CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Dongcheng Wu,Wenjie Yan,Xin Zhang,Jicai Zhang,Ting Liu,Zenghui Qiu,Yangqi Zhang,Xinmiao Liu,Shuwei Zhang,Haijun Xu
The induction electrode plays a critical role in determining triboelectric nanogenerator (TENG) performance through electrostatic induction. However, traditional fabrication methods involving metal tape adhesion face inherent limitations: i. The adhesive layer increases induction distance (which is inversely proportional to maximum surface charge density), consequently reducing output; ii. Their susceptibility to inelastic deformation prevents reliable operation under flexible/elastic strain required by wearable devices. To address these challenges, we developed a novel in-situ photocatalytic method for synthesizing silver nanoparticle (AgNPs) electrodes. Achievable even with ambient sunlight, this simple synthesis process can be accelerated to 1 min using high-power illumination. This method eliminates the adhesive layer required by traditional electrodes, enabling exceptional flexibility, stability, and adaptability. Free from expensive instruments, our low-cost method achieves 187 % enhanced output over traditional electrodes, rivaling magnetron-sputtered electrodes. The AgNPs electrode hybridized with minimal silver nanowires (AgNWs) exhibits superior resistance stability compared to the pure AgNWs electrode, using only 2.5 % AgNWs nano-material. Benefiting from the structural merits of AgNPs and their hybrid architecture, the developed electrodes achieve good flexibility and elastic strain performance. These advancements demonstrate the high potential of AgNPs induction electrodes for high-performance TENGs and wearable applications.
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Materials Today Energy
·
2025
·
IF 8.6
Fucheng Yu,Zehao Wu,Cheng Qian,Zengguang Huang,Yueyi liu,Jinghong Zhang,Sihua Zhong
Antimony sulfide (Sb 2 S 3 ) has emerged as a promising top cell candidate for tandem solar architectures due to its suitable bandgap, environmentally friendly and earth-abundant composition. However, sulfur volatilization during the preparation process always affects the quality of the thin film and the photovoltaic performance. To address this challenge, we developed a simple in-situ passivation approach applied during Sb 2 S 3 hydrothermal deposition via the strategic supplementation of sulfur source in precursor solutions. This methodology effectively boosts minority charge carrier life time during preparation processing, concurrently enhancing crystalline quality and improving power conversion efficiency (PCE) of the device. Besides reducing the defect of Sb 2 S 3 absorber, we further systematic optimized the electron transport layer (ETL) architecture by using TiO 2 /CdS bilayer to accelerate the charge transfer rate at the interface of Sb 2 S 3 and ETL and to reduce parasitic light absorption. As an overall result, a PCE of 6.83% with a high open-circuit voltage ( V oc ) of 811.5 mV has been achieved, which is the highest V oc for Sb 2 S 3 solar cells to date. This study provides a promising sulfur passivation strategy for the Sb 2 S 3 solar cells by hydrothermal method.
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2025
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IF 6.1
Jiezhen Huang,Zheng Huang,Na Chen,Qiufen Li,Yiyuan Fu,Xiaolong Jin,Xiaohui Xie,Honggang Li,Xiaoyan Wan
Increasing evidence indicates that the maternal preconception environment and lifestyle affect offspring health; however, the effects of paternal preconception environment and lifestyle have rarely been examined. Therefore, we aimed to examine whether paternal infertility-related factors affect offspring produced via assisted reproductive technology in mice. Scrotal heat impairment, which can result from factors such as varicoceles, sauna use, physical inactivity, or occupations such as welding, is a common risk factor associated with reduced male fertility. To model these effects, we exposed the scrota of C57BL/6 J male mice to 39 °C water for 30 min once weekly for 5 consecutive weeks, establishing frequent and mild scrotal heat stress (fmSHS) that mimics human SHS. Sperm from these mice, along with untreated female oocytes, were used for in vitro fertilization with embryo transfer to produce first-generation (F1) offspring. Second-generation (F2) offspring were obtained by mating F1 males with untreated females. Reduced spatial memory was observed in F1 males derived from fmSHS-exposed fathers, whereas F2 fmSHS males showed no significant impairment in spatial-memory testing. In F1 fmSHS offspring, hippocampal histology and N-methyl-D-aspartate receptor expression did not differ from controls. However, genes involved in the long-term potentiation pathway were dysregulated in the hippocampi of F1 fmSHS males, and abnormal methylation of the Pi3kcg promoter was observed in both the sperm of fmSHS fathers and the hippocampi of F1 males. These findings highlight the adverse effects of paternal preconception scrotal heat stress on offspring health.
