Acta Biomaterialia
·
2025
·
IF 9.6
Yating Wang,Yixuan Xu,Dejia Chen,Xin Li,Dalong Yin,Lifeng Yan
Photothermal therapy (PTT) utilizes localized hyperthermia above 50 °C generated by nanomaterials upon exposure to near-infrared (NIR) laser light for effective cancer cell eradication. Yet, in high-temperature PTT, tumor cells develop heat stress tolerance due to elevated heat shock protein (HSP) levels, diminishing therapeutic efficacy. Moreover, excessive heat can trigger inflammatory conditions and promote cancer metastasis. Targeting the glycolytic pathway in highly metabolically active tumor cells offers a promising strategy for inducing starvation therapy, capitalizing on their vigorous energy demands amidst rapid proliferation. Here, we synthesized a highly luminous NIR-II dye, FNF, followed by its encapsulation alongside myricetin (My) within amphiphilic polypeptide carriers through a self-assembly method. The resulting nanoparticles exhibited great NIR-II imaging capabilities and boasted a notable photothermal conversion efficiency of 55.58 %. Furthermore, My effectively impeded glucose transport facilitated by glucose transporter protein 1 (GLUT1), curtailing glucose supply to tumor cells. This interference disrupted mitochondrial energy production, resulting in decreased adenosine triphosphate (ATP) synthesis and subsequent downregulation of HSP70 expression. By leveraging this approach, which targeted HSP expression via GLUT1 inhibition, we enhance the efficacy of PTT while achieving a synergistic effect for mild photothermal therapy through starvation. Statement of significance High expression of heat shock proteins (HSPs) in cancer cells impairs the efficacy of photothermal therapy (PTT) and triggers inflammation or metastasis, among other effects. Rapid malignant proliferation of tumor cells results in high energy metabolism, so interfering with their glucose metabolism to inhibit the glycolytic process is a feasible route for tumor starvation therapy. Here, we employed an amphiphilic polypeptide encapsulated photosensitizer (FNF) and myricetin (My) to construct nanoparticles with both NIR-II imaging capability and high photothermal conversion efficiency (55.58 %). Among them, My blocked glucose transport mediated by glucose transporter protein 1 (GLUT1), reduced the glucose supply and ATP synthesis in cancer cells, and then down regulated HSP70 expression. Thus, this strategy achieves starvation synergistic mild photothermal therapy through metabolic disruption.
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Qing Li,Ning Liu,Dayu Wang,Lie Ma,Mingzhou Wu,Enna Ha,Junqing Hu,Zhe Zhang,Shuqing He
Silver sulfide (Ag 2 S) quantum dots (QDs), which emit light in the near-infrared II window (NIR-II, 1000–1700 nm), exhibit unique and remarkable potential in bioluminescence. However, their widespread application in experimental research is currently limited by a relatively low quantum efficiency. Cation exchange reactions have emerged as a remarkably versatile approach for synthesizing nanomaterials with adjustable structures and customizable compositions. In this study, we developed a NIR-II fluorescent probe based on Sn-doped silver sulfide (Sn-Ag 2 S) QDs via a straightforward cation exchange method. The stoichiometric ratios of precursors play a crucial role in tailoring the optical properties of the resultant materials during structural modifications involving cation exchange processes. By optimizing the ratio of Ag and Sn, we obtained ca. 16-fold quantum yields enhancement of Sn-Ag 2 S QDs in the NIR-II range, specifically around strong emission peak at ca. 1200 nm. Following hydrophilic modification, the Sn-Ag 2 S-GSH/MPA QDs exhibited high NIR-II fluorescence signal signal-to-noise ratio (S/N) with a ca. 1.7-fold increase compared to Ag 2 S-GSH/MPA QDs in the femur of mice, showing significant potential for bone imaging. To further investigate the QDs biodistribution mechanisms within osseous microenvironments, we devised a comprehensive multimodal analytical approach incorporating: (1) optical spectral analysis, (2) ultrastructural validation through transmission electron microscopy (TEM), and (3) spatial resolution mapping via laser scanning confocal microscopy (LSCM). These integrated methodologies consistently demonstrated preferential QDs accumulation within trabecular bone marrow compartments, revealing distinct biodistribution patterns in mineralized tissues.
