ANALYST
·
2020
·Vol. 145
·期 24
·7849-7857
·
IF 3.978
Chang Liu,Chunyu Huang,Ruixue Ma,Wanying Zhai,Jingjing Deng,Tianshu Zhou
This work demonstrates a new strategy for sensing cerebrospinal acetylcholinesterase (AChE) as a cholinergic biomarker for brain dysfunction based on graphene quantum dot (GQD)-functionalized lanthanide infinite coordination polymer (Ln-ICP) nanoparticles. The ICPs used in this work were comprised of two components, i.e. a supramolecular Ln-ICP host formed by the coordination between the GMP ligand and central metal ion Tb3+, and guest GQDs with abundant functional groups, which were utilized as antenna ligands to further sensitize the fluorescence of Tb/GMP. Upon excitation at 300 nm, the obtained GQD@Tb/GMP ICP nanoparticles exhibited enhanced green fluorescence from Tb/GMP. With the addition of Cu2+, the competitive coordination between Cu2+ and GQDs weakened the antenna effect, leading to a decrease in the fluorescence of GQD@Tb/GMP ICPs. However, in the presence of thiocholine (TCh), a thiol-containing compound hydrolyzed from acetylthiocholine (ATCh) by AChE, a stronger coordination interaction between Cu2+ and TCh occurred, resulting in the restoration of the fluorescence of GQD@Tb/GMP ICPs. Using the method established herein, the cerebrospinal AChE fluctuation of rats with acute organophosphorus pesticide (OP) poisoning or chronic Alzheimer's disease (AD) could be monitored. This study essentially provides a novel approach to realize the direct monitoring of a biomarker for brain dysfunction by regulating the competitive coordination interaction reversibly, which is critical in the early diagnosis and therapy of brain diseases.
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高影响因子
MATERIALS RESEARCH BULLETIN
·
2019
·
IF 3.355
Xiao Jiang,Qing-Da An,Zuo-Yi Xiao,Shang-Ru Zhai,Zhan Shi
Versatile adsorptive materials that can efficiently capture anionic and cationic heavy metals are extremely significant in purification of complex wastewater systems. Herein, a new type of amine modified, biopolymer-derived core/shell-like adsorbents were employed in heavy metal anion and cation adsorption. The maximum adsorption capacities for Cr(VI), Pb(II), and Cu(II) were measured to be 497.1, 535.6, and 163.7 mg/g, respectively. The adsorbent also showed great performance in heavy metal cation adsorption in fixed bed column experiments. Additionally, removal efficiency and rapid adsorption kinetics on low concentration heavy metal pollutions for both anion and cations were well discussed to demonstrate the potential in real accidental heavy metal pollution. The prepared core/shell-like biopolymer adsorbents were demonstrated to be a kind of versatile adsorbent for both anionic and cationic heavy metal ions in aqueous solutions.
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ANALYST
·
2015
·Vol. 140
·期 12
·4121-4129
·
IF 4.107
Hong Yan Zou,Peng Fei Gao,Ming Xuan Gao,Cheng Zhi Huang
Full understanding and easy construction of specific biosensing principles is necessary for disease diagnostics and therapeutics in the hope of creating new types of biosensors. Herein, we developed a new conceptual nanobiosensing platform by coupling nanometal surface energy transfer (NSET) and photo-induced electron transfer (PET) with polydopamine-embedded Cu2−xSe nanoparticles (Cu2−xSeNPs@pDA) and DNA-conjugated fluorescent organic dyes. The new prepared Cu2−xSeNPs@pDA has intense and broad localized surface plasmon resonance (LSPR) absorption over UV to near infrared (NIR) wavelengths, with different affinities toward ssDNA versus dsDNA. It also exhibits a high multiplexed fluorescence quenching ability, and thus can act as an acceptor in the energy transfer and electron transfer interactions between Cu2−xSeNPs@pDA and fluorescent organic dyes. As a proof of concept, a new biosensing platform has been successfully developed to target biomacromolecules such as DNA and proteins, in which the NSET and PET interactions between Cu2−xSeNPs@pDA and three different DNA-conjugated fluorescent dyes have been identified using steady-state and time-resolved fluorescence. A simple mathematical model was further applied to simulate the respective contributions of the coexisting NSET and PET to the total quenching observed for each DNA-conjugated dye in this sensing system. This study highlights the importance of understanding the mechanistic details of NSET and PET coupling processes, and the disclosed coupling mechanism of NSET and PET (NSET©PET) in the systems of Cu2−xSeNPs@pDA with wide wavelength range dyes provides new opportunities for sensitive biosensing applications.