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2025
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IF 6.1
Rui Li,Jiangbo Qu,Xinyuan Hu,Tianjia Song,JunXia Hu,Yuanqing Zhang
Methylisothiazolinone (MIT), a prevalent antimicrobial agent utilized in pharmaceuticals, cosmetics, and industrial contexts, presents potential toxicity concerns. Recent investigations have corroborated its neurotoxic effects in zebrafish and suggested involvement of the Hedgehog signaling pathway, although the specific regulatory mechanisms remain to be elucidated. In this study, transcriptome-based gene-pathway network analysis identified hhip within the Hedgehog pathway. Expression profiling and in situ hybridization revealed it is suppressed by MIT exposure and displays high expression in the zebrafish midbrain and hypothalamus. Dual-luciferase reporter assays in the zebrafish Pac2 cell line demonstrated that hhip suppresses transcription of the Hedgehog target gene gli1 and modulates reactive oxygen species (ROS) levels and oxidative stress-related gene expression. Moreover, pharmacological inhibition of the Hedgehog pathway with Ciliobrevin A (CA) during MIT exposure ameliorated anxiety-like behaviors in zebrafish, such as aberrant edge preference (thigmotaxis). This intervention downregulated Hedgehog pathway activity, elevated expression of oxidative stress genes (e.g., gpx4 ), reduced expression of the ferroptosis marker gene tf , attenuated the loss of Nissl bodies in brain tissue, and decreased brain iron content. These findings suggested that MIT exposure is associated with molecular signatures indicative of Hedgehog pathway activation. This cascade of molecular events is associated with subsequent anxiety-like behaviors, implying its potential contribution to the behavioral phenotype. In vitro studies using Pac2 cells further corroborated that inhibition of the Hedgehog pathway alleviates the increase in lipid peroxidation induced by the ferroptosis inducer Erastin. Collectively, these results elucidated the molecular regarding MIT-induced neurotoxicity and offer potential preventive and interventional strategies for addressing toxicity associated with this class of compounds.
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Advanced Science
·
2025
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IF 14.1
Hang Zhang,Xin Shen,Haiyang Liu,Xinxi Yuan,Mumin Cao,Xuepeng Lv,Ziji Ling,Songsong Guo,Rongyao Xu,Xiang Li,Hongbing Jiang
Mitochondria-driven macrophage dysregulation contributes significantly to inflammatory disease progression; however, the mechanism underlying bisphosphonate-related osteonecrosis of the jaw (BRONJ) remains unclear. This study demonstrates that zoledronic acid (ZA) disrupts mitochondrial bioenergetic function in macrophages, leading to elevated mitochondrial membrane potential, excessive mitochondrial reactive oxygen species (mtROS), and increased HIF-1α expression, which together promote a pro-inflammatory transition in macrophages. ZA further inhibits autophagy by activating the TLR4-MyD88/PI3K-AKT-mTOR pathway, preventing the clearance of dysfunctional mitochondria and sustaining superoxide production. Genetic loss of Atg5 in innate immune cells disrupts autophagosome maturation and markedly worsens ZA-induced BRONJ development. To restore mitochondrial degradation and biofunction, ZA-loaded nanoparticles incorporating the mTOR inhibitor rapamycin (ZDPR) are developed. ZDPR effectively prevents BRONJ and exerts therapeutic benefits in osteoporosis and osteolysis. These findings highlight bone-targeted mitochondria rescue as a promising strategy to enhance antiresorptive therapy.
