
·Vol. 15
·期 3
·263
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IF 4
Kaijie Li,Qin Wang,Qifan Zhao,Hongbo Yu,Hongfeng Yin
In this article, Pt-SnxOyhybrid nanoparticles encaged in porous silica nanospheres (Pt-SnxOy@PSNs) were prepared by using 1-dodecanethiol (C12-SH) as a coordination agent to confine Pt and Sn ions in a microemulsion system, which is formed by cetyltrimethylammonium bromide (CTAB) and C12-SH as co-surfactants in water. Compared with Pt@PSNs, when different molar ratios of SnxOywere introduced into Pt@PSNs to form Pt-SnxOy@PSNs, the catalytic efficiency of 4-nitrophenol (4-NP) reduction with NaBH4can be significantly enhanced. At molar ratios of 4-NP/Pt of 150/1, the 4-NP conversion reached 100% over Pt-SnxOy@PSNs with Pt/Sn molar ratios of 1/0.75 in 8 min. This catalytic performance showed a slight decrease after six reaction cycles. This enhanced catalytic efficiency can be ascribed to the synergistic effect between Pt and SnxOy,and the protection of porous silica nanostructures can effectively improve the stability of the catalyst.
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Frontiers in Microbiology
·
2024
·
IF 4
Wang Liping,Liang Aihua,Huang Jukai
Introduction: Diabetic nephropathy (DN) presents a significant therapeutic challenge, compounded by complex pathophysiological mechanisms. Recent studies suggest Exendin-4 (Ex-4) as a potential ameliorative agent for DN, albeit with unclear mechanisms. This research investigates the effects and underlying mechanisms of Ex-4-enriched exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSCs) on DN, focusing on their renoprotective properties and interactions with gut microbiota.Method: Exosomes from hUCMSCs (hUCMSCs-Exo) were loaded with Ex-4 via electroporation. A streptozotocin (STZ) -induced DN mouse model was employed to assess the therapeutic impact of these engineered exosomes. The study further explored immune cell dynamics, mainly CD4+ regulatory T (Treg) cells, using bioinformatics, flow cytometry, and the influence of gut microbiota through antibiotic treatment and specific bacterial reintroduction.Results: Treatment with hUCMSCs-Exo@Ex-4 significantly improved key DN markers, including blood glucose and proteinuria, alleviating kidney damage. A notable decrease in natural Treg cell infiltration in DN was observed, while Ex-4-loaded exosomes promoted CD4+ Treg cell induction. The therapeutic benefits of hUCMSCs-Exo@Ex-4 were diminished upon CD4+ Treg cell depletion, underscoring their role in this context. Notably, CD4+ Treg cell induction correlated with the presence of Prevotella species, and disruption of gut microbiota adversely affected these cells and the therapeutic efficacy of the treatment. However, the reintroduction of Prevotella strains counteracted these adverse effects.Discussion: This study elucidates a novel therapeutic mechanism of Ex-4-loaded hUCMSCs exosomes in DN, highlighting the induction of CD4+ Treg cells mediated by specific gut microbiota components. These findings underscore the potential of leveraging gut microbiota and immune cell interplay in developing effective DN treatments.
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ACS Applied Nano Materials
·
2024
·
IF 5.3
Liming Yang,Yanjun Cui,Bing Hu,Qian Yang,Xia Xu
Perovskite quantum dots (PQDs) offer high photoluminescence quantum yields. However, their poor stability and aqueous-quenching of fluorescence limit their wider application, especially in biochemical detection. In this work, a simple and highly successful coating strategy was used to encapsulate Mn2+-doped CsPbCl3 PQDs in poly(ethylene glycol) (PEG), effectively increasing the water stability of PQDs. After dispersion in deionized water for 25 days, the CsPbCl3/Mn2+/PEG nanocrystals (NCs) retained 40% of their initial fluorescence intensity. In addition, due to the FRET mechanism, 4-nitrophenol (4-NP) can effectively quench the fluorescence of CsPbCl3/Mn2+/PEG NCs. Therefore, utilizing the excellent water stability of CsPbCl3/Mn2+/PEG NCs and their interaction with 4-NP, a fast and conservative fluorescent probe can be established, which can perform highly selective and ultrasensitive quantitative detection of 4-NP in aqueous solutions. In addition, the molecular weight of PEG used for encapsulation, the fluorescence intensity of CsPbCl3/Mn2+/PEG NCs, and the detection range for 4-NP vary. Fortunately, the detection limits are all lower than the drinking water concentrations allowed by the U.S. Environmental Protection Agency. This study also provides a theoretical basis and methodological support for the subsequent application of PQDs in the detection of water pollutants.
