Food Bioscience
·
2024
·
IF 4.8
Linhui Feng,Heping Cui,Khizar Hayat,Xiaoming Zhang,Chi-Tang Ho
The Amadori rearrangement product (GR-ARP) derived from glutathione/ribose mixture (GSH/Rib) was prepared through spray drying characterized by short-term high temperature dehydration. The water activity of spray-dried samples containing GR-ARP decreased continuously with an intensified degree of dehydration. Lower water activity (from 0.23 to 0.13) and higher GR-ARP yield (from 46.56% to 64.02%) in the spray-dried products were found with the increase of inlet temperature, the slowdown of feed speed, and the alkalization of stock solution. Moreover, during the spray drying and formation of powders, the intensified dissipation of bound water to free water promoted intermolecular condensation that compensated bound water, favoring the directed conversion of GSH/Rib into GR-ARP. Compared to rotary evaporation at 80 °C, spray drying enabled a stronger restraint of amide cleavage and sulfhydryl oxidation in GSH, which reduced the yield of GSH-derived byproducts by 16.39%. Thus, GR-ARP was achieved a peak yield of 64.02% at an initial pH of 7.00 based on more efficient intermolecular condensation and controlled side reactions of GSH when the inlet temperature was set at 170 °C. The spray-dried sample containing richer GR-ARP and other flavor precursors showed a more similar flavor profile to the heated GSH/Rib mixture (complete Maillard reaction products) than other GR-ARP-related thermal processing samples, such as vacuum-dehydrated, GR-ARP, GR-ARP + GSH, and GR-ARP + Rib samples, revealing a great potential of the ARP mixture prepared by spray drying for flavor enhancement.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
·
2024
·
IF 4.8
Yun-Lu Xu,Xue-Jian Li,Wei Cai,Wen-Ying Yu,Jing Chen,Qin Lee,Yong-Jun Choi,Fang Wu,Ying-Jun Lou,Hua-Zhong Ying,Chen-Huan Yu,Qiao-Feng Wu
Ethnopharmacological relevance Viral pneumonia is the leading cause of death after SARS-CoV-2 infection. Despite effective at early stage, long-term treatment with glucocorticoids can lead to a variety of adverse effects and limited benefits. The Chinese traditional herb Pogostemonis Herba is the aerial part of Pogostemon Cablin (Blanco) Benth., which has potent antiviral, antibacterial, anti-inflammatory, and anticancer effects. It was used widely for treating various throat and respiratory diseases, including COVID-19, viral infection, cough, allergic asthma, acute lung injury and lung cancer. Aim of the study To investigate the antiviral and anti-inflammatory effects of chemical compounds from Pogostemonis Herba in SARS-CoV-2-infected hACE2-overexpressing mouse macrophage RAW264.7 cells and hACE2 transgenic mice. Materials and methods The hACE2-overexpressing RAW264.7 cells were exposed with SARS-CoV-2. The cell viability was detected by CCK8 assay and cell apoptotic rate was by flow cytometric assay. The expressions of macrophage M1 phenotype markers (TNF-α and IL-6) and M2 markers (IL-10 and Arg-1) as well as the viral loads were detected by qPCR. The mice were inoculated intranasally with SARS-CoV-2 omicron variant to induce viral pneumonia. The levels of macrophages, neutrophils, and T cells in the lung tissues of infected mice were analyzed by full spectrum flow cytometry. The expressions of key proteins were detected by western blot assay. Results Diosmetin-7-O-β-D-glucopyranoside (DG) presented the strongest anti-SARS-CoV-2 activity. Intervention with DG at the concentrations of 1.25-50 μM not only reduced the viral replication, cell apoptosis, and the productions of inflammatory cytokines (IL-6 and TNF-α) in SARS-CoV-2-infected RAW264.7 cells, but also reversed macrophage polarity from M1 to M2 phenotype. Furthermore, treatment with DG (25-100 mg/kg) alleviated acute lung injury, and reduced macrophage infiltration in SARS-COV-2-infected mice. Mechanistically, DG inhibited SARS-COV-2 gene expression and HK3 translation via targeting YTHDF1, resulting in the inactivation of glycolysis-mediated NF-κB pathway. Conclusions DG exerted the potent antiviral and anti-inflammatory activities. It reduced pneumonia in SARS-COV-2-infected mice via inhibiting the viral replication and accelerating M2 macrophage polarization via targeting YTHDF1, indicating its potential for COVID-19 treatment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2024