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ACS Nano
·
2017
·
IF 13.942
Yu Zou,Chao Sun,Wenbin Gong,Xianfeng Yang,Xin Huang,Ting Yang,Weibang Lu,Jiang Jiang
Integrating a plasmonic metal and a semiconductor at the nanoscale is of great importance for exploring their optical coupling properties. However, the synthesis and fine structural control of such nanostructures remain challenging. Herein we report the facile aqueous-phase Se-mediated overgrowth of metal selenides onto Au nanocrystals. Taking plasmonic Cu2–xSe as an example, the introduction of a Se template allows deposition of large Cu2–xSe crystalline grains onto Au nanocrystal seeds in various shapes, including spheres, rods, and plates. Moreover, the configuration of Au–Cu2–xSe hybrids can be tuned from core–shell to heterodimer structure by controlling the growth behavior of the Se template. Se overgrowth depends critically on the absorption strength of stabilizers on Au seeds: a strongly absorbing stabilizer inhibits isotropic overgrowth, which is in agreement with molecular dynamics simulations. The resultant Au–Cu2–xSe hybrid nanocrystals possess multiple surface plasmon resonance modes. Finally, our synthetic strategy can be extended to prepare other Au–metal selenide hybrids such as Au–Ag2Se and Au–CdSe with controllable morphologies.
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RSC Advances
·
2016
·Vol. 6
·期 90
·87230-87236
·
IF 3.289
Qian Li,Qitong Huang,Jie-Ji Zhu,Wen-Gang Ji,Qing-Xiao Tong
In this paper, a novel quinoline derivative: 8-(pyridin-2-ylmethoxy)quinoline-2-carboxylic acid (Q) has been successfully synthesized, then it was coupled with carbon dots (CDs) to synthesize a CDs–Q nanocomposite by a simple and green method. The CDs–Q nanocomposite can act as a “turn-off” fluorescent chemosensor for detection of Cu2+ ions. It's a good candidate for Cu2+ sensing on account of its excellent properties such as its high sensitivity and selectivity, easy synthesis, excellent fluorescence stability towards temperature and pH, direct detection in aqueous solution and tap water and distinct fluorescence quenching towards Cu2+. We have also discussed the fluorescence quenching mechanism of CDs–Q and the possible coordination mode of CDs–Q with Cu2+. CDs–Q have a wide linear range (0.01–1.2 μM) and high sensitivity towards Cu2+ ions with a detection limit of 0.56 nM. In addition, this fluorescent chemosensor was also applied to determine Cu2+ in tap water with satisfying results.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Jie Jin,Yang Bao,Feihu Li
Integrating MnO2 with carbon is a reliable strategy to improve capacitive deionization (CDI) performance by leveraging the unique properties of both components (i.e., MnO2 and carbon). However, the influences of preliminary functionalization of carbon (e.g., nitrogen doping, KOH activation) and pairing of cathodes and anodes on the CDI performance have yet to be systematically explored. Herein, we prepared a group of MnO2-decorated mesoporous carbon composites with nitrogen as a dopant (i.e., MK-NMCS, K-NMCS, NMCS, and CS), and systematically evaluated the desalination performance of various cathode//anode pairs in a hybrid capacitive deionization (HCDI) for capturing Na+, Cu2+, and Pb2+, respectively. Of all electrodes, the MK-NMCS//K-NMCS pair demonstrates the optimum desalination performance based on salt adsorption capacity (SAC) and cycling stability, offering a SAC of 25.4 mg g–1 and a SAC retention of 102.4% after 50 consecutive charge–discharge cycles at 1.2 V in 500 ppm of NaCl solution. In addition, the MK-NMCS//K-NMCS electrodes also show the maximum ion adsorption capacity (IAC) toward Cu2+ and Pb2+ ions compared to other cathode//anode pairs, attaining an IAC of 37.0 and 30.0 mg Cu2+ per gram electrode materials at 1.2 V in 500 and 200 ppm of Cu2+ solutions, respectively (cf. 32.2 mg of Pb2+ per gram of electrode materials in 200 ppm of Pb2+ solution). Besides, these electrodes exhibit excellent cycling stability when applied in removing each heavy metal ion separately, with IAC retentions of 90.0 and 98.5% after 50 cycles toward Cu2+ and Pb2+ ions, respectively. Mechanical analysis reveals that both heavy metals are likely to be sequestered via capacitive electrosorption by carbon, intercalation with MnO2, and surface complexation at the external surface of the [MnO6] octahedral layers. Our results demonstrated a great potential of the MnO2-decorated N-doped carbon//prefunctionalized carbon pairs, in particular, the MK-NMCS//K-NMCS electrode pair for capturing heavy metal ions via HCDI platforms. Such prefunctionalization and pairing strategies are very promising for screening high-performance composite electrodes for wastewater remediation.