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IMMUNITY
·
2024
·
IF 25.5
Rui Ding,Xiaoyan Yu,Zhilin Hu,Yu Dong,Haiyan Huang,Yuerong Zhang,Qiaoqiao Han,Zhi-Yu Ni,Ren Zhao,Youqiong Ye,Qiang Zou
RNA splicing is involved in cancer initiation and progression, but how it influences host antitumor immunity in the metabolically abnormal tumor microenvironment (TME) remains unclear. Here, we demonstrate that lactate modulates Foxp3-dependent RNA splicing to maintain the phenotypic and functional status of tumor-infiltrating regulatory T (Treg) cells via CTLA-4. RNA splicing in Treg cells was correlated with the Treg cell signatures in the TME. Ubiquitin-specific peptidase 39 (USP39), a component of the RNA splicing machinery, maintained RNA-splicing-mediated CTLA-4 expression to control Treg cell function. Mechanistically, lactate promoted USP39-mediated RNA splicing to facilitate CTLA-4 expression in a Foxp3-dependent manner. Moreover, the efficiency of CTLA-4 RNA splicing was increased in tumor-infiltrating Treg cells from patients with colorectal cancer. These findings highlight the immunological relevance of RNA splicing in Treg cells and provide important insights into the environmental mechanism governing CTLA-4 expression in Treg cells.
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MICROPOROUS AND MESOPOROUS MATERIALS
·
2024
·
IF 4.8
Ximei Sun,Feirong Wang,Jieqiong Wang,Hao Xiao,Qiang Kang,Yiqian Zeng,Qinglai Yang,Xiaofeng Tan
Designing the robust catalysts with a self-supported open structure and engineering surface would be beneficial for promoting intrinsic activity, increasing active sites, and enhancing electron/mass transfer during catalysis. The metallic aerogels (MAs) with hierarchical porous nanostructures and pure metal skeleton could be a favorable platform for fabricating high-performance catalysts. The introduction of an interface engineering strategy causes beneficial structural and electronic properties of MAs. Herein, the ionic liquid (IL) induced metallic Pd aerogels with well-defined nanowires are developed for the efficient catalytic reduction of 4-nitrophenol (4-NP) in the presence of NH 3 BH 3 . The engineered IL-Pd aerogels exhibit the integrated advantages of exceptional catalytic activities (including a high k value of 31.2 × 10 −2 s −1 and a high turnover frequency (TOF) of 320.4 h −1 ), acceptable costeffectiveness with a low NH 3 BH 3 concentration (n[NH 3 BH 3 ]/n[4-NP] of 120), remarkable cyclability, and noticeable longstanding stability. This work opens a new avenue for developing high-performance MAs with improved activity and durability.
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Synthetic and Systems Biotechnology
·
2024
·
IF 4.4
Ming Zhao,Mengkai Hu,Rumeng Han,Chao Ye,Xiangfei Li,Tianwen Wang,Yan Liu,Zhenglian Xue,Kun Liu
The production of androst-4-ene-3,17-dione (AD) by the steroidal microbial cell factory requires transcription factors (TFs) to participate in metabolic regulation. However, microbial cell factory lacks effective TFs that can respond to AD in its metabolic pathway. Additionally, finding and obtaining natural TFs that specifically respond to AD is a complex and onerous task. In this study, we devised an artificial TF that responds to AD, termed AdT, based on structure-guided molecular dynamics (MD) simulation. According to MD analysis of the conformational changes of AdT after binding to AD, an LBD in which the N - and C -termini exhibited convergence tendencies was used as a microswitch to guide the assembly of a DNA-binding domain lexA, a linker (GGGGS) 2 , and a transcription activation domain B42 into an artificial TF. As a proof of design, a AD biosensor was designed and constructed in yeast on the basis of the ligand-binding domain (LBD) of hormone receptor. In addition, the transcription factor activity of AdT was increased by 1.44-fold for its variant F320Y. Overall, we created non-natural TF elements for AD microbial cell factory, and expected that the design TF strategy will be applied to running in parallel to the signaling machinery of the host cell.