·
IF 4.3
Mingyi Guan,Hui Li,Man Tu,Chenchen Fu,Xiyu Yang,Feng Wang
Trivalent chromium (Cr 3+ ) causes serious environmental pollution, degradation of the quality of edible agricultural products and human diseases. A novel phenanthro[9,10-d]imidazole-derived conjugated polymers (PIPF) was obtained from 4-(5,10-dibromo-1H-phenanthro[9,10-d]imidazol-2-yl)phenol and diethyl 4,4′-(2,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-9H-fluorene-9,9-diyl)dibutyrate by Suzuki polymerization reaction, which was reasonably demonstrated by 1 H NMR spectroscopy, infrared spectroscopy and quantum chemical calculations. The PIPF exhibits a “turn-on” fluorescence response to Cr 3+ in DMSO/H 2 O (98:2, v/v) with naked-eye detection. The limit of detection for Cr 3+ was calculated to be 0.073 μM with a linear range of 3–9 μM. The possible mechanism of the PIPF-based Cr 3+ fluorescence “turn-on” sensor is due to the inhibition of the PET process by the coordination of Cr 3+ to the hexaalkyl ester carbon chain of PIPF (RCOO-). The high sensitivity, good selectivity, and utility of this sensor indicated that PIPF-based “turn-on” fluorescence sensor is a potential fluorescence application for measuring Cr 3+ in environmental samples.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Desalination and Water Treatment
·
2024
·
IF 1
Chun Bai,Kexin Li,Yanping Wang,Haining Liu,Huifang Zhang,Quan Li,Jun Li,Xiushen Ye,Zhijian Wu
ABSTRACT A novel boron flotation agent (N-2-hydroxyoctadecyl-N-Methylglucamine, NHO-NMDG) was fabricated using 1,2-epoxyoctadecane and N-methyl-D-glucamine. The obtained collector possesses both collecting and foaming properties and it was characterized by nuclear magnetic resonance, mass spectrometry, Fourier-transform infrared spectroscopy and X-ray photoelectron spectroscopy methods. The flotation performance for boron removal from the salt lake brine has been studied. The flotation experiments indicated a highly effective removal of boron from the salt lake brine. The boron removal rate in the Da Qaidam brine could reach 67.08% by NHO-NMDG. The mechanism analysis shows that the meglumine group in the bifunctional flotation agent can be complexed with boron, and the long-chain alkyl group can attach to the surface of the bubble and enter into the bubble layer, so as to separate boron from the aqueous solution.
✓ 已验证
DOI
高影响因子
DYES AND PIGMENTS
·
2017
·
IF 3.473
Yafei Wang,Wanhui Liu,Zuoming Qu,Hua Tan,Yu Liu,Guohua Xie,Weiguo Zhu
To explore the structure-property of donor-acceptor (D-A) type blue emitter, in this contribution, four star-shaped compounds of p -TPA, m -TPA, p -TPA-TPE and m -TPA-TPE using spirotriphenylamine as the donor unit and triazine as the acceptor core were designed and prepared. The tetraphenylethene (TPE) unit was introduced into the D-A molecules to enhance the emission efficiency in solid state. The photophysical properties of all compounds were comparatively studied through experimental and theoretical methods. All these D-A compounds displayed blue emission (443–487 nm) both in solution and neat film. Compared to p -TPA and m -TPA, p -TPA-TPE and m -TPA-TPE possessed clear aggregated-induced emission (AIE) property and higher emission efficiency in the solid state. Both the doped and non-doped organic light-emitting diodes (OLEDs) based on m -TPA and m -TPA-TPE were fabricated by solution-processable approach. The m -TPA-TPE based non-doped device showed a satisfying performance with a high current efficiency of 4.2 cd/A and an external quantum efficiency of 1.8% in the bluish-green region. This research demonstrates that integrating AIE unit into D-A molecule is an effective strategy for design high efficient blue emitter in non-doped OLEDs.