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2025
·
IF 12.9
Jingchuan He,Tingting Li,Xiaoqin Pan,Zhihua Deng,Jifu Huang,Xiaocheng Mo,Xiaoju Shen,Xiumei Qin,Xingye Yang,Ming Gao,Jie Yang
Combination therapy is a promising strategy for lung adenocarcinoma (LUAD), due to the advantages of overcoming drug resistance, side effects, and tumor heterogeneity. Herein, we report a novel dual-targeting bimetallic nanozyme (MH-iRGD) consisting of nanosized manganese ferrite (MF) after encapsulating with dopamine and methacrylic anhydride to modify hyaluronic acid, followed by integrin receptor targeting peptide (HS-PEG3400-iRGD) modification for LUAD targeted therapy. Our study confirmed that MH-iRGD combined with near-infrared irradiation (NIR) possessed dramatic photothermal effects and reactive oxygen species (ROS) production and GSH depletion abilities. Importantly, MH-iRGD possessed dual-targeting capacities for LUAD cells overexpressed CD44 and αV-integrin receptors owing to hyaluronic acid coating and iRGD modification. Inhibitors of CD44 and integrins could impair the uptake of MH-iRGD in LUAD cells. Moreover, MH-iRGD+NIR displayed excellent anti-LUAD effects as a result of the production of intracellular ROS, consumption of glutathione (GSH) and mitochondrial dysfunction. Mechanistically, NIR robustly strengthened MH-iRGD-induced ferroptosis and apoptosis by down-regulating SLC7A11, GPX4, Bcl-2 levels while up-regulating Bax level. Specifically, ferroptosis and apoptosis were increased while the LUAD progression was inhibited after intravenous injection of MH-iRGD+NIR in xenograft mouse models. Taken together, our results indicate that MH-iRGD+NIR serves as a promising targeted therapy for LUAD, which broadens the applications of highly active dual-targeting bimetallic nanozymes.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Earth and Space Chemistry
·
2025
·
IF 2.9
Qi Tao,Yonglei Zhang,Tianqi Zhang,Xiaorong Qin,Binglong Ye,Hongping He,Sridhar Komarneni
Over the past decade, remote sensing exploration has revealed widespread detection of clay minerals in Noachian terrains (>3.7 Ga) on Mars, suggesting a period of active near-surface water–rock interaction. The in-depth characterization of the crystal structure and chemistry of laboratory-synthesized smectite minerals with varying compositions offers a unique perspective to further constrain their formation mechanism, environmental conditions, and the climate of early Mars. This study synthesized smectites with varying Fe/Mg ratios to compare their near-infrared (NIR) spectral characteristics with those of representative areas on Mars. The study revealed that the characteristic metal–OH (M–OH) band in the range of 2270–2320 nm shifted toward longer wavelengths as the octahedral Fe3+ content decreased. When the octahedral Fe/Mg ratio was close to 1, the position of M–OH was similar to that of Mg-smectite (saponite), indicating that although the M–OH band of smectite is located at ca. 2308–2312 nm, it may still contain a significant amount of octahedral Fe3+. This suggests that there are likely still many Fe-smectites in Mg-rich smectite outcrops (ca. 20% as in the literature) on the Martian surface. Furthermore, correlation analysis between the smectite layer stacking order index (V/P) and the second-order derivative band intensity ratio (Deriv2 ratio) showed that when the Deriv2 ratio is small (generally <8), smectite has a relatively high degree of layer stacking order. When the Deriv2 ratio is >10 and tends toward infinity (+∞), the layer stacking order of smectite is very low. The above results suggest that the crystal chemical characteristics of smectites should be carefully studied when analyzing the mineral composition of the Mars surface using remote sensing or in situ NIR spectra. Smectites on Mars generally exhibit a high layer stacking order, indicating the presence of a relatively long-term warm and humid climate in Martian history. However, later alteration processes can significantly reduce their crystallinity.
