DYES AND PIGMENTS
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2026
·
IF 3.9
Jia Cheng,Yu Wang,Zhi-Gang Jia,Zhi-Wei Shi,Jun-Feng Duan,Kai Wang,Jiong Yan,Yang Yang
To address the impaired healing of diabetic wounds driven by the overproduction of peroxynitrite (ONOO − ), we developed HD-ONOO , a near-infrared (NIR) activatable fluorescent probe based on a hemicyanine scaffold. The probe utilizes an ONOO − -triggered degradation of a boronic acid pinacol ester moiety to initiate an intramolecular charge transfer (ICT) process, resulting in a robust fluorescence “turn-on” response at 750 nm. HD-ONOO exhibits exceptional selectivity and high sensitivity, with a calculated limit of detection (LOD) of 0.02 μM. Beyond monitoring endogenous ONOO − fluctuations in RAW264.7 cells, the probe enabled high-contrast visualization and spatiotemporal quantification of ONOO − concentration in both the serum and cutaneous wound beds of diabetic mice. Furthermore, the probe successfully tracked the attenuation of ONOO − levels following metformin (MET) administration, highlighting its utility for evaluating therapeutic efficacy. Collectively, this research establishes HD-ONOO as a versatile molecular imaging tool for the early diagnosis, precision monitoring, and therapeutic assessment of diabetes-associated inflammatory complications.
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JOURNAL OF MOLECULAR LIQUIDS
·
2026
·
IF 5.2
Fangxu Li,Qing Tang
To enhance the enrichment efficiency of copper oxide ores, calcium polysulfide (CaSx) in combination with potassium n-butoxypropyl xanthate (BPX) was applied for the sulfidization flotation of malachite in this study—marking the first reported use of this reagent system for such a purpose. Flotation experiments demonstrated that the CaSx-BPX system exhibited superior selectivity and separation performance for malachite relative to calcite and quartz, outperforming three reference systems: CaSx-Sodium isobutyl xanthate(IBX), Na 2 S-BPX, and Na 2 S-IBX. Under optimized conditions (pH = 7, CaSx dosage of 200 mg/L, and BPX dosage of 100 mg/L), the recovery of malachite, calcite, and quartz were 98.23%, 5.89%, and 2.35%, respectively. Zeta potential analyses showed a negative shift in the surface potential of malachite over the pH range of 7–12 after the addition of CaSx, followed by a further negative shift upon BPX adsorption. The XPS results further indicate that CaSx forms stable Cu(I/II)–S chelates on the malachite surface. Subsequently, the sulfided malachite chemically reacts with BPX to form C–S–Cu(I/II) chemical bonds. Contact angle measurements revealed that malachite undergoes a transition from hydrophilic to hydrophobic upon treatment with CaSx–BPX, whereas calcite and quartz retain their hydrophilic nature. This differential wettability provides a rational explanation for the high flotation selectivity achieved among the three minerals.
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FOOD HYDROCOLLOIDS
·
2026
·
IF 13.8
Zhiyan Lai,Xin Li,Xiaotian Liu,Siyi Li,Tao Liu
The combination of proteins and flavonoids has been proven to enhance protein stability, increase small molecule solubility, and exhibit additional advantageous properties. However, traditional experimental methods for studying protein-flavonoid binding are inefficient due to complex influencing factors. To address multivariate nonlinear interactions and improve mechanistic reliability, this study established an integrated framework combining machine learning, molecular docking, and systematic experimental validation using phycocyanin—a natural blue pigment with significant bioactivity but prone to degradation under heat, light, and pH variations, limiting its food applications—and two structurally similar flavonoids (rutin and hesperidin) for experimental validation. LightGBM was identified as the optimal predictive model (R 2 > 0.84), revealing key determinants such as molecular weight. The model quantitatively identified structure–property relationships, which were subsequently verified through spectroscopic, physicochemical, and stability analyses. Experimental results demonstrated that both flavonoids induced significant fluorescence quenching in phycocyanin. FT-IR analysis confirmed enhanced hydrogen bonding and hydrophobic interactions, which tightened local protein structures. Surface hydrophobicity measurements further demonstrated reduced exposure of hydrophobic patches after complexation. The complexes exhibited uniformly dispersed particle sizes consistent with model predictions. Critically, rutin and hesperidin improved phycocyanin's UV stability, heat resistance, and color retention. Molecular docking further indicated their binding to critical phycocyanin domains via hydrogen bonding, van der Waals forces, and other interactions. This bidirectional strategy, in which machine learning guides experimental interpretation and experimental results validate predictive outcomes, provides a robust framework for rational design of optimized protein-flavonoid systems in food science.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Hu Gao,Bing-Wei Guo,Yuan Chen,Hong Chen,Zhiqiang Yang,Ming-Yu Wu,Yan Jiang
