Journal of Integrative Plant Biology
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2025
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IF 9.3
Guangzheng Sun,Jun Chen,Tang Li,Qinsheng Zhu,Xinrui Li,Xuan Mi,Wenxia Wang,Zhichao Zhang,Keyi Huang,Ruoting Yao,Bo Yang,Wenwu Ye,Kaixuan Duan,Zhenchuan Ma,Ke Yu,Yiming Wang,Suomeng Dong,Yan Wang,Heng Yin,Yuanchao Wang
Chitin and its deacetylated derivative chitosan are the major components of fungal cell walls and are recognized by plant pattern-recognition receptors (PRRs) as pathogen-associated molecular patterns that induce innate immunity. Recognition of chitin oligosaccharide (CTOS) in Arabidopsis ( Arabidopsis thaliana ) and rice ( Oryza sativa ) requires the membrane-localized lysin-motif (LysM)-domain-containing receptors AtLYK5 and OsCEBiP, respectively. However, the mechanism underlying chitosan oligosaccharide (CSOS)-induced plant immunity remains unclear. In this study, we determined that CTOS and CSOS trigger immune responses and boost disease resistance in soybean ( Glycine max ) through the LysM-domain-containing protein GmNRF5a and its co-receptor GmCERK1. Surprisingly, both GmNFR5a and GmCERK1 bind directly to CTOS and CSOS, with distinct binding sites. The receptor-like kinase GmCAK1 acts downstream of GmCERK1 and is essential for CTOS/CSOS-mediated immune activation. Overall, these findings uncovered how soybean plants respond to CSOS and initiate immune signaling, demonstrating that soybean exploits shared immune sectors to transduce immune signals triggered by CTOS/CSOS, paving the way for the development of disease-resistant crops with broad-spectrum resistance.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Yumiao Lang,Mingru Wang,Shasha Zhou,Dandan Han,Peng Xie,Cuiping Li,Xiaoxi Yang
Polysaccharides are employed to modify proteins, forming complexes that enhance the functional properties of proteins, such as emulsification and stability. In this study, myofibrillar protein (MP)-chitosan (CS) complexes were formed between CS and MP under acidic conditions (pH 3.0–6.0). Results showed that CS can improve the solubility and emulsifying properties of MP, and the MP-CS complexes at pH 3.0 and 6.0 had better emulsifying properties. Concurrently, the particle size results indicated that better the emulsifying properties of the complex, the smaller the particle size. Consequently, the characteristics of the MP-CS complexes (at pH 3.0 and 6.0) were investigated. Our analysis using Fourier transform infrared spectroscopy revealed that the amide I band of MP was blue-shifted with the addition of CS, signifying a decrease in hydrogen bonding within MP. The endogenous fluorescence spectra showcased that the hydrophobicity surrounding the tryptophan residues in the protein changed, leading to enhanced polarity. Thermogravimetric analysis and differential scanning calorimetry further confirmed that the addition of CS improved the thermal stability of MP. These findings provide valuable insights into the interactions between MP and CS. Furthermore, the MP-CS complex can be leveraged to create a Pickering emulsion system for the efficient delivery of bioactive substances.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Chao Wang,Youfeng Guo,Siyi Xue,Cui Jin,Yufeng Huang,Lifeng Yan,Shidong Ji,Xiao Ma
Natural biomaterial-derived membranes show great potential for guided bone regeneration (GBR) and bone tissue engineering due to excellent biocompatibility and degradability. While incorporating inorganic nanoparticles like hydroxyapatite (HA) is a common strengthening strategy, the systematic impact of nanoparticle morphology on the integrated performance of composite membranes remains a critical, yet underexplored, knowledge gap. Here, we developed chitosan (CS)-based composite membranes incorporating hydroxyapatite (HA) nanoparticles of four morphologies: large lamellar (LHA), small lamellar (SHA), wire-like (WHA), and rod-like (RHA). Additionally, HA’s capacity as an ion carrier enabled the loading of silver (Ag) to impart antibacterial properties. High-aspect-ratio fillers (LHA, WHA) promoted crack deflection and energy dissipation, achieving tensile strengths up to 82.47 ± 4.10 MPa and toughness up to 28.61 ± 5.02 MJ·m −3 —significantly outperforming pure CS membranes. This reinforcement mechanism extended to other matrices, such as sodium alginate. Simultaneously, the Ag-loaded HA (Ag-HA) composite membranes synergistically enhanced osteogenic activity (alkaline phosphatase) and exhibited strong antibacterial efficacy. These findings elucidate morphology–size–performance correlations, providing a framework for designing multifunctional GBR biomaterials with enhanced mechanical properties, osteogenesis, and antimicrobial capabilities.