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Food & Function
·
2021
·Vol. 13
·期 1
·437-450
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IF 5.396
Xiao-Feng Zhang,Yu-Jun Tang,Xiao-Xian Guan,Xin Lu,Jiao Li,Xiao-Li Chen,Jin-Lan Deng,Jian-Ming Fan
Amomum tsao-ko Crevost et Lemarie (A. tsao-ko) is a well-known dietary spice and traditional Chinese medicine. This study aimed to identify the flavonoids in A. tsao-ko and evaluate their antioxidant and antidiabetic activities in in vitro and in vivo studies. A. tsao-ko methanol extracts possessed a high flavonoid content (1.21 mg QE per g DW) and a total of 29 flavonoids were identified by employing UPLC-MS/MS. In vitro, A. tsao-ko demonstrated antioxidant activity (ORAC value of 34276.57 μM TE/100 g DW, IC50 of ABTS of 3.49 mg mL−1 and FRAP value of 207.42 μM Fe2+ per g DW) and α-amylase and α-glucosidase inhibitory ability with IC50 values of 14.23 and 1.76 mg mL−1, respectively. In vivo, type 2 diabetes mellitus (T2DM) models were induced by a combined high-fat diet (HFD) and streptozotocin (STZ) injection in rats. Treatment with the A. tsao-ko extract (100 mg freeze-dried powder per kg bw) for 6 weeks could significantly improve impaired glucose tolerance, decrease the levels of fasting blood glucose (FBG), insulin, and malondialdehyde (MDA), and increase the superoxide dismutase (SOD) level. Histopathology revealed that the A. tsao-ko extract preserved the architecture and function of the pancreas. In conclusion, the flavonoid composition of A. tsao-ko exhibits excellent antioxidant and antidiabetic activity in vitro and in vivo. A. tsao-ko could be a novel natural material and developed as a related functional food and medicine in T2DM management.
研究领域:
药理学
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营养学
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药物化学
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糖尿病研究
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ENERGY & FUELS
·
2021
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IF 3.605
Zejun Zhang,Xuening Feng,Guanxin Zeng,Huanyu Liu,Liwei Shen,Ying Yang,Huaikui Yuan,Xuemin Yan,Yuanzhu Mi
Hyperbranched poly(amido amine) demulsifiers (PNDA-1 or PNDA-2) were synthesized with 1,5-diaminonaphthalene or 1,8-diaminonaphthalene as the central core by an improved “one-pot” method. Fourier transform infrared spectroscopy, nuclear magnetic resonance hydrogen spectra, and thermogravimetric analysis were utilized to explore their structure and thermal stability. It indicated that the two hyperbranched demulsifiers had good thermal stability. To evaluate their demulsification performance, some important factors such as concentration of the demulsifier, types of emulsion, temperature, and settling time were systematically investigated. When 80 mg/L of PNDA-1 or PNDA-2 was used in oily wastewater (O/W emulsion) at room temperature for 4 h, the light transmittance of the separated water reached 73.7 and 59.3%, respectively. The corresponding oil removal rate reached as high as 99.62 and 99.50%, respectively. After demulsifying with the concentration of 80 mg/L at 70 °C for 120 min, the demulsification efficiency (DE) of PNDA-1 and PNDA-2 in the crude oil emulsion (W/O emulsion) reached 92 and 83%, respectively. The DE of PNDA-1 is obviously better than that of PNDA-2 in both O/W and W/O emulsions. The possible demulsification mechanism was discussed by the interfacial tension, zeta potential, and micrograph analysis. The current work provided new hyperbranched demulsifiers, and the discussion on the mechanism also provided some references for the research of a demulsifier.