Polymicrobial infections, particularly those involving both Gram-positive (G+) and Gram-negative (G−) bacteria, present a severe public health threat due to the lack of effective treatments. The formation of polymicrobial biofilms further complicate this challenge, underscoring the urgent need for innovative therapeutic strategies. To address this issue, we designed a series of amphiphilic cationic photosensitizers (PSs) featuring distinct hydrophilic cationic side chains (pyridinium, imidazolium, alkyl quaternary ammonium, and quaternary phosphonium) and systematically investigated their structure–activity relationships. Among them, the pyridinium-modified PS, TBTCP-PY, demonstrated a superior performance. It efficiently generates hydroxyl radicals (•OH) and singlet oxygen (1O2) upon light irradiation, enabling it to target and disrupt the membranes of both G+ and G– bacteria. Furthermore, TBTCP-PY exhibits a strong capacity to penetrate extracellular polymeric substances (EPS), leading to the effective eradication of polymicrobial biofilms formed by methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Pseudomonas aeruginosa (MDR-PA). In a murine model, TBTCP-PY successfully eliminated MRSA-MDR-PA polymicrobial biofilms from implanted medical catheters, reduced subsequent inflammation, and promoted wound healing. This work not only presents a promising candidate for treating complex polymicrobial biofilm infections but also provides valuable theoretical insights into developing novel antibiofilm materials.
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ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19.9
Yi Cui,Youzhi Xie,Qin Luo,Lianpeng Li,Jingqin Cui,Chaozhi Wang,Qiulong Wei,Xiaoliang Fang
Hard carbon (HC) anodes are regarded as the most promising anodes for sodium-ion batteries (SIBs), yet their energy density is severely limited by low-voltage plateau capacity, which remains difficult to enhance without sacrificing Initial Coulombic efficiency (ICE) or structural integrity. Here, we report a convenient air-etching strategy for the scalable synthesis of HC via a precursor-independent pore evolution pathway. By introducing a mild air oxidation process within a narrow kinetic window, the oxidation of pre-carbonized precursors preferentially occurs at edge and defect sites and suppresses over-etching, generating closable ultra-micropores (∼0.8 nm) without framework collapse. Upon graphitization, the ultra-micropores evolve into uniform distributed closed nanopores (∼2.8 nm) while maintaining a low specific surface area. The resulting HC exhibits a plateau-dominated sodium storage behavior and delivers a high ICE of 91.8% and a high reversible capacity of 460 mAh g −1 with a remarkably enlarged plateau capacity of 346.4 mAh g −1 , superior to most of HC reported previously. More importantly, the air-etching approach is applicable to diverse precursors, offering a low-cost and powerful route for achieving high-energy-density HC anodes and SIBs.
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ANALYST
·
2026
·
IF 3.6
Yu Sun,Shuo Li,Peng Tang,Yuankai Zhang,Chao Yi,Wang Peng
To address the limitations of traditional pesticide detection methods, including reliance on costly equipment, operational complexity, and time-consuming procedures, an AuNPs-modified Photonic Crystal (AuPC) microfluidic chip is proposed for sensitive and rapid detection of acetamiprid and myclobutanil. A Photonic Crystal (PC) sensor functionalized with AuNPs was developed. Numerical simulations revealed that AuNPs modification significantly enhanced localized electric field intensities, generating high-density electromagnetic hotspots in microsphere gaps, with a maximum field enhancement of 4.8-fold compared to unmodified counterparts. The sensor demonstrated a detection limit of 10−4 g L−1 for both analytes, with linear concentration-dependent spectral red shifts (R2 > 0.96) observed across 1 g L−1 to 10−4 g L−1. Sensitivity enhancement was achieved through synergistic photonic-plasmonic interactions, and a microfluidic-integrated PC platform was constructed, enabling efficient pesticide residue screening.