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APPLIED ORGANOMETALLIC CHEMISTRY
·
2026
·Vol. 40
·期 4
·e70549
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IF 4.3
Linjun Shao,Zheng Yin,Ke Long,Faliang Gou,Guiying Xing,Peng Yang,Xianman Zhang
Chitosan (CS) is a widely distributed and abundant biopolymer in nature. In this study, CS was blended with poly(methacrylic acid) (PMAA) to prepare stable chitosan composite nanofibers (CS/PMAA) via electrospinning, followed by annealing. The nanofibers were then functionalized through Schiff base reactions between CS amino groups and aldehydes and used to support palladium catalysts. Their catalytic performance was evaluated by the Heck reactions. Notably, the Pd 2+ ions anchored on the CS/PMAA nanofibers exhibited higher activity than those on the 2-pyridylimino-functionalized chitosan nanofibers (2PyCS/PMAA). In contrast, the Pd 0 species supported on the 2PyCS/PMAA nanofibers showed outstanding catalytic activity and remarkable reusability. HR-TEM was utilized to monitor the morphological changes and Pd 0 nanoparticle contents on the CS/PMAA and 2PyCS/PMAA nanofibers during reuse. Chelating interactions between the nanofibers and Pd 2+ ions were studied by FT-IR, adsorption distribution analysis, XRD, and HR-TEM. The strong nucleophilic affinity of Pd 2+ ions for the CS nanofibers was further verified by PALS. In conclusion, this work presents an effective and straightforward approach for preparing highly active and stable supported palladium catalysts.
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SOLAR ENERGY MATERIALS AND SOLAR CELLS
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2026
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IF 6.6
Runda Nie,Yanke Li,Jin Huang,Peng Zhang
Solar-driven interfacial evaporation using graphene-based materials shows promise for desalination, but poor durability limits practical application. Here, a robust aerogel is developed by incorporating green electrochemically exfoliated graphene oxide (EGO) into a chitosan/waterborne polyurethane (CS/WPU) system. The EGO/CS/WPU aerogel still maintains 94% of its evaporation performance after 1000 compression cycles (more than 1.98 kg m −2 h −1 under 1 sun irradiation), demonstrating exceptional mechanical stability. Meanwhile, it also exhibits that The EGO/CS/WPU aerogel possesses high salt tolerance, acid/alkali resistance, and anti-fouling capability, enabling treat diverse contaminated water sources. Finally, this work offers a green, scalable route to sustainable solar desalination materials for addressing the global water crisis.
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FULLERENES NANOTUBES AND CARBON NANOSTRUCTURES
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2023
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IF 2.3
Yuzhe Zhang,Yan Zhang,Yuxi Liu,Hao Wu,Man Zhou,Peiyang Gu,Zhongyu Li
Currently, Lithium is the lightest metal known in nature, which is widely applied in most walks of life. However, the present storage of lithium resources in the world is far from meeting the consumption market surge demand for lithium resources. Liquid lithium resources such as Salt Lake brine and seawater brine will become the primary source and inevitable choice for lithium extraction in the future due to a large amount of lithium, and its recovery requires a simple and effective process. This study synthesized TEG4MEC, a pseudo-crown ether monomer with a ring unit, to achieve effective Lithium-ion (Li+) recognition through specific interaction with Li+. Then, the TEG4MEC monomer was grafted onto the surface of cross-linked chitosan microspheres (CCS) by surface initiation polymerization. A series of static and dynamic adsorption studies showed that the pH value of the solution had a significant effect on Li+ adsorption. For CCS-TEG4MEC microspheres, the best adsorption effect was observed at pH = 7.0. The maximum adsorption capacity of Li+ on CCS-TEG4MEC microspheres obtained by Langmuir isotherm fitting is 156.16 mg g−1. In addition, CCS-TEG4MEC microspheres also showed effective regeneration performance and highly stable adsorption capacity, which could be reused.