研究领域:
化学工程
·
材料科学
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BMC Veterinary Research
·
2026
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IF 2.6
Qihang Liang,Qi Wang,Pinqi Chi,Depeng Fan,Beiping Tan,Shiwei Xie,Junming Deng,Hongyu Liu,Ling Zeng
Antimicrobial peptide BmKn2-7, a rationally optimized derivative of the scorpion venom peptide BmKn2, shows strong potential as an antibiotic alternative for controlling Vibrio parahaemolyticus in aquaculture. This study evaluated its antibacterial mechanisms and in vivo efficacy in Litopenaeus vannamei through biochemical assays, transcriptomic profiling, and challenge experiments. BmKn2-7 exhibited potent in-vitro activity (MIC = 125 µg/mL) and disrupted bacterial homeostasis by increasing membrane permeability, inducing oxidative stress, and inhibiting P-type ATPase. RNA-seq analysis revealed extensive transcriptional reprogramming, including the downregulation of quorum-sensing, virulence, and β-lactam resistance–associated genes. In vivo, BmKn2-7 significantly improved shrimp survival following V. parahaemolyticus infection and selectively reduced Vibrio abundance in the gut without compromising overall microbiota diversity. Together, these findings demonstrate that BmKn2-7 acts through complementary bactericidal and anti-virulence pathways while promoting intestinal microbial resilience, supporting its potential as a promising antimicrobial candidate for reducing vibriosis risk in shrimp aquaculture.
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Journal of Traditional Chinese Medicine
·
2026
·Vol. 46
·期 3
·552
·
IF 2.6
Xiaoxiao LU,Yipeng XU,Minjie ZHOU,Chengshun ZHANG,Dingjun CAI,Zhengyu ZHAO
OBJECTIVE: To test whether acupuncture improves sleep by enhancing gamma-aminobutyric acid-ergic (GABA) neuronal activity in the thalamic reticular nucleus (TRN). METHODS: We established an animal model using p-chlorophenylalanine (PCPA). We assessed the impact of acupuncture on insomnia through wheel-running activity and sodium pentobarbital-induced sleep tests. Subsequently, the calcium indicator GCaMP6m was injected into the TRN of Vgat-Cre mice, and the activity of GABA neurons in the TRN was analyzed before and after acupuncture using fiber photometry recording. Additionally, cortical electroencephalography (EEG) recordings were compared between groups following chemogenetic inhibition of GABA neurons in the TRN. RESULTS: Following acupuncture, we observed a reduction in sleep latency and an increase in sleep duration in comparison to the PCPA-induced insomnia ( P < 0.01). Furthermore, acupuncture positively influenced the diurnal phase of insomnia ( P < 0.01). Ca 2+ signals in GABA neurons within the TRN increased post-acupuncture (paired t- test, P < 0.01). Acupuncture also reduced the proportion of EEG power in the elevated Beta and Gamma frequencies associated with PCPA injection, while simultaneously increasing the Delta power ratio ( P < 0.01). Chemogenetic inhibition of TRN GABA neurons blocked these acupuncture effects: the hM4Di + MA group showed no significant differences from the PCPA group in Beta and Gamma power, but exhibited elevated Beta and Theta activity compared to controls ( P < 0.05). CONCLUSIONS: Acupuncture activates GABA neurons in the TRN, thereby regulating the sleep-wake cycle in the context of PCPA-induced insomnia.
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DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
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2019
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IF 2.367
Qiuxuan Yang,Qilong Wang,Yingshu Feng,Qiuyu Wei,Congyong Sun,Caleb Kesse Firempong,Michael Adu-Frimpong,Ran Li,Rui Bao,Elmurat Toreniyazov,Hao Ji,Jiangnan Yu,Ximing Xu
The prevalence of hyperuricemia is relatively high worldwide, and a great number of patients are suffering from its complications. 6-shogaol, an alkylphenol compound purified from the root of ginger (Zingiber officinale Roscoe), has been proved to possess diverse pharmacological activities. However, its poor aqueous solubility usually leads to low bioavailability, and further clinical applications will be greatly discounted. The current study aimed to formulate a 6-shogaol-loaded-Self Microemulsifying Drug Delivery System (SMEDDS) to amend low aqueous solubility and bioavailability orally, as well as, potentiate the hyperuricemic activity of the 6-shogaol. SMEDDS was developed with central composite design established on a two system components viz., 18.62% W/W ethyl oleate (oil phase) and ratio of tween 80 (surfactant) to PEG 400 (co-surfactant) (1.73:1, W/W). Based on quadratic model, the navigation of the design space could generate spherically-shaped and homogenous droplets with respective mean particle diameter, polydispersity and of 20.00 ± 0.26 nm and 0.18 ± 0.02. The 6-shogaol-SMEDDS showed significant elevation of cumulative release compared with the free 6-shogaol and more importantly a 571.18% increment in the relative oral bioavailability of the drug. The predominant accumulation of 6-shogaol-SMEDDS in the liver suggested hepatic-targeting potentiality of the drug. Oral administration of 6-shogaol-SMEDDS in hyperuricemic rats also significantly decreased uric acid level and xanthine oxidase activity. Histological studies confirmed formulation groups indeed could provide better protection of kidney than free drug groups. Collectively, these findings indicated that the SMEDDS hold much promise in enhancing the oral delivery and therapeutic efficacy of 6-shogaol.