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ACS Applied Energy Materials
·
2026
·
IF 5.5
Zhang Lei,Zhang Yunlong,Zhao Mengfan,Wang Jing,Hou Yifan,Liu Jifan,Huang Jitao,Wang Qian,Jin Zhong,Wang Shi
While polymer electrolytes offer a promising path to suppress dendrite growth and side reactions in aqueous zinc-ion batteries, their implementation often compromises ion transport kinetics and interfacial stability. Here, we report an ion-regulating copolymer electrolyte, poly(4-acryloylmorpholine)-co-poly(3-sulfopropyldimethyl-3-methacrylamidopropylammonium inner salt), engineered through a facile one-pot synthesis. This molecularly designed architecture combines multi-dentate zinc-binding sites with dynamic zwitterionic channels, enabling simultaneous anion confinement and rapid zinc-ion transport. The copolymer electrolyte promotes uniform ion flux and dense zinc deposition while maintaining intimate electrode contact, effectively eliminating dendrite formation and interfacial degradation. Symmetric Zn||Zn cells achieve excellent cycling stability over 1400 h with minimal polarization (∼110 mV) at 0.5 mA cm –2 . When integrated with V 2 O 5 cathodes, full cells exhibit outstanding reversibility, rate capability, and cycling durability. This work demonstrates a rational electrolyte design strategy that synchronizes bulk and interfacial ion regulation, providing a viable platform for high-performance, long-lived zinc batteries.
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TALANTA
·
2026
·
IF 6.7
Hang Tian,Lingli Qu,Shihui Chen,Zhuwang Shao,Kerui Li,Qinghong Zhang,Yaogang Li,Hongzhi Wang,Chengyi Hou
Wearable cortisol monitoring offers a noninvasive approach for assessing dynamic physiological stress, but reliable on-body analysis remains challenging owing to limited sweat availability, unstable electrode contact, and use-induced mechanical deformation. Here, we report a compartmentalized multi-lumen, hydrogel-integrated cortisol-sensing fiber (HCSF) for rapid and reliable detection of cortisol in sweat that combines sweat collection, molecular recognition, and wireless readout in a glove-based wearable platform. The interface-engineered interlayer provides topological anchoring for the MIP matrix and promotes efficient charge transfer, while the porous compartmentalized hydrogel sheath functions as an in situ sweat collector, hydrated ion-conducting medium, electrode spacer, and mechanical buffer, collectively stabilizing the fiber–polymer interface under repeated bending. With Prussian blue embedded in the MIP network as an internal redox probe, the sensor enables label-free quantitative cortisol detection through steric-hindrance-mediated signal modulation, achieving a low limit of detection of 0.87 pM and a broad linear range from 1 pM to 10 μM. After integration into a wearable glove with a miniaturized wireless readout module, the platform tracks dynamic cortisol fluctuations during physical exercise and acute cold-pressor tests. This robust and ergonomically integrated platform provides a promising strategy for noninvasive endocrine monitoring and personalized stress assessment.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-16
·
IF 12.6
Jin Yi,Yang Nengjie,Chen Siyu,Wei Yanan,Wei Xiangyu,Zhu Yujuan,Sun Chi
The inflammatory cascade is a key driver of chronic inflammation in rheumatoid arthritis (RA) and facilitates the migration of circulating immune cells into the inflamed joints. Recent studies have unveiled the complexity of this cascade, which involves intricate interactions between immune cells, neutrophil extracellular traps (NETs), reactive oxygen species (ROS), and inflammatory cytokines. Given the central role of the inflammatory cascade in RA pathogenesis, targeting it represents a highly promising therapeutic strategy. However, research specifically focused on modulating the inflammatory cascade remains limited. In this study, we introduce a novel bioinspired catalytic nanogel designed to target the inflammatory cascade for the immunotherapy of RA. Nanogel coated with cationic polymer enables the targeted penetration into cartilage as well as the capture of NETs via charge-trapping effects. The captured NETs are further degraded by DNase I-conjugating nanogel. To fundamentally reduce ROS that can induce NETs generation, nanogels exhibit intrinsic catalase, superoxide dismutase, and hydroxyl radical activities, effectively inhibiting oxidative stress responses. Of note, the enhanced therapeutic effects are observed in mouse RA model including targeted and long-term accumulation of cascade nanogel in the inflamed joints, efficient NETs scavenging, alleviated intra-articular inflammation, and reduced bone destruction. Also, transcriptome analysis indicates that nanogel treatment markedly downregulates NETs formation signaling pathway, upregulates anti-inflammatory pathways and finally reduces neutrophil infiltration-caused autoimmune damage. These results make the bioinspired catalytic nanogel system an ideal inflammatory cascades-targeting therapy for the systemic autoimmune disease.