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CARBOHYDRATE POLYMERS
·
2024
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IF 10.7
Xinyi Chen,Yitong Ding,Mingjiao Li,Hao Wu,Ze Kan,Zhibo Li
Chemically synthesized poly(4-hydroxybutyrate) (P4HB) is a new generation of biomass-derived and degradable semi-crystalline polymer with good comprehensive properties, but high costs limit its application. Starch, as an inexpensive natural polymer , can reduce the cost of P4HB products. However, starch lacks thermoplastic behavior and has poor compatibility with P4HB, thus its extensive use will inevitably impair the mechanical properties of P4HB. In this study, the ball-milling starch grafting process is adopted, which can simultaneously solve the two major deficiencies of starch, and the prepared ball-milling starch-g-polycaprolactone (BSt-g-PCL) has thermoplasticity and better compatibility with P4HB. BSt-g-PCL can melt near 55 °C, and the interweaving of its molecular chains with P4HB reduces the binding energy ( E interaction ) of both, making the phase interface blurred or even disappear. Therefore, the elongation at break retention ( R EB ) of P4HB/BSt-g-PCL can increase from 37.1 % to 74.3 % compared to P4HB/starch at the same filling (70 Phr). Additionally, BSt-g-PCL can exert the effect of accelerating P4HB degradation and still make it maintain excellent anti-aging ability. The ball-milling starch graft process provides a simple and effective method for the preparation of inexpensive fully biodegradable P4HB composite films with excellent mechanical properties.
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Journal of Materials Chemistry A
·
2024
·
IF 10.7
Tao Chen,Yulong Li,Fangpei Ma,Mingdong Sun,Ping Fu,Xiaoling Liu,Yu Zhou,Jun Wang
Paired electrocatalytic systems have emerged as a promising approach for the synthesis of high-value-added fine chemicals from renewable resources like biomass, however, a high-performing bifunctional catalyst is urgent to reduce the overall cell voltage and enhance the current efficiency. Herein, amino-tethered Ni3S2/MoS2 heterojunction (NiMoSx-NH2) was constructed as the bifunctional catalyst simultaneously for the anodic 5-Hydroxymethylfurfural oxidation into furan dicarboxylic acid and cathodic 4-nitrophenol hydrogenation into P-aminophenol, providing the high conversion/yield/Faradic efficiency above 98% on both electrodes. Amino-tethered Ni3S2/MoS2 heterojunction, on the one hand, accelerated the electron transfer, and on the other hand, promoted the catalysts’ proton-coupled electron transfer process to generate NiIII-O(OH)ad at the anode and H* desorption at the cathode. A highly efficient paired electrolyzer with NiMoSx-NH2 as a bifunctional catalyst was assembled, showing an extremely low cell voltage of 0.89 V at 10 mA cm-2 and ~200% current efficiency at 1.75 V for the overall reaction.
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JOURNAL OF HAZARDOUS MATERIALS
·
2020
·
IF 9.038
Hao Dai,Ziyi Deng,Yanbo Zeng,Jian Zhang,Yiwen Yang,Qinyan Ma,Wenling Hu,Longhua Guo,Lei Li,Shulin Wan,Haiying Liu
A coumarin-based fluorescent molecularly imprinted poly (ionic liquid) (FL-MIPIL) was prepared using a new coumarin-based alkenyl fluorescent ionic liquid (coumarin-FL-IL) as the functional monomer, IL [V 2 C 4 (mim) 2 ][(PF 6 ) 2 ] and ethyleneglycol dimethacrylate as the cross-linkers, and 4-NP as the template molecule. The absolute quantum yields of coumarin-FL-IL and FL-MIPIL were 7.26 % and 30.66 %, respectively. As a result of the electron transfer between coumarin-FL-IL which contains amino groups and 4-NP bearing hydroxyl groups, FL-MIPIL fluorescence was effectively quenched by 4-NP. The prepared FL-MIPIL sensor can rapidly respond to 4-NP within 60 s. The FL-MIPIL sensor had good linear response to 4-NP from 0.001–7.5 μM and low detection limit of 0.5 nM (S/N = 3). The FL-MIPIL sensor exhibited high sensitivity and good selectivity for 4-NP. The outstanding performance of FL-MIPIL could be ascribed to high fluorescence intensity of FL-MIPIL without matrixes and more interactions between FL-MIPIL and 4-NP. The FL-MIPIL sensor has successfully applied to the determination of 4-NP in lake, rain and waste water samples, river sediment, soil and urine samples.
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