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Food Analytical Methods
·
2024
·
IF 2.6
Zhai Yajie,Shi Yingkun,Feng Yingjie,Chen Sichun,Wang Songlei
Copper ions (Cu 2+ ) are commonly present in meat and their presence has been shown to affect human health. Therefore, there is an urgent need to develop a rapid and sensitive method for detecting trace amounts of Cu 2+ . In this study, we developed an electrochemical sensor based on g-C 3 N 4 @FeP-C/GCE for the detection of Cu 2+ in beef and the beef liver. The incorporation of FeP-C into the g-C 3 N 4 framework enhances the catalytic performance of the sensor through strong electrostatic interactions between the positively charged metal cations in FeP-C and the negatively charged nitrogen in g-C 3 N 4 . The combination of g-C 3 N 4 (graphitic carbon nitride) and FeP-C (Fe 3 O 4 phosphorylated doped carbon) resulted in the generation of additional active sites for the sensor, further improving its catalytic performance. The morphology and internal structure of the nanocomposite were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The developed sensor exhibited sensitive Cu 2+ detection in meat, with a limit of detection (LOD) of 16.7 nM and a linear range of 0.05—150 μM. Furthermore, the method demonstrated satisfactory recoveries in beef and beef liver, with a relative standard deviation (RSD) not exceeding 5%.
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Open Life Sciences
·
2024
·Vol. 19
·期 1
·
IF 1.7
Xu Haitao,Li Siyuan,Guo Sutong,Guo Yu,Xu Peirong,Wang Ling,Ding Yujian,Feng Dehong
Because of stress shielding effects, traditional titanium (Ti) alloy scaffolds have a high elastic modulus, which might promote looseness and bone disintegration surrounding the implant, increasing the likelihood of a second surgery. In contrast, 3D-printed porous Ti alloy scaffolds can reduce the scaffold weight while enhancing biocompatibility. Further, these scaffolds’ porous nature allows bone tissue ingrowth as well as strong pore connectivity, which can improve nutrient absorption. Nevertheless, bare Ti alloy implants may fail because of inadequate bone integration; hence, adding a coating on the implant surface is an effective technique for improving implant stability. In this study, a composite coating comprising hydroxyapatite (HAP), chitosan (CS), tannic acid (TA) and copper ions (Cu 2+ ) (Cu 2+ /TA/HAP composite coating) was prepared on the surface of 3D printed porous Ti alloy scaffolds using electrophoretic deposition. Using the standard plate count method, Live/Dead bacteria staining assay, FITC Phalloidin and 4′,6-diamidino-2-phenylindole staining assay, and live/dead staining of cells we determined that the composite coating has better antibacterial properties and cytocompatibility as well as lower cytotoxicity. The Alkaline Phosphatase assay revealed that the coating results showed good osteogenesis potential. Overall, the composite coatings produced in this investigation give new potential for the application of Ti alloys in clinics.
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MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Xinyu Luo,Ziyi Liu,Linfan Wang,Liwei Gao,Dingfeng Wang,Ting Zhang,Da Chen
Rapid and selective detection of copper ion (Cu 2+ ) and glyphosate (GLY) is crucial to environmental pollution control, especially when using a simple and portable device. In this study, an enzyme-free and visual fluorescence sensor based on nitrogen-doped carbon dots (N-CDs) is successfully designed, featuring strong blue fluorescence and excellent stability. The sensor shows a linear response to Cu 2+ over a wide detection range of 0.048 to 40 μM with a low limit of detection (LOD, 48 nM), resulting in fluorescence quenching at 435 nm. Meanwhile, the rapid enhancement in fluorescence intensity of the quenched N-CDs/Cu 2+ system can be triggered by GLY owing to the strong complexation between Cu 2+ and GLY, with a LOD of GLY as low as 0.24 μM. Furthermore, we develop a smartphone-assisted sensing platform using N-CDs/polyvinyl alcohol films, which captures and analyzes fluorescence images to detect Cu 2+ and GLY with sensitive LODs of 73 nM and 0.32 μM, respectively. Satisfactory recoveries, ranging from 94.0 % to 104.6 %, are achieved in real sample detection, implying the potential application in the field of enzyme-free and on-site pesticides detection.