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Materials Today Advances
·
2025
·
IF 8
Jiayi Chen,Jijun Li,Yaqian Liu
Omnidirectional strain sensors are of paramount importance in the accurate detection of human movements. The mask printing technology is employed to fabricate an integrated omnidirectional flexible strain sensor for human motion monitoring. Silica particles were incorporated into the liquid metal to improve its rheological properties and enhance its patterning capability. The developed sensor exhibits excellent characteristics, including a wide strain sensing range (1–300 %), high sensitivity as evidenced by gauge factors ranging from 1.82 to 3.34 across its operational range, and excellent cyclic stability (more than 5000 cycles) with minimal signal degradation, ensuring reliable long-term monitoring. It is particularly noteworthy that the integrated flexible strain sensor can achieve real-time decoupling of both the magnitude and direction of the principal strain at the measurement point. The reliability of the sensor is verified by utilizing the specified strain magnitude and direction. This unique capability to resolve complex multi-axis deformation patterns provides higher accuracy than conventional unidirectional strain sensors and enables precise and intelligent identification of various human actions. The strain sensing platform has great application potential in fields such as health monitoring and rehabilitation medicine.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Shan Li,Longlong Zhang,Bin Xu,Weihua Qin,Mengdan Wang,Bingli Pan,Hongyu Liu,Honggang Wang
Nanoparticles are of great significance to enhance tribological performances and can be employed as effective lubricant additives. 1T-MoS 2 has been widely applied in many fields. However, it is rarely studied in lubrication application. In this study, a novel core-shell lubricant additive was prepared by combining CuNi-MOF and 1T-MoS 2 via a facile hydrothermal method. The as-prepared CuNi-MOF@1T-MoS 2 exhibited a flower-like structure. Both experimental and theoretical calculation results showed the interlamellar interactions between the layered 1T-MoS 2 and CuNi-MOF sheets. Tribological properties of PEG200 containing CuNi-MOF@1T-MoS 2 were systematically investigated by a four-ball test machine. In comparison with PEG200, the friction coefficient and wear scar diameter were remarkably reduced by 56.8 % and 34.0 %, respectively. Therefore, the combination of 1T-MoS 2 and CuNi-MOF presents a promising candidate for enhancing the tribological properties of PEG200.
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Journal of Chemistry
·
2016
·Vol. 2016
·期 1
·8608567
·
IF 0.996
Xueyan Cui,Jun Yin,Ying Lin,Na Li,Meizhen Wang,Dongsheng Shen
The rapid development of nanoparticles (NPs), such as silicon nanoparticles (Si NPs) and ferric oxide nanoparticles (Fe 2 O 3 NPs), and their use in myriad commercial applications have raised questions of their potential impacts on wastewater treatment systems. In this study, we investigated the consequences of the presence of Si NPs and Fe 2 O 3 NPs in the denitrification of anoxic sludge. Fe 2 O 3 NPs, at a concentration up to 50 mg/L, had no significant impact on nitrate removal, whereas Si NPs, at concentrations up to 50 mg/L, increased the rate of nitrate removal. We used transmission electron microscopy (TEM) to investigate the effect of Si NPs and Fe 2 O 3 NPs. Si NPs exposure enhanced the abundance of narG -1 gene, which might promote nitrate removal process directly. Finally, we reviewed and identified the specific properties of a variety of NPs responsible for toxicity and found NPs larger than about 100 nm and without ion release in general possible to energy safety and nontoxic or low toxic to environment. Our results provide useful information to understand the response of anoxic sludge to Si NPs and Fe 2 O 3 NPs in complex environmental matrix as well as potent support for wide use of the environmentally friendly NPs.
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