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 48
·9908-9922
·
IF 6.331
Qi Xu,Qiuting Li,Zhe Yang,Piao Huang,Han Hu,Zhimin Mo,Zizhen Qin,Zushun Xu,Tianyou Chen,Shengli Yang
Lenvatinib (LT) is gradually replacing sorafenib as an alternative targeted drug against advanced hepatocellular carcinoma (HCC). However, the anticancer effects of LT are still limited because of its low cytotoxicity, multidrug resistance (MDR), and tumor relapse. Herein, we constructed a smart biophotonic nanoplatform to overcome the barriers preventing high performance. LT and copper sulfide nanocrystals (Cu2−xS NCs) with excellent photothermal properties in the near-infrared-II (NIR-II) zone were co-encapsulated in poly(D,L-lactide-co-glycolide) (PLGA) through nanoprecipitation. Both in vitro and in vivo evaluations demonstrated that Cu2−xS NCs enhanced the anticancer efficacy of LT, without recurrence. In addition, the presence of copper ions could allow glutathione (GHS) to be consumed and oxygen to be produced, likely suppressing the expression of P-glycoprotein (P-gp) and overcoming the issue of MDR relating to LT. More importantly, synergistic chemo-photothermal therapy with LT and Cu2−xS NCs was more effective than any single therapy or theoretical combination. This nanoplatform is promising for advancing future LT-based treatment strategies for HCC therapy.
✓ 已验证
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Qian Zha,Xin Wang,Xu Cheng,Shengxiang Fu,Guanqing Yang,Weijing Yao,Rupei Tang
This work describes an acid–degradable and tumor–targeted nanogels prepared by the copolymerization between lactobionic acid-modified methacrylated carboxymethyl chitosan and acid–labile methacrylated orthoester–based monomers. The size distribution and micromorphology of the prepared nanogels were observed by dynamic light scattering, transmission electron microscopy and scanning electron microscopy. The stability of nanogels in various environments was then investigated. Doxorubicin as a model drug was successfully encapsulated into nanogels. In vitro cellular uptake and MTT results indicate that the tumor–targeting and pH–sensitive nanogels display higher cellular internalization and cytotoxicity than non–target nanogels and free DOX. The improved penetration and growth inhibition against 3–D multicellular spheroids further demonstrate that the dual–functional nanogels may be a potential nano-carrier for drug delivery in cancer therapy.