✓ 已验证
产品关联
DOI
高影响因子
Analytical Chemistry Letters
·
2025
·
IF 1.6
Xiaoyan Duan,Shiyi Chen,Feiyan Tian,Ganghui Chu
In this study, the newly synthesized ScAg-MOFs was used as a like-peroxidase. Based on the positive correlation between uric acid concentration and the (3,3,5,5-tetramethylbenzidine) TMB oxidation inhibition rate, a partial least squares (PLS) model was developed to predict the oxidative inhibition of TMB. The results indicate that the combination of standard normal variable transform and continuous wavelet transform (SNV + CWT) with competitive adaptive reweighted sampling (CARS) yielded a root-mean-square error of cross-validation (RMSECV) of 8.6460%, and a root-mean-square error of prediction (RMSEP) of 7.9731%. The correlation coefficient for the calibration set (R_CV) was 0.9430, for the validation set (R) it was 0.9459, and the prediction deviation ratio (RPD) was 3.0268. This suggests that the model is quite accurate, and it demonstrates the feasibility of this method for rapid uric acid detection.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Zhongyu Tong,Jiamin Li,Yuqing Yan,Feifeng Huang,Guanyu Zhu,Huanping Wang,Hua Yu,Degang Deng
The development of tunable broadband near-infrared (NIR) fluorescent materials with excellent luminescent properties is still a challenge for the next generation of intelligent NIR light sources. Here, a series of Cr 3+ doped magnetoplum type NIR phosphors were prepared by the high-temperature solid-state method. Their luminescent properties and the methods to broaden the luminescence bandwidth were discussed in detail. In BaAl 12 O 19 : Cr 3+ phosphor, Cr 3+ -Cr 3+ ion pair was constructed based on heavily doped Cr 3+ ions, so as to broaden its spectral emission range. With the increase of Cr 3+ doping concentration, the full width at half maximum (FWHM) of BaAl 12 O 19 : Cr 3+ sample increased from 18.5 nm to 93.7 nm. Furthermore, the crystal field environment of Cr 3+ ions in BaAl 12 O 19 : Cr 3+ phosphors was changed by cationic substitution (Sr 2+ substituted Ba 2+ ion site). The FWHM of NIR emission increases from 49.37 nm to 123.78 nm, and the internal quantum efficiency (IQE) increases from 65.6 % to 76.2 %, with good thermal stability ( I 373 K / I 298 K = 77.3 %). An intense NIR emission of 31.3 mW at 100 mA is produced by the phosphor-converted light-emitting diode (pc-LED), exhibiting a photoelectric efficiency of 15.3 %.
✓ 已验证
产品关联
DOI
高影响因子
Biosensors-Basel
·
2021
·Vol. 11
·期 5
·148
·
IF 5.519
Tingting Peng,Rui Pu,Baoju Wang,Zhimin Zhu,Kai Liu,Fan Wang,Wei Wei,Haichun Liu,Qiuqiang Zhan
Lanthanide-doped upconversion nanoparticles (UCNPs) are promising bioimaging nanoprobes due to their excellent photostability. As one of the most commonly used lanthanide activators, Tm3+ions have perfect ladder-type electron configuration and can be directly excited by bio-friendly near-infrared-II (NIR-II) wavelengths. Here, the emission characteristics of Tm3+-doped nanoparticles under laser excitations of different near-infrared-II wavelengths were systematically investigated. The 1064 nm, 1150 nm, and 1208 nm lasers are proposed to be three excitation strategies with different response spectra of Tm3+ions. In particular, we found that 1150 nm laser excitation enables intense three-photon 475 nm emission, which is nearly 100 times stronger than that excited by 1064 nm excitation. We further optimized the luminescence brightness after investigating the luminescence quenching mechanism of bare NaYF4: Tm (1.75%) core. After growing an inert shell, a ten-fold increase of emission intensity was achieved. Combining the advantages of NIR-II wavelength and the higher-order nonlinear excitation, a promising facile excitation strategy was developed for the application of thulium-doped upconversion nanoparticles in nanoparticles imaging and cancer cell microscopic imaging.Keywords:upconversion nanoparticles;near-infrared-II;excitation mechanisms;luminescence quenching;microscopic imaging
✓ 已验证
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2025
·Vol. 51
·期 25
·44694-44701
·
IF 5.6
Honglei Yuan,Huizhong Ma,Gaoliang Wang,Huanxia Jia,Liwei Wang