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Materials Today Bio
·
2026
·
IF 10.2
Shanshan Li,Haichao Yu,Ruirui Guan,Xiaoyun Li,Junzhao Duan,Hua Wang,Xuesong Zhang,Xiaoying Wang
In clinical, critical bone defects are often treated with molded bone implants, yet they are prone to loosening, shape mismatch with the defect, and infection and inflammation. Herein, we present a limited oxidation strategy of catechol-chitosan (CC) to fabricate an injectable, adhesive, multifunctional nanocomposite hydrogel (OCCL) to assist bone implants in bone defects. Specifically, the oxidative cross-linking of CC within layered nanoclay (LAP) is moderately restricted to avoid excessive oxidation, thereby enhancing its adhesion to the tissue interface. By moderate oxidation of CC and the physical crosslinking boosted by LAP, the OCCL hydrogels show high adhesive strength, underwater adhesion, high antioxidant activity, good biodegradability and excellent antibacterial activity. Taking advantage of these features, the multifunctional OCCL can effectively promote cell growth, cell adhesion, angiogenesis and osteogenesis to facilitate bone regeneration, as demonstrated by in vitro and in vivo analyses. This work presents a promising strategy of limited oxidation to develop injectable and multifunctional adhesives, providing a safe and easy-to-process solution for reliable bone grafts.
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 2
·121777
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IF 7.5
Yuangao Li,Shan Chen,Rengfeng Luo,Liyan Xue,Heng Chen,Fengzhi Tan,Minzhong Huang,Zhaoli Liu,Fan Yang
Solar-driven interfacial evaporation presents a promising solution to the global water crisis. However, there are challenges in developing low-cost multi-functional evaporators using existing materials. Herein, we developed a double-layer evaporator consisting of a NiCo 2 O 4 nanofibers/chitosan composite aerogel (top layer) and a polyurethane (PU) sponge (bottom layer). The top layer achieves a light absorption rate of 96.42 % across the full spectrum, while the bottom layer effectively reduces heat loss and ensures a continuous water supply. The evaporator achieves a high evaporation rate of 2.23 kg m −2 h −1 under one solar illumination, and has good salt tolerance and excellent stability. In particular, due to the reasonable combination of evaporators, the water yield reached 17.03 kg m −2 in the outdoor experiment with natural light for 9 h. In addition, the antibacterial rate of NiCo 2 O 4 nanofibers/chitosan aerogels against Escherichia coli was as high as 94 %. In this study, a bifunctional composite aerogel with high evaporation efficiency and strong antibacterial activity was proposed, which is expected to be applied in seawater desalination.
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POLYMER TESTING
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2021
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IF 4.282
Yuanfei Ge,Xiangsong Chen,Xiangqin Wang,Lixia Yuan,Jinyong Wu,Jianming Yao
In this study, CS-NeuAc hydrogel was prepared from chitosan (CS) and N-acetylneuraminic acid (NeuAc) using cyclic freeze/thaw under 1-ethyl-3-(3-dimethylaminopropyl)-carbodiiminde/N-hydroxysuccinimide catalysis. Fourier transformed infrared spectroscopy, X-ray diffraction, and scanning electron microscopy analyses confirmed the successful synthesis of CS-NeuAc hydrogel. CS-NeuAc hydrogels were found to be equipped with suitable swelling behaviour, porosity, water evaporation rate, degradation rate, and good mechanical properties compared to CS. The swelling rate, water evaporation rate, and degradation rate of prepared hydrogel with a CS/NeuAc molar ratio of 10:1 were 710.7 ± 28.6%, 78.2 ± 1.6%, and 58.6 ± 1.5%, respectively. Moreover, CS-NeuAc hydrogel exhibited excellent biocompatibility. The evaluation of CS-NeuAc hydrogels’ antibacterial activity confirmed that they serve as effective antibacterial materials against Escherichia coli and Staphylococcus aureus with antibacterial rates above 95% and 92%, respectively, and the minimum inhibitory concentrations was above 400 μg/ml. In conclusion, CS-NeuAc hydrogel can be a candidate for biological antibacterial materials.