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Analytical Methods
·
2025
·
IF 2.6
Dongxu Yan,Wen Yao,CHEN Siwei,Xinrong Guo,Lishi Wang
The issue of Cu2+ contamination is severe due to its potential to induce diseases upon exposure. This study has developed a novel down-conversion fluorescent material, α-phase NaY0.47F4:Ce0.1,Gd0.4,Eu0.03@PEIF nanoparticles (Eu@PEIF NPs). It was synthesized using thermal decomposition combined with epitaxial growth methods, to synthesize the Eu NPs that show high crystallinity and regular morphology; after functionalization with fluorinated PEI (PEIF) to obtain Eu@PEIF NPs with good water solubility and optical properties. The Cu2+ can bind to Eu@PEIF NPs through surface amino groups resulting in fluorescence quenching attributed to inner filter effect (IFE) and Förster resonance energy transfer (FRET). Thus, a new label-free fluorescence sensing platform based on Eu@PEIF NPs was constructed and quantitatively analysize Cu2+ over the concentration range of 0.03-2.5 μM, with a low detection limit and high selectivity to Cu2+. And this fluorescence sensor exhibits excellent recovery rates (94.93 % ~ 104.61 %) when applied to the detection of Cu2+ in real water samples. This proposed method provides a new approach for Cu2+ detection and offers guidance for the design of Cu2+-sensitive fluorescent probes.
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INORGANIC CHEMISTRY
·
2024
·
IF 4.3
Alimujiang Yalikun,Yanhong Wang,Yun Lv,Yaling Dou,Hyun-Joo Koo,Jiaojiao Cao,Wei Qi,Keke Huang,Myung-Hwan Whangbo,Zhongwen Ouyang,Hongcheng Lu
A series of analogous chain selenite chlorides Ba2M(SeO3)2Cl2 (M = Cu 1, Ni 2, Co 3, Mn 4) and Pb2Cu(SeO3)2Cl2 5 with tunable spin S from S = 1/2 to S = 5/2 have been hydrothermally synthesized and characterized. These analogues crystallized in the orthorhombic Pnnm space group (monoclinic P21/n space group for 5) all containing M2+–SeO3–M2+ spin chains, which are further separated by the Ba2+ ions (Pb2+ for 5). The magnetic susceptibility results of 1, 2, and 5 show broad maxima around 80.0, 18.9, and 78.0 K, respectively, indicating good one-dimensional (1D) magnetism. Meanwhile, no long-range order (LRO) is observed down to 2 K for both 1 and 5, while the isostructural compounds 2, 3, and 4 exhibit LRO at 3.4 K, 10.8 K, and 5.7 K, respectively, which are further confirmed by the heat capacity and electron spin resonance results, as well as the observed spin-flop transitions in the M–H curves measured at 2 K below TN. The magnetizations of 1–5 at 7 T are still far from saturation. In addition, thermal stability and FT-IR and UV–vis–NIR spectroscopy of 1–5 are reported.
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Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 48
·9908-9922
·
IF 6.331
Qi Xu,Qiuting Li,Zhe Yang,Piao Huang,Han Hu,Zhimin Mo,Zizhen Qin,Zushun Xu,Tianyou Chen,Shengli Yang
Lenvatinib (LT) is gradually replacing sorafenib as an alternative targeted drug against advanced hepatocellular carcinoma (HCC). However, the anticancer effects of LT are still limited because of its low cytotoxicity, multidrug resistance (MDR), and tumor relapse. Herein, we constructed a smart biophotonic nanoplatform to overcome the barriers preventing high performance. LT and copper sulfide nanocrystals (Cu2−xS NCs) with excellent photothermal properties in the near-infrared-II (NIR-II) zone were co-encapsulated in poly(D,L-lactide-co-glycolide) (PLGA) through nanoprecipitation. Both in vitro and in vivo evaluations demonstrated that Cu2−xS NCs enhanced the anticancer efficacy of LT, without recurrence. In addition, the presence of copper ions could allow glutathione (GHS) to be consumed and oxygen to be produced, likely suppressing the expression of P-glycoprotein (P-gp) and overcoming the issue of MDR relating to LT. More importantly, synergistic chemo-photothermal therapy with LT and Cu2−xS NCs was more effective than any single therapy or theoretical combination. This nanoplatform is promising for advancing future LT-based treatment strategies for HCC therapy.
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