✓ 已验证
DOI
PubMed
高影响因子
Journal of Energy Storage
·
2025
·
IF 9.8
Y.L. Chen,W.W. Yan,Y.F. Yuan,K.Q. Du,G.S. Cai,B.X. Wang,M. Zhu
Conventional electrolyte additives often suffer from insufficient zincophilic/hydrophilic sites and limited molecular dimensions, constraining their regulation capability. Herein, we investigate D-lactitol (LAC), a super polyol additive featuring nine uniformly distributed hydroxyl groups and extended molecular length of 7.605 Å. Abundant zincophilic/hydrophilic sites enable LAC to concurrently coordinate three Zn 2+ solvation sheaths while maintaining interactions with surrounding free water molecules through remaining hydroxyls. Moreover, vertically oriented adsorption of LAC molecules on Zn anode surface expands inner Helmholtz plane from 1.5 Å to 8 Å. The unique adsorption geometry and sterically distributed hydroxyl groups bring about physical blocking, chemical screening, Zn 2+ flux homogenization, and structural resilience. These effects collectively inhibit water and SO 4 2− access, guide dominant Zn (002) plane deposition, promote uniform transport of high-flux Zn 2+ . Consequently, LAC extends cycling lifetime of Zn||Zn symmetric cells from 27 h to 1582 h at 10 mA cm −2 /1 mAh cm −2 and from 24 h to 310 h at 20 mA cm −2 /20 mAh cm −2 , and achieves stable cycling for 326 h at a high depth of discharge (58.07 %). In Zn||Cu asymmetric cell, over 5420 cycles, LAC maintains an exceptional average Coulombic efficiency of 99.74 %. Furthermore, LAC enhances cycling stability and rate performance of Zn||MnVO full cells. This study advances molecular engineering of electrolyte additives for advanced Zn anodes.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Macromolecular Science Part B-Physics
·
2022
·
IF 1.366
Jiaming Gu,Zhihua Zhou,Tianlong Huang,Wei Wu,Wenjuan Liu,Yanmin Zhao,Ping Chen,Ziwei Zhou,Dan Wang,Chao Zhang,Meilin Yi,Xiao He,Jianjun Fang
Composite porous microspheres based on blends of poly(D,L-lactide-co-glycolide-co-ε-caprolactone) (PLGCL) and 1,4-butanediamine modified poly(D,L-lactide-co-glycolide) (BMPLGA) were prepared by using a combined solvent evaporation and particle leaching technique. The morphologies and porous structure of the PLGCL/BMPLGA microspheres were observed by using scanning electron microscopy (SEM). The in-vitro degradation behaviors and cytocompatibility were studied. The resultant microspheres showed a porous surface and a three-dimensional network structure with interconnecting pores. The changes of morphologies, pH value and mass loss during in-vitro degradation in phosphate buffered solution (PBS) at 37°C indicated that the degradation rate of the BMPLGA was faster than that of the PLGCL in the PLGCL/BMPLGA blends. We suggest the PLGCL/BMPLGA porous microspheres were non-cytotoxic and showed excellent cytocompatibility. We suggest the PLGCL/BMPLGA porous polymeric microspheres have great potential for application for drugs delivery and tissue regeneration.
✓ 已验证
DOI
高影响因子
Microbial Cell Factories
·
2026
·
IF 5.8
Lin Menghui,Zheng Miao,Chen Kaiyi,Xu Xinyu,Chen Li,Guo Xiaogang,Le Thanh Ninh,Zhao Minjie,Feng Yanru,Cai Haiying
Heat stress is prevalent in industrial biomanufacturing processes including Baijiu brewing and bioethanol production. It disrupts the membrane structure and lipid homeostasis of Saccharomyces cerevisiae , interferes with genome-wide gene transcription and retards cell growth, thereby greatly lowering fermentation efficiency and product yields. There is an urgent demand for food-safe additives to alleviate heat-induced damage to industrial yeast. Although vitamin D₂ (VD₂) shares a similar sterol structure with endogenous yeast ergosterol, its regulatory effects on yeast under heat stress remain poorly understood. Here, we adopted an integrated strategy combining phenotypic characterization, lipidomics, transcriptomics and molecular docking to explore the protective effects and regulatory pathways of exogenous VD₂ against heat stress in S. cerevisiae . Phenotypic assays showed that VD₂ supplementation effectively alleviated heat-induced growth retardation, elevated intracellular glutathione peroxidase activity and reduced membrane injury. Lipidomic analysis revealed that VD₂ remodelled cellular lipid profiles by increasing triglyceride levels, decreasing phosphatidylcholine content