研究领域:
生物材料
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高分子科学
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抗菌材料
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组织工程
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药学
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Yongyan Yang,Gangying Feng,Jingfei Wang,Ruiting Zhang,Shuangling Zhong,Jia Wang,Xuejun Cui
In this study, a supramolecular hydrogel was fabricated with orotic acid (OA) modified chitosan (OACS) and 2,6-diaminopurine (DAP). The obtained OACS-DAP supramolecular hydrogels have dual responsiveness to temperature and pH. Phase transition experiments indicate this is a temperature-dependent thermoreversible supramolecular hydrogel. Rheological experiments proved the formation of the supramolecular hydrogel and its thixotropic properties. FTIR spectra confirmed that hydrogen bonds and π-π interactions are the main driving forces for OACS and DAP to form hydrogels through intermolecular self-assembly. XRD pattern confirmed the amorphous morphology of OACS-DAP hydrogels. The hydrogel has excellent electrical conductivity with a conductivity of 9.48 μ S·cm −1 . And can achieve the precise release of gastrointestinal drugs. OACS-DAP hydrogel is expected to have better applications in the field of gastrointestinal drug release.
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International Journal of Nanomedicine
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2022
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IF 7.033
Zi Chao Wu,Xin Yu Liu,Jia Yan Liu,Jing Shu Piao,Ming Guan Piao
Aim: Liver fibrosis is mainly characterized by the formation of fibrous scars. Galactosylated chitosan (GC) has gained increasing attention as a liver-targeted drug carrier in recent years. The present study aimed to investigate the availability of betulinic acid-loaded GC nanoparticles (BA-GC-NPs) for liver protection. Covalently-conjugated galactose, recognized by asialoglycoprotein receptors exclusively expressed in hepatocytes, was employed to target the liver.Materials and Methods: Galactose was coupled to chitosan by chemical covalent binding. BA-GC-NPs were synthesized by wrapping BA into NPs via ion-crosslinking method. The potential advantage of BA-GC-NP as a liver-targeting agent in the treatment of liver fibrosis has been demonstrated in vivo and in vitro.Results: BA-GC-NPs with diameters Conclusion: The findings showed that BA-GC-NPs form a safe and effective anti-hepatic fibrosis medication delivery strategy.
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FOOD CHEMISTRY
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2022
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IF 9.231
Chunhua Wu,Zijian Zhi,Mengxia Duan,Jishuang Sun,Haixin Jiang,Jie Pang
To improve the sustainable antibacterial active of nisin, nisin-loaded carboxymethyl chitosan (CMCS-nisin) nanogels (CN NGs) are prepared via a combination method of electrostatic self-assembly and chemical cross-linking. The as-prepared CN NGs are profiled using dynamic light scattering, zeta potential, transmission electron microscopy, fourier transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS). We found CN NGs to be spherical and well dispersed, with an average particle diameter of 45 ± 5.62 nm. Besides, the molecular interactions (electrostatic interactions and hydrogen bonding) between nisin and CMCS are the main driving force in the formation of CN NGs, which is demonstrated by FT-IR, XPS and molecular dynamic simulation analysis. Additionally, the CN NGs showed a great nisin-controlled release behavior and the excellent antimicrobial activity against food-borne bacteria. These results suggested that CN NGs have the potential to be used as a promising bio-preservative in food industry.
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