研究领域:
药剂学
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代谢病学
·
中药学
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2016
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IF 2.857
Qian Li,Xieyi Wang,Taotao Dai,Chengmei Liu,Ti Li,David Julian McClements,Jun Chen,Jiyan Liu
The production of new blood vessels (angiogenesis) is an important stage in the growth and spread of cancerous tumors. Anti-angiogenesis is one strategy for controlling tumor progression. This study evaluated the antioxidant and anti-angiogenic activities of a proanthocyanidins (PAs) extract from Choerospondias axillaris peels. HPLC-MS analysis revealed that numerous oligomeric forms of the PAs were detected in the PAs extract, including dimers, trimers, tetramers, and flavan-3-ol monomers. The PAs extract possessed appreciable free radical scavenging activity (IC50/DPPH = 164 ± 7 μg/mL, IC50/ABTS = 154 ± 6 μg/mL), potent reducing power (0.930 ± 0.030 g AAE/g), and strong cellular antioxidant activity (EC50 = 10.2 ± 1.4 and 38.9 ± 2.1 μg/mL without or with PBS-wash, respectively). It could also retard various stages of angiogenesis, such as the migration of endothelial cells and the creation of tubes, without causing toxicity to the cells. With regard to intracellular signal transduction, the PAs extract attenuated the phosphorylation of Akt, ERK, and p38MAPK dose-dependently in endothelial cells from human umbilical veins. In transgenic zebrafish embryo, new blood vessel formation was suppressed by PAs extract in a concentration-dependent manner at 72 h post fertilization. Thus, these results suggest that PAs from C. axillaris peels could be a good source of natural inhibitors to target angiogenesis.
研究领域:
药理学
·
肿瘤学
·
植物化学
·
分子生物学
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高影响因子
CELLULOSE
·
2022
·Vol. 29
·期 2
·1017-1034
·
IF 6.123
Sun Lijian,Qian Xueren,An Xianhui
Cellulose-based bioplastics with degradability and remarkable mechanical performance have recently attracted increasing attention. As a high-performance material, cellulose-based bioplastics have a strong potential to replace synthetic plastic substrates in many applications. However, its poor shielding performance to UV light limit its application. In this work, transparent and UV-blocking MIL-68(In)-NH 2 @cellulose bioplastic (M(In)CBP) sheets are fabricated via a featured processing method, i.e., cellulose liquefaction, rapid solidification, in-situ synthesis and hot-press drying. The as-obtained functional bioplastic sheet (M(In)CBP1) exhibits high visible-light transparence (74.7% a 600 nm) and the existence of MIL-68(In)-NH 2 allows superior UV-blocking ability (below 400 nm, transmittance was under 4%). The M(In)CBP sheets show high photostability even after continuous UV irradiation (365 nm) for over 12 h. The superior UV-shielding performance is attributed to the uniform distribution and the high UV absorbance of MIL-68(In)-NH 2 in M(In)CBP sheets. High resistance to penetration by aqueous/nonaqueous liquids was proved. Moreover, the M(In)CBP sheets also show excellent mechanical properties and thermal stability. The present work designed a UV-blocking bioplastic constructed from cellulose and MIL-68(In)-NH 2 , which is potential candidates to replace synthetic plastics in many advanced applications such as a UV protection layer for electronic products, or useful as packaging materials to prevent food spoilage. Graphical abstract
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危险品化学品经营许可证（带存储）