and promoting sphingolipid synthesis. Transcriptomic results further demonstrated significant upregulation of key genes involved in the S-adenosylmethionine (SAM) metabolic axis. Integrated multi-omics data and molecular docking prediction support a tentative mechanistic hypothesis: VD₂ may interact with Opi3p and potentially interfere with its catalytic function, which could further drive downstream metabolic reprogramming. In conclusion, this study reveals that VD₂ alleviates heat-triggered growth suppression by remodelling the SAM-dependent lipid metabolic network. As a food-grade additive, VD₂ possesses promising potential to alleviate heat-induced growth retardation of yeast starters in industrial fermentation. Our findings provide a theoretical basis for developing natural additives to mitigate yeast heat damage and optimizing high-temperature fermentation bioprocesses.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Liangmin Ning,Shuai Li,Shiyan Sheng,Jiuheng Ma,Jiawen Wang,Tianyu Zhang,Shun Wang,Jingyi Han,Jiaoyang Wang,Wei Chen,Meng Gao,Kunhua Wang,Min Fu,Hao Yu
Addressing the key challenges of controllable hydrogen transfer and directional C O bond activation in Meerwein-Ponndorf-Verley (MPV) reactions, this study constructed a Pt-CuO/Al 2 O 3 catalyst featuring Pt δ- Lewis acid-metal pairs for selective hydrogenation of biomass-derived furfural via the MPV reduction pathway. Under optimized conditions, the catalyst achieved 99.9% conversion with 98.0% selectivity. Density functional theory (DFT) analysis revealed that compared to isolated Pt, the d -band center of Pt in Pt-CuO/Al 2 O 3 shifts downward by 0.14 eV, while the d -band center of Cu shifts upward by 0.28 eV. Combined with the distinct metal-support interactions observed in EXAFS spectra, these results confirm that d -band center modulation creates a synergistic electronic structure of Pt δ– Cu δ+ : the upshifted d -band center of Cu δ+ enhances oxygen affinity, promoting co-adsorption of carbonyl and hydroxyl groups and facilitating six-membered ring transition state formation, while the downshifted d -band center of Pt δ- optimizes hydrogen transfer through interfacial electron transfer (Cu → Pt). These findings demonstrate the stable coordination environment of these Lewis acid-metal pairs. This work reveals the synergistic mechanism of Pt δ– Cu δ+ active sites and elucidates the cooperative “metal electron enrichment-oxide electron deficiency” effect in MPV reactions, providing new insights for designing highly efficient and selective biomass hydrogenation catalysts.
✓ 已验证
产品关联
DOI
高影响因子
Food Bioscience
·
2026
·
IF 6.2
Siyi Liu,Mingqin Kang,Zhongping Dong,Shuyan Xiao
The occurrence of pharmaceutical residues, including antibiotic ciprofloxacin (CIP) and the chelating drug D-penicillamine (D-PA), in food and environmental samples has raised increasing concerns regarding food safety and public health. Herein, a bioinspired single-atom copper nanozyme was synthesized via a template-guided strategy by encapsulating sodium copper chlorophyllin (SCC) within zeolitic imidazolate framework-8 (ZIF-8). SCC served as a biomimetic precursor, mimicking the active sites of natural oxidase enzymes. Upon pyrolysis, it guided the in-situ formation of atomically dispersed Cu–N x sites. The resulting nanozyme efficiently catalyzed 3,3′,5,5′-tetramethylbenzidine oxidation and enabled dual colorimetric detection of CIP and D-PA. CIP produced a signal-enhancement response by coordinating with the Cu centers, which facilitated interfacial electron transfer and accelerated the oxidase-like catalytic reaction. In contrast, D-PA induced a signal-suppression response by competitively occupying the Cu active sites through its thiol and amino groups and by reducing oxidized TMB (oxTMB) to its colorless form. Linear detection ranges were 1–7 μg/mL for both analytes, limits of detection of 0.097 μg/mL for CIP and 0.108 μg/mL for D-PA. Recoveries ranged from 94.38% to 103.71% in milk and from 97.73% to 105.18% in river water samples, demonstrating reliable performance in real samples. This work provides a straightforward approach for multi-target colorimetric sensing using Cu single-atom nanozymes, with promising applications in food safety and environmental analysis.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）