This study systematically investigates the structural and luminescent characteristics of LaSc 3 (BO 3 ) 4 :x %Cr 3+ and La (1-y) Gd y Sc 3 (BO 3 ) 4 :1.0 %Cr 3+ phosphors. X-ray diffraction confirms the formation of a pure hunter-type structure for all samples, with Cr 3+ occupying Sc 3+ sites and Gd 3+ substituting La 3+ , inducing lattice contraction. Luminescent analysis reveals that LaSc 3 (BO 3 ) 4 :Cr 3+ exhibits an emission at 980 nm under 430 nm excitation, attributed to the 4 T 2 → 4 A 2 transition of Cr 3+ in a weak crystal field. The substitution of Gd 3+ enhances photoluminescence intensity by 2.15-fold, and blue-shifts emission to 938 nm because of increased crystal field splitting and structural rigidity. The broadened full width at half maximum is also formed due to the enhanced degree of disorder in GdSc 3 (BO 3 ) 4 . Thermal stability studies show that GdSc 3 (BO 3 ) 4 :Cr 3+ retains 49 % intensity at 540 K, outperforming LaSc 3 (BO 3 ) 4 :Cr 3+ (41 %), supported by higher activation energy (ΔE = 0.338 eV vs. 0.296 eV). The improved thermal resistance is linked to lattice rigidity and reduced electron-phonon coupling. NIR-pc-LEDs fabricated with GdSc 3 (BO 3 ) 4 :Cr 3+ demonstrate superior radiant flux (68.7 mW at 200 mA) compared to La-based devices. These results highlight the critical role of host lattice engineering in optimizing Cr 3+ luminescence for high-power NIR applications.
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2023
·Vol. 19
·期 19
·2300203
·
IF 13.3
Jun Guan,Chang Liu,Chendong Ji,Wenchao Zhang,Zongyang Fan,Penggang He,Qiuhong Ouyang,Meng Qin,Meizhen Yin
Extensive efforts have been devoted to the design of organic photothermal agents (PTAs) that absorb in the second near-infrared (NIR-II) bio-window, which can provide deeper tissue penetration that is significant for phototheranostics of lethal brain tumors. Herein, the first example of NIR-II-absorbing small organic molecule (N1) derived from perylene monoamide (PMI) and its bio-application after nano-encapsulation of N1 to function as a nano-agent for phototheranostics of deep orthotopic glioblastoma (GBM) is reported. By adopting a dual modification strategy of introducing a donor-acceptor unit and extending π-conjugation, the obtained N1 can absorb in 1000–1400 nm region and exhibit high photothermal conversation due to the apparent intramolecular charge transfer (ICT). A choline analogue, 2-methacryloyloxyethyl phosphorylcholine, capable of interacting specifically with receptors on the surface of the blood-brain barrier (BBB), is used to fabricate the amphiphilic copolymer for the nano-encapsulation of N1. The obtained nanoparticles demonstrate efficient BBB-crossing due to the receptor-mediated transcytosis as well as the small nanoparticle size of approximately 26 nm. The prepared nanoparticles exhibit excellent photoacoustic imaging and significant growth inhibition of deep orthotopic GBM. The current study demonstrates the enormous potential of PMI-based NIR-II PTAs and provides an efficient phototheranostic paradigm for deep orthotopic GBM.
✓ 已验证
DOI
PubMed
高影响因子
Small
·
2020
·Vol. 16
·期 37
·2002748
·
IF 11.459
Kai Cai,Weiyun Zhang,Mohamed F. Foda,Xuyu Li,Jin Zhang,Yeteng Zhong,Huageng Liang,Huiqiao Li,Heyou Han,Tianyou Zhai
The miniaturization of gold nanorods exhibits a bright prospect for intravital photoacoustic imaging (PAI) and the hollow structure possesses a better plasmonic property. Herein, miniature hollow gold nanorods (M-AuHNRs) (≈46 nm in length) possessing strong plasmonic absorbance in the second near-infrared (NIR-II) window (1000–1350 nm) are developed, which are considered as the most suitable range for the intravital PAI. The as-prepared M-AuHNRs exhibit 3.5 times stronger photoacoustic signal intensity than the large hollow Au nanorods (≈105 nm in length) at 0.2 optical density under 1064 nm laser irradiation. The in vivo biodistribution measurement shows that the accumulation in tumor of miniature nanorods is twofold as high as that of the large counterpart. After modifying with a tumor-targeting molecule and fluorochrome, in living tumor-bearing mice, the M-AuHNRs group gives a high fluorescence intensity in tumors, which is 3.6-fold that of the large ones with the same functionalization. Moreover, in the intravital PAI of living tumor-bearing mice, the M-AuHNRs generate longer-lasting and stronger photoacoustic signal than the large counterpart in the NIR-II window. Overall, this study presents the fabrication of M-AuHNRs as a promising contrast agent for intravital PAI.
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Qian Wang,Botao Qu,Juan Li,Yuqin Liu,Jie Dong,Xiaoyang Peng,Ruiping Zhang
Regulating the level of reactive oxygen species (ROS) in a tumor is an efficient and innovative anticancer strategy. However, the therapeutic efficacy of ROS-based therapies, such as chemodynamic therapy (CDT) and photodynamic therapy (PDT), offers finite outcomes due to the oxygen dependence and limited concentration of hydrogen peroxide (H2O2) and overexpression of glutathione (GSH) within the tumor microenvironment (TME), so a single therapeutic strategy is insufficient to completely eliminate tumors. Therefore, we demonstrated an omnipotent nanoplatform MnO2/Ag3SbS3 (abbreviated as MA) with strong optical absorbance in the NIR-II biowindow and oxygen self-sufficient ROS-mediated ability, which not only relieves tumor hypoxia significantly but also enhances the photothermal therapy (PTT)/PDT/CDT efficacy. By 1064 nm laser irradiation, MnO2/Ag3SbS3 nanoparticles (NPs) reveal a favorable photothermal conversion efficiency of 23.15% and achieve a single-laser-triggered NIR-II PTT/PDT effect, resulting in effective tumor elimination. Once internalized into the tumor, MnO2/Ag3SbS3 NPs will be degraded to Mn2+ and Ag3SbS3. The released Ag3SbS3 NPs as a NIR-II phototherapy agent could be utilized for photoacoustic imaging-guided NIR-II PDT/PTT. Mn2+ could be used as a Fenton-like catalyst to continuously catalyze endogenous H2O2 for generating highly virulent hydroxyl radicals (•OH) for CDT and O2 for PDT, enhancing the efficiency of PDT and CDT, respectively. Meanwhile, Mn2+ realizes magnetic resonance imaging-guided accurate tumor therapy. Moreover, the MnO2/Ag3SbS3 NPs could deplete intracellular GSH in TME to promote oxidative stress of the tumor, further strengthening ROS-mediated antitumor treatment efficacy. Overall, this work presents a distinctive paradigm of TME-responsive PDT/CDT/PTT in the second near-infrared biowindow by depleting GSH and decomposing H2O2 for efficient and precise cancer treatment.
✓ 已验证
DOI
PubMed
高影响因子
NANOTECHNOLOGY
·
2022
·Vol. 33
·期 22
·225101
·
IF 3.953
Yaqun Ma,Yanxing Wang,Xin Hui,Bi Lin,Ying Yuan,Xiaofeng Tao,Ruichan Lv
In this research, a fluorescent probe of 7-(diethylamine) coumarin derivatives with multiple binding sites to detect biothiols in tumor cell with strong NIR II luminescence in vivo was synthesized. The biothiols include cysteine (Cys) and glutathione (GSH) in tumor cells, and the tumor-response luminescence was proved by the cell experiment. Importantly, the monolayer functional phospholipid (DSPE-PEG) coating and aggregation induced emission (AIE) dye of TPE modification made the probe have good stability and biocompatibility with little luminescence quenching in aqueous phase, which was proved by in vitro and in vivo experiments. The final aqueous NIR II probe combined with bevacizumab (for VEGF recognition in the cancer cells) and Capmatinib (for Met protein recognition in the cancer cells) has stronger targeted imaging on head and neck squamous cell carcinoma (HNSCC) cancer with intravenous injection. This GSH/Cys detection in the tumor cell and strong dual-molecular NIR II bioimaging in vivo may provide new strategy to tumor detection.
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）